flucytosine has been researched along with Cancer of Head in 6 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the majority of cases, HNSCC overexpress the epidermal growth factor receptor (EGFR), and its presence is associated with a poor outcome." | 1.38 | Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus. ( Bossow, S; Grossardt, C; Kalle, Cv; Leber, MF; Plinkert, PK; Springfeld, C; Ungerechts, G; Zaoui, K, 2012) |
| "Head and neck squamous cell carcinoma was permissive to green fluorescent protein expression in100% of cells by OncoVEX(GFP) at a multiplicity of infection of 1 after 48 hours and supported logarithmic viral replication." | 1.36 | Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma. ( Coffin, RS; Fong, Y; Han, Z; Li, S; Lin, SF; Price, DL; Simpson, G; Wong, J; Wong, RJ, 2010) |
| "In addition, when SCCVII murine squamous cell carcinoma cells were infected in vitro at low rates of infection (< or =10%) there was no significant cytotoxicity toward BCD-expressing cells while there was potent cytotoxicity to both YCD-expressing cells and "bystander cells" even at this low level of expression." | 1.30 | Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. ( Fahmy, S; Hamstra, DA; Rehemtulla, A; Rice, DJ; Ross, BD, 1999) |
| "An orthotopic model of squamous cell cancer of the head and neck was used in vivo to study the CD/5-FC system both alone and with concurrent radiation due to the radiosensitizing properties that 5-FU generates in situ." | 1.30 | Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model. ( Hamstra, DA; Oyedijo, D; Pu, A; Rehemtulla, A; Rice, DJ; Ross, BD, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Price, DL | 1 |
| Lin, SF | 1 |
| Han, Z | 1 |
| Simpson, G | 1 |
| Coffin, RS | 1 |
| Wong, J | 1 |
| Li, S | 1 |
| Fong, Y | 1 |
| Wong, RJ | 1 |
| Dias, JD | 1 |
| Liikanen, I | 1 |
| Guse, K | 1 |
| Foloppe, J | 1 |
| Sloniecka, M | 1 |
| Diaconu, I | 1 |
| Rantanen, V | 1 |
| Eriksson, M | 1 |
| Hakkarainen, T | 1 |
| Lusky, M | 1 |
| Erbs, P | 1 |
| Escutenaire, S | 1 |
| Kanerva, A | 1 |
| Pesonen, S | 1 |
| Cerullo, V | 1 |
| Hemminki, A | 1 |
| Zaoui, K | 1 |
| Bossow, S | 1 |
| Grossardt, C | 1 |
| Leber, MF | 1 |
| Springfeld, C | 1 |
| Plinkert, PK | 1 |
| Kalle, Cv | 1 |
| Ungerechts, G | 1 |
| Nemunaitis, J | 1 |
| Cunningham, C | 1 |
| Senzer, N | 1 |
| Kuhn, J | 1 |
| Cramm, J | 1 |
| Litz, C | 1 |
| Cavagnolo, R | 1 |
| Cahill, A | 1 |
| Clairmont, C | 1 |
| Sznol, M | 1 |
| Hamstra, DA | 2 |
| Rice, DJ | 2 |
| Fahmy, S | 1 |
| Ross, BD | 2 |
| Rehemtulla, A | 2 |
| Pu, A | 1 |
| Oyedijo, D | 1 |
1 trial available for flucytosine and Cancer of Head
| Article | Year |
|---|---|
Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients.
Topics: Aged; Aged, 80 and over; Cytosine Deaminase; Escherichia coli; Female; Flucytosine; Fluorouracil; Ge | 2003 |
5 other studies available for flucytosine and Cancer of Head
| Article | Year |
|---|---|
Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Gene Transfer Technique | 2010 |
Targeted chemotherapy for head and neck cancer with a chimeric oncolytic adenovirus coding for bifunctional suicide protein FCU1.
Topics: Adenoviridae; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Cytosine Deaminase; Female; Flucy | 2010 |
Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chlorocebus aethiops; Cytosine Deaminase; ErbB | 2012 |
Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase.
Topics: Animals; Antifungal Agents; Carcinoma, Squamous Cell; COS Cells; Cytosine Deaminase; Escherichia col | 1999 |
Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Division; Combined Modality | 1999 |