floxuridine has been researched along with Sarcoma 180 in 23 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Sarcoma 180: An experimental sarcoma of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| " They were then evaluated as potential growth inhibitors of murine Sarcoma 180 cells in culture, of herpes simplex virus type 1 in vitro, and of Streptococcus faecium, a folic acid or deoxythymidine dependent bacterial strain." | 3.66 | Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides. ( Chen, MS; Prusoff, WH; Schinazi, RF, 1978) |
| " dosing of 6a was maintained for as long as 24 h." | 1.29 | Synthesis and antitumor activities of 5'-O-aminoacyl-3'-O-benzyl derivatives of 2'-deoxy-5-fluorouridine and related compounds. ( Tada, Y; Takeda, S; Uchida, J; Uemura, A; Yamashita, J, 1996) |
| " FdUrd, in particular, had a very minor effect on rRNA production even at very toxic drug concentrations." | 1.27 | Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity. ( Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY, 1987) |
| " At the 1st hr after dosing the 5-FU level in the small intestine was close to, but that in other tissues was much lower than, the 5-FU level in the tumor of both types." | 1.26 | Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats. ( Fukazawa, H; Hongu, Y; Ichihara, S; Shimizu, H; Suzuki, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (91.30) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schinazi, RF | 1 |
| Chen, MS | 1 |
| Prusoff, WH | 2 |
| Cook, AF | 2 |
| Holman, MJ | 2 |
| Kramer, MJ | 2 |
| Trown, PW | 1 |
| Lin, TS | 1 |
| Yamashita, J | 2 |
| Takeda, S | 2 |
| Matsumoto, H | 1 |
| Unemi, N | 1 |
| Yasumoto, M | 1 |
| THIELE, EH | 1 |
| ARISON, RN | 1 |
| BOXER, GE | 1 |
| Hartmann, HR | 3 |
| Matter, A | 1 |
| Miwa, M | 4 |
| Nakamura, J | 1 |
| Ishitsuka, H | 4 |
| Fujita, H | 1 |
| Ogawa, K | 1 |
| Nakagawa, H | 1 |
| Kawaguchi, K | 1 |
| Nakagawa, Y | 1 |
| Doi, Y | 1 |
| Takemoto, K | 1 |
| Fukuoka, K | 1 |
| Itoga, A | 1 |
| Maruyama, HB | 1 |
| Bollag, W | 2 |
| Suzuki, S | 1 |
| Hongu, Y | 1 |
| Fukazawa, H | 1 |
| Ichihara, S | 1 |
| Shimizu, H | 1 |
| Uemura, A | 1 |
| Tada, Y | 1 |
| Uchida, J | 1 |
| Harada, N | 1 |
| Hongu, M | 1 |
| Kawaguchi, T | 1 |
| Ohohashi, M | 1 |
| Oda, K | 1 |
| Hashiyama, T | 1 |
| Tsujihara, K | 1 |
| Jato, JG | 1 |
| Lake, LM | 1 |
| Grunden, EE | 1 |
| Johnson, BM | 1 |
| Takimoto, CH | 1 |
| Tan, YY | 1 |
| Cadman, EC | 1 |
| Armstrong, RD | 1 |
| Fujii, S | 2 |
| Shirasaka, T | 1 |
| Nishimura, J | 1 |
| Kamiyama, T | 1 |
| Eda, H | 1 |
| Fukuda, H | 1 |
| Fujimoto, K | 1 |
| Divekar, AY | 1 |
| Fleysher, MH | 1 |
| Slocum, HK | 1 |
| Kenny, LN | 1 |
| Hakala, MT | 1 |
| Khwaja, TA | 1 |
| Heidelberger, C | 1 |
23 other studies available for floxuridine and Sarcoma 180
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexv | 1978 |
Fluorinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5-fluoropyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Flucytosine; Fluorouracil; Mice; Pyrimidine Nucleosides; Sarcoma 180 | 1979 |
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cells, Cu | 1978 |
Studies on antitumor agents. 8. Antitumor activities of O-alkyl derivatives of 2'-deoxy-5-(trifluoromethyl)uridine and 2'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Floxuridine; Ma | 1989 |
Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Floxuridine; Fluorouracil; Mice; Sarcoma 180; Tegafur | 1980 |
ONCOLYSIS BY CLOSTRIDIA. III. EFFECTS OF CLOSTRIDIA AND CHEMOTHERAPEUTIC AGENTS ON RODENT TUMORS.
Topics: Adenocarcinoma; Animals; Antimetabolites; Antineoplastic Agents; Aziridines; Bacteriological Techniq | 1964 |
Antiproliferative action of a novel fluorinated uridine analog, 5'-deoxy-5-fluorouridine, measured in vitro and in vivo on four different murine tumor lines.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Floxuridine; Isomerism; Lung Neoplasms; Lymphoma; | 1982 |
A simple and convenient assay method for phosphorolysis of 5'-deoxy-5-fluorouridine.
Topics: Animals; Bacteriological Techniques; Floxuridine; Humans; Mice; Mice, Inbred Strains; Micrococcus; M | 1981 |
[Pharmacokinetics of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Animals; Cricetinae; Floxuridine; Kinetics; Male; Mice; Neoplasms, Experimenta | 1983 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera | 1980 |
Tumor inhibitory effects of a new fluorouracil derivative: 5'-deoxy-5-fluorouridine.
Topics: Animals; Female; Floxuridine; Lethal Dose 50; Lung Neoplasms; Mice; Neoplasms, Experimental; Sarcoma | 1980 |
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Te | 1980 |
Synthesis and antitumor activities of 5'-O-aminoacyl-3'-O-benzyl derivatives of 2'-deoxy-5-fluorouridine and related compounds.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Screening Assays, Antitumor; Floxuridine; Male; Mice; | 1996 |
Synthesis and biological activity of O-alkyl-3-N-aminoacyloxymethyl-5-fluoro-2'-deoxyuridine derivatives.
Topics: Animals; Antimetabolites, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Deoxyuridine; Fem | 1996 |
Effect of deoxyuridine coadministration on toxicity and antitumor activity of fluorouracil and floxuridine.
Topics: Animals; Antineoplastic Agents; Biological Assay; Deoxyuridine; Drug Combinations; Drug Synergism; F | 1975 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Mes | 1987 |
[Studies of the antitumor activity and enzymology of 2'-deoxy-5-fluorouridine (FdUrd) derivatives].
Topics: Animals; Antineoplastic Agents; Floxuridine; Intestine, Small; Liver; Male; Mice; Rats; Rats, Inbred | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung N | 1986 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.
Topics: Adenosine; Alkenes; Aminohydrolases; Animals; Carbon Isotopes; Cell Division; Cells, Cultured; Chrom | 1972 |
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Escherichia coli; Floxuridine; HeLa Ce | 1967 |