Page last updated: 2024-11-06

floxuridine and Hepatocellular Carcinoma

floxuridine has been researched along with Hepatocellular Carcinoma in 71 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
"To conduct a pilot trial of hepatic arterial infusion (HAI) of floxuridine (FUDR), leucovorin, Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), and cisplatin (FLAP) in nonresectable hepatocellular cancer (HCC) confined to the liver and assess the effects of hepatitis B (HBV) and hepatitis C (HCV) viral markers on toxicity, response to treatment, and patient survival."9.07Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma: effects of hepatitis B and C viral infection on drug toxicity and patient survival. ( Carrasco, H; Charnsangavej, C; Chase, J; Chuang, V; Fischer, H; Lawrence, D; Patt, YZ; Roh, M; Smith, R; Yoffe, B, 1994)
"We report a series of novel O-(substituted benzyl) phosphoramidate prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of hepatocellular carcinoma."7.83Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma. ( Chang, J; Jiang, J; Kang, J; Li, E; Li, L; Liu, B; Peng, Y; Wang, Q; Wang, Y; Wu, J; Yang, Q; Yu, W; Zhang, J, 2016)
"Doxifluridine is an oral fluoropyrimidine derivative activated to 5-fluorouracil by uridine phosphorylase which is more expressed in malignant cells."6.69Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study. ( Allegrini, G; Bartolozzi, C; Brunetti, I; Conte, PF; Di Marsico, R; Falcone, A; Fontana, E; Lencioni, M; Masi, G; Orlandini, C; Pfanner, E; Stampino, CG, 2000)
"Thirty-nine patients with hepatocellular carcinoma were treated with oral 5'-DFUR for more than 4 d before operation."5.335-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma. ( Wang, HD; Zheng, JF, 2005)
"This study reports the results of hepatic arterial infusion (HAI) with floxuridine (FUDR) and dexamethasone (dex) in patients with unresectable intrahepatic cholangiocarcinoma (ICC) or hepatocellular carcinoma (HCC) and investigates dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) assessment of tumor vascularity as a biomarker of outcome."5.14Regional chemotherapy for unresectable primary liver cancer: results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival. ( Blumgart, LH; D'Angelica, M; DeMatteo, R; Fong, Y; Gönen, M; Gultekin, DH; Haviland, D; Jarnagin, WR; Kemeny, N; Schwartz, LH; Shia, J; Tse, A, 2009)
"The results suggest that, compared with historical controls, high-dose focal liver irradiation with hepatic artery floxuridine prolongs survival in patients with unresectable chemotherapy-refractory metastatic colorectal cancer and primary hepatobiliary tumors."5.11Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies. ( Ben-Josef, E; Dawson, LA; Ensminger, WD; Knol, J; Lawrence, TS; Normolle, D; Pan, C; Tatro, D; Ten Haken, RK; Walker, S, 2005)
"To conduct a pilot trial of hepatic arterial infusion (HAI) of floxuridine (FUDR), leucovorin, Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), and cisplatin (FLAP) in nonresectable hepatocellular cancer (HCC) confined to the liver and assess the effects of hepatitis B (HBV) and hepatitis C (HCV) viral markers on toxicity, response to treatment, and patient survival."5.07Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma: effects of hepatitis B and C viral infection on drug toxicity and patient survival. ( Carrasco, H; Charnsangavej, C; Chase, J; Chuang, V; Fischer, H; Lawrence, D; Patt, YZ; Roh, M; Smith, R; Yoffe, B, 1994)
"We report a series of novel O-(substituted benzyl) phosphoramidate prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of hepatocellular carcinoma."3.83Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma. ( Chang, J; Jiang, J; Kang, J; Li, E; Li, L; Liu, B; Peng, Y; Wang, Q; Wang, Y; Wu, J; Yang, Q; Yu, W; Zhang, J, 2016)
"To investigate the efficacy of hepatic arterial infusion chemotherapy (HAIC) using floxuridine (FUDR) in patients with advanced hepatocellular carcinoma (HCC) confined to the liver."3.78Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma. ( Baek, YH; Cho, JH; Choi, YM; Han, SY; Jeong, JS; Kim, KT; Kim, YH; Lee, HS; Lee, SW; Nam, KJ; Park, BH; Roh, YH, 2012)
"The action of floxuridine depends greatly on its concentration for treatment of liver metastases of colorectal carcinomas and other tumors."3.66[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors]. ( Balch, CM; Urist, MM, 1983)
"Patients with unresectable intrahepatic cholangiocarcinoma (ICC) or hepatocellular carcinoma (HCC) were treated with HAI FUDR/Dex plus IV Bev."2.76Treating primary liver cancer with hepatic arterial infusion of floxuridine and dexamethasone: does the addition of systemic bevacizumab improve results? ( Allen, P; D'Angelica, MI; Fong, Y; Gewirtz, AN; Gönen, M; Gultekin, D; Haviland, D; Jarnagin, WR; Kemeny, NE; Schwartz, L; Yopp, A, 2011)
"Doxifluridine is an oral fluoropyrimidine derivative activated to 5-fluorouracil by uridine phosphorylase which is more expressed in malignant cells."2.69Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study. ( Allegrini, G; Bartolozzi, C; Brunetti, I; Conte, PF; Di Marsico, R; Falcone, A; Fontana, E; Lencioni, M; Masi, G; Orlandini, C; Pfanner, E; Stampino, CG, 2000)
"In all three studies, the incidence of hyperbilirubinemia and biliary stent placement within 1 year of treatment was increased with the addition of Bev."1.40Floxuridine hepatic arterial infusion associated biliary toxicity is increased by concurrent administration of systemic bevacizumab. ( Allen, P; Capanu, M; Cercek, A; D'Angelica, M; DeMatteo, RP; Fong, Y; Gewirtz, A; Jarnagin, WR; Kemeny, NE; Patel, D; Power, D, 2014)
"To establish a multidrug-resistant hepatocellular carcinoma cell line BEL-7402/5-deoxy-5-fluorouridine (5'-DFUR) and study the mechanisms of the drug resistance."1.35[Establishment of a 5-DFUR-resistant human hepatocellular carcinoma cell model and preliminary study of the mechanisms of the drug resistance]. ( Li, RP; Liang, P; Tang, H, 2008)
"Thirty-nine patients with hepatocellular carcinoma were treated with oral 5'-DFUR for more than 4 d before operation."1.335-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma. ( Wang, HD; Zheng, JF, 2005)
"A total of 22 patients (11 with hepatocellular carcinoma and 11 with cholangiocarcinoma) were treated."1.30Long-term results of hepatic artery fluorodeoxyuridine and conformal radiation therapy for primary hepatobiliary cancers. ( Andrews, JC; Ensminger, WD; Kessler, ML; Lawrence, TS; Robertson, JM; Walker, S, 1997)
"A 65-year-old female patient with liver cirrhosis complicated with hepatocellular carcinoma (HCC) was treated with oral administration of 5'-DFUR (600 mg/day)."1.29[A case of hepatocellular carcinoma responding to oral administration of 5'-DFUR]. ( Mizuno, M; Ogino, M; Tanaka, Y; Tokuda, H; Yamauchi, M, 1996)
"Twelve of the patients had primary hepatocellular carcinoma and six had metastatic liver carcinoma originating from an unknown primary site."1.27Hepatic arterial chemotherapy and occlusion for palliation of primary hepatocellular and unknown primary neoplasms in the liver. ( Benjamin, RS; Chuang, VP; Fuqua, R; Mavligit, GM; Patt, YZ; Wallace, S, 1983)
"Three patients with primary hepatocellular carcinoma demonstrated less than 50% reduction in tumor size."1.27Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump. ( Jones, LS; McCune, CS; Schwartz, SI, 1985)
"Of 13 patients with hepatoma, nine had clinically significant regression with a median survival of 11 months."1.26The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol. ( Al-Sarraf, M; Baker, L; Izbicki, R; Reed, ML; Sexon-Porte, M; Singhakowinta, A; Straatsma, GW; Vaitkevicius, VK; Vaughn, CB, 1981)
"Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts."1.25Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975)

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-199037 (52.11)18.7374
1990's13 (18.31)18.2507
2000's11 (15.49)29.6817
2010's8 (11.27)24.3611
2020's2 (2.82)2.80

Authors

AuthorsStudies
Peng, Y1
Yu, W1
Li, E1
Kang, J1
Wang, Y1
Yang, Q1
Liu, B1
Zhang, J2
Li, L1
Wu, J1
Jiang, J1
Wang, Q1
Chang, J1
Rico, L1
Østergaard, ME1
Bell, M1
Seth, PP1
Hanessian, S1
Peng, X1
Gao, J1
Yuan, Y1
Liu, H1
Lei, W1
Li, S1
Wang, S2
Xue, F1
Lin, X2
Cai, Z1
Liu, X1
Ma, Y1
Wu, M1
Zhang, H1
Xu, H1
Tang, Q1
Bi, F1
Cercek, A1
D'Angelica, M2
Power, D1
Capanu, M1
Gewirtz, A1
Patel, D1
Allen, P2
Fong, Y3
DeMatteo, RP1
Jarnagin, WR3
Kemeny, NE2
Zhao, C1
Wang, XJ1
Feng, WH1
Shi, L1
Yu, CP1
Tang, H1
Liang, P1
Li, RP1
Schwartz, LH1
Gultekin, DH1
Gönen, M2
Haviland, D2
Shia, J1
DeMatteo, R1
Tse, A1
Blumgart, LH1
Kemeny, N1
Schwartz, L1
Yopp, A1
Gultekin, D1
D'Angelica, MI1
Gewirtz, AN1
Baek, YH1
Kim, KT1
Lee, SW1
Jeong, JS1
Park, BH1
Nam, KJ1
Cho, JH1
Kim, YH1
Roh, YH1
Lee, HS1
Choi, YM1
Han, SY1
Wang, J1
Yin, C1
Tang, G1
Wu, Q1
Feun, LG1
O'Brien, C1
Molina, E1
Rodriguez, M1
Jeffers, L1
Schiff, ER1
Marini, A1
Savaraj, N1
Ardalan, B1
MORSE, PA1
POTTER, VR1
Elias, D1
de Baere, T1
Sideris, L1
Ducreux, M1
Zhou, J1
Xiao, YS1
Tang, ZY1
Fan, J1
Wu, ZQ1
Zhao, Y1
Xue, Q1
Shen, ZZ1
Liu, YK1
Ye, SL1
Zheng, JF1
Wang, HD1
Ben-Josef, E1
Normolle, D2
Ensminger, WD3
Walker, S3
Tatro, D1
Ten Haken, RK2
Knol, J1
Dawson, LA2
Pan, C1
Lawrence, TS4
Hao, MZ1
Lin, HL1
Chen, Q1
Wu, H1
Yu, WC1
Chen, TG1
Balch, CM2
Urist, MM2
Patt, YZ2
Chuang, VP1
Wallace, S2
Benjamin, RS1
Fuqua, R1
Mavligit, GM1
Reed, ML1
Vaitkevicius, VK1
Al-Sarraf, M1
Vaughn, CB1
Singhakowinta, A1
Sexon-Porte, M1
Izbicki, R1
Baker, L1
Straatsma, GW1
Niederhuber, JE2
Friedman, MA1
Curley, SA1
Wada, M1
Jin, H1
Kinugasa, A1
Shintani, S1
Sawada, K1
Yamashita, M1
Yamamura, M1
Nishigami, T1
Kano, M1
Shimoyama, T1
Miyazaki, K1
Yakushiji, H1
Kitahara, K1
Mori, M1
Sasatomi, E1
Tsutsumi, N1
Hirohashi, Y1
Iwanaga, A1
Iyama, A1
Fukagawa, H1
Charnsangavej, C2
Yoffe, B1
Smith, R1
Lawrence, D1
Chuang, V1
Carrasco, H1
Roh, M1
Chase, J1
Fischer, H1
Kessler, ML2
Robertson, JM2
Campbell, KA1
Burns, RC1
Sitzmann, JV1
Lipsett, PA1
Grochow, LB1
Tanaka, Y1
Ogino, M1
Tokuda, H1
Mizuno, M1
Yamauchi, M1
Andrews, JC1
Ikeda, K1
Saitoh, S1
Suzuki, Y1
Koida, I1
Tsubota, A1
Kobayashi, M1
Arase, Y1
Chayama, K1
Murashima, N1
Kumada, H1
Merle, P1
Trepo, C1
Port, R1
Hanisch, F1
Becker, M1
Bachert, P1
Zeller, J1
McGinn, CJ1
Ensminger, W1
Lencioni, M1
Falcone, A1
Allegrini, G1
Pfanner, E1
Masi, G1
Brunetti, I1
Di Marsico, R1
Fontana, E1
Orlandini, C1
Stampino, CG1
Bartolozzi, C1
Conte, PF1
Clavien, PA1
Selzner, N1
Morse, M1
Selzner, M1
Paulson, E1
Oberfield, RA3
Moertel, CG1
Wilkinson, DS2
Tlsty, TD1
Hanas, RJ1
Jackson, RC1
Weber, G1
Solomonson, LP1
Cory, JG1
Ryan, R1
Metman, EH1
Oberfield, R1
Glouse, M1
Wellwood, JM1
Cady, B2
Yamashita, Y3
Takahashi, M3
Shinzato, J1
Bussaka, H2
Baba, Y1
Oguni, T1
Koga, Y1
Saito, R1
Nanakawa, S1
Hatanaka, Y1
Sato, N1
Nakashima, K1
Urata, J1
Yoshizumi, K1
Strohmeyer, G1
Porschen, R1
Seeger, J1
Woodcock, TM1
Blumenreich, MS1
Richardson, JD1
Shibata, T1
Sasaki, Y1
Imaoka, S1
Wada, H1
Nagano, H1
Ishikawa, O1
Ohigashi, H1
Fukuda, I1
Kabuto, T1
Hiratsuka, M1
Fukushima, S1
Kawaguchi, T1
Nakano, M1
Schwartz, SI1
Jones, LS1
McCune, CS1
Carrasco, CH1
Richli, W1
Haynie, TP1
Blachly, RJ1
Reid, IS1
Hutchins, LF1
Lang, NP1
Neilan, BA1
Ortego, SG1
Lai, KH1
Tsai, YT1
Lee, SD1
Yeh, YS1
Wang, SS1
Ng, WW1
Wang, JY1
Chiang, TT1
Lay, CS1
Yang, CF1
Bresnick, E1
Thompson, UB1
Khwaja, TA1
Heidelberger, C3
Van Dyk, JJ1
Clarkson, BD1
Duschinsky, R1
Keller, O1
La Sala, E1
Krakoff, IH1
Baden, H1
Umeda, M1
Wolberg, WH2
Sanderson, TA1
McBride, CM1
Bloomenthal, ED1
Spellberg, MA1
Nesnow, S1
Mian, AM1
Oki, T1
Dexter, DL1
Tsou, KC1
Ledis, S1
McCoy, MG1
Norman, EJ1
Nagyvary, J1
Morgenthaler, FR1
Pettavel, J1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Single-Arm Phase II Study of Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver[NCT03366155]Phase 240 participants (Anticipated)Interventional2019-06-24Recruiting
Pilot Study of Hepatic Arterial Infusion Therapy in Patients With Unresectable or Borderline Resectable Intrahepatic Cholangiocarcinoma[NCT01525069]Phase 127 participants (Actual)Interventional2012-04-03Terminated (stopped due to Equipment that was used in the study was discontinued)
A Phase II Study of Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Intravenous Bevacizumab (A Monoclonal Antibody to Vascular Endothelial Growth Factor-A), in Patients With Unresectable Primary Hepatic Malignancy[NCT00410956]Phase 255 participants (Anticipated)Interventional2007-05-31Active, not recruiting
A Phase 2 Study of Low-Dose Fractionated Radiation Therapy to the Whole Liver in Combination With Gemcitabine and Cisplatin in Locally Advanced Mass-Forming Intrahepatic Cholangiocarcinoma[NCT02254681]Phase 26 participants (Actual)Interventional2014-09-30Terminated (stopped due to lack of funding)
A Humanitarian Device Exemption Use Protocol of Therasphere® for Treatment of Unresectable Hepatocellular and Metastatic Liver Tumors - HDE #980006[NCT00701168]0 participants Expanded AccessNo longer available
Human Liver Explants for HIF-1 Alpha- Analysis/Comparison[NCT00866957]180 participants (Actual)Observational2006-02-28Completed
A Phase III Randomized Trial of Standard Dose Stereotactic Body Radiation Therapy (SBRT) Versus Radiobiologically-Guided Dose Selected SBRT In Primary or Secondary Liver Carcinoma (SAVIOR).[NCT04745390]110 participants (Anticipated)Interventional2021-08-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Intrahepatic Disease Progression After Treatment With Combination Low-dose Radiotherapy and Gemcitabine-cisplatin.

To determine the number of participants with Intrahepatic disease progression assessed by MRI of the abdomen with intravenous gadolinium contrast using RECIST criteria. (NCT02254681)
Timeframe: From date of first treatment until date of first documented progression or date of death from any cause, which ever comes first, assessed up to 24 months.

InterventionParticipants (Count of Participants)
Treatment6

Number of Participants With Intrahepatic Recurrence After Partial Hepatectomy With Antecedent Combination Low-dose Radiotherapy and Gemcitabine-cisplatin.

To determine the number of participants with Intrahepatic recurrence assessed by RECIST criteria using MRI of the abdomen with intravenous gadolinium contrast. (NCT02254681)
Timeframe: From date of partial hepatectomy until date of first documented recurrence or date of death from any cause, assessed up to 24 months.

InterventionParticipants (Count of Participants)
Treatment1

Number of Participants With Post-operative Complications After Partial Hepatectomy After Antecedent Combination Low-dose Radiotherapy and Gemcitabine-cisplatin.

Measured post-operative complications include (but not limited to) bile leak, liver failure, ascites, infection, any organ failure or insufficiency, venous thromboembolism, and mortality. (NCT02254681)
Timeframe: up to 90 days after partial hepatectomy

InterventionParticipants (Count of Participants)
Treatment1

Reviews

5 reviews available for floxuridine and Hepatocellular Carcinoma

ArticleYear
Regional chemotherapeutic techniques for liver tumors: current knowledge and future directions.
    The Surgical clinics of North America, 2004, Volume: 84, Issue:2

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Colorectal Neoplasms; Dose-Response Relationship,

2004
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:5

    Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Art

1983
Update on regional treatments for hepatobiliary malignancies.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Carcinoma, Hepatocellular;

1995
Antiblastic drug targeting to hepatocellular carcinoma cells: a potential therapeutic improvement?
    Italian journal of gastroenterology and hepatology, 1998, Volume: 30, Issue:2

    Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoco

1998
[Interdisciplinary therapy concepts in primary and secondary neoplasms of the liver].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1989, Volume: 24

    Topics: Carcinoma, Hepatocellular; Combined Modality Therapy; Floxuridine; Fluorouracil; Follow-Up Studies;

1989

Trials

12 trials available for floxuridine and Hepatocellular Carcinoma

ArticleYear
Regional chemotherapy for unresectable primary liver cancer: results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bi

2009
Treating primary liver cancer with hepatic arterial infusion of floxuridine and dexamethasone: does the addition of systemic bevacizumab improve results?
    Oncology, 2011, Volume: 80, Issue:3-4

    Topics: Aged; Alkaline Phosphatase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplasti

2011
Recombinant leukocyte interferon, doxorubicin, and 5FUDR in patients with hepatocellular carcinoma-A phase II trial.
    Journal of cancer research and clinical oncology, 2003, Volume: 129, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin;

2003
Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Bile Duct Neoplasms; Bile Ducts, In

2005
[Efficacy of transcatheter arterial chemoembolization combined thalidomide on hepatocellular carcinoma: a controlled randomized trial].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:8

    Topics: Administration, Oral; Adult; Aged; Angiogenesis Inhibitors; Carcinoma, Hepatocellular; Chemoemboliza

2007
Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma: effects of hepatitis B and C viral infection on drug toxicity and patient survival.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Doxorubi

1994
A prospective randomized administration of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy for hepatocellular carcinoma treated with transcatheter arterial chemoembolization.
    American journal of clinical oncology, 1997, Volume: 20, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Combined Moda

1997
Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Colorect

2000
Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Colorect

2000
Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Colorect

2000
Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Colorect

2000
Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study.
    Oncology, 2000, Volume: 59, Issue:3

    Topics: Administration, Oral; Aged; Ambulatory Care; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellu

2000
Evaluation of oil-soluble FUdR ester for transcatheter arterial treatment of hepatomas.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1992, Volume: 3, Issue:5

    Topics: Carcinoma, Hepatocellular; Catheters, Indwelling; Chemoembolization, Therapeutic; Doxorubicin; Drug

1992
Hepatic infusional chemotherapy in metastatic colorectal carcinoma and hepatoma.
    The Journal of the Arkansas Medical Society, 1985, Volume: 82, Issue:7

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuri

1985
Clinical trial of doxifluridine in the treatment of primary hepatocellular carcinoma.
    Cancer treatment reports, 1986, Volume: 70, Issue:11

    Topics: Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Female; Floxuridine; Humans; Liver Neopla

1986

Other Studies

54 other studies available for floxuridine and Hepatocellular Carcinoma

ArticleYear
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
    Journal of medicinal chemistry, 2016, 04-28, Volume: 59, Issue:8

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Carcinoma, Hepatocellular; D

2016
Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma.
    Bioorganic & medicinal chemistry letters, 2018, 08-15, Volume: 28, Issue:15

    Topics: Antineoplastic Agents; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Deoxyuridine; Drug De

2018
Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy.
    Bioconjugate chemistry, 2019, 11-20, Volume: 30, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation;

2019
Doxifluridine-based pharmacosomes delivering miR-122 as tumor microenvironments-activated nanoplatforms for synergistic treatment of hepatocellular carcinoma.
    Colloids and surfaces. B, Biointerfaces, 2021, Volume: 197

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Floxuridine; Gene Expres

2021
The selective serotonin reuptake inhibitors enhance the cytotoxicity of sorafenib in hepatocellular carcinoma cells.
    Anti-cancer drugs, 2021, 09-01, Volume: 32, Issue:8

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combina

2021
Floxuridine hepatic arterial infusion associated biliary toxicity is increased by concurrent administration of systemic bevacizumab.
    Annals of surgical oncology, 2014, Volume: 21, Issue:2

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bile

2014
Lobaplatin combined floxuridine/pirarubicin-based transcatheter hepatic arterial chemoembolization for unresectable primary hepatocellular carcinoma.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therap

2014
[Establishment of a 5-DFUR-resistant human hepatocellular carcinoma cell model and preliminary study of the mechanisms of the drug resistance].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2008, Volume: 28, Issue:11

    Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma,

2008
Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma.
    World journal of gastroenterology, 2012, Jul-14, Volume: 18, Issue:26

    Topics: Aged; Carcinoma, Hepatocellular; Dexamethasone; Disease-Free Survival; Female; Floxuridine; Humans;

2012
Glucose-functionalized multidrug-conjugating nanoparticles based on amphiphilic terpolymer with enhanced anti-tumorous cell cytotoxicity.
    International journal of pharmaceutics, 2013, Jan-30, Volume: 441, Issue:1-2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cytarabine; Drug Carriers

2013
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
    Cancer research, 1965, Volume: 25

    Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liv

1965
Transfection of thymidine phosphorylase cDNA to human hepatocellular carcinoma cells enhances sensitivity to fluoropyrimidine but augments endothelial cell migration.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:8

    Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Movement; Disea

2005
5-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma.
    World journal of gastroenterology, 2005, Jul-07, Volume: 11, Issue:25

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorour

2005
[Intra-arterial chemotherapy using an implantable infusion pump in liver metastases of colorectal tumors and hepatomas].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1984, Volume: 55, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxoru

1984
Hepatic arterial chemotherapy and occlusion for palliation of primary hepatocellular and unknown primary neoplasms in the liver.
    Cancer, 1983, Apr-15, Volume: 51, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin;

1983
The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol.
    Cancer, 1981, Jan-15, Volume: 47, Issue:2

    Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-

1981
[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-01, Volume: 108, Issue:26

    Topics: Carcinoma, Hepatocellular; Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepa

1983
Surgical considerations in the management of hepatic neoplasia.
    Seminars in oncology, 1983, Volume: 10, Issue:2

    Topics: Adenoma, Bile Duct; Antineoplastic Agents; Carcinoma, Hepatocellular; Catheterization; Floxuridine;

1983
Simultaneous occurrence of adenomas in stomach, duodenal bulb, and colon: disappearance of gastric and duodenal adenomas during oral administration of 5'-deoxy-5-fluorouridine.
    The American journal of gastroenterology, 1994, Volume: 89, Issue:11

    Topics: Adenoma; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Colonic Neoplasms; Duodenal Neoplas

1994
[A comparative study on the serum and tissue 5-FU concentrations in patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepato

1994
Conformal high-dose radiation plus intraarterial floxuridine for hepatic cancer.
    Oncology (Williston Park, N.Y.), 1993, Volume: 7, Issue:10

    Topics: Aged; Carcinoma, Hepatocellular; Combined Modality Therapy; Floxuridine; Humans; Injections, Intra-A

1993
Regional chemotherapy devices: effect of experience and anatomy on complications.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:5

    Topics: Adult; Analysis of Variance; Carcinoma, Hepatocellular; Catheters, Indwelling; Colorectal Neoplasms;

1993
[A case of hepatocellular carcinoma responding to oral administration of 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:4

    Topics: Administration, Oral; Aged; alpha-Fetoproteins; Antineoplastic Agents; Carcinoma, Hepatocellular; Fe

1996
Long-term results of hepatic artery fluorodeoxyuridine and conformal radiation therapy for primary hepatobiliary cancers.
    International journal of radiation oncology, biology, physics, 1997, Jan-15, Volume: 37, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcino

1997
Local disposition kinetics of floxuridine after intratumoral and subcutaneous injection as monitored by [19F]-nuclear magnetic resonance spectroscopy in vivo.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Delayed-Action Preparations; Fe

1999
Downstaging of hepatocellular carcinoma and liver metastases from colorectal cancer by selective intra-arterial chemotherapy.
    Surgery, 2002, Volume: 131, Issue:4

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemoth

2002
Current status of regional arterial infusion chemotherapy.
    The Medical clinics of North America, 1975, Volume: 59, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization;

1975
Clinical management of advanced gastrointestinal cancer.
    Cancer, 1975, Volume: 36, Issue:2

    Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther

1975
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
    Cancer research, 1975, Volume: 35, Issue:11 Pt 1

    Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Floxuridine; Fluorouracil; In Vitro Techniques;

1975
Enzyme pattern directed chemotherapy. The effects of combinations of methotrexate, 5-fluorodeoxyuridine and thymidine on rat hepatoma cells in vitro.
    Biochemical pharmacology, 1976, Dec-01, Volume: 25, Issue:23

    Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Depression, Chemical; Floxuridine; Liv

1976
Increased thymidylate synthetase activity in 5-fluorodeoxyuridine-resistant Novikoff hepatoma cells.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1977, Volume: 154, Issue:3

    Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cell Line; Drug Resistance; Floxuridine; Liver

1977
[Fluorinated pyrimidines administered by percutaneous arterial perfusion in primary or secondary cancers of the liver].
    Bulletin du cancer, 1977, Volume: 64, Issue:3

    Topics: Carcinoma, Hepatocellular; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neopl

1977
Treatment of primary liver cancer: response to regional chemotherapy.
    Clinical oncology, 1979, Volume: 5, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Reg

1979
Prognostic factors in the treatment of hepatocellular carcinoma with transcatheter arterial embolization and arterial infusion.
    Cancer, 1991, Jan-15, Volume: 67, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Combine

1991
Hepatic perfusion with FUdR utilizing an implantable system in patients with liver primary cancer or metastatic cancer confined to the liver.
    Cancer investigation, 1989, Volume: 7, Issue:1

    Topics: Adenocarcinoma; Adenoma, Bile Duct; Adult; Aged; Carcinoma, Hepatocellular; Colorectal Neoplasms; Fl

1989
[Selective anticancer effects of intra-arterial infusion of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (TT82) in hepatocellular carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:8 Pt 2

    Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Combined Modality Therapy; Drug Ev

1989
Intraarterial infusion of 5-fluoro-2-deoxyuridine-C8 dissolved in a lymphographic agent in malignant liver tumors. A preliminary report.
    Cancer, 1989, Dec-15, Volume: 64, Issue:12

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Iodi

1989
Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump.
    Annals of surgery, 1985, Volume: 201, Issue:5

    Topics: Adenoma, Islet Cell; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Catheterization; Catheters

1985
Hepatic arterial flow distribution with hepatic neoplasms: significance in infusion chemotherapy.
    Radiology, 1987, Volume: 165, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellul

1987
Properties of deoxythymidine kinase partially purified from animal tumors.
    The Journal of biological chemistry, 1965, Volume: 240, Issue:10

    Topics: Adenosine Triphosphate; Animals; Barium; Bromodeoxyuridine; Calcium Chloride; Carcinoma 256, Walker;

1965
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.
    Journal of medicinal chemistry, 1967, Volume: 10, Issue:6

    Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Escherichia coli; Floxuridine; HeLa Ce

1967
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
    Cancer research, 1967, Volume: 27, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carci

1967
Infusion of liver tumours.
    British medical journal, 1968, Aug-10, Volume: 3, Issue:5614

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Floxurid

1968
[Continuous intra-arterial infusion of 5-fluor-2-deoxyuridine in primary and metastatic liver cancer].
    Ugeskrift for laeger, 1968, Apr-25, Volume: 130, Issue:17

    Topics: Adenoma, Bile Duct; Adult; Aged; Arteries; Carcinoma, Hepatocellular; Female; Floxuridine; Gastroint

1968
Comparative studies of fluorinated pyrimidines with various cell lines.
    Cancer research, 1968, Volume: 28, Issue:12

    Topics: Animals; Carcinoma, Hepatocellular; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA, Neo

1968
Development of resistance of Novikoff hepatoma to 5-fluoro-2'-deoxyuridine.
    International journal of cancer, 1970, Sep-15, Volume: 6, Issue:2

    Topics: Carbon Isotopes; Carcinoma, Hepatocellular; Culture Techniques; DNA, Neoplasm; Floxuridine; Liver Ne

1970
Considerations in the development of a predictive system for cancer chemotherapy.
    Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 102, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; DNA; Floxuridine; Fluorouracil; Liver N

1971
Experience with hepatic arterial infusions.
    Texas medicine, 1971, Volume: 67, Issue:3

    Topics: Adult; Aged; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorouracil; Gall

1971
Therapy for carcinoma of the liver.
    The American journal of gastroenterology, 1971, Volume: 56, Issue:4

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Angiography; Aspartate Aminotransferases; Carcino

1971
Fluorinated pyrimidines. 41. Syntheses of 5-trifluoromethyl-3'-deoxyuridine and 5-fluoro-3'-deoxyuridine.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:6

    Topics: Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Ion Exc

1972
5'-Nucleotide phosphodiesterase isoenzyme pattern in the serum of human hepatoma.
    Cancer research, 1973, Volume: 33, Issue:10

    Topics: Adenoma; Carcinoma, Hepatocellular; Electrophoresis, Polyacrylamide Gel; Fetal Proteins; Floxuridine

1973
Arterial infusion chemotherapy of hepatoma.
    Surgery, gynecology & obstetrics, 1974, Volume: 138, Issue:3

    Topics: Adolescent; Adult; Aged; Carcinoma, Hepatocellular; Catheterization; Child; Female; Floxuridine; Hum

1974
Synthesis of some trinucleoside monophosphates of biological interest.
    Journal of medicinal chemistry, 1974, Volume: 17, Issue:4

    Topics: Animals; Biodegradation, Environmental; Bromodeoxyuridine; Carcinoma, Hepatocellular; Chromatography

1974
[Combined drug-surgical treatment in primary and secondary liver tumors].
    Helvetica chirurgica acta, 1974, Volume: 41, Issue:5-6

    Topics: Carcinoma, Hepatocellular; Drug Therapy, Combination; Floxuridine; Humans; Injections, Intra-Arteria

1974