floxuridine has been researched along with Renal Insufficiency in 2 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Plasma concentration data were pooled and analyzed using a population pharmacokinetic program (NONMEM)." | 2.71 | Gemcitabine in patients with solid tumors and renal impairment: a pharmacokinetic phase I study. ( Delaloge, S; Di Palma, M; Forgue, ST; Le Chevalier, T; Llombart, A; Ni, L; Tourani, JM; Turpin, F, 2004) |
| "Gemcitabine was rapidly eliminated from plasma even in patients with renal dysfunction." | 1.35 | Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer. ( Hirobe, M; Itoh, T; Kunishima, Y; Masumori, N; Takayanagi, A; Takeuchi, M; Tsukamoto, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delaloge, S | 1 |
| Llombart, A | 1 |
| Di Palma, M | 1 |
| Tourani, JM | 1 |
| Turpin, F | 1 |
| Ni, L | 1 |
| Forgue, ST | 1 |
| Le Chevalier, T | 1 |
| Masumori, N | 1 |
| Kunishima, Y | 1 |
| Hirobe, M | 1 |
| Takeuchi, M | 1 |
| Takayanagi, A | 1 |
| Tsukamoto, T | 1 |
| Itoh, T | 1 |
1 trial available for floxuridine and Renal Insufficiency
| Article | Year |
|---|---|
Gemcitabine in patients with solid tumors and renal impairment: a pharmacokinetic phase I study.
Topics: Antimetabolites, Antineoplastic; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Male; Midd | 2004 |
1 other study available for floxuridine and Renal Insufficiency
| Article | Year |
|---|---|
Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer.
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Cystectomy; Deoxycytidine; Fatal | 2008 |