flucytosine has been researched along with Carcinoma, Hepatocellular in 9 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the antitumor effects of cytosine deaminase (CD) gene in combination with prodrug flucytosine (Flu, 5-fluorocytosine) on human hepatocellular carcinoma." | 7.70 | Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine. ( Gao, HZ; Gu, B; Liang, YQ; Lü, HZ; Wan, YL; Wang, JX; Wu, DZ, 1999) |
| " Although it has been shown in several in vitro studies that the bacterial cytosine deaminase (CD) gene/5-fluorocytosine (5-FC) system is superior to the herpes simplex virus thymidine kinase (HSV-TK) gene/ganciclovir (GCV) system, we examined here which suicide gene system was more promising in vivo for the treatment of hepatocellular carcinoma (HCC)." | 3.70 | Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. ( Akahane, T; Fukui, H; Kojima, H; Kuriyama, S; Mitoro, A; Nakatani, T; Okamoto, S; Toyokawa, Y; Tsujinoue, H; Yamazaki, M, 1999) |
| "To investigate the antitumor effects of cytosine deaminase (CD) gene in combination with prodrug flucytosine (Flu, 5-fluorocytosine) on human hepatocellular carcinoma." | 3.70 | Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine. ( Gao, HZ; Gu, B; Liang, YQ; Lü, HZ; Wan, YL; Wang, JX; Wu, DZ, 1999) |
| "Treatment of Hep3B, human liver cancer cells, with the prodrug 5-fluorocytosine (5-FC) in the presence of HB1." | 1.38 | Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells. ( Choi, KC; Hwang, KA; Jeung, EB; Kang, NH; Kim, HC; Kim, SU; Yi, BR, 2012) |
| "In mice bearing liver cancer, (60)Co-irradiated MM45T." | 1.31 | [Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes]. ( Chen, S; Sun, W; Tang, Y; Tang, Z; Wei, D, 2001) |
| "After transfecting three human hepatoma cell lines and one non-hepatoma cell line with LX2." | 1.30 | [Experimental studies in vitro on the alpha-fetoprotein-specific promoter mediated target gene therapy of hepatocellular carcinoma]. ( Fang, F; Liu, D; Lu, C; Pan, G; Quan, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, XP | 1 |
| Liu, L | 1 |
| Wang, P | 1 |
| Ma, SL | 1 |
| Sia, KC | 1 |
| Huynh, H | 1 |
| Chinnasamy, N | 1 |
| Hui, KM | 1 |
| Lam, PY | 1 |
| Lu, YC | 1 |
| Chen, YJ | 1 |
| Yu, YR | 1 |
| Lai, YH | 1 |
| Cheng, JC | 1 |
| Li, YF | 1 |
| Shen, CH | 1 |
| Tai, CK | 1 |
| Yi, BR | 1 |
| Hwang, KA | 1 |
| Kang, NH | 1 |
| Kim, SU | 1 |
| Jeung, EB | 1 |
| Kim, HC | 1 |
| Choi, KC | 1 |
| Li, XJ | 1 |
| Wang, KM | 1 |
| Xu, Y | 1 |
| Wang, ZH | 1 |
| Xia, AD | 1 |
| Chen, SS | 1 |
| Qian, GX | 1 |
| Quan, S | 1 |
| Pan, G | 1 |
| Lu, C | 1 |
| Liu, D | 1 |
| Fang, F | 1 |
| Kuriyama, S | 1 |
| Mitoro, A | 1 |
| Yamazaki, M | 1 |
| Tsujinoue, H | 1 |
| Nakatani, T | 1 |
| Akahane, T | 1 |
| Toyokawa, Y | 1 |
| Kojima, H | 1 |
| Okamoto, S | 1 |
| Fukui, H | 1 |
| Lü, HZ | 1 |
| Wu, DZ | 1 |
| Wan, YL | 1 |
| Gu, B | 1 |
| Gao, HZ | 1 |
| Liang, YQ | 1 |
| Wang, JX | 1 |
| Sun, W | 1 |
| Tang, Z | 1 |
| Wei, D | 1 |
| Tang, Y | 1 |
| Chen, S | 1 |
9 other studies available for flucytosine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cytosine Deaminase | 2015 |
Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Foot-and-Mout | 2012 |
Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carcinoma, Hepatocellular; Cell Survival; Cytosin | 2012 |
Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Migration Assays; | 2012 |
[Ionizing radiation-regulated killing of human hepatoma cells by liposome-mediated CDglyTK gene delivery].
Topics: Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Survival; Cytomegalovirus; Cy | 2003 |
[Experimental studies in vitro on the alpha-fetoprotein-specific promoter mediated target gene therapy of hepatocellular carcinoma].
Topics: alpha-Fetoproteins; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Cytosine Deamin | 1999 |
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Topics: Animals; Antifungal Agents; Antiviral Agents; Carcinoma, Hepatocellular; Cytosine Deaminase; Escheri | 1999 |
Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cytosine Deaminase; Female; Flucytosine; | 1999 |
[Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes].
Topics: Animals; Carcinoma, Hepatocellular; Combined Modality Therapy; Cytosine Deaminase; Disease Models, A | 2001 |