floxuridine has been researched along with Leukemia L5178 in 6 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Leukemia L5178: An experimental lymphocytic leukemia of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of antitumor activity of 5-fluorouracil (FU) was studied in mouse leukemia L5178Y cells in vitro." | 3.66 | The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells. ( Hoshi, A; Kuretani, K; Yoshida, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanzawa, F | 2 |
| Hoshi, A | 3 |
| Kuretani, K | 3 |
| Yoshida, M | 1 |
| Satake, H | 1 |
| Takechi, T | 1 |
| Nakano, K | 1 |
| Saito, H | 1 |
| Uchida, J | 1 |
| Takeda, S | 1 |
| Unemi, N | 1 |
| Fukushima, M | 1 |
| Balińska, M | 1 |
| Szablewska, I | 1 |
| Janiszewska, D | 1 |
| Brzezińska, A | 1 |
| Pawełczak, K | 1 |
| Felczak, K | 1 |
| Bretner, M | 1 |
| Dzik, JM | 1 |
| Gołos, B | 1 |
| Zieliński, Z | 1 |
| Rode, W | 1 |
| Kulikowski, T | 1 |
6 other studies available for floxuridine and Leukemia L5178
| Article | Year |
|---|---|
Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemi | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leuke | 1980 |
[Antimetastatic effects of UFT on murine liver metastasis model using L5178YHM lymphoma].
Topics: Animals; Body Weight; Drug Combinations; Floxuridine; Leukemia L5178; Liver Neoplasms; Male; Mice; T | 1996 |
Synergistic effect of 5-fluorodeoxyuridine and quinazoline antifolates on murine leukemia self-cultured in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Survival; DNA, Neoplasm; Drug Resistance; Drug Synerg | 1997 |
N4-hydroxy-5-halogeno-2'-deoxycytidine S and their 5'-mono-phosphates as inhibitors of thymidylate synthase and in vitro antileukemic agents.
Topics: Animals; Antineoplastic Agents; Cell Survival; Deoxycytidine; Drug Design; Drug Resistance, Neoplasm | 1998 |