flucytosine has been researched along with Chemical and Drug Induced Liver Injury in 10 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Invasive fungal infection is a well-known cause of morbidity and mortality in immunocompromised patients." | 5.43 | Evaluation of Hepatotoxicity with Treatment Doses of Flucytosine and Amphotericin B for Invasive Fungal Infections. ( Ardelean, A; Balta, C; Boldura, OM; Cotoraci, C; Dinescu, S; Folk, A; Herman, H; Hermenean, A; Paiusan, L; Suciu, M, 2016) |
| "Invasive fungal infection is a well-known cause of morbidity and mortality in immunocompromised patients." | 1.43 | Evaluation of Hepatotoxicity with Treatment Doses of Flucytosine and Amphotericin B for Invasive Fungal Infections. ( Ardelean, A; Balta, C; Boldura, OM; Cotoraci, C; Dinescu, S; Folk, A; Herman, H; Hermenean, A; Paiusan, L; Suciu, M, 2016) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Folk, A | 1 |
| Cotoraci, C | 1 |
| Balta, C | 1 |
| Suciu, M | 1 |
| Herman, H | 1 |
| Boldura, OM | 1 |
| Dinescu, S | 1 |
| Paiusan, L | 1 |
| Ardelean, A | 1 |
| Hermenean, A | 1 |
| Song, JC | 1 |
| Deresinski, S | 1 |
| Block, ER | 1 |
| Eilard, T | 1 |
| Alestig, K | 1 |
| Wahlén, P | 1 |
2 reviews available for flucytosine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Hepatotoxicity of antifungal agents.
Topics: Allylamine; Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Flucytosine; Humans; | 2005 |
8 other studies available for flucytosine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Evaluation of Hepatotoxicity with Treatment Doses of Flucytosine and Amphotericin B for Invasive Fungal Infections.
Topics: Amphotericin B; Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Flucytosine; Fun | 2016 |
Effect of hepatic insufficiency on 5-fluorocytosine concentrations in serum.
Topics: Animals; Antifungal Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1973 |
Treatment of disseminated candidiasis with 5-fluorocytosine.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Candidiasis; Chemical and Drug Induced Liver I | 1974 |