Page last updated: 2024-11-06

floxuridine and Hypoxia

floxuridine has been researched along with Hypoxia in 6 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"This study utilized the imaging data of primary liver cancer (PLC) treated with floxuridine (FUDR) and bevacizumab to test the hypothesis that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters correlate with tissue hypoxia markers and treatment outcome."5.15Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response. ( Allen, PJ; Bamboat, Z; D'Angelica, MI; DeMatteo, RP; Fong, Y; Gönen, M; Gultekin, DH; Haviland, D; Jarnagin, WR; Kemeny, N; Schwartz, LH; Shia, J; Yopp, AC, 2011)
"Floxuridine oligomers are anticancer oligonucleotide drugs composed of a number of floxuridine residues."1.62Floxuridine Oligomers Activated under Hypoxic Environment. ( Ishinabe, T; Morihiro, K; Okamoto, A; Osawa, T; Osumi, H; Takatsu, M, 2021)
"Furthermore, the fog-2(q71) long-term anoxia survival phenotype was suppressed when oocyte maturation and ovulation were induced by mating with males that have functional or nonfunctional sperm."1.35Reduction in ovulation or male sex phenotype increases long-term anoxia survival in a daf-16-independent manner in Caenorhabditis elegans. ( LeBlanc, MG; Mendenhall, AR; Mohan, DP; Padilla, PA, 2009)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Peng, X1
Gao, J1
Yuan, Y1
Liu, H1
Lei, W1
Li, S1
Zhang, J1
Wang, S1
Morihiro, K1
Ishinabe, T1
Takatsu, M1
Osumi, H1
Osawa, T1
Okamoto, A1
Weiss, JT1
Carragher, NO1
Unciti-Broceta, A1
Mendenhall, AR1
LeBlanc, MG1
Mohan, DP1
Padilla, PA1
Yopp, AC1
Schwartz, LH1
Kemeny, N1
Gultekin, DH1
Gönen, M1
Bamboat, Z1
Shia, J1
Haviland, D1
D'Angelica, MI1
Fong, Y1
DeMatteo, RP1
Allen, PJ1
Jarnagin, WR1

Reviews

1 review available for floxuridine and Hypoxia

ArticleYear
Radiation sensitizers.
    Cancer, 1976, Volume: 37, Issue:4 Suppl

    Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs

1976

Trials

1 trial available for floxuridine and Hypoxia

ArticleYear
Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response.
    Annals of surgical oncology, 2011, Volume: 18, Issue:8

    Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antigens, Neopl

2011

Other Studies

4 other studies available for floxuridine and Hypoxia

ArticleYear
Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy.
    Bioconjugate chemistry, 2019, 11-20, Volume: 30, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation;

2019
Floxuridine Oligomers Activated under Hypoxic Environment.
    Journal of the American Chemical Society, 2021, 03-10, Volume: 143, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Floxuridine; Humans; Hypoxia; Mice, Inbr

2021
Palladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategy.
    Scientific reports, 2015, Mar-19, Volume: 5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Dealkylation; Drug Screening Assays, Antitumor; Floxuridine

2015
Reduction in ovulation or male sex phenotype increases long-term anoxia survival in a daf-16-independent manner in Caenorhabditis elegans.
    Physiological genomics, 2009, Feb-02, Volume: 36, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Caenorhabditis elegans; Caenorhabditis elegans Proteins; F

2009