floxuridine has been researched along with Sarcoma in 8 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the current study, the authors set out to determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) associated with a combination of gemcitabine and dacarbazine (DTIC) in patients with advanced soft tissue sarcoma (ASTS), to obtain preliminary information on the activity of this combination, and to explore possible pharmacodynamic interactions between gemcitabine and DTIC." | 9.11 | Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation. ( Buesa, JM; Díaz, A; Esteban, E; Fernández, A; Fra, J; López-Pousa, A; Losa, R; Sierra, M, 2004) |
| "In the current study, the authors set out to determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) associated with a combination of gemcitabine and dacarbazine (DTIC) in patients with advanced soft tissue sarcoma (ASTS), to obtain preliminary information on the activity of this combination, and to explore possible pharmacodynamic interactions between gemcitabine and DTIC." | 5.11 | Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation. ( Buesa, JM; Díaz, A; Esteban, E; Fernández, A; Fra, J; López-Pousa, A; Losa, R; Sierra, M, 2004) |
| " Such simultaneous administration enabled us to substantially increase the dosage intensity of both, thereby increasing the effectiveness of each drug." | 2.40 | Infusional chemotherapy combined with recombinant human granulocyte colony stimulating factor: advantages and limitations. ( Lackman, RD; Weiss, AJ, 1997) |
| "There were seven malignant fibrous histiocytomas, four liposarcomas, two fibrosarcomas, one leiomyosarcoma, and one rhabdomyosarcoma; 73% were grade III." | 1.28 | Intraarterial chemotherapy with limb-sparing resection of large soft-tissue sarcomas of the extremities. ( Bonn, J; Gardiner, GA; Lackman, RD; Shapiro, MJ; Soulen, MC; Sullivan, KL; Weiss, AJ; Weissmann, JR, 1992) |
| "In metastatic brain tumors from lung, breast, and gastric cancer, the average time from the diagnosis of primary cancer to brain metastasis was shorter in cases with high activities and longer in cases with low activities." | 1.27 | [Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR]. ( Miki, Y; Miwa, M; Nomura, K; Shibui, S; Watanabe, T, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| OETTGEN, HF | 1 |
| CLIFFORD, P | 1 |
| CANDLER, P | 1 |
| RICH, MA | 1 |
| PEREZ, AG | 1 |
| EIDINOFF, ML | 1 |
| Buesa, JM | 1 |
| Losa, R | 1 |
| Fernández, A | 1 |
| Sierra, M | 1 |
| Esteban, E | 1 |
| Díaz, A | 1 |
| López-Pousa, A | 1 |
| Fra, J | 1 |
| Shibui, S | 1 |
| Watanabe, T | 1 |
| Miki, Y | 1 |
| Nomura, K | 1 |
| Miwa, M | 1 |
| Weiss, AJ | 2 |
| Lackman, RD | 2 |
| Soulen, MC | 1 |
| Weissmann, JR | 1 |
| Sullivan, KL | 1 |
| Shapiro, MJ | 1 |
| Bonn, J | 1 |
| Gardiner, GA | 1 |
| Nomura, S | 1 |
| Dunn, KJ | 1 |
| Mattern, CF | 1 |
| Hartley, JW | 1 |
| Fischinger, PJ | 1 |
| Van Dyk, JJ | 1 |
| Clarkson, BD | 1 |
| Duschinsky, R | 1 |
| Keller, O | 1 |
| La Sala, E | 1 |
| Krakoff, IH | 1 |
1 review available for floxuridine and Sarcoma
| Article | Year |
|---|---|
Infusional chemotherapy combined with recombinant human granulocyte colony stimulating factor: advantages and limitations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Clinical Trials as Topic; Doxorubicin; Dr | 1997 |
1 trial available for floxuridine and Sarcoma
| Article | Year |
|---|---|
Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Comb | 2004 |
6 other studies available for floxuridine and Sarcoma
| Article | Year |
|---|---|
CONTINUOUS INTRA-ARTERIAL OR INTRAVENOUS INFUSION OF 5-FLUORO-2-DEOXYURIDINE: THERAPEUTIC AND TOXIC EFFECTS.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Chemotherapy, Cancer, Regiona | 1963 |
Effect of 5-fluorodeoxyuridine on the proliferation of Rous sarcoma virus.
Topics: Floxuridine; Neoplasms; Nucleosides; Nucleotides; Rous sarcoma virus; Sarcoma; Viruses | 1962 |
[Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR].
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Floxuridine; Glioma; Humans; Meningeal Neoplasm | 1983 |
Intraarterial chemotherapy with limb-sparing resection of large soft-tissue sarcomas of the extremities.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; D | 1992 |
Revertants of mouse cells transformed by murine sarcoma virus: flat variants without a rescuable sarcoma virus from a clone of BALB/3T3 transformed by Kirsten MSV.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Colchicine; Conca | 1974 |
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carci | 1967 |