floxuridine has been researched along with Sensitivity and Specificity in 20 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To improve bioavailability and provide resistance to deamination, an array of gemcitabine (dFdC) prodrugs carrying the acyl modifications has been successful in the optimization of pharmacokinetic properties of dFdC, but the reports about 4-N-carbobenzoxy-dFdC (Cbz-dFdC), a dFdC prodrug bearing alkyloxycarbonyl modification, are relatively rare." | 1.48 | Simultaneous determination of gemcitabine prodrug, gemcitabine and its major metabolite 2', 2'-difluorodeoxyuridine in rat plasma by UFLC-MS/MS. ( Aa, L; Fei, F; Hao, K; Jiang, W; Liu, J; Lu, L; Pei, X; Peng, Y; Sun, Y; Wang, G; Wang, J; Zhen, L, 2018) |
| "The Hollow Fibre Assay (HFA) is usually applied as an early in vivo model for anti-cancer drug screening, but is potentially an excellent model for short-term in vivo pharmacodynamic studies." | 1.34 | The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. ( Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E, 2007) |
| " A sensitive analytical method for the quantitation of gemcitabine is required for the assessment of alternative dosage and treatment schemes." | 1.34 | Rapid determination of gemcitabine in plasma and serum using reversed-phase HPLC. ( Cerny, T; Früh, M; Lanz, C; Lauterburg, BH; Thormann, W, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 13 (65.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Zhen, L | 1 |
| Peng, Y | 1 |
| Wang, J | 1 |
| Fei, F | 1 |
| Aa, L | 1 |
| Jiang, W | 1 |
| Pei, X | 1 |
| Lu, L | 1 |
| Liu, J | 1 |
| Wang, G | 1 |
| Hao, K | 1 |
| Buchner, P | 1 |
| Mihola, E | 1 |
| Sahmanovic, A | 1 |
| Steininger, T | 1 |
| Dittrich, C | 1 |
| Czejka, M | 1 |
| Wickremsinhe, ER | 1 |
| Lee, LB | 1 |
| Schmalz, CA | 1 |
| Torchia, J | 1 |
| Ruterbories, KJ | 1 |
| Woo, YA | 1 |
| Kim, GH | 1 |
| Jeong, EJ | 1 |
| Kim, CY | 1 |
| Kovalova, L | 1 |
| McArdell, CS | 1 |
| Hollender, J | 1 |
| Bowen, C | 1 |
| Wang, S | 1 |
| Licea-Perez, H | 1 |
| Carli, D | 1 |
| Honorat, M | 1 |
| Cohen, S | 1 |
| Megherbi, M | 1 |
| Vignal, B | 1 |
| Dumontet, C | 1 |
| Payen, L | 1 |
| Guitton, J | 1 |
| Zhuo, LJ | 1 |
| Gao, MQ | 1 |
| Huang, AM | 1 |
| Wang, LZ | 1 |
| Goh, BC | 1 |
| Lee, HS | 1 |
| Noordhuis, P | 2 |
| Peters, GJ | 3 |
| Sironi, S | 1 |
| Messa, C | 1 |
| Mangili, G | 1 |
| Zangheri, B | 1 |
| Aletti, G | 1 |
| Garavaglia, E | 1 |
| Vigano, R | 1 |
| Picchio, M | 1 |
| Taccagni, G | 1 |
| Maschio, AD | 1 |
| Fazio, F | 1 |
| Holwerda, U | 1 |
| Van Laar, JA | 1 |
| Van der Wilt, CL | 1 |
| Pohlen, U | 1 |
| Rieger, H | 1 |
| Binnenhei, M | 1 |
| Reszka, RC | 1 |
| Buhr, HJ | 1 |
| Berger, G | 1 |
| Guichard, SM | 1 |
| Mayer, I | 1 |
| Jodrell, DI | 1 |
| Temmink, OH | 1 |
| Prins, HJ | 1 |
| van Gelderop, E | 1 |
| Vainchtein, LD | 1 |
| Rosing, H | 1 |
| Thijssen, B | 1 |
| Schellens, JH | 1 |
| Beijnen, JH | 1 |
| Lanz, C | 1 |
| Früh, M | 1 |
| Thormann, W | 1 |
| Cerny, T | 1 |
| Lauterburg, BH | 1 |
| Marangon, E | 1 |
| Sala, F | 1 |
| Caffo, O | 1 |
| Galligioni, E | 1 |
| D'Incalci, M | 1 |
| Zucchetti, M | 1 |
| Gutierrez, MM | 1 |
| Giacomini, KM | 1 |
| Pujari, MP | 1 |
| Barrientos, A | 1 |
| Muggia, FM | 1 |
| Koda, RT | 1 |
| Avril, N | 1 |
| Dose, J | 1 |
| Ziegler, S | 1 |
| Jänicke, F | 1 |
| Schwaiger, M | 1 |
1 review available for floxuridine and Sensitivity and Specificity
| Article | Year |
|---|---|
[Diagnosis of breast carcinoma and locoregional lymph nodes with positron emission tomography].
Topics: Blood Glucose; Breast Neoplasms; Female; Floxuridine; Humans; Lymph Nodes; Lymphatic Metastasis; Neo | 1997 |
2 trials available for floxuridine and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Smal | 2008 |
Determination of hydroxyurea in plasma and peritoneal fluid by high-performance liquid chromatography using electrochemical detection.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Chromatography | 1997 |
17 other studies available for floxuridine and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous determination of gemcitabine prodrug, gemcitabine and its major metabolite 2', 2'-difluorodeoxyuridine in rat plasma by UFLC-MS/MS.
Topics: Animals; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Gemcitabi | 2018 |
Validation of a simple assay for the quantification of the capecitabine metabolites 5'-DFCR and 5'-DFUR for drug monitoring in patients receiving outpatient chemotherapy.
Topics: Calibration; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Monitoring; Drug Stability; F | 2013 |
High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS.
Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Deoxycytidine; Deoxyuridine; Floxuridine; G | 2013 |
Simultaneous determination of doxifluridine and 5-fluorouracil in monkey serum by high performance liquid chromatography with tandem mass spectrometry.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid | 2008 |
Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry.
Topics: Adsorption; Chromatography, Liquid; Cytostatic Agents; Deoxycytidine; Drug Residues; Floxuridine; Fl | 2009 |
Development of a sensitive and selective LC-MS/MS method for simultaneous determination of gemcitabine and 2,2-difluoro-2-deoxyuridine in human plasma.
Topics: Antineoplastic Agents; Chromatography, Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Neop | 2009 |
Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS.
Topics: Cell Line; Cell Line, Tumor; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Stability; Floxur | 2009 |
[Improved sensitivity of gastric carcinoma cells to fluorouracil-related drugs by transfection of thymidine phosphorylase gene].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Deoxycytidine; Floxuridine; Fluorou | 2011 |
An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; | 2003 |
Integrated FDG PET/CT in patients with persistent ovarian cancer: correlation with histologic findings.
Topics: Adult; Aged; Female; Floxuridine; Humans; Middle Aged; Ovarian Neoplasms; Positron-Emission Tomograp | 2004 |
A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA; Drug Screening A | 2004 |
Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.
Topics: Animals; Biological Availability; Blood Flow Velocity; Chromatography, High Pressure Liquid; Disease | 2005 |
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
Topics: Animals; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Dr | 2005 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neopla | 2007 |
Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
Topics: Antineoplastic Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Complex Mixtur | 2007 |
Rapid determination of gemcitabine in plasma and serum using reversed-phase HPLC.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Chemical Analysis; Calibration; Chemistry, Clinical; | 2007 |
Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney.
Topics: 2-Chloroadenosine; Adult; Aged; Biological Transport; Carrier Proteins; Dose-Response Relationship, | 1993 |