flucytosine has been researched along with Astrocytoma, Grade IV in 20 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Temozolomide (TMZ) with radiation is the most frequently used first-line treatment for patients with glioblastoma, the most common and aggressive form of primary brain cancer in adults." | 7.79 | Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model. ( Espinoza, FL; Gruber, HE; Gunzburg, W; Hlavaty, J; Huang, TT; Ibañez, CE; Jolly, DJ; Kasahara, N; Martin, B; Ostertag, D; Pertschuk, D; Petznek, H; Robbins, JM; Rodriguez-Aguirre, M, 2013) |
| "Lomustine is a treatment option for patients with high-grade glioma." | 5.43 | Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. ( Gruber, HE; Huang, TT; Ibañez, CE; Jolly, DJ; Lopez Espinoza, F; Mendoza, D; Robbins, JM; Yagiz, K, 2016) |
| "5-Fluorouracil (5-FU) is a potent antimetabolite used for chemotherapy of gastrointestinal (GI), breast, and head and neck malignancies." | 5.31 | Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. ( Buchsbaum, DJ; Gillespie, GY; Miller, CR; Williams, CR, 2002) |
| " Temozolomide (TMZ) with radiation is the most frequently used first-line treatment for patients with glioblastoma, the most common and aggressive form of primary brain cancer in adults." | 3.79 | Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model. ( Espinoza, FL; Gruber, HE; Gunzburg, W; Hlavaty, J; Huang, TT; Ibañez, CE; Jolly, DJ; Kasahara, N; Martin, B; Ostertag, D; Pertschuk, D; Petznek, H; Robbins, JM; Rodriguez-Aguirre, M, 2013) |
| "Glioblastoma and anaplastic astrocytoma are two of the most aggressive and common glioma malignancies in adults." | 2.61 | Early clinical trials of Toca 511 and Toca FC show a promising novel treatment for recurrent malignant glioma. ( Adamson, DC; Philbrick, BD, 2019) |
| "The fatal nature of glioblastoma is caused by tumor-initiating glioblastoma cells." | 2.48 | Stem cell based glioblastoma gene therapy. ( Altaner, C; Altanerova, V, 2012) |
| "Lomustine is a treatment option for patients with high-grade glioma." | 1.43 | Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. ( Gruber, HE; Huang, TT; Ibañez, CE; Jolly, DJ; Lopez Espinoza, F; Mendoza, D; Robbins, JM; Yagiz, K, 2016) |
| "5-Fluorouracil (5-FU) is a potent antimetabolite used for chemotherapy of gastrointestinal (GI), breast, and head and neck malignancies." | 1.31 | Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. ( Buchsbaum, DJ; Gillespie, GY; Miller, CR; Williams, CR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Philbrick, BD | 1 |
| Adamson, DC | 1 |
| Kazlauskas, A | 1 |
| Darinskas, A | 1 |
| Meškys, R | 1 |
| Tamašauskas, A | 1 |
| Urbonavičius, J | 1 |
| Niu, J | 1 |
| Xing, C | 1 |
| Yan, C | 1 |
| Liu, H | 1 |
| Cui, Y | 1 |
| Peng, H | 1 |
| Chen, Y | 1 |
| Li, D | 1 |
| Jiang, C | 1 |
| Li, N | 1 |
| Yang, H | 1 |
| Huang, TT | 2 |
| Hlavaty, J | 2 |
| Ostertag, D | 1 |
| Espinoza, FL | 1 |
| Martin, B | 1 |
| Petznek, H | 2 |
| Rodriguez-Aguirre, M | 1 |
| Ibañez, CE | 2 |
| Kasahara, N | 1 |
| Gunzburg, W | 1 |
| Gruber, HE | 2 |
| Pertschuk, D | 1 |
| Jolly, DJ | 2 |
| Robbins, JM | 2 |
| Altaner, C | 3 |
| Altanerova, V | 3 |
| Cihova, M | 2 |
| Ondicova, K | 2 |
| Rychly, B | 2 |
| Baciak, L | 1 |
| Mravec, B | 2 |
| Yagiz, K | 1 |
| Lopez Espinoza, F | 1 |
| Mendoza, D | 1 |
| Strebe, JK | 1 |
| Lubin, JA | 1 |
| Kuo, JS | 1 |
| Breton, E | 1 |
| Goetz, C | 1 |
| Kintz, J | 1 |
| Accart, N | 1 |
| Aubertin, G | 1 |
| Grellier, B | 1 |
| Erbs, P | 1 |
| Rooke, R | 1 |
| Constantinesco, A | 1 |
| Choquet, P | 1 |
| Jandl, G | 1 |
| Liszt, M | 1 |
| König-Schuster, M | 1 |
| Sedlak, J | 1 |
| Egerbacher, M | 1 |
| Weissenberger, J | 1 |
| Salmons, B | 1 |
| Günzburg, WH | 1 |
| Renner, M | 1 |
| Lee, SJ | 1 |
| Kim, Y | 1 |
| Jo, MY | 1 |
| Kim, HS | 1 |
| Jin, Y | 1 |
| Kim, SU | 1 |
| Jin, J | 1 |
| Joo, KM | 1 |
| Nam, DH | 1 |
| Babic, M | 1 |
| Dabrowska, A | 1 |
| Szary, J | 1 |
| Kowalczuk, M | 1 |
| Szala, S | 1 |
| Ugorski, M | 1 |
| Bourbeau, D | 2 |
| Lavoie, G | 2 |
| Nalbantoglu, J | 2 |
| Massie, B | 2 |
| Chen, JK | 1 |
| Hu, LJ | 1 |
| Wang, D | 1 |
| Lamborn, KR | 1 |
| Deen, DF | 1 |
| Lau, CJ | 1 |
| Jaime, J | 1 |
| Koty, Z | 1 |
| Zehntner, SP | 1 |
| Mes-Masson, AM | 1 |
| Haberkorn, U | 2 |
| Oberdorfer, F | 2 |
| Gebert, J | 1 |
| Morr, I | 1 |
| Haack, K | 1 |
| Weber, K | 1 |
| Lindauer, M | 2 |
| van Kaick, G | 1 |
| Schackert, HK | 2 |
| Rowley, S | 1 |
| Gebert, JF | 1 |
| Moebius, U | 1 |
| Herfarth, C | 1 |
| Noble, M | 1 |
| Miller, CR | 1 |
| Williams, CR | 1 |
| Buchsbaum, DJ | 1 |
| Gillespie, GY | 1 |
3 reviews available for flucytosine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Early clinical trials of Toca 511 and Toca FC show a promising novel treatment for recurrent malignant glioma.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cytosi | 2019 |
Stem cell based glioblastoma gene therapy.
Topics: Animals; Cytosine Deaminase; Flucytosine; Ganciclovir; Genetic Therapy; Glioblastoma; Humans; Mesenc | 2012 |
Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?
Topics: Animals; Brain Neoplasms; Cell Movement; Combined Modality Therapy; Cytosine Deaminase; Flucytosine; | 2000 |
17 other studies available for flucytosine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line, | 2019 |
Lentivirus-mediated CD/TK fusion gene transfection neural stem cell therapy for C6 glioblastoma.
Topics: Animals; Antimetabolites; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Apoptosi | 2013 |
Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytosine Deaminase; Dacarb | 2013 |
Complete regression of glioblastoma by mesenchymal stem cells mediated prodrug gene therapy simulating clinical therapeutic scenario.
Topics: Adipose Tissue; Animals; Antimetabolites; Bone Marrow; Brain Neoplasms; Cell Proliferation; Cells, C | 2014 |
Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytosine Deaminase; Diseas | 2016 |
"Tag Team" Glioblastoma Therapy: Results From a Phase 1 Trial of Toca 511 and 5-Fluorocytosine for Recurrent High-Grade Glioma.
Topics: Brain Neoplasms; Flucytosine; Glioblastoma; Glioma; Humans | 2016 |
In vivo preclinical low-field MRI monitoring of tumor growth following a suicide-gene therapy in an orthotopic mice model of human glioblastoma.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Brain Neoplasms; Cytosine Deaminase; Fe | 2010 |
Comparative evaluation of preclinical in vivo models for the assessment of replicating retroviral vectors for the treatment of glioblastoma.
Topics: Animals; Brain Neoplasms; Bystander Effect; Cytosine Deaminase; Disease Models, Animal; Drug Evaluat | 2011 |
Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Movement; Combined Modality Therapy; Cytosine | 2011 |
Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma.
Topics: Adipose Tissue; Animals; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Cytosine Deam | 2012 |
CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter.
Topics: Base Sequence; Carcinoembryonic Antigen; Cell Line, Tumor; Cytosine Deaminase; DNA, Complementary; D | 2004 |
Suicide gene therapy with an adenovirus expressing the fusion gene CD::UPRT in human glioblastomas: different sensitivities correlate with p53 status.
Topics: Adenoviridae; Antimetabolites; Brain Neoplasms; Cytosine Deaminase; Flucytosine; Gene Expression Pro | 2004 |
Cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioblastoma cells in vitro.
Topics: Antimetabolites, Antineoplastic; Bystander Effect; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cy | 2007 |
Improvement of antitumor activity by gene amplification with a replicating but nondisseminating adenovirus.
Topics: Adenoviridae; Animals; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorouracil; Gene Amplifi | 2007 |
Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine.
Topics: Chromatography, High Pressure Liquid; Cytosine Deaminase; Flucytosine; Fluorouracil; Genetic Therapy | 1996 |
Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer.
Topics: Base Sequence; Cell Death; Cloning, Molecular; Colorectal Neoplasms; Cytosine Deaminase; Escherichia | 1996 |
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cytosine Deaminase; Flucyto | 2002 |