floxuridine has been researched along with Thrombocytopenia in 13 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Thrombocytopenia: A subnormal level of BLOOD PLATELETS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma." | 5.27 | Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983) |
| "Gemcitabine alone was given in cycle 1 as a 24-h, 2-h or 1-h i." | 2.71 | A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin. ( Chen, A; Grem, JL; Hamilton, JM; Harold, N; Keith, B; Monahan, BP; Morrison, G; Nguyen, D; Pang, J; Quinn, MG; Rowedder, A; Takimoto, CH; Xu, Y, 2003) |
| "Six Japanese cancer patients treated with gemcitabine plus cisplatin were examined." | 2.71 | Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. ( Furuse, J; Hasegawa, R; Ikeda, M; Ishii, H; Kaniwa, N; Kikura-Hanajiri, R; Kim, SR; Okusaka, T; Ozawa, S; Saijo, N; Saito, Y; Sawada, J; Sugiyama, E; Ueno, H; Yamamoto, N; Yonemori, K; Yoshida, T, 2005) |
| " However, a WHO grade 4 hematologic toxicity was observed in 9 patients, and 2 toxic deaths were related to severe granulocytopenia and sepsis." | 1.28 | [Doxifluridine toxicity, a fluorouracil analog with low myelosuppressive effect]. ( Alberto, P; Mermillod, B; Winkelmann, JJ, 1990) |
| "Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma." | 1.27 | Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983) |
| "Stomatitis was severe at high doses of DFUR." | 1.26 | Phase I clinical study with 5'-deoxy-5-fluorouridine, a new fluoropyrimidine derivative. ( Abele, R; Alberto, P; Bollag, W; Germano, G; Heintz, R; Seematter, RJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grem, JL | 1 |
| Quinn, MG | 1 |
| Keith, B | 1 |
| Monahan, BP | 1 |
| Hamilton, JM | 1 |
| Xu, Y | 1 |
| Harold, N | 1 |
| Nguyen, D | 1 |
| Takimoto, CH | 1 |
| Rowedder, A | 1 |
| Pang, J | 1 |
| Morrison, G | 1 |
| Chen, A | 1 |
| Yonemori, K | 1 |
| Ueno, H | 1 |
| Okusaka, T | 1 |
| Yamamoto, N | 1 |
| Ikeda, M | 1 |
| Saijo, N | 1 |
| Yoshida, T | 1 |
| Ishii, H | 1 |
| Furuse, J | 1 |
| Sugiyama, E | 1 |
| Kim, SR | 1 |
| Kikura-Hanajiri, R | 1 |
| Hasegawa, R | 1 |
| Saito, Y | 1 |
| Ozawa, S | 1 |
| Kaniwa, N | 1 |
| Sawada, J | 1 |
| Kemeny, N | 1 |
| Eid, A | 1 |
| Stockman, J | 1 |
| Gonen, M | 1 |
| Schwartz, L | 1 |
| Tetzlaff, E | 1 |
| Paty, P | 1 |
| Takiuchi, H | 1 |
| Goto, M | 1 |
| Imamura, H | 1 |
| Furukawa, H | 1 |
| Imano, M | 1 |
| Imamoto, H | 1 |
| Kimura, Y | 1 |
| Ishida, H | 1 |
| Fujitani, K | 1 |
| Narahara, H | 1 |
| Shimokawa, T | 1 |
| Abele, R | 2 |
| Alberto, P | 3 |
| Seematter, RJ | 1 |
| Germano, G | 1 |
| Heintz, R | 1 |
| Bollag, W | 1 |
| Barone, RM | 2 |
| Byfield, JE | 2 |
| Goldfarb, PB | 1 |
| Frankel, S | 1 |
| Ginn, C | 1 |
| Greer, S | 1 |
| Kaplan, S | 1 |
| Siegenthaler, P | 1 |
| Hofmann, V | 1 |
| Ryssel, HJ | 1 |
| Hartmann, D | 1 |
| Holdener, EE | 1 |
| Cavalli, F | 1 |
| Frankel, SS | 1 |
| Sharp, TR | 1 |
| Patt, YZ | 1 |
| Mavligit, GM | 1 |
| Chuang, VP | 1 |
| Wallace, S | 1 |
| Johnston, S | 1 |
| Benjamin, RS | 1 |
| Valdivieso, M | 1 |
| Hersh, EM | 1 |
| Seong, J | 1 |
| Cho, JH | 1 |
| Kim, NK | 1 |
| Min, JS | 1 |
| Suh, CO | 1 |
| Lokich, J | 1 |
| Moore, C | 1 |
| Anderson, N | 1 |
| Bern, M | 1 |
| Winkelmann, JJ | 1 |
| Mermillod, B | 1 |
| Ansfield, FJ | 1 |
| Ramirez, G | 1 |
5 trials available for floxuridine and Thrombocytopenia
| Article | Year |
|---|---|
A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Dr | 2003 |
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
Topics: Aged; Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cis | 2005 |
Hepatic arterial infusion of floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dexamethasone; Dose- | 2005 |
Multi-center phase II study for combination therapy with paclitaxel/doxifluridine to treat advanced/recurrent gastric cancer showing resistance to S-1 (OGSG 0302).
Topics: Adenocarcinoma; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Disease-Free | 2008 |
Preoperative chemoradiotherapy with oral doxifluridine plus low-dose oral leucovorin in unresectable primary rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C | 2001 |
8 other studies available for floxuridine and Thrombocytopenia
| Article | Year |
|---|---|
Phase I clinical study with 5'-deoxy-5-fluorouridine, a new fluoropyrimidine derivative.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; | 1982 |
Intra-arterial chemotherapy using an implantable infusion pump and liver irradiation for the treatment of hepatic metastases.
Topics: Adult; Aged; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Drug Admin | 1982 |
Phase II study of doxifluridine in advanced colorectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms | 1983 |
Treatment with combined intra-arterial 5-FUdR infusion and whole-liver radiation for colon carcinoma metastatic to the liver. Preliminary results.
Topics: Adult; Colonic Neoplasms; Combined Modality Therapy; Drug Implants; Evaluation Studies as Topic; Flo | 1984 |
Percutaneous hepatic arterial infusion (HAI) of mitomycin C and floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver.
Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human | 1980 |
Infusion of floxuridine plus etoposide plus cisplatin in human malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ci | 1991 |
[Doxifluridine toxicity, a fluorouracil analog with low myelosuppressive effect].
Topics: Administration, Oral; Antineoplastic Agents; Bone Marrow; Central Nervous System; Floxuridine; Heart | 1990 |
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin | 1971 |