floxuridine has been researched along with Leukemia L 1210 in 71 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Virtually non toxic concentrations of dThd potentiated the cytotoxicity of MNNG more than 10-fold but that of MMS was potentiated only about 2-fold showing that O-alkylation of DNA was associated not only with the facilitation of mutagenesis but also with the potentiation of cytotoxicity." | 2.37 | Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis. ( Danenberg, PV; Ibric, LL; Peterson, AR; Peterson, H, 1985) |
| " The dosage of the oral clinical use for human cancer of 5-FU, HCFU, 5'-DFUR and UFT as tegafur (FT) is 200-300mg/d, 600mg/d, 800-1,200mg/d and 300-600mg/d respectively." | 1.31 | Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. ( Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M, 2001) |
| "Treatment of mitomycin C with pyrimidine nucleotides in acidic media produced derivatives of 2,7-diaminomitosene in which C-1 was covalently bound to the phosphate group of the nucleotides." | 1.27 | Nucleotide derivatives of 2,7-diaminomitosene. ( Dorr, RT; Iyengar, BS; Kowal, CD; Remers, WA, 1988) |
| " At an optimum dosage level of 40 mg/kg, 7 and 8 produced 90% and 60% "cures" (greater than 60-day survivors), respectively." | 1.27 | Antineoplastic activity of 3'-(chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine. ( Brubaker, WF; Lin, TS; Park, S; Prusoff, WH; Wang, ZH, 1986) |
| " The cytostatic effect of cytosine arabinoside (ara-C) prodrug liposomes against L1210 leukemia showed to be superior to free ara-C treatment in respect to drug dosage and treatment schedule." | 1.27 | [Liposomes as carriers of lipophilic cytosine arabinoside and fluorodeoxyuridine derivatives. Their cytostatic effect and possibilities of tumor cell specific therapy]. ( Hartmann, HR; Hengartner, H; Rubas, W; Schott, H; Schwendener, RA; Supersaxo, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (78.87) | 18.7374 |
| 1990's | 10 (14.08) | 18.2507 |
| 2000's | 3 (4.23) | 29.6817 |
| 2010's | 2 (2.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Béres, J | 1 |
| Sági, G | 1 |
| Bentrude, WG | 1 |
| Balzarini, J | 4 |
| De Clercq, E | 3 |
| Otvös, L | 1 |
| Iyengar, BS | 1 |
| Dorr, RT | 1 |
| Remers, WA | 1 |
| Kowal, CD | 1 |
| Holshouser, MH | 1 |
| Shipp, AM | 1 |
| Ferguson, PW | 1 |
| Robins, MJ | 1 |
| Hatfield, PW | 1 |
| Ajmera, S | 1 |
| Bapat, AR | 1 |
| Danenberg, K | 1 |
| Danenberg, PV | 4 |
| Hunston, RN | 1 |
| Jones, AS | 1 |
| McGuigan, C | 2 |
| Walker, RT | 1 |
| Shealy, YF | 1 |
| Frye, JL | 1 |
| DuBois, NF | 1 |
| Shaddix, SC | 1 |
| Brockman, RW | 2 |
| Bretner, M | 2 |
| Kulikowski, T | 2 |
| Dzik, JM | 2 |
| Balińska, M | 1 |
| Rode, W | 2 |
| Shugar, D | 2 |
| Novotny, L | 2 |
| Rauko, P | 2 |
| Schott, H | 3 |
| Vande Voorde, J | 1 |
| Liekens, S | 1 |
| Murziani, PG | 1 |
| Slusarczyk, M | 1 |
| ANDERSON, EP | 1 |
| Mego, M | 1 |
| Saiko, P | 1 |
| Szekeres, T | 1 |
| Fernandes, DJ | 1 |
| Bertino, JR | 1 |
| Benz, C | 1 |
| Cadman, E | 2 |
| Kufe, DW | 2 |
| Scott, P | 1 |
| Fram, R | 1 |
| Major, P | 1 |
| Grant, S | 1 |
| Moran, RG | 5 |
| Heidelberger, C | 4 |
| Roberts, D | 1 |
| Franklin, P | 1 |
| Odom, G | 1 |
| Peck, C | 1 |
| Chwang, TL | 1 |
| Au, JL | 1 |
| Rustum, YM | 3 |
| Minowada, J | 1 |
| Srivastava, BI | 1 |
| Roobol, C | 2 |
| De Dobbeleer, GB | 2 |
| Bernheim, JL | 2 |
| Ishitsuka, H | 2 |
| Miwa, M | 2 |
| Takemoto, K | 1 |
| Fukuoka, K | 1 |
| Itoga, A | 1 |
| Maruyama, HB | 1 |
| Major, PP | 1 |
| Egan, EM | 1 |
| Loh, E | 1 |
| Kanzawa, F | 1 |
| Hoshi, A | 1 |
| Kuretani, K | 1 |
| Saneyoshi, M | 3 |
| Kawaguchi, T | 3 |
| Mulkins, MA | 2 |
| Peterson, AR | 2 |
| Pogolotti, AL | 1 |
| Nolan, PA | 1 |
| Santi, DV | 3 |
| Fries, KM | 1 |
| Joswig, C | 2 |
| Borch, RF | 2 |
| Chong, LK | 1 |
| Tattersall, MH | 1 |
| van Laar, JA | 1 |
| Durrani, FA | 1 |
| Gołos, B | 1 |
| Jarmuła, A | 1 |
| Poznański, J | 1 |
| Freel Meyers, CL | 1 |
| Hong, L | 1 |
| Ooi, A | 1 |
| Ohkubo, T | 1 |
| Higashigawa, M | 1 |
| Kawasaki, H | 1 |
| Kakito, H | 1 |
| Kagawa, Y | 1 |
| Kojima, M | 1 |
| Sakurai, M | 1 |
| Chadwick, M | 2 |
| Chang, C | 1 |
| Ullman, B | 1 |
| Lee, M | 1 |
| Martin, DW | 1 |
| Danhauser, L | 1 |
| Wang, G | 1 |
| Washtien, WL | 1 |
| Kumar, R | 1 |
| Wiebe, LI | 1 |
| Knaus, EE | 1 |
| Allen, TM | 1 |
| Tempest, ML | 1 |
| Seither, RL | 2 |
| Rape, TJ | 2 |
| Goldman, ID | 4 |
| Matherly, LH | 2 |
| Czajkowski, CA | 1 |
| Muench, SP | 1 |
| Psiakis, JT | 1 |
| Cory, JG | 1 |
| Halley, MC | 1 |
| Jeney, A | 1 |
| Lapis, K | 1 |
| Keyomarsi, K | 4 |
| Trent, DF | 1 |
| Mikulecky, DC | 1 |
| Uchida, M | 1 |
| Ho, DH | 1 |
| Kamiya, K | 1 |
| Yoshimura, T | 1 |
| Sasaki, K | 1 |
| Tsutani, H | 1 |
| Nakamura, T | 1 |
| Uehara, N | 1 |
| Baba, H | 1 |
| Nitta, K | 1 |
| Kunimoto, T | 1 |
| Takeuchi, M | 1 |
| Sasaki, T | 1 |
| Tanaka, T | 1 |
| Jackman, AL | 1 |
| Alison, DL | 1 |
| Calvert, AH | 1 |
| Harrap, KR | 2 |
| Lin, TS | 1 |
| Brubaker, WF | 1 |
| Wang, ZH | 1 |
| Park, S | 1 |
| Prusoff, WH | 1 |
| Saito, M | 2 |
| Hartmann, HR | 2 |
| Bollag, W | 1 |
| FitzGerald, GB | 2 |
| Wick, MM | 2 |
| Barlowe, CK | 1 |
| Phillips, VM | 1 |
| Nishimura, J | 1 |
| Kamiyama, T | 1 |
| Schwendener, RA | 1 |
| Supersaxo, A | 1 |
| Rubas, W | 1 |
| Hengartner, H | 1 |
| Ratliff, J | 1 |
| Schuetz, JD | 1 |
| Gorse, KM | 1 |
| Westin, EH | 1 |
| Belt, JA | 1 |
| Noel, LD | 1 |
| Ibric, LL | 1 |
| Peterson, H | 1 |
| Yalowich, JC | 1 |
| Kalman, TI | 1 |
| Fujimoto, S | 1 |
| Wang, Y | 1 |
| Inoue, K | 1 |
| Ogawa, M | 1 |
| Glick, JL | 2 |
| Sahler, C | 1 |
| Crystal, HA | 1 |
| Giovanella, BC | 1 |
| Lohman, WA | 1 |
| Grindey, GB | 1 |
| Nichol, CA | 1 |
| Rogers, WI | 1 |
| Jato, J | 1 |
| Windheuser, JJ | 1 |
| Jackson, RC | 1 |
| Sharma, RA | 1 |
| Bobek, M | 1 |
| Bloch, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine[NCT00359606] | Phase 1 | 58 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for floxuridine and Leukemia L 1210
| Article | Year |
|---|---|
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis.
Topics: Alkylating Agents; Animals; Azaguanine; Cell Line; Cell Survival; Cricetinae; Deoxyadenosines; Deoxy | 1985 |
69 other studies available for floxuridine and Leukemia L 1210
| Article | Year |
|---|---|
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Deoxyuracil Nucleotides; Drug Evaluatio | 1986 |
Nucleotide derivatives of 2,7-diaminomitosene.
Topics: Alkylation; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia L1210; Leukemia | 1988 |
Synthesis and antitumor activity of a series of ftorafur analogues: the effect of varying electronegativity at the 1'-position.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Female; Fluorouracil; Leukemia L1210; Leukemia P388 | 1985 |
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Cell Line; Kidney; Leukemia L1210; Mice; | 1984 |
Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.
Topics: Animals; Cell Division; Deoxyuracil Nucleotides; Dideoxynucleosides; Dideoxynucleotides; Floxuridine | 1984 |
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Deoxycytidine; Deoxyuridine; Drug Resis | 1984 |
Carbocyclic analogues of 5-fluorouracil nucleosides.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Nucleosides; Thym | 1981 |
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Binding, Competitive; Carcinoma, Ehrlich Tumor; Cell Divi | 1993 |
Cytotoxicity and antileukaemic activity of new duplexes linking 3-C-ethynylcytidine and 5-fluorodeoxyuridine.
Topics: Animals; Antineoplastic Agents; Cell Growth Processes; Cytidine; Female; Floxuridine; Leukemia L1210 | 2010 |
The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Enzyme Activation; Floxuridine; Humans; Leukemia L | 2011 |
In vitro and in vivo antileukemic effect of novel dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cy | 2007 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Metho | 1980 |
Biochemical alterations during unperturbed suspension growth of L1210 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; DNA, Neoplasm; Floxuridine; Leukemia L1210; Me | 1981 |
Biologic effect of 5-fluoro-2'-deoxyuridine incorporation in L1210 deoxyribonucleic acid.
Topics: Animals; Cell Survival; DNA; Floxuridine; Leukemia L1210; RNA | 1983 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; D | 1982 |
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytosol; Deoxyuracil Nucleotides; Flo | 1982 |
Cytotoxicity of 5-fluoro-5'-O-nitro-2'-deoxyuridine, a new fluorinated pyrimidine derivative, in L1210 cultures.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; Drug | 1982 |
Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; B-Lymphocytes; Biotransformation; Cell Division; Cell | 1983 |
5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
Topics: Animals; Cell Survival; Cells, Cultured; DNA, Neoplasm; Floxuridine; Fluorouracil; Isomerism; Leukem | 1984 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera | 1980 |
5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA.
Topics: Animals; DNA, Neoplasm; Floxuridine; Kinetics; Leukemia L1210; Mice; RNA, Neoplasm | 1981 |
Antitumor activity of 3',5'-diesters of 5-fluoro-2'-deoxyuridine against murine leukemia L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Floxuridine; Leukemia | 1981 |
The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells.
Topics: Animals; DNA Replication; DNA, Neoplasm; Floxuridine; Kinetics; Leukemia L1210; Mice; Thymidylate Sy | 1981 |
Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts.
Topics: Animals; Biotransformation; Cell Extracts; Cells, Cultured; Chromatography, High Pressure Liquid; Fl | 1981 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug R | 1982 |
Synthesis and biological evaluation of 5-fluoro-2'-deoxyuridine phosphoramidate analogs.
Topics: Amides; Animals; Antineoplastic Agents; Floxuridine; Leukemia L1210; Magnetic Resonance Spectroscopy | 1995 |
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
Topics: Animals; Cell Survival; Deoxyadenine Nucleotides; Drug Interactions; Floxuridine; Folic Acid; Hypoxa | 1995 |
Antitumor activity of the weekly intravenous push schedule of 5-fluoro-2'-deoxyuridine +/- N-phosphonacetyl-L-aspartate in mice bearing advanced colon carcinoma 26.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Cytidine Triphosphate; Dose-Respon | 1993 |
Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of dUMP and 5-fluoro-dUMP.
Topics: Animals; Binding Sites; Cell Division; Deoxyuracil Nucleotides; Drug Resistance, Neoplasm; Enzyme In | 1996 |
Synthesis and biological activity of novel 5-fluoro-2'-deoxyuridine phosphoramidate prodrugs.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Screening Assays, Antitumor; F | 2000 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; F | 2001 |
Comparative physiologic dispositions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
Topics: Animals; Drug Administration Schedule; Floxuridine; Fluorouracil; Leukemia L1210; Mice | 1976 |
Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.
Topics: Animals; Cells, Cultured; Floxuridine; Folic Acid; Leukemia L1210; Methotrexate | 1978 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans | 1979 |
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
Topics: Animals; Chromatography, Gel; Culture Techniques; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Flu | 1979 |
Synthesis, antiviral and cytotoxic activity of 2'-deoxyuridines, 2'-fluoro-2'-deoxyuridines and 2'-arabinouridines containing 5-(1-hydroxy-2-halo-2-ethoxycarbonylethyl)-, 5-(1-hydroxy-2-iodo-2- carboxyethyl)- and 5-[1-hydroxy (or methoxy)-2-iodoethyl] sub
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Deoxyuridine; Floxuridine; | 1992 |
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Topics: Animals; Computer Simulation; Deoxyuridine; DNA; Enzyme Reactivators; Floxuridine; Folic Acid; Folic | 1992 |
Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Topics: Adenocarcinoma; Animals; Carrier Proteins; Cell Division; Chromatography, Gel; Colonic Neoplasms; Fl | 1990 |
5-Hexyl-2'-deoxyuridine blocks the cytotoxic effects of 5-fluorodeoxyuridine or deoxyadenosine in leukemia L1210 cells in culture.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Survival; Deoxyadenosines; Deoxyuridin | 1990 |
Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
Topics: Animals; Binding Sites; Cytidine Monophosphate; Floxuridine; Fluorodeoxyuridylate; Folic Acid; Folic | 1990 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formate | 1989 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia | 1989 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experime | 1985 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorou | 1986 |
Antineoplastic activity of 3'-(chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine.
Topics: Alkylation; Animals; Antineoplastic Agents; Deoxyuridine; Dideoxynucleosides; Female; Floxuridine; L | 1986 |
Potentiation by acyclothymidine esters of the antitumor effect of orally administered 5-fluoro-2'-deoxyuridine esters on L1210 in mice.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxu | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung N | 1986 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fl | 1986 |
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Deoxyuracil Nucleotides; Depression, Chemical; DNA Rep | 1987 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mi | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L | 1987 |
[Liposomes as carriers of lipophilic cytosine arabinoside and fluorodeoxyuridine derivatives. Their cytostatic effect and possibilities of tumor cell specific therapy].
Topics: Animals; Antibodies, Monoclonal; Cytarabine; Drug Therapy; Floxuridine; Humans; Leukemia L1210; Lipo | 1987 |
Biochemical rationale for the synergism of 5-fluorouracil and folinic acid.
Topics: Animals; Cell Division; Cell Survival; Deoxyuracil Nucleotides; Drug Synergism; Floxuridine; Fluorou | 1987 |
Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine.
Topics: Animals; Cytarabine; Daunorubicin; Deoxyuridine; DNA; Dopamine; Floxuridine; Hydroxyurea; Kinetics; | 1987 |
Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.
Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Drug Resistance; Floxuridine; Gene Amplification; G | 1988 |
Isolation and characterization of a mutant of L1210 murine leukemia deficient in nitrobenzylthioinosine-insensitive nucleoside transport.
Topics: Animals; Biological Transport; Carrier Proteins; Cytarabine; Floxuridine; Inosine; Leukemia L1210; M | 1988 |
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1 | 1988 |
Potentiation of the antitumor effect of 5-fluoro-2'-deoxyuridine esters in combination with acyclothymidine esters on L1210 in mice via oral administration.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Dogs; Drug Synergism; Floxu | 1988 |
5-Fluoro-5'-deoxyuridine is an inhibitor of uridylate nucleotidase in L1210 leukaemia.
Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Cycle; DNA, Neopl | 1986 |
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Floxuridine | 1985 |
Antitumor activity of a new fluoropyrimidine derivative, 5'-deoxy-5-fluorouridine, against murine and human experimental tumors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Humans; Leukemia L1210; Leuke | 1985 |
Specific metabolic changes in DNA-treated L1210 leukemia cells.
Topics: Animals; Carbon Isotopes; Culture Techniques; Dactinomycin; DNA; DNA, Bacterial; DNA, Neoplasm; Esch | 1967 |
The influence of partial synchronization of cell growth on the inhibition of L1210 cell viability by mouse thymus DNA.
Topics: Animals; Antineoplastic Agents; Culture Techniques; Depression, Chemical; DNA; DNA, Neoplasm; Floxur | 1968 |
Effects of elevated temperatures and drugs on the viability of L1210 leukemia cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Culture Media; Culture Techniques; Dactinomycin; Female; | 1970 |
Interaction of drugs inhibiting different steps in the synthesis of DNA.
Topics: Animals; Cells, Cultured; Cytarabine; Depression, Chemical; DNA, Neoplasm; Drug Antagonism; Drug Int | 1972 |
The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
Topics: Animals; Bone Marrow; Brain; Carbon Isotopes; Cerebellum; Chromatography, Ion Exchange; Chromatograp | 1972 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyurid | 1973 |
Studies with a mathematical model of folate metabolism.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Folic Acid; Formates; Glyci | 1973 |
Synthesis and biological activity of 2'-amino-2'-deoxy-5-fluorouridine.
Topics: Amino Sugars; Animals; Antimetabolites; Antineoplastic Agents; Drug Resistance, Microbial; Escherich | 1974 |