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floxuridine and Leukemia, Lymphocytic

floxuridine has been researched along with Leukemia, Lymphocytic in 10 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
"A line of human lymphocytic leukemia cells (CCRF-CEM) has been obtained which is 140-fold resistant to the potent cell growth inhibitor 5-fluoro-2'-deoxyuridine (FdUrd)."1.27Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. ( Bapat, AR; Danenberg, PV; Zarow, C, 1983)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-199010 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SILBER, R1
GABRIO, BW1
HUENNEKENS, FM1
Tanaka, M1
Kimura, K1
Yoshida, S1
Gewert, DR1
Moore, G1
Clemens, MJ1
Bapat, AR1
Zarow, C1
Danenberg, PV2
Lockshin, A1
Moran, RG1
Roberts, D1
Warmath, EV1
Mini, E2
Moroson, BA1
Bertino, JR2
Mazzei, T1
Coronnello, M1
Criscuoli, L1
Gualtieri, M1
Periti, P1
Rao, PN1
Heerema, NA1
Palmer, CG1
Fleischmajer, R1

Other Studies

10 other studies available for floxuridine and Leukemia, Lymphocytic

ArticleYear
STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. VI. THYMIDYLATE SYNTHETASE AND DEOXYCYTIDYLATE DEAMINASE.
    The Journal of clinical investigation, 1963, Volume: 42

    Topics: Adenosine Triphosphate; Aminohydrolases; Carbon Isotopes; Chromatography; Clinical Enzyme Tests; DCM

1963
Increased incorporation of 5-fluorodeoxyuridine into DNA of human T-lymphoblastic cell lines.
    Gan, 1984, Volume: 75, Issue:11

    Topics: Cell Line; DNA Glycosylases; DNA, Neoplasm; Floxuridine; Humans; Leukemia, Lymphoid; N-Glycosyl Hydr

1984
Inhibition of cell division by interferons. The relationship between changes in utilization of thymidine for DNA synthesis and control of proliferation in Daudi cells.
    The Biochemical journal, 1983, Sep-15, Volume: 214, Issue:3

    Topics: Cell Division; Cell Line; Deoxyribonucleosides; DNA; Floxuridine; Humans; Interferons; Leukemia, Lym

1983
Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
    The Journal of biological chemistry, 1983, Apr-10, Volume: 258, Issue:7

    Topics: Cell Line; Deoxyribonucleotides; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Leuke

1983
Thymidylate synthetase purified to homogeneity from human leukemic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:2

    Topics: Cations; Cell Line; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Floxuridine; Humans; Hydrog

1979
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
    European journal of cancer, 1975, Volume: 11, Issue:11

    Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antago

1975
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
    Cancer treatment reports, 1987, Volume: 71, Issue:4

    Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovor

1987
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
    Biochemical pharmacology, 1987, Sep-15, Volume: 36, Issue:18

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship

1987
Expression of fragile sites in childhood acute lymphoblastic leukemia patients and normal controls.
    Human genetics, 1988, Volume: 79, Issue:4

    Topics: Aphidicolin; Bone Marrow; Caffeine; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mappi

1988
Epithelial-mesenchymal interactions.
    Science (New York, N.Y.), 1967, Sep-22, Volume: 157, Issue:3795

    Topics: Animals; Cell Differentiation; Cell Division; Chick Embryo; Culture Techniques; Epithelium; Feathers

1967