flucytosine has been researched along with Cell Transformation, Neoplastic in 2 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " siRNA targeting of choline kinase-α (Chk-α), an enzyme significantly up-regulated in aggressive breast cancer cells, was combined with the prodrug enzyme bacterial cytosine deaminase (bCD) that converts the nontoxic prodrug 5-fluorocytosine (5-FC) to cytotoxic 5-fluorouracil (5-FU)." | 3.76 | Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy. ( Artemov, D; Bhujwalla, ZM; Chen, Z; Li, C; Penet, MF; Takagi, T; Wildes, F; Winnard, PT, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Cai, S | 2 |
| Yang, L | 1 |
| Yu, S | 1 |
| Jiang, J | 1 |
| Yan, X | 1 |
| Zhang, H | 1 |
| Liu, L | 1 |
| Liu, Q | 1 |
| Du, J | 1 |
| Sung, KL | 1 |
| Li, C | 1 |
| Penet, MF | 1 |
| Wildes, F | 1 |
| Takagi, T | 1 |
| Chen, Z | 1 |
| Winnard, PT | 1 |
| Artemov, D | 1 |
| Bhujwalla, ZM | 1 |
2 other studies available for flucytosine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Targeting eradication of malignant cells derived from human bone marrow mesenchymal stromal cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Antigens, CD; Antimetabolites; A | 2010 |
Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy.
Topics: Animals; Bacteria; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplasti | 2010 |