floxuridine has been researched along with Uterine Cervical Neoplasms in 17 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 5-Fluorouracil (5-FU) was effective against only one bladder cancer xenograft among 6 cancer xenografts tested." | 3.68 | [Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice]. ( Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H, 1991) |
| "Sixteen patients with squamous carcinoma of the cervix were prospectively treated in a Phase I study." | 2.68 | Treatment of locally advanced cervical cancer with concurrent radiation and intra-arterial chemotherapy. ( Burke, TW; Eifel, PJ; Gershenson, DM; Kavanagh, JJ; Levenback, C; McNamara, MM; Morris, M, 1995) |
| "Total 21 cases of cervical cancer were alloted randomly into 5'-DFUR group (daily dose 800 mg for 3 days) consisting of 11 patients and UFT group (daily dose 600 mg for 3 days) consisting of 10 patients, the unchanged substances (5'-DFUR in the 5'-DFUR group and tegafur concentrations in the UFT group) and 5-FU concentrations in serum and tissues were measured 6 hours after administration of the drugs." | 2.68 | [5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer]. ( Aida, I; Kasuga, Y; Ohwada, M; Sato, I; Suzuki, M; Tamura, T, 1995) |
| "The overall response rate was 20." | 1.28 | [Phase II study of 5'-DFUR in uterine cervical cancer and ovarian cancer]. ( Ikeda, M; Noda, K; Ochiai, K; Saito, Y; Sato, A; Suzuki, M; Takada, M; Terashima, Y; Yajima, A; Yoshida, K, 1991) |
| "In uterine cervical cancer, each group of 9 cases administered single dose of 400 mg of 5'-DFUR and 7 cases administered 400 mg of 5'-DFUR 3 times a day continuously for 7 days was investigated." | 1.28 | [Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR]. ( Hasegawa, K; Ikeda, M; Kinugasa, M; Kobashi, Y; Noda, K; Odagiri, H; Ohiwa, T; Sekiba, K; Takeuchi, K; Watanabe, Y, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mou, Q | 1 |
| Ma, Y | 1 |
| Pan, G | 1 |
| Xue, B | 1 |
| Yan, D | 1 |
| Zhang, C | 1 |
| Zhu, X | 1 |
| Hasegawa, K | 3 |
| Okamoto, H | 1 |
| Kawamura, K | 1 |
| Kato, R | 1 |
| Kobayashi, Y | 1 |
| Sekiya, T | 1 |
| Udagawa, Y | 1 |
| SULLIVAN, RD | 1 |
| NORCROSS, JW | 1 |
| WATKINS, E | 1 |
| OETTGEN, HF | 2 |
| CLIFFORD, P | 1 |
| CANDLER, P | 1 |
| ANSFIELD, FJ | 1 |
| Oberfield, RA | 1 |
| Morris, M | 1 |
| Eifel, PJ | 1 |
| Burke, TW | 1 |
| McNamara, MM | 1 |
| Levenback, C | 1 |
| Kavanagh, JJ | 1 |
| Gershenson, DM | 1 |
| Suzuki, M | 2 |
| Aida, I | 1 |
| Ohwada, M | 1 |
| Sato, I | 1 |
| Tamura, T | 1 |
| Kasuga, Y | 1 |
| Ueda, M | 2 |
| Ueki, M | 2 |
| Terai, Y | 1 |
| Morimoto, A | 1 |
| Fujii, H | 1 |
| Yoshizawa, K | 1 |
| Yanagihara, T | 1 |
| Onishi, Y | 2 |
| Hatae, M | 2 |
| Noda, K | 3 |
| Yajima, A | 2 |
| Sato, S | 1 |
| Terashima, Y | 2 |
| Ochiai, K | 2 |
| Sasaki, H | 1 |
| Mizutani, K | 1 |
| Honjo, H | 1 |
| Yamamoto, T | 1 |
| Ozaki, M | 1 |
| Yamamoto, K | 1 |
| Nishimura, R | 1 |
| Kudo, T | 1 |
| Kobashi, Y | 2 |
| Yakushiji, M | 1 |
| Sugiyama, T | 1 |
| Hasuo, Y | 1 |
| Hussey, HJ | 1 |
| Todorov, PT | 1 |
| Field, WN | 1 |
| Inagaki, N | 1 |
| Tanaka, Y | 1 |
| Ishitsuka, H | 2 |
| Tisdale, MJ | 1 |
| Ikeda, M | 2 |
| Saito, Y | 1 |
| Sato, A | 1 |
| Yoshida, K | 1 |
| Takada, M | 1 |
| Miwa, M | 1 |
| Sekiguchi, F | 1 |
| Akaza, H | 1 |
| Tokita, H | 1 |
| Nitta, K | 1 |
| Adachi, S | 1 |
| Kanazawa, K | 1 |
| Watanabe, Y | 1 |
| Takeuchi, K | 1 |
| Kinugasa, M | 1 |
| Sekiba, K | 1 |
| Ohiwa, T | 1 |
| Odagiri, H | 1 |
| Misaki, O | 1 |
| Yamada, T | 1 |
| Okamoto, Y | 1 |
| Goto, M | 1 |
| Maeda, T | 1 |
| Okamura, S | 1 |
| Sugimoto, O | 1 |
3 trials available for floxuridine and Uterine Cervical Neoplasms
| Article | Year |
|---|---|
Treatment of locally advanced cervical cancer with concurrent radiation and intra-arterial chemotherapy.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Catheters, Indwelling; Cisplatin; Combined Modality Therapy; | 1995 |
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluoroura | 1995 |
[Effect of 5'-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer--pilot study. Study of 5'-DFUR for Uterine Cervical Cancer].
Topics: Adjuvants, Immunologic; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality The | 1998 |
14 other studies available for floxuridine and Uterine Cervical Neoplasms
| Article | Year |
|---|---|
DNA Trojan Horses: Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy.
Topics: Animals; Antimetabolites, Antineoplastic; DNA; Drug Carriers; Female; Floxuridine; HeLa Cells; Human | 2017 |
The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Chemoradiother | 2012 |
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colo | 1964 |
CONTINUOUS INTRA-ARTERIAL OR INTRAVENOUS INFUSION OF 5-FLUORO-2-DEOXYURIDINE: THERAPEUTIC AND TOXIC EFFECTS.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Chemotherapy, Cancer, Regiona | 1963 |
[REGIONAL CHEMOTHERAPY OF MALIGNANT TUMORS. I. PROLONGED INTRA-ARTERIAL INFUSION OF ANTIMETABOLITES].
Topics: Antimetabolites; Catheterization; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Injections | 1964 |
A LESS TOXIC FLUOROURACIL DOSAGE SCHEDULE.
Topics: Alopecia; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Eruptions; Epistaxis; Female; Floxurid | 1964 |
Intra-arterial infusion in tumors of the pelvis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality T | 1983 |
Stimulatory effects of EGF and TGF-alpha on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in uterine cervical-carcinoma SKG-IIIb cells.
Topics: Basement Membrane; Carcinoma, Squamous Cell; Chemotaxis; Collagen; Collagenases; Dose-Response Relat | 1997 |
[A case of complete response of metastasis of cervical cancer with a combination of CBDCA and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Female; Floxuridine; Humans; Lung Neopl | 1998 |
Effect of a fluorinated pyrimidine on cachexia and tumour growth in murine cachexia models: relationship with a proteolysis inducing factor.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Appetite Stimulants; Blood Proteins; Body | 2000 |
[Phase II study of 5'-DFUR in uterine cervical cancer and ovarian cancer].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Administration, Oral; Adult; Aged; Antineoplastic Agents; | 1991 |
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; | 1991 |
[Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR].
Topics: Administration, Oral; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; | 1991 |
[In vitro studies of 5-FU sensitivity on uterine cervical cancer cell lines--comparison between squamous cell carcinoma and adenocarcinoma].
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Survival; DNA, Neoplasm; Drug Screening Assays, Antit | 1989 |