floxuridine has been researched along with Leukemia, Lymphocytic in 10 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A line of human lymphocytic leukemia cells (CCRF-CEM) has been obtained which is 140-fold resistant to the potent cell growth inhibitor 5-fluoro-2'-deoxyuridine (FdUrd)." | 1.27 | Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. ( Bapat, AR; Danenberg, PV; Zarow, C, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SILBER, R | 1 |
| GABRIO, BW | 1 |
| HUENNEKENS, FM | 1 |
| Tanaka, M | 1 |
| Kimura, K | 1 |
| Yoshida, S | 1 |
| Gewert, DR | 1 |
| Moore, G | 1 |
| Clemens, MJ | 1 |
| Bapat, AR | 1 |
| Zarow, C | 1 |
| Danenberg, PV | 2 |
| Lockshin, A | 1 |
| Moran, RG | 1 |
| Roberts, D | 1 |
| Warmath, EV | 1 |
| Mini, E | 2 |
| Moroson, BA | 1 |
| Bertino, JR | 2 |
| Mazzei, T | 1 |
| Coronnello, M | 1 |
| Criscuoli, L | 1 |
| Gualtieri, M | 1 |
| Periti, P | 1 |
| Rao, PN | 1 |
| Heerema, NA | 1 |
| Palmer, CG | 1 |
| Fleischmajer, R | 1 |
10 other studies available for floxuridine and Leukemia, Lymphocytic
| Article | Year |
|---|---|
STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. VI. THYMIDYLATE SYNTHETASE AND DEOXYCYTIDYLATE DEAMINASE.
Topics: Adenosine Triphosphate; Aminohydrolases; Carbon Isotopes; Chromatography; Clinical Enzyme Tests; DCM | 1963 |
Increased incorporation of 5-fluorodeoxyuridine into DNA of human T-lymphoblastic cell lines.
Topics: Cell Line; DNA Glycosylases; DNA, Neoplasm; Floxuridine; Humans; Leukemia, Lymphoid; N-Glycosyl Hydr | 1984 |
Inhibition of cell division by interferons. The relationship between changes in utilization of thymidine for DNA synthesis and control of proliferation in Daudi cells.
Topics: Cell Division; Cell Line; Deoxyribonucleosides; DNA; Floxuridine; Humans; Interferons; Leukemia, Lym | 1983 |
Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
Topics: Cell Line; Deoxyribonucleotides; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Leuke | 1983 |
Thymidylate synthetase purified to homogeneity from human leukemic cells.
Topics: Cations; Cell Line; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Floxuridine; Humans; Hydrog | 1979 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antago | 1975 |
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovor | 1987 |
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship | 1987 |
Expression of fragile sites in childhood acute lymphoblastic leukemia patients and normal controls.
Topics: Aphidicolin; Bone Marrow; Caffeine; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mappi | 1988 |
Epithelial-mesenchymal interactions.
Topics: Animals; Cell Differentiation; Cell Division; Chick Embryo; Culture Techniques; Epithelium; Feathers | 1967 |