floxuridine has been researched along with Osteosarcoma in 8 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Growth inhibition assays indicated that the IC50 values for methotrexate (MTX) and 5-fluorodeoxyuridine (FdUrd) in HS-18, a liposarcoma cell line lacking retinoblastoma protein (pRB), and SaOS-2, an osteosarcoma cell line with a truncated and nonfunctional pRB, were 10- to 12-fold and 4- to 11-fold higher, respectively, than for the HT-1080 (fibrosarcoma) cell line, which has wild-type pRB." | 3.69 | Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. ( Almasan, A; Banerjee, D; Bertino, JR; Fan, J; Hochhauser, D; Kelly, R; Li, W; Wahl, GM; Yin, Y; Zielinski, Z, 1995) |
| "The first was treated for synovial sarcoma of a metatarsal." | 1.30 | Soft-tissue complications of intra-arterial chemotherapy for extremity sarcomas. ( Bezwada, HP; Granick, MS; Lackman, RL; Long, CD; Moore, JH; Weiss, AJ, 1998) |
| " With use of these studies, a therapeutic ratio (concentration that prevented 25% clonal growth compared to untreated control of bone marrow divided by LD50 of tumor) was calculated for each drug in each tumor." | 1.27 | 5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. ( Armstrong, RD; Cadman, E, 1983) |
| " FUdR was found to be chemically toxic in itself to 2 canine tissue culture lines at doses used in the literature to increase 125IUdR uptake." | 1.27 | The toxicity of fluorodeoxyuridine when used to increase the uptake of 125I-iododeoxyuridine into tissue culture cells in vitro. ( Holmes, JM, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morin, KW | 1 |
| Duan, W | 1 |
| Knaus, EE | 1 |
| McEwan, AJ | 1 |
| Wiebe, LI | 1 |
| Armstrong, RD | 2 |
| Cadman, E | 2 |
| Gesmonde, J | 1 |
| Wu, T | 1 |
| Holmes, JM | 1 |
| Li, W | 1 |
| Fan, J | 1 |
| Hochhauser, D | 1 |
| Banerjee, D | 1 |
| Zielinski, Z | 1 |
| Almasan, A | 1 |
| Yin, Y | 1 |
| Kelly, R | 1 |
| Wahl, GM | 1 |
| Bertino, JR | 1 |
| Bezwada, HP | 1 |
| Granick, MS | 1 |
| Long, CD | 1 |
| Moore, JH | 1 |
| Lackman, RL | 1 |
| Weiss, AJ | 2 |
| Imperato, S | 1 |
| Manca, F | 1 |
| Dessì, V | 1 |
| Di Crescenzo, L | 1 |
| Testa, D | 1 |
| Kashdan, BJ | 1 |
| Sullivan, KL | 1 |
| Lackman, RD | 1 |
| Shapiro, MJ | 1 |
| Bonn, J | 1 |
| Gardiner, GA | 1 |
8 other studies available for floxuridine and Osteosarcoma
| Article | Year |
|---|---|
A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.
Topics: Bone Neoplasms; Cell Line, Tumor; Floxuridine; Herpesvirus 1, Human; Humans; Iodine Radioisotopes; O | 2005 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; | 1983 |
Cytotoxic activity of 5'-deoxy-5-fluorouridine in cultured human tumors.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Female; | 1983 |
The toxicity of fluorodeoxyuridine when used to increase the uptake of 125I-iododeoxyuridine into tissue culture cells in vitro.
Topics: Animals; Cell Line; Cells; Culture Techniques; Dogs; Floxuridine; Idoxuridine; Iodine Radioisotopes; | 1983 |
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Base Sequence; Bone Neoplasms; Cell Division | 1995 |
Soft-tissue complications of intra-arterial chemotherapy for extremity sarcomas.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chondrosarcoma; Cisplatin; Doxorubicin; Extre | 1998 |
[Cytotoxicity test of antilymphocyte globulin to tumor cells with 51Cr and 1251-IUDR: comparison between the 2 methods].
Topics: Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; Floxuridine; Idoxuridine; Iodine Radioisoto | 1977 |
Extremity osteosarcomas: intraarterial chemotherapy and limb-sparing resection with 2-year follow-up.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Combined | 1990 |