flucytosine has been researched along with Breast Neoplasms in 26 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " siRNA targeting of choline kinase-α (Chk-α), an enzyme significantly up-regulated in aggressive breast cancer cells, was combined with the prodrug enzyme bacterial cytosine deaminase (bCD) that converts the nontoxic prodrug 5-fluorocytosine (5-FC) to cytotoxic 5-fluorouracil (5-FU)." | 3.76 | Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy. ( Artemov, D; Bhujwalla, ZM; Chen, Z; Li, C; Penet, MF; Takagi, T; Wildes, F; Winnard, PT, 2010) |
| "CD vectors converted the prodrug 5-fluorocytosine (5-FC) to the toxic nucleotide analog 5-fluorouracil in a breast cancer cell-specific manner, with a conversion rate of 40% and 52% in T47D cells and 50% and 41% in MCF7 cells, respectively." | 3.70 | Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach. ( Anderson, LM; Krotz, S; Thimmapaya, B; Weitzman, SA, 2000) |
| "Breast cancer is the most prevalent cancer in women worldwide and is classified into ductal and lobular carcinoma." | 2.48 | Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: evidence that they exert tumoricidal effects via tumor tropism (review). ( Choi, KC; Choi, KJ; Kim, SU; Yi, BR, 2012) |
| "The infected breast cancer cells did not show any significant changes in morphology, ultrastructure, cell growth, and cell‑cycle distribution compared to the uninfected cells." | 1.40 | Effects of an adenoviral vector containing a suicide gene fusion on growth characteristics of breast cancer cells. ( Huang, Z; Kong, H; Li, Q; Liu, C; Yang, L; Zhu, T, 2014) |
| " The major finding of this study is that the CD-annexin V fusion protein in combination with the prodrug 5-fluorocytosine has significant cytotoxic activity against endothelial cells and two breast cancer cells lines in vitro that expose phosphatidylserine on their surface." | 1.37 | Annexin V-targeted enzyme prodrug therapy using cytosine deaminase in combination with 5-fluorocytosine. ( Harrison, RG; Van Rite, BD, 2011) |
| "In subcutaneous MDA-MB-435 human breast cancer xenograft models, RRV-mediated yCD and TK suicide gene therapy significantly suppressed tumor growth after prodrug administration." | 1.36 | Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors. ( Lu, YC; Luo, YP; Tai, CK; Wang, YW, 2010) |
| "In nude mice bearing human breast cancer, the recombinant adenovirus vector was injected directly into the tumor followed by intraperitoneal injection of the prodrugs GCV and/or 5-FC, and the subsequent tumor growth was observed." | 1.35 | [Adenovirus-mediated double suicide gene selectively kills breast cancer MCF-7 cells in vitro]. ( Huang, ZH; Kong, H; Li, Q; Li, Z; Yang, LC; Yu, JL, 2008) |
| "In vivo, MDA-MB-435 human breast cancer cells were implanted into the brain of immune-deficient mouse stereotactically, and F3." | 1.35 | Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases. ( Jin, J; Jo, MY; Joo, KM; Kang, BG; Kim, MH; Kim, SU; Lee, SJ; Nam, DH; Park, IH; Shin, JY, 2009) |
| "Human CD34(+) cells spiked with breast cancer cells were infected with an adenoviral vector encoding the cytosine deaminase transgene (Ad-CMV-CD)." | 1.31 | Efficient and nontoxic adenoviral purging method for autologous transplantation in breast cancer patients. ( Alvarez, A; Avilés, MJ; Balas, A; Bueren, JA; Díez, JL; Fernández de Velasco, J; García-Castro, J; García-Sánchez, F; Gómez-Pineda, A; Lillo, R; Ramírez, M; Santos, S; Vicario, JL, 2002) |
| "Peripheral blood progenitor harvests of breast cancer patients are contaminated with tumor cells, suggesting a potential role for these cells in the relapse after high-dose chemotherapy." | 1.30 | Ex vivo breast cancer cell purging by adenovirus-mediated cytosine deaminase gene transfer and short-term incubation with 5-fluorocytosine completely prevents tumor growth after transplantation. ( Arnold, W; Dörken, B; Körner, IJ; Mapara, MY; Schumacher, A; Wolff, G, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 12 (46.15) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Roy, S | 1 |
| Brasino, M | 1 |
| Beirne, JM | 1 |
| Harguindey, A | 1 |
| Chapnick, DA | 1 |
| Liu, X | 1 |
| Cha, JN | 1 |
| Goodwin, AP | 1 |
| Emamian, M | 1 |
| Abbaspour, A | 1 |
| Shahani, T | 1 |
| Biglari, A | 1 |
| Sharafi, A | 1 |
| Altanerova, U | 1 |
| Jakubechova, J | 1 |
| Benejova, K | 1 |
| Priscakova, P | 1 |
| Pesta, M | 1 |
| Pitule, P | 1 |
| Topolcan, O | 1 |
| Kausitz, J | 1 |
| Zduriencikova, M | 1 |
| Repiska, V | 1 |
| Altaner, C | 2 |
| Hickey, MJ | 1 |
| Malone, CC | 1 |
| Erickson, KL | 1 |
| Lin, A | 1 |
| Soto, H | 1 |
| Ha, ET | 1 |
| Kamijima, S | 1 |
| Inagaki, A | 1 |
| Takahashi, M | 1 |
| Kato, Y | 1 |
| Kasahara, N | 1 |
| Mueller, BM | 1 |
| Kruse, CA | 1 |
| Kong, H | 3 |
| Tao, L | 1 |
| Qi, K | 1 |
| Wang, Y | 1 |
| Li, Q | 3 |
| Du, J | 1 |
| Huang, Z | 2 |
| Kang, W | 1 |
| Seol, HJ | 1 |
| Seong, DH | 1 |
| Kim, J | 1 |
| Kim, Y | 1 |
| Kim, SU | 4 |
| Nam, DH | 2 |
| Joo, KM | 2 |
| Liu, C | 1 |
| Zhu, T | 1 |
| Yang, L | 1 |
| Huang, ZH | 2 |
| Yang, LC | 1 |
| Yu, JL | 1 |
| Li, Z | 1 |
| Park, IH | 1 |
| Shin, JY | 1 |
| Jin, J | 1 |
| Kang, BG | 1 |
| Kim, MH | 1 |
| Lee, SJ | 1 |
| Jo, MY | 1 |
| Lu, YC | 1 |
| Luo, YP | 1 |
| Wang, YW | 1 |
| Tai, CK | 1 |
| Li, C | 3 |
| Penet, MF | 2 |
| Wildes, F | 1 |
| Takagi, T | 2 |
| Chen, Z | 1 |
| Winnard, PT | 2 |
| Artemov, D | 3 |
| Bhujwalla, ZM | 3 |
| Van Rite, BD | 1 |
| Harrison, RG | 1 |
| Li, XH | 1 |
| Zhou, P | 1 |
| Wang, LH | 1 |
| Tian, SM | 1 |
| Qian, Y | 1 |
| Chen, LR | 1 |
| Zhang, P | 1 |
| Kang, NH | 1 |
| Hwang, KA | 1 |
| Yi, BR | 2 |
| Lee, HJ | 1 |
| Jeung, EB | 1 |
| Choi, KC | 2 |
| Su, GQ | 1 |
| Su, G | 1 |
| Choi, KJ | 1 |
| Lillo, R | 1 |
| Ramírez, M | 1 |
| Alvarez, A | 1 |
| Santos, S | 1 |
| García-Castro, J | 1 |
| Fernández de Velasco, J | 1 |
| Avilés, MJ | 1 |
| Gómez-Pineda, A | 1 |
| Díez, JL | 1 |
| Balas, A | 1 |
| Vicario, JL | 1 |
| Bueren, JA | 1 |
| García-Sánchez, F | 2 |
| Akbulut, H | 1 |
| Zhang, L | 1 |
| Tang, Y | 1 |
| Deisseroth, A | 1 |
| Ramnaraine, M | 1 |
| Pan, W | 1 |
| Clohisy, DR | 1 |
| Pastorakova, A | 1 |
| Hlubinova, K | 1 |
| Winnard, P | 1 |
| Harris, JD | 1 |
| Gutierrez, AA | 1 |
| Hurst, HC | 1 |
| Sikora, K | 1 |
| Lemoine, NR | 1 |
| Pizzorno, G | 1 |
| Fu, SQ | 1 |
| Nanakorn, T | 1 |
| Krause, DS | 1 |
| Liang, J | 1 |
| Adams, E | 1 |
| Leffert, JJ | 1 |
| Yin, LH | 1 |
| Cooperberg, MR | 1 |
| Hanania, E | 1 |
| Wang, WL | 1 |
| Won, JH | 1 |
| Peng, XY | 1 |
| Cote, R | 1 |
| Brown, R | 1 |
| Burtness, B | 1 |
| Giles, R | 1 |
| Crystal, R | 1 |
| Deisseroth, AB | 1 |
| Wolff, G | 1 |
| Körner, IJ | 1 |
| Schumacher, A | 1 |
| Arnold, W | 1 |
| Dörken, B | 1 |
| Mapara, MY | 1 |
| Anderson, LM | 1 |
| Krotz, S | 1 |
| Weitzman, SA | 1 |
| Thimmapaya, B | 1 |
1 review available for flucytosine and Breast Neoplasms
| Article | Year |
|---|---|
Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: evidence that they exert tumoricidal effects via tumor tropism (review).
Topics: Breast Neoplasms; Camptothecin; Cytosine Deaminase; Female; Flucytosine; Fluorouracil; Ganciclovir; | 2012 |
25 other studies available for flucytosine and Breast Neoplasms
| Article | Year |
|---|---|
Enzymes Photo-Cross-Linked to Live Cell Receptors Retain Activity and EGFR Inhibition after Both Internalization and Recycling.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cytosine Deaminase; ErbB Receptors; Femal | 2020 |
Non-viral Suicide Gene Therapy: Cytosine Deaminase Gene Directed by VEGF Promoter and 5-fluorocytosine as a Gene Directed Enzyme/prodrug System in Breast Cancer Model.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cytosine Deaminase; Escherichia coli; Female; Flucytosi | 2021 |
Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytosine De | 2019 |
Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain.
Topics: Adenoviridae; Animals; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cytosine Deamin | 2013 |
Thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell apoptosis in breast cancer cells.
Topics: Adenoviridae; Antimetabolites; Antiviral Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cas | 2013 |
Adenosine potentiates the therapeutic effects of neural stem cells expressing cytosine deaminase against metastatic brain tumors.
Topics: Adenosine; Animals; Antimetabolites, Antineoplastic; Apoptosis; Blood-Brain Barrier; Blotting, Weste | 2013 |
Effects of an adenoviral vector containing a suicide gene fusion on growth characteristics of breast cancer cells.
Topics: Adenoviridae; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytosine Deaminase | 2014 |
[Adenovirus-mediated double suicide gene selectively kills breast cancer MCF-7 cells in vitro].
Topics: Adenoviridae; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyt | 2008 |
Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases.
Topics: Animals; Brain Neoplasms; Breast Neoplasms; Cell Line; Cell Proliferation; Cell Survival; Coculture | 2009 |
Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors.
Topics: Animals; Antimetabolites; Antiviral Agents; Breast Neoplasms; Cell Line; Cytosine Deaminase; Female; | 2010 |
Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy.
Topics: Animals; Bacteria; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplasti | 2010 |
Annexin V-targeted enzyme prodrug therapy using cytosine deaminase in combination with 5-fluorocytosine.
Topics: Annexin A5; Antimetabolites; Aorta; Breast Neoplasms; Cell Survival; Cells, Cultured; Combined Modal | 2011 |
The targeted gene (KDRP-CD/TK) therapy of breast cancer mediated by SonoVue and ultrasound irradiation in vitro.
Topics: Analysis of Variance; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Cytosine Deaminase; Female | 2012 |
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Topics: Amniotic Fluid; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line | 2012 |
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Topics: Adenoviridae; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; | 2012 |
Efficient and nontoxic adenoviral purging method for autologous transplantation in breast cancer patients.
Topics: Adenoviridae; Animals; Bone Marrow Purging; Breast Neoplasms; Cytosine Deaminase; Female; Flucytosin | 2002 |
Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon.
Topics: Adenoviridae; Adenovirus E1A Proteins; Animals; Breast Neoplasms; Cell Death; Colonic Neoplasms; Cyt | 2003 |
Osteoclasts direct bystander killing of cancer cells in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow Cells; Bone Neoplasms; Breast Neoplasms; Cell | 2006 |
Multimodal image-guided enzyme/prodrug cancer therapy.
Topics: Breast Neoplasms; Cell Line, Tumor; Cytosine Deaminase; Enzyme Stability; Flucytosine; Heterocyclic | 2006 |
Treatment of human tumor cells by combine gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and bacterial cytosine deaminase suicide gene.
Topics: Adenocarcinoma; Antimetabolites; Breast Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Cyto | 2006 |
Image-guided enzyme/prodrug cancer therapy.
Topics: Animals; Breast Neoplasms; Catalogs, Drug as Topic; Cytosine Deaminase; Female; Flucytosine; Fluorou | 2008 |
Gene therapy for cancer using tumour-specific prodrug activation.
Topics: Base Sequence; Biotransformation; Breast Neoplasms; Cytosine Deaminase; DNA Primers; Female; Flucyto | 1994 |
Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Death; Cytosine Deami | 1998 |
Ex vivo breast cancer cell purging by adenovirus-mediated cytosine deaminase gene transfer and short-term incubation with 5-fluorocytosine completely prevents tumor growth after transplantation.
Topics: Adenoviridae; Animals; Antigens, CD34; Breast Neoplasms; Cytosine Deaminase; Female; Flucytosine; Fl | 1998 |
Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach.
Topics: Adenoviridae; Animals; Breast Neoplasms; Candida albicans; Carrier Proteins; Cell Survival; Cytosine | 2000 |