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floxuridine and Urinary Bladder Neoplasms

floxuridine has been researched along with Urinary Bladder Neoplasms in 20 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.

Research Excerpts

ExcerptRelevanceReference
"A total of 112 patients with pTa or pT1 bladder cancer were eligible for the analysis and were allocated to either an adjuvant group (TURBT+5'-DFUR; n = 47; initial 23 months) or a control group (TURBT alone; n = 65, final 23 months)."6.71Novel prophylactic effect of doxifluridine in superficial bladder cancer. ( Aoki, A; Baba, Y; Jojima, K; Matsuyama, H; Naito, K; Shimabukuro, T; Suga, A; Suyama, K; Uchiyama, K; Yamamoto, N, 2004)
"Thymosin is a glycoprotein extract obtained from the calf thymus and is a potent immunopotentiating preparation."5.30Augmentation of antitumor activity of 5'-deoxy-5-fluorouridine by thymosin fraction 5 in mouse bladder cancer cells in vitro and in vivo. ( Ikemoto, S; Kishimoto, T; Sugimura, K; Wada, S; Yamamoto, K; Yasumoto, R, 1999)
" 5-Fluorouracil (5-FU) was effective against only one bladder cancer xenograft among 6 cancer xenografts tested."3.68[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice]. ( Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H, 1991)
"Iododeoxyuridine (IdUrd) potentiated the lethal but not the growth inhibitory properties of fluorouracil (FUra) and fluorodeoxyuridine (FdUrd) in human bladder cancer cells (T24)."3.67Modulation of 5-iodo-2'-deoxyuridine metabolism and cytotoxicity in human bladder cancer cells by fluoropyrimidines. ( Benson, AB; Cummings, KB; Fischer, PH; Trump, DL, 1985)
"A total of 112 patients with pTa or pT1 bladder cancer were eligible for the analysis and were allocated to either an adjuvant group (TURBT+5'-DFUR; n = 47; initial 23 months) or a control group (TURBT alone; n = 65, final 23 months)."2.71Novel prophylactic effect of doxifluridine in superficial bladder cancer. ( Aoki, A; Baba, Y; Jojima, K; Matsuyama, H; Naito, K; Shimabukuro, T; Suga, A; Suyama, K; Uchiyama, K; Yamamoto, N, 2004)
"However, in bladder cancer, response rates have only been reported in Phase II clinical trials."2.69[5'-DFUR chemoprophylaxis in superficial bladder cancer. Kanagawa Urology 5'-DFUR Study Group]. ( Chiba, K; Ebato, T; Fukuda, M; Fukuoka, H; Fukushima, S; Hirokawa, M; Hosaka, M; Ikeda, I; Kanno, H; Kitami, K; Kondo, I; Kubota, Y; Masuda, M; Miura, T; Miyai, K; Moriyama, M; Noguchi, K; Noguchi, S; Sasaki, K; Sato, K; Senga, Y, 2000)
"Therapy of metastatic bladder cancer with doxorubicin-cisplatin was made more tolerable by this same circadian approach resulting in a 57% objective response rate."2.41Circadian chemotherapy for gynecological and genitourinary cancers. ( Hrushesky, WJ; Kobayashi, M; Wood, PA, 2002)
"Thymidine kinase is a key enzyme responsible for the activation of several anticancer and antiviral drugs."2.39Modulation of thymidine kinase activity: a biochemical strategy to enhance the activation of antineoplastic drugs. ( Vázquez-Padua, MA, 1994)
"Gemcitabine was rapidly eliminated from plasma even in patients with renal dysfunction."1.35Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer. ( Hirobe, M; Itoh, T; Kunishima, Y; Masumori, N; Takayanagi, A; Takeuchi, M; Tsukamoto, T, 2008)
"The mean activity in 37 bladder cancers and in 8 samples of normal bladder epithelial tissue was 108."1.30Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer. ( Hosaka, M; Kubota, Y; Matsuzaki, J; Miura, T; Moriyama, M; Noguchi, S; Takebayashi, S, 1997)
"Human solid tumor histocultures represent a clinically relevant experimental system for pharmacodynamic study."1.30Regional heterogeneity and pharmacodynamics in human solid tumor histoculture. ( Au, JL; Weaver, JR; Wientjes, MG, 1999)
"Thymosin is a glycoprotein extract obtained from the calf thymus and is a potent immunopotentiating preparation."1.30Augmentation of antitumor activity of 5'-deoxy-5-fluorouridine by thymosin fraction 5 in mouse bladder cancer cells in vitro and in vivo. ( Ikemoto, S; Kishimoto, T; Sugimura, K; Wada, S; Yamamoto, K; Yasumoto, R, 1999)
"Forty-one patients with bladder cancer and 12 patients with prostatic cancer were evaluated."1.28[Phase II study of 5'-DFUR treatment of the bladder and prostatic cancer]. ( Akebi, N; Josen, T; Kobashi, K; Matsumura, Y; Nanba, K; Nasu, Y; Ochi, J; Ohmori, H; Saika, T; Tanahashi, T, 1991)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19905 (25.00)18.7374
1990's7 (35.00)18.2507
2000's8 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nagata, Y1
Masuda, A1
Wang, H1
Li, H1
Zang, M1
Xu, F1
Li, G1
Yan, CY1
Wen, DG1
Ding, Q1
Zhang, YF1
Matsuyama, H1
Baba, Y1
Shimabukuro, T1
Uchiyama, K1
Aoki, A1
Suga, A1
Jojima, K1
Suyama, K1
Yamamoto, N1
Naito, K1
Masumori, N1
Kunishima, Y1
Hirobe, M1
Takeuchi, M1
Takayanagi, A1
Tsukamoto, T1
Itoh, T1
Kawamura, H1
Hashimoto, Y1
Oberfield, RA1
Vázquez-Padua, MA2
Kubota, Y3
Miura, T3
Moriyama, M3
Noguchi, S2
Matsuzaki, J1
Takebayashi, S1
Hosaka, M3
Weaver, JR1
Wientjes, MG1
Au, JL1
Ikemoto, S1
Sugimura, K1
Wada, S1
Yasumoto, R1
Yamamoto, K1
Kishimoto, T1
Soga, H1
Hayashida, H1
Yoshiki, T1
Higuchi, K1
Okada, Y1
Masuda, M1
Noguchi, K1
Sasaki, K1
Ikeda, I1
Kondo, I2
Senga, Y1
Fukushima, S2
Ebato, T1
Fukuda, M1
Kitami, K1
Fukuoka, H2
Sato, K1
Hirokawa, M1
Chiba, K1
Kanno, H1
Miyai, K2
Kobayashi, M1
Wood, PA1
Hrushesky, WJ1
Carter, SK1
Wasserman, TH1
Miwa, M1
Sekiguchi, F1
Akaza, H1
Tokita, H1
Nitta, K1
Adachi, S1
Kanazawa, K1
Ishitsuka, H1
Shuin, T1
Kinoshita, Y1
Ohmori, H1
Matsumura, Y1
Ochi, J1
Kobashi, K1
Akebi, N1
Saika, T1
Nanba, K1
Tanahashi, T1
Josen, T1
Nasu, Y1
Risueno, C1
Fischer, PH2
Benson, AB1
Trump, DL1
Cummings, KB1

Reviews

2 reviews available for floxuridine and Urinary Bladder Neoplasms

ArticleYear
Modulation of thymidine kinase activity: a biochemical strategy to enhance the activation of antineoplastic drugs.
    Puerto Rico health sciences journal, 1994, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Biotransformation; Chlorocebus aethiops; DNA Damag

1994
Circadian chemotherapy for gynecological and genitourinary cancers.
    Chronobiology international, 2002, Volume: 19, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Cycle; Chronotherapy; Circadian Rhythm;

2002

Trials

3 trials available for floxuridine and Urinary Bladder Neoplasms

ArticleYear
[Prevention and treatment of bladder tumors recurrence with furtulon].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2000, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols

2000
Novel prophylactic effect of doxifluridine in superficial bladder cancer.
    Scandinavian journal of urology and nephrology, 2004, Volume: 38, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Cystectomy; Dose

2004
[5'-DFUR chemoprophylaxis in superficial bladder cancer. Kanagawa Urology 5'-DFUR Study Group].
    Hinyokika kiyo. Acta urologica Japonica, 2000, Volume: 46, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Flo

2000

Other Studies

15 other studies available for floxuridine and Urinary Bladder Neoplasms

ArticleYear
Bladder tumor associated with phenacetin abuse: a case report and a review of the literature.
    The Tokai journal of experimental and clinical medicine, 2007, Sep-20, Volume: 32, Issue:3

    Topics: Aged, 80 and over; Analgesics, Non-Narcotic; Antineoplastic Combined Chemotherapy Protocols; Doxorub

2007
[Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5'-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:8

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; Floxuridine; Fluorouracil; Humans; Interfer

2004
Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer.
    Japanese journal of clinical oncology, 2008, Volume: 38, Issue:3

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Cystectomy; Deoxycytidine; Fatal

2008
Inhibitory effect of 5-halogenated deoxyuridines on in vitro keratinization of a transformed rat urinary bladder epithelial cell line.
    Gan, 1981, Volume: 72, Issue:2

    Topics: Animals; Binding, Competitive; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; DNA Re

1981
Intra-arterial infusion in tumors of the pelvis.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1983, Volume: 86

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality T

1983
Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:6

    Topics: Epithelial Cells; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasm Invasiveness; Neoplasm Stagi

1997
Regional heterogeneity and pharmacodynamics in human solid tumor histoculture.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Transitional Cell; Cell Division; Culture Techniques; Drug Screeni

1999
Augmentation of antitumor activity of 5'-deoxy-5-fluorouridine by thymosin fraction 5 in mouse bladder cancer cells in vitro and in vivo.
    Cancer letters, 1999, Oct-18, Volume: 145, Issue:1-2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Drug Screening Assays, Antit

1999
[Case report of a patient with invading bladder cancer and lymph node swelling which decreased following 5'-DFUR treatment].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:2

    Topics: Aged; Antineoplastic Agents; Child, Preschool; Floxuridine; Humans; Lymph Nodes; Lymphatic Metastasi

2000
The chemotherapy of urologic cancer.
    Cancer, 1975, Volume: 36, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Doxorubicin; Drug Therapy, Co

1975
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:10

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine;

1991
[Phase II study of 5'-DFUR (Furtulon) capsule for bladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:13

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Carcinoma, Squamous

1991
[Phase II study of 5'-DFUR treatment of the bladder and prostatic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:13

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Diarrhea; Dru

1991
Regulation of the activation of fluorodeoxyuridine by substrate competition and feedback inhibition in 647V cells.
    Cancer research, 1989, Feb-01, Volume: 49, Issue:3

    Topics: Cell Line; Floxuridine; Humans; Models, Biological; Phosphorylation; Thymidine Kinase; Thymine Nucle

1989
Modulation of 5-iodo-2'-deoxyuridine metabolism and cytotoxicity in human bladder cancer cells by fluoropyrimidines.
    Biochemical pharmacology, 1985, Nov-01, Volume: 34, Issue:21

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; DNA; Floxuridine; Fluorour

1985