flucytosine has been researched along with Cancer of Pancreas in 18 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The bleak prognosis associated with pancreatic cancer (PDAC) drives the need for the development of novel treatment methodologies." | 1.42 | Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer. ( Guillen, KP; Harrison, RG; Kurkjian, C; Restuccia, A, 2015) |
| "Pancreatic cancer is the fourth most common cause of cancer-related mortality." | 1.39 | Pancreatic tumor mass in a xenograft mouse model is decreased by treatment with therapeutic stem cells following introduction of therapeutic genes. ( Choi, KC; Kim, DJ; Kim, SU; Lee, HR; Yi, BR, 2013) |
| "Furthermore, two freshly isolated human pancreatic cancer specimens had significantly increased levels of PDX-1." | 1.32 | Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter. ( Brunicardi, FC; Fisher, WE; Kohn, D; Wang, XP; Yang, J; Yazawa, K, 2004) |
| "The human pancreatic cancer SW1990 cells (CEA-producing) were infected with recombinant adenoviruses (Adex1CEA-prCD or Adex1CEA-prZ)." | 1.31 | Apoptosis induced by 5-flucytosine in human pancreatic cancer cells genetically modified to express cytosine deaminase. ( Huang, ZQ; Wen, ZF; Yuan, SZ; Zeng, ZY; Zhang, SN; Zhu, ZH, 2000) |
| "An in vivo model of pancreatic cancer was established by injecting 2." | 1.30 | In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer. ( Crystal, RG; Daly, JM; Evoy, D; Hirschowitz, EA; Li, XK; Lieberman, MD; Naama, HA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 10 (55.56) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Kurosaki, H | 1 |
| Nakatake, M | 1 |
| Sakamoto, T | 1 |
| Kuwano, N | 1 |
| Yamane, M | 1 |
| Ishii, K | 1 |
| Fujiwara, Y | 1 |
| Nakamura, T | 1 |
| Kim, DJ | 1 |
| Yi, BR | 1 |
| Lee, HR | 1 |
| Kim, SU | 1 |
| Choi, KC | 1 |
| Réjiba, S | 1 |
| Bigand, C | 1 |
| Parmentier, C | 1 |
| Masmoudi, A | 1 |
| Hajri, A | 2 |
| Guillen, KP | 1 |
| Restuccia, A | 1 |
| Kurkjian, C | 1 |
| Harrison, RG | 1 |
| Kaliberova, LN | 1 |
| Della Manna, DL | 1 |
| Krendelchtchikova, V | 1 |
| Black, ME | 1 |
| Buchsbaum, DJ | 2 |
| Kaliberov, SA | 1 |
| Hlavaty, J | 1 |
| Petznek, H | 1 |
| Holzmüller, H | 1 |
| Url, A | 1 |
| Jandl, G | 1 |
| Berger, A | 1 |
| Salmons, B | 1 |
| Günzburg, WH | 1 |
| Renner, M | 1 |
| Zhang, L | 2 |
| Liu, T | 2 |
| Cui, Q | 2 |
| Gao, J | 1 |
| Wack, S | 1 |
| Lehn, P | 1 |
| Vigneron, JP | 1 |
| Lehn, JM | 1 |
| Marescaux, J | 1 |
| Aprahamian, M | 1 |
| Wang, XP | 1 |
| Yazawa, K | 1 |
| Yang, J | 1 |
| Kohn, D | 1 |
| Fisher, WE | 1 |
| Brunicardi, FC | 1 |
| Eisold, S | 1 |
| Antolovic, D | 1 |
| Schmidt, J | 1 |
| Wiessner, R | 1 |
| Klar, E | 1 |
| von Knebel-Doeberitz, M | 1 |
| Linnebacher, M | 1 |
| Fogar, P | 1 |
| Navaglia, F | 1 |
| Basso, D | 1 |
| Greco, E | 1 |
| Zambon, CF | 1 |
| Fadi, E | 1 |
| Falda, A | 1 |
| Stranges, A | 1 |
| Vannozzi, F | 1 |
| Danesi, R | 1 |
| Pedrazzoli, S | 1 |
| Plebani, M | 1 |
| Harris, JD | 1 |
| Gutierrez, AA | 1 |
| Hurst, HC | 1 |
| Sikora, K | 1 |
| Lemoine, NR | 1 |
| Evoy, D | 1 |
| Hirschowitz, EA | 1 |
| Naama, HA | 1 |
| Li, XK | 1 |
| Crystal, RG | 1 |
| Daly, JM | 1 |
| Lieberman, MD | 1 |
| Kanyama, H | 1 |
| Tomita, N | 1 |
| Yamano, T | 1 |
| Aihara, T | 1 |
| Miyoshi, Y | 1 |
| Ohue, M | 1 |
| Sekimoto, M | 1 |
| Sakita, I | 1 |
| Tamaki, Y | 1 |
| Kaneda, Y | 1 |
| Senter, PD | 1 |
| Monden, M | 1 |
| Zhang, SN | 1 |
| Yuan, SZ | 1 |
| Zhu, ZH | 1 |
| Wen, ZF | 1 |
| Huang, ZQ | 1 |
| Zeng, ZY | 1 |
| Zhang, S | 1 |
| Yuan, S | 1 |
| Miller, CR | 1 |
| Gustin, AN | 1 |
| Vickers, SM | 1 |
| Manne, U | 1 |
| Grizzle, WE | 1 |
| Cloud, GA | 1 |
| Diasio, RB | 1 |
| Johnson, MR | 1 |
18 other studies available for flucytosine and Cancer of Pancreas
| Article | Year |
|---|---|
Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice.
Topics: Animals; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Proliferation; Combined Modality Therapy; Cyt | 2021 |
Pancreatic tumor mass in a xenograft mouse model is decreased by treatment with therapeutic stem cells following introduction of therapeutic genes.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Movement; Cell Proliferati | 2013 |
Oncosuppressive suicide gene virotherapy "PVH1-yCD/5-FC" for pancreatic peritoneal carcinomatosis treatment: NFκB and Akt/PI3K involvement.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cytosine Deaminase; DNA, Recombinant; Female; Flucytosine; | 2013 |
Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer.
Topics: Adenine; Adenocarcinoma; Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Carbon-Sulfur L | 2015 |
Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene.
Topics: Adenoviridae; Amino Acid Substitution; Animals; Apoptosis Regulatory Proteins; Cell Death; Cell Line | 2008 |
Evaluation of a gene-directed enzyme-product therapy (GDEPT) in human pancreatic tumor cells and their use as in vivo models for pancreatic cancer.
Topics: Animals; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzym | 2012 |
[Cytosine diaminase/5-flurocytosine mediated inhibiting effect on the growth of human pancreatic carcinoma cells].
Topics: Animals; Cell Division; Cytosine Deaminase; Escherichia coli; Female; Flucytosine; Gene Transfer Tec | 2000 |
Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes.
Topics: Animals; Biopsy; Carcinoembryonic Antigen; Cell Division; Cell Line, Tumor; Cholesterol; Cytosine De | 2004 |
Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter.
Topics: Antimetabolites; Blotting, Western; Cytosine Deaminase; Flucytosine; Genes, Transgenic, Suicide; Gen | 2004 |
Effective antitumoral immune responses are not induced by cytosine deaminase suicide gene transfer in a syngeneic rat pancreatic carcinoma model.
Topics: Adenoviridae; Animals; Apoptosis; CD4-Positive T-Lymphocytes; Cytosine Deaminase; Cytotoxicity, Immu | 2006 |
Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biotransformation; Cell Line, Tumor; Colorectal Neo | 2007 |
Gene therapy for cancer using tumour-specific prodrug activation.
Topics: Base Sequence; Biotransformation; Breast Neoplasms; Cytosine Deaminase; DNA Primers; Female; Flucyto | 1994 |
In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer.
Topics: Adenoviridae; Animals; Carcinoma, Ductal, Breast; Cell Division; Cytosine Deaminase; Escherichia col | 1997 |
Usefulness of repeated direct intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cytosine Deaminase; Feasibility Studies; Fe | 2001 |
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2].
Topics: Cell Division; Cytosine Deaminase; Escherichia coli; Flucytosine; Ganciclovir; Genetic Therapy; Nucl | 1998 |
Apoptosis induced by 5-flucytosine in human pancreatic cancer cells genetically modified to express cytosine deaminase.
Topics: Adenoviruses, Human; Antimetabolites; Apoptosis; Cytosine Deaminase; DNA Fragmentation; Flucytosine; | 2000 |
[Experimental study on human pancreatic carcinoma treated by cytosine deaminase gene therapy].
Topics: Adenocarcinoma; Adenoviruses, Human; Animals; Antimetabolites, Antineoplastic; Carcinoembryonic Anti | 2000 |
Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro.
Topics: Antimetabolites; Carcinoma; Cell Survival; Colonic Neoplasms; Cytomegalovirus; Cytosine Deaminase; F | 2002 |