floxuridine and Lymph Node Metastasis studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

Excerpt	Relevance	Reference
"Irinotecan (CPT-11) and doxifluridine (5'-DFUR) are active agents against colorectal cancer."	9.11	Sequential treatment with irinotecan and doxifluridine: optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer. ( Fujimoto-Ouchi, K; Kato, T; Kikkawa, N; Mishima, H; Nishisho, I; Tanaka, Y; Tsujie, M; Tsujinaka, T; Yanagisawa, M, 2005)
"We compared the therapeutic usefulness of doxifluridine (5'-DFUR) alone and a combination of 5'-DFUR plus cyclophosphamide (CPM), both of which are considered effective against advanced and recurrent breast cancer, to determine which treatment is more beneficial as postoperative adjuvant chemotherapy."	9.10	Randomized controlled trial comparing oral doxifluridine plus oral cyclophosphamide with doxifluridine alone in women with node-positive breast cancer after primary surgery. ( Abe, O; Asaishi, K; Hirata, K; Ikeda, T; Kimijima, I; Koyama, H; Miura, S; Monden, Y; Morimoto, T; Noguchi, S; Nomura, Y; Ohashi, Y; Ota, J; Sonoo, H; Sugimachi, K; Toge, T; Toi, M; Tominaga, T; Yamaguchi, S, 2003)
"To evaluate the feasibility and efficacy of weekly paclitaxel and 5'-DFUR combination therapy in advanced or recurrent breast cancer, 13 patients were enrolled in this pilot study."	7.72	[Evaluation of weekly paclitaxel and doxifluridine (5'-DFUR) combination therapy in patients with advanced or recurrent breast cancer]. ( Kou, Y; Okamoto, Y; Okuyama, N; Sawada, T; Tominaga, T, 2003)
"An advanced breast cancer patient refractory to CAF (Cyclophosphamide, Adriamycin, 5-fluorouracil), 5-FU-Methotrexate sequential therapy and Tamoxifen was treated with the combination 5' DFUR, MMC, Etoposide and MPA."	7.68	[5'-deoxy-5-fluorouridine (5'-DFUR), mitomycin C (MMC), etoposide and medroxy progesterone acetate (MPA) in a previously treated patient with advanced breast cancer]. ( Ohtagaki, S; Toge, T; Toi, M; Yagi, M; Yoshinaka, K, 1991)
"Although most patients with gestational trophoblastic neoplasia (GTN) are cured by conventional chemotherapy, some develop drug resistance or relapse."	5.37	Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia. ( Feng, F; Geng, S; Wan, X; Wang, T; Xiang, Y, 2011)
"Two patients were diagnosed as advanced breast cancer with multiple bone metastases."	5.33	[Two cases of advanced breast cancer responding to oral chemoendocrine therapy with 5'-deoxy-5-fluorouridine, medroxyprogesterone acetate and cyclophosphamide (DMpC)]. ( Kihara, M; Kontani, K; Yamauchi, A; Yokomise, H, 2005)
"For metastatic breast cancer patients who have hormone receptor-positive tumors, hormonal therapy aiming at optimal palliation and prolongation of life is the initial treatment of choice."	5.32	[Combination therapy with Anastrozole and 5'-DFUR as a treatment for metastatic breast cancer]. ( Fuchimoto, S; Inagaki, M; Miyoshi, K; Nakagawa, T; Ohsaki, T; Ohtsuka, S; Yumura, M, 2004)
"She was diagnosed as having advanced breast cancer of stage T4N3 (supraclavicular lymph node) M1 (bone)."	5.31	[Efficacy of combined chemoendocrine therapy with doxifluridine, cyclophosphamide, and fadrozole hydrochloride hydrate in a case of stage T4N3M1 breast cancer]. ( Fujii, T; Hanaoka, T; Ishida, K; Kawashima, K; Mihara, Y; Takahashi, T, 2000)
"Mitoxantrone (MIT) is a new anthraquinone anticancer agent."	5.30	[Intra-arterial injection therapy of mitoxantrone for locally advanced breast cancer]. ( Ichikawa, W; Iida, S; Miyanaga, T; Nihei, Z; Nishi, N; Osanai, T; Shimizu, C; Sugihara, K; Togo, S; Uetake, H; Yamashita, T, 1998)
"Irinotecan (CPT-11) and doxifluridine (5'-DFUR) are active agents against colorectal cancer."	5.11	Sequential treatment with irinotecan and doxifluridine: optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer. ( Fujimoto-Ouchi, K; Kato, T; Kikkawa, N; Mishima, H; Nishisho, I; Tanaka, Y; Tsujie, M; Tsujinaka, T; Yanagisawa, M, 2005)
"We compared the therapeutic usefulness of doxifluridine (5'-DFUR) alone and a combination of 5'-DFUR plus cyclophosphamide (CPM), both of which are considered effective against advanced and recurrent breast cancer, to determine which treatment is more beneficial as postoperative adjuvant chemotherapy."	5.10	Randomized controlled trial comparing oral doxifluridine plus oral cyclophosphamide with doxifluridine alone in women with node-positive breast cancer after primary surgery. ( Abe, O; Asaishi, K; Hirata, K; Ikeda, T; Kimijima, I; Koyama, H; Miura, S; Monden, Y; Morimoto, T; Noguchi, S; Nomura, Y; Ohashi, Y; Ota, J; Sonoo, H; Sugimachi, K; Toge, T; Toi, M; Tominaga, T; Yamaguchi, S, 2003)
"High-dose toremifene therapy (120 mg/day) is useful for the recurrence of receptor-positive breast cancer."	3.74	[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy]. ( Murakami, S; Yamamoto, Y, 2007)
"To evaluate the feasibility and efficacy of weekly paclitaxel and 5'-DFUR combination therapy in advanced or recurrent breast cancer, 13 patients were enrolled in this pilot study."	3.72	[Evaluation of weekly paclitaxel and doxifluridine (5'-DFUR) combination therapy in patients with advanced or recurrent breast cancer]. ( Kou, Y; Okamoto, Y; Okuyama, N; Sawada, T; Tominaga, T, 2003)
"Two hundred and sixteen T2 breast cancer patients were treated consecutively with surgery followed by 5'DFUR (600 mg/body/day) + tamoxifen (20 mg/body/day) for 2 years."	3.70	Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer. ( Akasaka, Y; Hata, Y; Nakanishi, Y; Ogita, M; Sasaki, F; Sawada, Y; Takahashi, H; Uchino, J; Yoshimoto, M, 2000)
"An advanced breast cancer patient refractory to CAF (Cyclophosphamide, Adriamycin, 5-fluorouracil), 5-FU-Methotrexate sequential therapy and Tamoxifen was treated with the combination 5' DFUR, MMC, Etoposide and MPA."	3.68	[5'-deoxy-5-fluorouridine (5'-DFUR), mitomycin C (MMC), etoposide and medroxy progesterone acetate (MPA) in a previously treated patient with advanced breast cancer]. ( Ohtagaki, S; Toge, T; Toi, M; Yagi, M; Yoshinaka, K, 1991)
"They had diagnosed colorectal cancer of TNM stages II and III, and underwent macroscopic curative resection."	2.71	A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines. ( Koda, K; Kodaira, S; Miyazaki, M; Nakazato, H; Ogawa, K; Saito, N; Sarashina, H; Suwa, T; Suzuki, M; Watanabe, S, 2003)
"Case 2: A 74-year-old female with anal squamous cell carcinoma Stage II was treated by chemoradiotherapy with tegafur/uracil, external irradiation (30 Gy) and interstitial irradiation (24 Gy)."	2.42	[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma]. ( Fujitani, K; Hirao, M; Ikenaga, M; Kashiwazaki, M; Masuda, N; Mishima, H; Sawamura, T; Takeda, Y; Takeno, A; Tsujinaka, T, 2004)
"Although most patients with gestational trophoblastic neoplasia (GTN) are cured by conventional chemotherapy, some develop drug resistance or relapse."	1.37	Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia. ( Feng, F; Geng, S; Wan, X; Wang, T; Xiang, Y, 2011)
"Gemcitabine was rapidly eliminated from plasma even in patients with renal dysfunction."	1.35	Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer. ( Hirobe, M; Itoh, T; Kunishima, Y; Masumori, N; Takayanagi, A; Takeuchi, M; Tsukamoto, T, 2008)
"A 82-year-old man with advanced gastric cancer underwent distal gastrectomy in January 2006."	1.35	[Complete response obtained with first-line therapy as S-1, followed by second-line 5'-DFUR plus paclitaxel therapy in a patient with multiple liver and lymph node metastases from gastric cancer]. ( Kitajima, Y; Miyazaki, K; Nakafusa, Y; Ohtsuka, T; Sato, S; Tanaka, M; Yakabe, T, 2009)
"Many patients with gastric cancer respond to TS-1, but some fail to respond or have recurrence."	1.34	Doxifluridine combined with weekly paclitaxel for second-line treatment in patients with gastric cancer resistant to TS-1. ( Arai, W; Haruta, H; Hirashima, Y; Hosoya, Y; Hyodo, M; Kurashina, K; Nagai, H; Saito, S; Sakuma, K; Yasuda, Y; Yokoyama, T; Zuiki, T, 2007)
"Two patients were diagnosed as advanced breast cancer with multiple bone metastases."	1.33	[Two cases of advanced breast cancer responding to oral chemoendocrine therapy with 5'-deoxy-5-fluorouridine, medroxyprogesterone acetate and cyclophosphamide (DMpC)]. ( Kihara, M; Kontani, K; Yamauchi, A; Yokomise, H, 2005)
"Type 3 gastric cancer in the midgastric region was diagnosed, and the patient underwent surgery."	1.33	[A long-term survivor with stage IV gastric cancer due to postoperative weekly paclitaxel and 5'-DFUR combination therapy]. ( Fukasawa, T; Gotoh, H; Shoji, T; Taniwaka, K, 2006)
"In advanced gastric cancer, the frequency of relapses such as metastasis to the peritoneum is high."	1.33	[Prediction and treatment of peritoneal dissemination in gastric cancer]. ( Aratake, K; Itabashi, M; Kameoka, S; Mitsuhashi, M; Ogawa, S; Seshimo, A; Shirotani, N, 2005)
"The data on 307 patients with colorectal cancer at stage II or III, who underwent potentially curative resection with lymphadenectomy, were reviewed."	1.33	The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer. ( Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Ogo, S; Ohkita, A; Ozasa, H; Sasatomi, T; Shirouzu, K, 2006)
"We designed a new regimen to evaluate the efficacy and feasibility of weekly paclitaxel combined with orally administered 5'-DFUR therapy against advanced and recurrent gastric cancer."	1.33	[Experience of weekly paclitaxel combined with orally administered doxifluridine therapy for advanced and recurrent gastric cancer-preliminary study]. ( Deguchi, Y; Kamimura, K; Kaneko, I; Kii, E; Murata, T; Tsubono, M; Yasumizu, R, 2005)
"We report a case of advanced gastric cancer with metastasis to the paraaortic lymph nodes that showed a remarkable response to treatment with a combination of weekly paclitaxel and doxifluridine (5'-DFUR)."	1.32	[A case of advanced gastric cancer successfully treated with neoadjuvant chemotherapy of combined weekly paclitaxel and doxifluridine (5'-DFUR)]. ( Hata, T; Hikino, H; Kanazawa, A; Nagaoka, S; Nakamura, K; Ozaki, N; Sugimoto, S; Tokuka, A; Yamada, T, 2004)
"For metastatic breast cancer patients who have hormone receptor-positive tumors, hormonal therapy aiming at optimal palliation and prolongation of life is the initial treatment of choice."	1.32	[Combination therapy with Anastrozole and 5'-DFUR as a treatment for metastatic breast cancer]. ( Fuchimoto, S; Inagaki, M; Miyoshi, K; Nakagawa, T; Ohsaki, T; Ohtsuka, S; Yumura, M, 2004)
"She was diagnosed as having advanced breast cancer of stage T4N3 (supraclavicular lymph node) M1 (bone)."	1.31	[Efficacy of combined chemoendocrine therapy with doxifluridine, cyclophosphamide, and fadrozole hydrochloride hydrate in a case of stage T4N3M1 breast cancer]. ( Fujii, T; Hanaoka, T; Ishida, K; Kawashima, K; Mihara, Y; Takahashi, T, 2000)
" Although the CDDP dosage had been reduced to 5 mg/week 1 year previously, the tumor was still reducing in size in November 2000."	1.31	Metastatic urothelial cancer showing an efficacy by low-dose cisplatin. ( Hirata, H; Matsuyama, H; Yamakawa, G, 2002)
"In a 79-year-old man with ascending colon cancer, multiple liver metastases were detected by computer tomography."	1.31	[A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine]. ( Hotokezaka, M; Ishimitsu, T; Matsumoto, S; Nakamura, K; Takeda, S, 2002)
"Its efficacy for lung metastases from colorectal cancer is known."	1.30	[PyNPase activity in primary and metastatic colorectal cancer]. ( Doi, O; Furukawa, H; Hiratsuka, M; Imaoka, S; Ishikawa, O; Iwanaga, T; Kabuto, T; Kameyama, M; Nakamori, S; Ohigashi, H; Sasaki, Y; Yasuda, T; Yokouchi, H, 1997)
"Mitoxantrone (MIT) is a new anthraquinone anticancer agent."	1.30	[Intra-arterial injection therapy of mitoxantrone for locally advanced breast cancer]. ( Ichikawa, W; Iida, S; Miyanaga, T; Nihei, Z; Nishi, N; Osanai, T; Shimizu, C; Sugihara, K; Togo, S; Uetake, H; Yamashita, T, 1998)
"When this agent is administered to gastric cancer patients, it can be expected to be more effective in the above types of patients because of its characteristics."	1.29	[Study on pyrimidine nucleoside phosphorylase (PyNPase) activity in resected tissues of patients with gastric cancer]. ( Ishikawa, S; Katsube, T; Konno, S; Miura, K; Naritaka, Y; Ogawa, K; Shimakawa, T; Wagatsuma, Y; Wakasugi, S; Watanabe, T, 1995)
"A 58-year-old woman with multiple organ metastases from breast cancer who had undergone radical mastectomy three years ago, was treated with oral 5'-DFUR 600 mg/day."	1.29	[A case of breast cancer with multiple organ metastases in which single low dose administration of 5'-DFUR proved effective]. ( Dohi, K; Gotoh, T; Kataoka, T; Nishiki, M; Okamoto, T; Sadamoto, S, 1993)
"A 71-year-old male with recurrent colon cancer was admitted to our hospital with obstructive jaundice."	1.29	[A case of recurrent colon cancer treated markedly effective with 5'-DFUR]. ( Hirano, M; Kato, A; Kikkawa, H; Kitagawa, K; Masuda, S; Mori, H; Murakami, N; Oosawa, T; Saito, H; Watanabe, S, 1993)
"We experienced 522 patients with breast carcinoma and 14 cases (2."	1.29	[A case resectable hepatic metastases of breast cancer following intrahepatic arterial chemotherapy]. ( Matsumine, T; Matsumoto, J; Minami, T; Takami, M; Takanishi, K, 1996)
"She was diagnosed as having an advanced gastric cancer, which was unresectable because of liver metastasis, esophageal invasion and paraaortic lymph node metastasis."	1.29	[Unresectable gastric cancer followed by remarkably effective tumor disappearance and good quality of life for 10 months after CDDP/5'-DFUR combination chemotherapy--a case report]. ( Hoshino, K; Ikeda, H; Kamoshita, N; Kobayashi, J; Koyama, T; Morishita, Y; Nakamura, M; Tanaka, T, 1996)
"5'-DFUR was administered orally at 800 mg/day, for total dosage of 57."	1.28	[A resected case of gastric carcinoma with complete remission of Virchow's node metastasis by 5'-DFUR administration]. ( Fukuda, H; Kitahara, T; Nagamine, H; Nakaguchi, K; Nakano, Y; Onoe, K, 1990)
"Cases included 5 gastric cancer, 18 colorectal cancer, 27 breast cancer and 1 malignant melanoma."	1.27	[Phase II study of 5'-DFUR in gastrointestinal and breast cancer]. ( Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T, 1985)
" Further pharmacological studies seem warranted to define the optimal dosage schedule and to obtain a better therapeutic index."	1.27	Phase II clinical evaluation of doxifluridine. ( Armand, JP; Bastit, P; Cappelaere, P; Fargeot, P; Fumoleau, P; Hurteloup, P; Keiling, R; Kerbrat, P; Metz, R; Schraub, S, 1986)
"5'-DFUR was administered orally to recurrent breast cancer patients at a daily dosage of 1,200 mg given 3 times a day for more than 8 weeks."	1.27	[Clinical trial of 5'-DFUR in patients with recurrent breast cancer]. ( Komaki, K; Konishi, Y; Miki, H; Monden, Y; Morimoto, T; Ooshimo, K; Tanaka, T; Uomine, Y; Yamakawa, T, 1988)

Research

Studies (86)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Clinical Response

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (12.79)	18.7374
1990's	27 (31.40)	18.2507
2000's	40 (46.51)	29.6817
2010's	8 (9.30)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Kang, YK	1
Chang, HM	1
Yook, JH	1
Ryu, MH	1
Park, I	1
Min, YJ	1
Zang, DY	1
Kim, GY	1
Yang, DH	1
Jang, SJ	1
Park, YS	1
Lee, JL	1
Kim, TW	1
Oh, ST	1
Park, BK	1
Jung, HY	1
Kim, BS	1
Kim, SG	1
Hwang, SH	1
Kitajima, Y	1
Yakabe, T	1
Ohtsuka, T	1
Tanaka, M	1
Sato, S	1
Nakafusa, Y	1
Miyazaki, K	1
Nukaya, H	1
Kajino, S	1
Tokuda, H	1
Tanaka, Y	2
Hasegawa, I	1
Kato, A	2
Joh, T	1
Feng, F	1
Xiang, Y	1
Wan, X	1
Geng, S	1
Wang, T	1
Solomon, N	1
Mezentsev, D	1
Reis, I	1
Lima, M	1
Rios, J	1
Avisar, E	1
Franceschi, D	1
Livingstone, A	1
Podolsky, L	1
Ardalan, B	1
Toya, H	1
Takeyoshi, I	1
Arakawa, K	1
Sunose, Y	1
Yoshinari, D	1
Totsuka, O	1
Ogawa, H	1
Hirai, K	1
Bolton, JS	1
O'Connell, MJ	1
Mahoney, MR	1
Farr, GH	1
Fitch, TR	1
Maples, WJ	1
Nagorney, DM	1
Rubin, J	1
Fuloria, J	1
Steen, PD	1
Alberts, SR	1
Cohen, DJ	1
Newman, E	1
Iqbal, S	1
Chang, RY	1
Potmesil, M	1
Ryan, T	1
Donahue, B	1
Chandra, A	1
Liu, M	1
Utate, M	1
Hiotis, S	1
Pachter, LH	1
Hochster, H	1
Muggia, F	1
Takizawa, M	1
Hirano, M	2
Murakami, N	2
Uno, Y	1
Kikuchi, T	1
Nozawa, H	1
Hara, T	1
Asaumi, Y	1
Kikkawa, H	2
Sawada, M	1
Ono, Y	1
Fukushima, M	1
Tominaga, T	3
Koyama, H	1
Toge, T	2
Miura, S	2
Sugimachi, K	1
Yamaguchi, S	1
Hirata, K	1
Monden, Y	2
Nomura, Y	1
Toi, M	2
Kimijima, I	1
Noguchi, S	1
Sonoo, H	2
Asaishi, K	1
Ikeda, T	1
Morimoto, T	3
Ota, J	1
Ohashi, Y	1
Abe, O	1
Koda, K	2
Miyazaki, M	2
Sarashina, H	1
Suwa, T	1
Saito, N	1
Suzuki, M	1
Ogawa, K	2
Watanabe, S	2
Kodaira, S	1
Nakazato, H	1
Okamoto, Y	1
Okuyama, N	1
Sawada, T	2
Kou, Y	1
ANSFIELD, FJ	1
CURRERI, AR	1
Akao, S	1
Inoue, K	1
Tomono, H	1
Kitamura, H	1
Iwase, M	1
Kuze, S	1
Ohi, S	1
Itoh, Y	1
Nakazawa, H	1
Fujita, H	2
Oya, J	1
Ichikawa, J	1
Koizumi, W	1
Tanabe, S	1
Takeuchi, H	1
Nagaba, S	1
Higuchi, K	2
Sasaki, T	2
Tahara, K	1
Murakami, S	2
Kitamura, T	1
Nakai, H	1
Saigenji, K	1
Hikino, H	1
Yamada, T	2
Hata, T	1
Nakamura, K	2
Sugimoto, S	1
Kanazawa, A	1
Tokuka, A	1
Ozaki, N	1
Nagaoka, S	1
Nishina, T	1
Hyodo, I	1
Miyaike, J	1
Inaba, T	1
Suzuki, S	1
Shiratori, Y	1
Yuyama, Y	1
Okazaki, Y	1
Miyoshi, K	2
Ohtsuka, S	1
Inagaki, M	1
Ohsaki, T	1
Fuchimoto, S	1
Yumura, M	1
Nakagawa, T	1
Takeno, A	1
Mishima, H	2
Ikenaga, M	1
Masuda, N	1
Kashiwazaki, M	1
Takeda, Y	1
Hirao, M	1
Fujitani, K	2
Sawamura, T	1
Tsujinaka, T	2
Kato, T	1
Yanagisawa, M	1
Nishisho, I	1
Tsujie, M	1
Fujimoto-Ouchi, K	1
Kikkawa, N	1
Kihara, M	2
Kontani, K	1
Yamauchi, A	1
Yokomise, H	1
Nishimura, M	1
Hirose, K	1
Ogata, Y	1
Matono, K	1
Sasatomi, T	1
Ishibashi, N	1
Ohkita, A	1
Mizobe, T	1
Ogo, S	1
Ikeda, S	2
Ozasa, H	1
Shirouzu, K	1
Tsubono, M	1
Kaneko, I	1
Kii, E	1
Murata, T	1
Kamimura, K	1
Deguchi, Y	1
Yasumizu, R	1
Seshimo, A	2
Mitsuhashi, M	1
Aratake, K	1
Ogawa, S	1
Itabashi, M	1
Shirotani, N	1
Kameoka, S	1
Naito, H	1
Hamada, T	1
Shinohara, T	1
Mino, K	1
Shibazaki, W	1
Minagawa, N	1
Orimo, T	1
Ichimura, W	1
Fukasawa, T	1
Shoji, T	1
Gotoh, H	1
Taniwaka, K	1
Mizutani, S	1
Oyama, T	1
Hatanaka, N	1
Uchikoshi, F	1
Yoshidome, K	1
Tori, M	1
Ueshima, S	1
Okuma, K	1
Hiraoka, K	1
Yamagami, Y	1
Takahashi, H	4
Sueyoshi, K	1
Taira, M	1
Nakahara, M	2
Nakao, K	2
Nakamura, Y	2
Nagao, J	1
Saida, Y	1
Enomoto, T	2
Katagiri, M	1
Nagao, S	1
Watanabe, M	1
Kusachi, S	1
Sumiyama, Y	1
Fujiwara, Y	1
Doki, Y	1
Takiguchi, S	1
Yasuda, T	2
Miyata, H	1
Monden, M	1
Arai, W	1
Hosoya, Y	1
Hyodo, M	1
Haruta, H	1
Kurashina, K	1
Saito, S	1
Hirashima, Y	1
Yokoyama, T	1
Zuiki, T	1
Sakuma, K	1
Yasuda, Y	1
Nagai, H	1
Yamamoto, Y	1
Masumori, N	1
Kunishima, Y	1
Hirobe, M	1
Takeuchi, M	1
Takayanagi, A	1
Tsukamoto, T	1
Itoh, T	3
Takiuchi, H	1
Goto, M	1
Imamura, H	1
Furukawa, H	2
Imano, M	1
Imamoto, H	1
Kimura, Y	1
Ishida, H	1
Narahara, H	1
Shimokawa, T	1
Gilbert, JM	1
Miura, K	1
Katsube, T	1
Wagatsuma, Y	1
Konno, S	1
Wakasugi, S	1
Watanabe, T	1
Shimakawa, T	1
Ishikawa, S	1
Naritaka, Y	1
Kirita, T	1
Hamano, K	1
Mabuchi, G	1
Kawase, A	1
Miyashita, M	1
Inada, N	1
Haruta, A	1
Umeno, T	1
Tanaka, S	1
Toriya, H	1
Jyozaki, H	1
Anzai, K	1
Ishii, M	1
Nishida, H	1
Kawada, T	1
Akita, Y	1
Onuki, M	1
Mitamura, K	1
Kawamura, M	1
Arai, K	1
Kataoka, T	1
Okamoto, T	1
Gotoh, T	1
Sadamoto, S	1
Nishiki, M	2
Dohi, K	1
Saito, H	1
Oosawa, T	1
Kitagawa, K	1
Masuda, S	1
Mori, H	1
Nishisaki, H	1
Yasutake, K	2
Oya, M	2
Nakashima, T	1
Hasegawa, H	1
Horita, K	1
Yoshida, R	1
Nakanishi, Y	2
Abo, K	1
Tsuji, K	1
Hori, K	1
Kimura, S	1
Takagaki, M	1
Koumoto, T	1
Andou, T	1
Matsumoto, J	1
Minami, T	1
Takami, M	1
Takanishi, K	1
Matsumine, T	1
Hoshino, K	1
Nakamura, M	1
Kamoshita, N	1
Ikeda, H	1
Kobayashi, J	1
Tanaka, T	2
Koyama, T	1
Morishita, Y	1
Matsui, T	1
Gangi, J	1
Shinoura, S	1
Sezaki, N	1
Kameyama, M	1
Nakamori, S	1
Imaoka, S	1
Ohigashi, H	1
Hiratsuka, M	1
Sasaki, Y	1
Kabuto, T	1
Ishikawa, O	1
Iwanaga, T	1
Yokouchi, H	1
Doi, O	1
Nishibe, M	1
Kuribayashi, H	1
Sato, T	1
Watanabe, I	1
Nishihara, H	1
Nishimura, G	1
Izumi, R	1
Matsuki, N	1
Takeyama, S	1
Konishi, K	1
Miyata, R	1
Kojima, Y	2
Takada, M	1
Takita, Y	1
Kanno, M	1
Ueno, K	1
Mura, T	1
Asano, K	1
Syouji, M	1
Yamazaki, H	1
Ooto, T	1
Ueda, H	1
Takigawa, Y	1
Sawa, T	1
Miyazaki, I	1
Avril, N	1
Dose, J	1
Ziegler, S	1
Jänicke, F	1
Schwaiger, M	1
Onishi, Y	1
Hatae, M	1
Ichikawa, W	1
Osanai, T	1
Shimizu, C	1
Uetake, H	1
Iida, S	1
Yamashita, T	1
Nishi, N	1
Togo, S	1
Miyanaga, T	1
Nihei, Z	1
Sugihara, K	1
Ishihata, R	1
Ito, K	1
Takano, M	1
Akatsuka, H	1
Sato, Y	1
Igari, H	1
Sekikawa, K	1
Matsusaka, K	1
Miyauchi, A	1
Maeda, M	1
Senoo, T	1
Takashima, S	1
Kokufu, I	1
Taniguchi, H	1
Kim, YH	1
Fukuda, K	1
Yamamoto, M	1
Yano, T	1
Yamada, K	1
Kitano, H	1
Nishi, H	1
Kido, T	1
Yamanishi, H	1
Tsujimoto, M	1
Soga, H	1
Hayashida, H	1
Yoshiki, T	1
Okada, Y	1
Nakagawa, H	1
Yamada, M	1
Maeda, N	1
Iwatsuki, K	1
Hirayama, A	1
Ikenaka, K	1
Ishida, K	1
Fujii, T	1
Takahashi, T	1
Kawashima, K	1
Hanaoka, T	1
Mihara, Y	1
Todo, S	2
Hata, Y	1
Sasaki, F	2
Ogita, M	1
Uchino, J	1
Yoshimoto, M	1
Akasaka, Y	1
Sawada, Y	1
Iwata, H	1
Mizutani, M	1
Iwase, T	1
Murai, H	1
Maeda, Y	1
Watanabe, K	1
Taguchi, K	1
Maruyama, S	1
Okumoto, T	1
Kawasaki, K	1
Ino, H	1
Kanaya, Y	1
Otani, J	1
Yokoyama, N	1
Soda, M	1
Maruyama, M	1
Toukairin, Y	1
Baba, H	1
Yoshida, T	1
Kure, N	1
Nagahama, T	1
Ebuchi, M	1
Ishii, R	1
Takiguchi, N	1
Oda, K	1
Matsuyama, H	1
Yamakawa, G	1
Hirata, H	1
Hotokezaka, M	1
Ishimitsu, T	1
Matsumoto, S	1
Takeda, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Nonrandomized Phase II Study: Feasibility and Outcome of Neo Adjuvant Chemotherapy With Oxaliplatin, Fluorodeoxyuridine (FUdR), Taxotere and Leucovorin in the Treatment of Previously Untreated Advanced Esophago-Gastric Carcinoma[NCT00448760]	Phase 2	29 participants (Actual)	Interventional	2004-10-31	Completed
A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver[NCT00001576]	Phase 1	28 participants	Interventional	1997-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Overall response = Complete response (CR) + Partial Response (PR). Evaluated via endoscopic ultrasounds, PET and CT scans of the chest:~Complete Response (CR) applies to participants complete disappearance of all measurable and evaluable disease. No new lesion. No disease related symptoms. No evidence of non-evaluable disease, including tumor markers and other laboratory values.~Partial Response (PR) applies to participants with at least 50 percent reduction in the sum of the products of bi-dimensional perpendicular diameters of all measurable lesions. No progression of evaluable disease. No new lesions." (NCT00448760)
Timeframe: 8 - 16 weeks

Median Progression-free Survival (PFS)

Overall Survival

Pathologic Complete Response

Intervention	percentage of participants (Number)
Single Arm	72.4

Intervention	months (Median)
Single Arm	13.6

Intervention	months (Median)
Single Arm	21.4

No evidence of cellular residual cancerous cells as evidenced by tumor tissue samples taken via surgery at the end of neo-adjuvant chemotherapy. (NCT00448760)
Timeframe: 8 - 16 weeks

Article	Year
[A case of 10-year survival after combination chemotherapy of 5'-deoxy-5-fluorouridine and cisplatin and adjuvant surgery for gastric cancer with liver metastasis]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:2 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality	2004
[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Chem	2004
[Diagnosis of breast carcinoma and locoregional lymph nodes with positron emission tomography]. Der Radiologe, 1997, Volume: 37, Issue:9 Topics: Blood Glucose; Breast Neoplasms; Female; Floxuridine; Humans; Lymph Nodes; Lymphatic Metastasis; Neo	1997
[A case report of gastric carcinoma with complete remission of paraaortic lymph node metastasis by 5'-DFUR and MMC administration after resection of primary tumor]. Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:13 Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Combined Modality Therapy; Floxuridine; Gastr	1999
[Thymidine phosphorylase as a prognostic factors of breast cancers]. Nihon rinsho. Japanese journal of clinical medicine, 2000, Volume: 58 Suppl Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Disease-Free Survival; Female; Floxuridine; Human	2000

Article	Year
Adjuvant chemotherapy for gastric cancer: a randomised phase 3 trial of mitomycin-C plus either short-term doxifluridine or long-term doxifluridine plus cisplatin after curative D2 gastrectomy (AMC0201). British journal of cancer, 2013, Apr-02, Volume: 108, Issue:6 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Floxurid	2013
A phase II study of neoadjuvant and adjuvant chemotherapy with 5-fluorodeoxyuridine, leucovorin, oxaliplatin and docetaxel in the treatment of previously untreated advanced esophageal adenocarcinoma. Japanese journal of clinical oncology, 2011, Volume: 41, Issue:4 Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Ch	2011
Hepatic arterial infusion and systemic chemotherapy after multiple metastasectomy in patients with colorectal carcinoma metastatic to the liver: a North Central Cancer Treatment Group (NCCTG) phase II study, 92-46-52. Clinical colorectal cancer, 2012, Volume: 11, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neop	2012
Randomized controlled trial comparing oral doxifluridine plus oral cyclophosphamide with doxifluridine alone in women with node-positive breast cancer after primary surgery. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6 Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemothe	2003
A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines. International journal of oncology, 2003, Volume: 23, Issue:1 Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorect	2003
The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine. European journal of cancer (Oxford, England : 1990), 2004, Volume: 40, Issue:10 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immu	2004
Sequential treatment with irinotecan and doxifluridine: optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer. Chemotherapy, 2005, Volume: 51, Issue:1 Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neopl	2005
Multi-center phase II study for combination therapy with paclitaxel/doxifluridine to treat advanced/recurrent gastric cancer showing resistance to S-1 (OGSG 0302). Japanese journal of clinical oncology, 2008, Volume: 38, Issue:3 Topics: Adenocarcinoma; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Disease-Free	2008
Adjuvant chemotherapy of large bowel cancer. Cancer treatment reviews, 1982, Volume: 9, Issue:3 Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxu	1982
[A study of preoperative administration of 5'-DFUR in patients with colo-rectal cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:14 Topics: Administration, Oral; Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans	1994
[Evaluation of combination chemotherapy for advanced gastric carcinoma as a neoadjuvant chemotherapy with CDDP, MMC, etoposide and 5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:4 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Admini	1994
[Effect of CDDP/5'-DFUR combination chemotherapy for advanced or recurrent gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:12 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chil	1998
[Usefulness of low dose 5'-DFUR (5'-deoxy-5-fluorouridine) for advanced or recurrent breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:7 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Drug Adm	1999
Clinical trial of intrathecal administration of 5-fluoro-2'-deoxyuridine for treatment of meningeal dissemination of malignant tumors. Journal of neuro-oncology, 1999, Volume: 45, Issue:2 Topics: Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Female; Floxuridine; Follow-Up Studies; Huma	1999
[Preoperative chemotherapy for advanced colorectal carcinomas--comparison of histological effect between 5'-DFUR + leucovorin tablet and 5'-DFUR alone]. Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:4 Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administrati	2001
A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Annals of surgery, 1987, Volume: 206, Issue:6 Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Infusions, I	1987

Article	Year
The association between the duration of fluoropyrimidine-based adjuvant chemotherapy and survival in stage II or III gastric cancer. World journal of surgical oncology, 2016, Apr-02, Volume: 14 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cape	2016
[Complete response obtained with first-line therapy as S-1, followed by second-line 5'-DFUR plus paclitaxel therapy in a patient with multiple liver and lymph node metastases from gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:5 Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Drug Co	2009
[Bi-weekly docetaxel and doxifluridine combination therapy in pretreated patients with unresectable and/or advanced gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Female; F	2010
Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia. Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:7 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Dactinomycin; Dru	2011
[A case of gastric cancer with lung, Virchow and para-aortic lymph node metastases treated successfully using PTX/5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Combined Modality Therapy; Fatal Outcome; Flo	2011
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma. Annals of surgical oncology, 2012, Volume: 19, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chem	2012
[A case of recurrent gastric cancer that responded dramatically to docetaxel and 5'-DFUR combination chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:9 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Administr	2002
[A case of advanced recurrent breast cancer responding to treatment with weekly docetaxel combined with doxorubicin]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Combine	2003
[Evaluation of weekly paclitaxel and doxifluridine (5'-DFUR) combination therapy in patients with advanced or recurrent breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dr	2003
FURTHER CLINICAL COMPARISON BETWEEN 5-FLUOROURACIL (5-FU) AND 5-FLUORO-2' -DEOXYURIDINE (5-FUDR). Cancer chemotherapy reports, 1963, Volume: 32 Topics: Brain Neoplasms; Breast Neoplasms; Diarrhea; Floxuridine; Fluorouracil; Geriatrics; Humans; Liver Ne	1963
[PyNPase and DPD expression potentially predict response to 5'-DFUR treatment for node-positive breast cancer patients]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:9 Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, Breast; Dihydrouracil De	2003
[A case of advanced breast cancer with multiple lung, bone and lymph node metastases successfully treated with 5'-DFUR alone]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:12 Topics: Aged; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Combined Modality Therapy;	2003
[A case of advanced gastric cancer successfully treated with neoadjuvant chemotherapy of combined weekly paclitaxel and doxifluridine (5'-DFUR)]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:4 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug A	2004
[A long-surviving patient with Stage IV breast cancer with no recurrence after combined therapy of medroxy progesterone acetate (MPA) and intra-arterial infusion chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:9 Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl	2004
[Combination therapy with Anastrozole and 5'-DFUR as a treatment for metastatic breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:10 Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplas	2004
[Two cases of advanced breast cancer responding to oral chemoendocrine therapy with 5'-deoxy-5-fluorouridine, medroxyprogesterone acetate and cyclophosphamide (DMpC)]. Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:5 Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast	2005
[Long-term survival in a case of large bowel cancer--efficacy of CPT-11-based chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Color	2005
The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5 Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemo	2006
[Experience of weekly paclitaxel combined with orally administered doxifluridine therapy for advanced and recurrent gastric cancer-preliminary study]. Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:9 Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Sche	2005
[Prediction and treatment of peritoneal dissemination in gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combination	2005
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combi	2005
[A long-term survivor with stage IV gastric cancer due to postoperative weekly paclitaxel and 5'-DFUR combination therapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Combined Modality Thera	2006
[Combined chemotherapy with weekly Paclitaxel and doxifluridine for advanced and recurrent gastric cancers]. Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; F	2006
[A case of advanced gastric cancer--efficacy of combination therapy of doxifluridine and weekly paclitaxel]. Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:10 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Aorta; Combined Modality Thera	2006
[Combination therapy with bi-weekly docetaxel and 5'-deoxy-5-fluorouridine for advanced gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:3 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Docetaxel; Drug Adm	2007
Doxifluridine combined with weekly paclitaxel for second-line treatment in patients with gastric cancer resistant to TS-1. International journal of clinical oncology, 2007, Volume: 12, Issue:2 Topics: Abdominal Neoplasms; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Antineoplastic Combine	2007
[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:7 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine	2007
Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer. Japanese journal of clinical oncology, 2008, Volume: 38, Issue:3 Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Cystectomy; Deoxycytidine; Fatal	2008
[Study on pyrimidine nucleoside phosphorylase (PyNPase) activity in resected tissues of patients with gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:9 Topics: Adult; Aged; CD4-CD8 Ratio; Female; Floxuridine; Gastrectomy; Humans; Lymphatic Metastasis; Lymphocy	1995
[Study of PyNPase activity in patients with gastric cancer--the association with preoperative IAP values]. Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Female; Floxuridine; Gastrectomy; Humans; Lymph N	1995
[A case of breast cancer with multiple organ metastases in which single low dose administration of 5'-DFUR proved effective]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:2 Topics: Antineoplastic Agents; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans;	1993
[A case of recurrent colon cancer treated markedly effective with 5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:8 Topics: Administration, Oral; Aged; Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Humans; Liver Neo	1993
[Combined chemotherapy with MMC, ADM, CDDP, etoposide (VP-16) and 5'-DFUR, (MACVD therapy) as a second-line chemotherapy for metastatic gastric cancer: three cases]. Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Etoposide; Female; Floxuridi	1996
[A case of effective chemotherapy by combination of 5'-DFUR and MMC for recurrent colon cancer with multiple liver metastasis]. Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:8 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Drug A	1996
[A case resectable hepatic metastases of breast cancer following intrahepatic arterial chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Femal	1996
[Unresectable gastric cancer followed by remarkably effective tumor disappearance and good quality of life for 10 months after CDDP/5'-DFUR combination chemotherapy--a case report]. Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:13 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Cisplatin; Esoph	1996
[A case of advanced gastric cancer that responded to long-term administration of low-dose 5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:1 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedul	1997
[PyNPase activity in primary and metastatic colorectal cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Floxuridine; Humans; L	1997
[A case of advanced breast cancer receiving combination therapy with 5'-DFUR and MPA with remarkable results]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:9 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Papillary; Combin	1997
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:13 Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Extracellular Matrix; Female; Floxuridine; Hu	1997
[A case of complete response of metastasis of cervical cancer with a combination of CBDCA and 5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Female; Floxuridine; Humans; Lung Neopl	1998
[Intra-arterial injection therapy of mitoxantrone for locally advanced breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Catheters, Indwelling; Combined Mo	1998
[A case of stage IV breast cancer showing long-term complete response to combination therapy with 5'-DFUR and MPA]. Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:13 Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Ne	1998
[A case of adriamycin and methotrexate-resistant recurrent breast cancer treated with doxifluridine and mitomycin C]. Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:9 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco	1999
[Case report of a patient with invading bladder cancer and lymph node swelling which decreased following 5'-DFUR treatment]. Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:2 Topics: Aged; Antineoplastic Agents; Child, Preschool; Floxuridine; Humans; Lymph Nodes; Lymphatic Metastasi	2000
[Efficacy of combined chemoendocrine therapy with doxifluridine, cyclophosphamide, and fadrozole hydrochloride hydrate in a case of stage T4N3M1 breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:5 Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclop	2000
Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer. Breast cancer (Tokyo, Japan), 2000, Volume: 7, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combin	2000
A case of metastatic breast cancer achieving complete response by combination therapy with 5'-deoxy-5-fluorouridine and cyclophosphamide. Breast cancer (Tokyo, Japan), 2000, Volume: 7, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Breast Neoplasms; Carcinoma, Duct	2000
Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment. International journal of oncology, 2000, Volume: 17, Issue:6 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemother	2000
[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5'-DFUR and MPA (medroxyprogesterone acetate)]. Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:14 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined M	2000
Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer. International journal of oncology, 2001, Volume: 19, Issue:4 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female;	2001
Metastatic urothelial cancer showing an efficacy by low-dose cisplatin. International journal of urology : official journal of the Japanese Urological Association, 2002, Volume: 9, Issue:5 Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P	2002
[A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine]. Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:6 Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Administration	2002
[A case of advanced breast cancer responding to low-dose 5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:7 Topics: Aged; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Drug Administration Schedule; Female;	1992
[5'-deoxy-5-fluorouridine (5'-DFUR), mitomycin C (MMC), etoposide and medroxy progesterone acetate (MPA) in a previously treated patient with advanced breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Etoposide; Female;	1991
[A study of combined chemotherapy with MMC, ADM, CDDP, etoposide (VP-16), 5'DFUR (MAC-VD therapy) in advanced cancer and local relapse of the stomach]. Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:3 Pt 1 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxoru	1990
[A resected case of gastric carcinoma with complete remission of Virchow's node metastasis by 5'-DFUR administration]. Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:10 Topics: Adenocarcinoma; Antineoplastic Agents; Combined Modality Therapy; Female; Floxuridine; Gastrectomy;	1990
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR]. Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:5 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Ne	1989
[Effect of combination chemotherapy of 5'-DFUR, cyclophosphamide and tamoxifen in a case of advanced breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:1 Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C	1989
[Phase II study of 5'-DFUR in gastrointestinal and breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarr	1985
[A case of remission of metastatic gastric cancer lesions in the chest and abdominal wall by 5'-DFUR administration]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11 Topics: Abdominal Muscles; Adenocarcinoma; Administration, Oral; Antineoplastic Agents; Female; Floxuridine;	1985
Phase II clinical evaluation of doxifluridine. Cancer treatment reports, 1986, Volume: 70, Issue:6 Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Diseases; Col	1986
[Clinical trial of 5'-DFUR in patients with recurrent breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:10 Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridi	1988
The evolution of colorectal cancer. Diseases of the colon and rectum, 1968, Volume: 11, Issue:6 Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Parenteral; Liver Neoplasms; Lymphatic Metastasis	1968
Practical aspects of investigation and treatment of colorectal cancer. The Medical clinics of North America, 1972, Volume: 56, Issue:3 Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function	1972

floxuridine and Lymph Node Metastasis