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floxuridine and Uterine Cervical Neoplasms

floxuridine has been researched along with Uterine Cervical Neoplasms in 17 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.

Research Excerpts

ExcerptRelevanceReference
" 5-Fluorouracil (5-FU) was effective against only one bladder cancer xenograft among 6 cancer xenografts tested."3.68[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice]. ( Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H, 1991)
"Sixteen patients with squamous carcinoma of the cervix were prospectively treated in a Phase I study."2.68Treatment of locally advanced cervical cancer with concurrent radiation and intra-arterial chemotherapy. ( Burke, TW; Eifel, PJ; Gershenson, DM; Kavanagh, JJ; Levenback, C; McNamara, MM; Morris, M, 1995)
"Total 21 cases of cervical cancer were alloted randomly into 5'-DFUR group (daily dose 800 mg for 3 days) consisting of 11 patients and UFT group (daily dose 600 mg for 3 days) consisting of 10 patients, the unchanged substances (5'-DFUR in the 5'-DFUR group and tegafur concentrations in the UFT group) and 5-FU concentrations in serum and tissues were measured 6 hours after administration of the drugs."2.68[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer]. ( Aida, I; Kasuga, Y; Ohwada, M; Sato, I; Suzuki, M; Tamura, T, 1995)
"The overall response rate was 20."1.28[Phase II study of 5'-DFUR in uterine cervical cancer and ovarian cancer]. ( Ikeda, M; Noda, K; Ochiai, K; Saito, Y; Sato, A; Suzuki, M; Takada, M; Terashima, Y; Yajima, A; Yoshida, K, 1991)
"In uterine cervical cancer, each group of 9 cases administered single dose of 400 mg of 5'-DFUR and 7 cases administered 400 mg of 5'-DFUR 3 times a day continuously for 7 days was investigated."1.28[Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR]. ( Hasegawa, K; Ikeda, M; Kinugasa, M; Kobashi, Y; Noda, K; Odagiri, H; Ohiwa, T; Sekiba, K; Takeuchi, K; Watanabe, Y, 1991)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19906 (35.29)18.7374
1990's8 (47.06)18.2507
2000's1 (5.88)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mou, Q1
Ma, Y1
Pan, G1
Xue, B1
Yan, D1
Zhang, C1
Zhu, X1
Hasegawa, K3
Okamoto, H1
Kawamura, K1
Kato, R1
Kobayashi, Y1
Sekiya, T1
Udagawa, Y1
SULLIVAN, RD1
NORCROSS, JW1
WATKINS, E1
OETTGEN, HF2
CLIFFORD, P1
CANDLER, P1
ANSFIELD, FJ1
Oberfield, RA1
Morris, M1
Eifel, PJ1
Burke, TW1
McNamara, MM1
Levenback, C1
Kavanagh, JJ1
Gershenson, DM1
Suzuki, M2
Aida, I1
Ohwada, M1
Sato, I1
Tamura, T1
Kasuga, Y1
Ueda, M2
Ueki, M2
Terai, Y1
Morimoto, A1
Fujii, H1
Yoshizawa, K1
Yanagihara, T1
Onishi, Y2
Hatae, M2
Noda, K3
Yajima, A2
Sato, S1
Terashima, Y2
Ochiai, K2
Sasaki, H1
Mizutani, K1
Honjo, H1
Yamamoto, T1
Ozaki, M1
Yamamoto, K1
Nishimura, R1
Kudo, T1
Kobashi, Y2
Yakushiji, M1
Sugiyama, T1
Hasuo, Y1
Hussey, HJ1
Todorov, PT1
Field, WN1
Inagaki, N1
Tanaka, Y1
Ishitsuka, H2
Tisdale, MJ1
Ikeda, M2
Saito, Y1
Sato, A1
Yoshida, K1
Takada, M1
Miwa, M1
Sekiguchi, F1
Akaza, H1
Tokita, H1
Nitta, K1
Adachi, S1
Kanazawa, K1
Watanabe, Y1
Takeuchi, K1
Kinugasa, M1
Sekiba, K1
Ohiwa, T1
Odagiri, H1
Misaki, O1
Yamada, T1
Okamoto, Y1
Goto, M1
Maeda, T1
Okamura, S1
Sugimoto, O1

Trials

3 trials available for floxuridine and Uterine Cervical Neoplasms

ArticleYear
Treatment of locally advanced cervical cancer with concurrent radiation and intra-arterial chemotherapy.
    Gynecologic oncology, 1995, Volume: 57, Issue:1

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Catheters, Indwelling; Cisplatin; Combined Modality Therapy;

1995
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:2

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluoroura

1995
[Effect of 5'-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer--pilot study. Study of 5'-DFUR for Uterine Cervical Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:5

    Topics: Adjuvants, Immunologic; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality The

1998

Other Studies

14 other studies available for floxuridine and Uterine Cervical Neoplasms

ArticleYear
DNA Trojan Horses: Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy.
    Angewandte Chemie (International ed. in English), 2017, 10-02, Volume: 56, Issue:41

    Topics: Animals; Antimetabolites, Antineoplastic; DNA; Drug Carriers; Female; Floxuridine; HeLa Cells; Human

2017
The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.
    European journal of obstetrics, gynecology, and reproductive biology, 2012, Volume: 163, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Chemoradiother

2012
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
    The New England journal of medicine, 1964, Feb-13, Volume: 270

    Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colo

1964
CONTINUOUS INTRA-ARTERIAL OR INTRAVENOUS INFUSION OF 5-FLUORO-2-DEOXYURIDINE: THERAPEUTIC AND TOXIC EFFECTS.
    Cancer chemotherapy reports, 1963, Volume: 32

    Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Chemotherapy, Cancer, Regiona

1963
[REGIONAL CHEMOTHERAPY OF MALIGNANT TUMORS. I. PROLONGED INTRA-ARTERIAL INFUSION OF ANTIMETABOLITES].
    Klinische Wochenschrift, 1964, Mar-01, Volume: 42

    Topics: Antimetabolites; Catheterization; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Injections

1964
A LESS TOXIC FLUOROURACIL DOSAGE SCHEDULE.
    JAMA, 1964, Nov-16, Volume: 190

    Topics: Alopecia; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Eruptions; Epistaxis; Female; Floxurid

1964
Intra-arterial infusion in tumors of the pelvis.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1983, Volume: 86

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality T

1983
Stimulatory effects of EGF and TGF-alpha on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in uterine cervical-carcinoma SKG-IIIb cells.
    International journal of cancer, 1997, Sep-17, Volume: 72, Issue:6

    Topics: Basement Membrane; Carcinoma, Squamous Cell; Chemotaxis; Collagen; Collagenases; Dose-Response Relat

1997
[A case of complete response of metastasis of cervical cancer with a combination of CBDCA and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Female; Floxuridine; Humans; Lung Neopl

1998
Effect of a fluorinated pyrimidine on cachexia and tumour growth in murine cachexia models: relationship with a proteolysis inducing factor.
    British journal of cancer, 2000, Volume: 83, Issue:1

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Appetite Stimulants; Blood Proteins; Body

2000
[Phase II study of 5'-DFUR in uterine cervical cancer and ovarian cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:15

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Administration, Oral; Adult; Aged; Antineoplastic Agents;

1991
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:10

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine;

1991
[Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:15

    Topics: Administration, Oral; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes;

1991
[In vitro studies of 5-FU sensitivity on uterine cervical cancer cell lines--comparison between squamous cell carcinoma and adenocarcinoma].
    Nihon Sanka Fujinka Gakkai zasshi, 1989, Volume: 41, Issue:9

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Survival; DNA, Neoplasm; Drug Screening Assays, Antit

1989