floxuridine has been researched along with Melanoma in 17 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-two patients with malignant melanoma were treated with doxifluridine, 4000 mg/m2 daily X 5, repeated every 3 weeks." | 7.67 | Phase II study of 5'-deoxy-5-fluorouridine (doxifluridine) in advanced malignant melanoma. ( Alberto, P; Bruntsch, U; Cavalli, F; Clavel, M; Gundersen, S; Pinedo, H; Renard, J; Rozencweig, M; Siegenthaler, P, 1986) |
| " Chicken embryotoxicity demonstrated that the duplex drugs were less toxic than 5-FdU at 0." | 5.38 | Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells. ( Berger, A; Busch, C; Garbe, C; Ikenberg, K; Meier, F; Niessner, H; Schott, S; Sinnberg, T; Venturelli, S; Villanueva, J, 2012) |
| "Frequency and distribution of 5-fluorodeoxyuridine (5-FdU) plus caffeine-induced fragile sites on chromosomes of peripheral blood lymphocytes (PBL) from 10 patients with cutaneous melanoma were studied in comparison with 10 PBL samples from normal donors of corresponding sex and age." | 3.68 | Enhanced expression of 1p32 and 1p22 fragile sites in lymphocytes in cutaneous malignant melanomas. ( Chebotarev, AN; Demidov, LV; Kirichenko, OP; Kopnin, BP; Mukeria, AF; Sokova, OI, 1992) |
| "Forty-two patients with malignant melanoma were treated with doxifluridine, 4000 mg/m2 daily X 5, repeated every 3 weeks." | 3.67 | Phase II study of 5'-deoxy-5-fluorouridine (doxifluridine) in advanced malignant melanoma. ( Alberto, P; Bruntsch, U; Cavalli, F; Clavel, M; Gundersen, S; Pinedo, H; Renard, J; Rozencweig, M; Siegenthaler, P, 1986) |
| " Chicken embryotoxicity demonstrated that the duplex drugs were less toxic than 5-FdU at 0." | 1.38 | Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells. ( Berger, A; Busch, C; Garbe, C; Ikenberg, K; Meier, F; Niessner, H; Schott, S; Sinnberg, T; Venturelli, S; Villanueva, J, 2012) |
| " FUdR was found to be chemically toxic in itself to 2 canine tissue culture lines at doses used in the literature to increase 125IUdR uptake." | 1.27 | The toxicity of fluorodeoxyuridine when used to increase the uptake of 125I-iododeoxyuridine into tissue culture cells in vitro. ( Holmes, JM, 1983) |
| "1% of cases; however, it was easily reduced by decreasing the dosage or discontinuing administration of the drug." | 1.27 | [Phase II study of 5'-DFUR in gastrointestinal and breast cancer]. ( Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (82.35) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schott, S | 1 |
| Niessner, H | 1 |
| Sinnberg, T | 1 |
| Venturelli, S | 1 |
| Berger, A | 1 |
| Ikenberg, K | 1 |
| Villanueva, J | 1 |
| Meier, F | 1 |
| Garbe, C | 1 |
| Busch, C | 1 |
| THIELE, EH | 1 |
| ARISON, RN | 1 |
| BOXER, GE | 1 |
| DOWD, JE | 1 |
| DIPAOLO, JA | 1 |
| WATNE, AL | 1 |
| SULLIVAN, RD | 1 |
| ZUREK, WZ | 1 |
| Hartmann, HR | 1 |
| Matter, A | 1 |
| Ellem, KA | 1 |
| Kay, GF | 1 |
| Holmes, JM | 1 |
| Oberfield, RA | 2 |
| Fritze, D | 1 |
| Kern, DH | 1 |
| Drogemuller, CR | 1 |
| Pilch, YH | 1 |
| Sokova, OI | 1 |
| Kirichenko, OP | 1 |
| Mukeria, AF | 1 |
| Demidov, LV | 1 |
| Chebotarev, AN | 1 |
| Kopnin, BP | 1 |
| Kidson, SH | 1 |
| De Haan, JB | 1 |
| Tominaga, T | 1 |
| Kitamura, M | 1 |
| Hayashi, K | 1 |
| Takahashi, I | 1 |
| Kosaki, G | 1 |
| Alberto, P | 1 |
| Rozencweig, M | 1 |
| Clavel, M | 1 |
| Siegenthaler, P | 1 |
| Cavalli, F | 1 |
| Gundersen, S | 1 |
| Bruntsch, U | 1 |
| Renard, J | 1 |
| Pinedo, H | 1 |
| Simoni, G | 1 |
| Bignami, P | 1 |
| Civalleri, D | 1 |
| Cosimelli, M | 1 |
| Craus, W | 1 |
| Percivale, PL | 1 |
| Repetto, M | 1 |
| Fujimoto, S | 1 |
| Wang, Y | 1 |
| Inoue, K | 1 |
| Ogawa, M | 1 |
| Johnson, FD | 1 |
| Jacobs, EM | 1 |
17 other studies available for floxuridine and Melanoma
| Article | Year |
|---|---|
Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chick Embryo; Cytidine; Cytidine Monoph | 2012 |
ONCOLYSIS BY CLOSTRIDIA. III. EFFECTS OF CLOSTRIDIA AND CHEMOTHERAPEUTIC AGENTS ON RODENT TUMORS.
Topics: Adenocarcinoma; Animals; Antimetabolites; Antineoplastic Agents; Aziridines; Bacteriological Techniq | 1964 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop | 1964 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exf | 1964 |
Antiproliferative action of a novel fluorinated uridine analog, 5'-deoxy-5-fluorouridine, measured in vitro and in vivo on four different murine tumor lines.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Floxuridine; Isomerism; Lung Neoplasms; Lymphoma; | 1982 |
The nature of conditioning nutrients for human malignant melanoma cultures.
Topics: Blood; Cell Count; Cell Line; Clone Cells; Culture Media; Floxuridine; Humans; Keto Acids; Melanoma; | 1983 |
The toxicity of fluorodeoxyuridine when used to increase the uptake of 125I-iododeoxyuridine into tissue culture cells in vitro.
Topics: Animals; Cell Line; Cells; Culture Techniques; Dogs; Floxuridine; Idoxuridine; Iodine Radioisotopes; | 1983 |
Intra-arterial infusion in tumors of the pelvis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality T | 1983 |
A new micromethod for the detection of HL-A antigens on cultured human tumor cells.
Topics: Adenocarcinoma; Antibody Specificity; Colonic Neoplasms; Culture Techniques; Cytotoxicity Tests, Imm | 1975 |
Current status of regional arterial infusion chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization; | 1975 |
Enhanced expression of 1p32 and 1p22 fragile sites in lymphocytes in cutaneous malignant melanomas.
Topics: Adult; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human | 1992 |
Effect of thymidine analogs on tyrosinase activity and mRNA accumulation in mouse melanoma cells.
Topics: Animals; Bromodeoxyuridine; Catechol Oxidase; Cell Line; Cell Transformation, Neoplastic; Floxuridin | 1990 |
[Phase II study of 5'-DFUR in gastrointestinal and breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarr | 1985 |
Phase II study of 5'-deoxy-5-fluorouridine (doxifluridine) in advanced malignant melanoma.
Topics: Drug Evaluation; Floxuridine; Humans; Melanoma | 1986 |
[Comparison of the performance of a totally implantable pump and conventional access systems in regional arterial chemotherapy of liver tumors].
Topics: Adenocarcinoma; Aged; Carcinoma; Carcinoma, Squamous Cell; Female; Floxuridine; Humans; Infusions, I | 1986 |
Antitumor activity of a new fluoropyrimidine derivative, 5'-deoxy-5-fluorouridine, against murine and human experimental tumors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Humans; Leukemia L1210; Leuke | 1985 |
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neop | 1971 |