flucytosine has been researched along with Colonic Neoplasms in 32 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In animal models, 12 days of 5-FC administration was superior to 6 days, but dosing beyond 12 days did not further enhance efficacy." | 1.38 | Oncolytic herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation. ( Fuchs, BC; He, X; Kuroda, T; Lanuti, M; McGinn, CM; Schmitt, A; Supko, JG; Tanabe, KK; Yamada, S, 2012) |
| "Orthotopic colon cancer models were developed." | 1.32 | Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer. ( Iwahashi, M; Matsuura, I; Nakamori, M; Nakamura, M; Ojima, T; Ueda, K; Yamaue, H, 2003) |
| "Clinical studies with oncolytic adenoviruses have shown that existing viruses are safe but lack efficacy." | 1.32 | 5-Fluorocytosine increases the toxicity of Wnt-targeting replicating adenoviruses that express cytosine deaminase as a late gene. ( Fuerer, C; Iggo, R, 2004) |
| "In vitro, AdCDUPRT infection of colon cancer cells resulted in a marked increase in sensitisation to 5-FU, compared with AdCD-infected or uninfected cells." | 1.31 | In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase. ( Anderson, D; Burton, A; Chen, MJ; Chung-Faye, GA; Green, NK; Kerr, DJ; Mautner, V; Searle, PF, 2001) |
| "HT29 human colon cancer cells transduced with yCD (HT29/yCD) were significantly more sensitive to 5-FC in vitro than HT29 cells transduced with bCD (HT29/bCD)." | 1.30 | Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. ( Bershad, E; Dev, I; Kievit, E; Lawrence, TS; Ng, E; Rehemtulla, A; Sethna, P, 1999) |
| "5-Fluorouracil (5-FU) is an effective antitumor agent used in treating various cancers." | 1.29 | 5-Fluoro-2-pyrimidinone, a liver aldehyde oxidase-activated prodrug of 5-fluorouracil. ( Chang, CN; Chang, CP; Chen, HX; Cheng, YC; Guo, X; Lerner-Tung, M; Lin, TS; Pizzorno, G; Zhu, JL, 1995) |
| "The growth of the human colon cancer cells was quantified by dot blot analysis of genomic DNA extracted from tumor-bearing liver, hybridized with a human-specific Alu probe." | 1.29 | Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. ( Crystal, RG; Hirschowitz, EA; Ohwada, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 19 (59.38) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bezborodova, OA | 1 |
| Nemtsova, ER | 1 |
| Gevorkov, AR | 1 |
| Boyko, AV | 1 |
| Venediktova, JB | 1 |
| Alekseenko, IV | 1 |
| Kostina, MB | 1 |
| Monastyrskaya, GS | 1 |
| Sverdlov, ED | 1 |
| Khmelevskiy, EV | 1 |
| Yakubovskaya, RI | 1 |
| Deng, LY | 1 |
| Wang, JP | 1 |
| Gui, ZF | 1 |
| Shen, LZ | 1 |
| Leng, A | 1 |
| Yang, J | 1 |
| Liu, T | 1 |
| Cui, J | 1 |
| Li, XH | 1 |
| Zhu, Y | 1 |
| Xiong, T | 1 |
| Chen, Y | 1 |
| Yamada, S | 1 |
| Kuroda, T | 1 |
| Fuchs, BC | 1 |
| He, X | 1 |
| Supko, JG | 1 |
| Schmitt, A | 1 |
| McGinn, CM | 1 |
| Lanuti, M | 1 |
| Tanabe, KK | 1 |
| King, I | 1 |
| Bermudes, D | 1 |
| Lin, S | 1 |
| Belcourt, M | 1 |
| Pike, J | 1 |
| Troy, K | 1 |
| Le, T | 1 |
| Ittensohn, M | 1 |
| Mao, J | 1 |
| Lang, W | 1 |
| Runyan, JD | 1 |
| Luo, X | 1 |
| Li, Z | 1 |
| Zheng, LM | 1 |
| Zhang, M | 1 |
| Li, S | 1 |
| Nyati, MK | 1 |
| DeRemer, S | 1 |
| Parsels, J | 1 |
| Rehemtulla, A | 2 |
| Ensminger, WD | 1 |
| Lawrence, TS | 2 |
| Ueda, K | 1 |
| Iwahashi, M | 1 |
| Nakamori, M | 1 |
| Nakamura, M | 1 |
| Matsuura, I | 1 |
| Ojima, T | 1 |
| Yamaue, H | 1 |
| Akbulut, H | 1 |
| Zhang, L | 1 |
| Tang, Y | 1 |
| Deisseroth, A | 1 |
| Fuerer, C | 1 |
| Iggo, R | 1 |
| Huang, JH | 1 |
| Wang, Y | 1 |
| Li, CH | 1 |
| Zhong, DG | 1 |
| Lü, HY | 1 |
| Yanagie, H | 1 |
| Eriguchi, M | 1 |
| Coelho, V | 1 |
| Dernedde, J | 1 |
| Petrausch, U | 1 |
| Panjideh, H | 1 |
| Fuchs, H | 1 |
| Menzel, C | 1 |
| Dübel, S | 1 |
| Keilholz, U | 1 |
| Thiel, E | 1 |
| Deckert, PM | 1 |
| Hirschowitz, EA | 2 |
| Ohwada, A | 3 |
| Pascal, WR | 1 |
| Russi, TJ | 1 |
| Crystal, RG | 4 |
| Guo, X | 1 |
| Lerner-Tung, M | 1 |
| Chen, HX | 1 |
| Chang, CN | 1 |
| Zhu, JL | 1 |
| Chang, CP | 1 |
| Pizzorno, G | 1 |
| Lin, TS | 1 |
| Cheng, YC | 1 |
| Hirschowitz, E | 1 |
| Lieberman, M | 1 |
| Daly, J | 1 |
| Kazam, E | 1 |
| Henschke, C | 1 |
| Yankelevitz, D | 1 |
| Kemeny, N | 1 |
| Silverstein, R | 1 |
| Russi, T | 1 |
| Mastrangeli, A | 1 |
| Sanders, A | 1 |
| Cooke, J | 1 |
| Harvey, BG | 1 |
| Topf, N | 1 |
| Worgall, S | 1 |
| Hackett, NR | 1 |
| Kievit, E | 1 |
| Bershad, E | 1 |
| Ng, E | 1 |
| Sethna, P | 1 |
| Dev, I | 1 |
| Gnant, MF | 1 |
| Puhlmann, M | 2 |
| Alexander, HR | 2 |
| Bartlett, DL | 2 |
| Pierrefite-Carle, V | 6 |
| Baqué, P | 6 |
| Gavelli, A | 6 |
| Mala, M | 2 |
| Chazal, M | 2 |
| Gugenheim, J | 2 |
| Bourgeon, A | 6 |
| Milano, G | 3 |
| Staccini, P | 5 |
| Rossi, B | 6 |
| Benchimol, D | 5 |
| Saint-Paul, MC | 3 |
| Brossette, N | 4 |
| Koyama, F | 2 |
| Sawada, H | 2 |
| Fujii, H | 2 |
| Hirao, T | 2 |
| Ueno, M | 1 |
| Hamada, H | 2 |
| Nakano, H | 2 |
| O'Boyle, KP | 1 |
| Senter, PD | 1 |
| Bhargava, K | 1 |
| Chun, S | 1 |
| Anthony, G | 1 |
| Markowitz, AL | 1 |
| Wadler, S | 1 |
| McCart, JA | 1 |
| Lee, J | 1 |
| Hu, Y | 1 |
| Libutti, SK | 1 |
| Huguet, C | 1 |
| Humphreys, MJ | 1 |
| Ghaneh, P | 1 |
| Greenhalf, W | 1 |
| Campbell, F | 1 |
| Clayton, TM | 1 |
| Everett, P | 1 |
| Huber, BE | 1 |
| Richards, CA | 1 |
| Ford, MJ | 1 |
| Neoptolemos, JP | 1 |
| Chung-Faye, GA | 1 |
| Chen, MJ | 1 |
| Green, NK | 1 |
| Burton, A | 1 |
| Anderson, D | 1 |
| Mautner, V | 1 |
| Searle, PF | 1 |
| Kerr, DJ | 1 |
| Miller, CR | 1 |
| Gustin, AN | 1 |
| Buchsbaum, DJ | 1 |
| Vickers, SM | 1 |
| Manne, U | 1 |
| Grizzle, WE | 1 |
| Cloud, GA | 1 |
| Diasio, RB | 1 |
| Johnson, MR | 1 |
| Saint Paul, MC | 1 |
1 review available for flucytosine and Colonic Neoplasms
| Article | Year |
|---|---|
[Gene therapy for liver metastasis of colon cancer].
Topics: Adenoviridae; Adenoviruses, Human; Clinical Trials as Topic; Colonic Neoplasms; Cytosine Deaminase; | 2005 |
1 trial available for flucytosine and Colonic Neoplasms
| Article | Year |
|---|---|
Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
Topics: Adenoviridae; Administration, Oral; Adolescent; Adult; Antimetabolites; Colonic Neoplasms; Cytosine | 1997 |
30 other studies available for flucytosine and Colonic Neoplasms
| Article | Year |
|---|---|
Antitumor efficacy of combined gene and radiotherapy in animals.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Combi | 2016 |
Antitumor activity of mutant bacterial cytosine deaminase gene for colon cancer.
Topics: Animals; Antimetabolites; Bacterial Proteins; Cell Line, Tumor; Colonic Neoplasms; Cytosine Deaminas | 2011 |
Nanoparticle-delivered VEGF-silencing cassette and suicide gene expression cassettes inhibit colon carcinoma growth in vitro and in vivo.
Topics: Animals; Antimetabolites; Calcium Phosphates; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasm | 2011 |
Oncolytic herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chlorocebus aethiops; Colonic Neoplasms; | 2012 |
Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent.
Topics: Animals; Antineoplastic Agents; Biotransformation; Colonic Neoplasms; Cytosine Deaminase; Escherichi | 2002 |
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; | 2003 |
Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer.
Topics: Adenoviridae; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; Cytosine | 2003 |
Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon.
Topics: Adenoviridae; Adenovirus E1A Proteins; Animals; Breast Neoplasms; Cell Death; Colonic Neoplasms; Cyt | 2003 |
5-Fluorocytosine increases the toxicity of Wnt-targeting replicating adenoviruses that express cytosine deaminase as a late gene.
Topics: Adenoviridae; Cell Line, Tumor; Colonic Neoplasms; Cytosine Deaminase; Flucytosine; Gene Expression; | 2004 |
[Experimental studies on the treatment of colon cancer by cytosine deaminase gene and 5-fluorocytosine].
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Cytosin | 2005 |
Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer.
Topics: Antibodies, Monoclonal; Antibody Specificity; Artificial Gene Fusion; Chromatography, Affinity; Clon | 2007 |
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.
Topics: Adenoviridae; Animals; Antineoplastic Agents; beta-Galactosidase; Cell Division; Cell Line; Colonic | 1995 |
5-Fluoro-2-pyrimidinone, a liver aldehyde oxidase-activated prodrug of 5-fluorouracil.
Topics: Administration, Oral; Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Biological Availability; | 1995 |
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.
Topics: Animals; Antineoplastic Agents; Blotting, Northern; Cell Division; Colonic Neoplasms; Cytosine Deami | 1996 |
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.
Topics: Adenoviridae; Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Escherichia coli; Flu | 1998 |
Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts.
Topics: Animals; Bacteria; Colonic Neoplasms; Cytosine Deaminase; Female; Flucytosine; Fluorouracil; Genetic | 1999 |
Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Cytosine Deaminase; Fem | 1999 |
Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.
Topics: Animals; Antifungal Agents; Antimetabolites; Antineoplastic Agents; Cancer Vaccines; Colonic Neoplas | 1999 |
Regression of experimental liver tumor after distant intra-hepatic injection of cytosine deaminase-expressing tumor cells and 5-fluorocytosine treatment.
Topics: Animals; Colonic Neoplasms; Cytosine Deaminase; Flucytosine; Genetic Therapy; Injections; Liver Neop | 2000 |
Re: Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.
Topics: Animals; Antimetabolites, Antineoplastic; Cancer Vaccines; Colonic Neoplasms; Cytosine Deaminase; Di | 2000 |
Enzyme/prodrug gene therapy for human colon cancer cells using adenovirus-mediated transfer of the Escherichia coli cytosine deaminase gene driven by a CAG promoter associated with 5-fluorocytosine administration.
Topics: Adenoviridae; Animals; Colonic Neoplasms; Cytosine Deaminase; Escherichia coli; Flucytosine; Gene Tr | 2000 |
Effects of a hybrid recombinant human alpha interferon (A/D) on in vitro cytotoxicity and in vivo localization of monoclonal antibody L6-cytosine deaminase conjugate in a colon cancer model.
Topics: Adenosine Deaminase; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Cell Survival; Col | 1998 |
Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine.
Topics: Adenoviridae; Animals; Colonic Neoplasms; Combined Modality Therapy; Cytosine Deaminase; DNA; DNA Pr | 2000 |
Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cytosine Deaminase; Dose-Response Relationship, Drug; Dr | 2000 |
[Vaccination by suicide gene therapy against a model of hepatic metastasis from colon cancer in the rat].
Topics: Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Disease Models, Animal; Flucytosine | 2000 |
Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases.
Topics: Animals; Antimetabolites; Carcinoembryonic Antigen; Carcinoma; Colonic Neoplasms; Cytosine Deaminase | 2001 |
In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase.
Topics: Adenoviridae; Analysis of Variance; Animals; Artificial Gene Fusion; Bystander Effect; Colonic Neopl | 2001 |
Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro.
Topics: Antimetabolites; Carcinoma; Cell Survival; Colonic Neoplasms; Cytomegalovirus; Cytosine Deaminase; F | 2002 |
Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Bystander Effect; Colonic Neoplasms; Cytosine Deaminase; D | 2002 |
Naked DNA injection for liver metastases treatment in rats.
Topics: Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Disease Models, Animal; Flucytosine | 2002 |