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floxuridine and Head and Neck Neoplasms

floxuridine has been researched along with Head and Neck Neoplasms in 19 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Research Excerpts

ExcerptRelevanceReference
"Four human head and neck xenograft (HNX) tumour lines grown in nude mice and two murine colon carcinomas (Colon 26 and 38) were tested for their sensitivity to 5-fluorouracil (5-FU) and its prodrug 5'deoxy-5-fluorouridine (Doxifluridine, 5'd-FUR)."3.67Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes. ( Braakhuis, BJ; de Bruijn, EA; Laurensse, EJ; Peters, GJ; Pinedo, HM; van Walsum, M, 1989)
"We used a human head and neck cancer cell line (CAL33) to examine the influence of cell cycle modifications on TS, TP, and dihydropyrimidine dehydrogenase activity."1.32ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine. ( Ciccolini, J; Dubreuil, A; Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Magné, N; Marchetti, S; Milano, G; Renée, N; Tiffon, C, 2003)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199016 (84.21)18.7374
1990's1 (5.26)18.2507
2000's1 (5.26)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Specenier, P1
Guetens, G1
Dyck, J1
De Boeck, G1
Weyler, J1
Van den Weyngaert, D1
Aelbrecht, K1
Vermorken, JB1
WATKINS, E2
SULLIVAN, RD2
CLIFFORD, P1
Magné, N1
Fischel, JL1
Dubreuil, A1
Formento, P1
Ciccolini, J1
Formento, JL1
Tiffon, C1
Renée, N1
Marchetti, S1
Etienne, MC1
Milano, G1
Abele, R1
Kaplan, E1
Grossenbacher, R1
Schmid, HJ1
Cavalli, F1
Cao, S1
McGuire, JJ1
Rustum, YM1
Cummings, FJ1
Hoovis, ML1
Calabresi, P1
Oberfield, RA2
Peters, GJ2
Braakhuis, BJ2
de Bruijn, EA1
Laurensse, EJ2
van Walsum, M1
Pinedo, HM2
Taguchi, T1
Sakai, K1
Terasawa, T1
Irie, K1
Okajima, K1
Yamamoto, M1
Kawahara, T1
Satomi, T1
Tomita, K1
Yamaguchi, A1
Forastiere, AA1
Baker, SR2
Wheeler, R1
Medvec, BR2
Wheeler, RH1
Goffinet, DR1
Bagshaw, MA1
Nervi, C1
Casale, C1
Cortese, M1
Couture, J1
Deschênes, L1
Poulin, F1
Cady, B1
Booth, JC1
Kenis, Y1

Reviews

2 reviews available for floxuridine and Head and Neck Neoplasms

ArticleYear
Clinical use of radiation sensitizing agents.
    Cancer treatment reviews, 1974, Volume: 1, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura

1974
Chemotherapy of residual disease in solid tumours.
    Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1971, Volume: 16, Issue:2

    Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lun

1971

Other Studies

17 other studies available for floxuridine and Head and Neck Neoplasms

ArticleYear
Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:1

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Deoxycytidine;

2011
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
    Surgery, gynecology & obstetrics, 1964, Volume: 118

    Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Re

1964
THE ADMINISTRATION OF CHEMO-THERAPEUTIC AGENTS IN THE TREATMENT OF ADVANCED HEAD AND NECK CANCER.
    The Journal of laryngology and otology, 1964, Volume: 78

    Topics: Alkylating Agents; Antineoplastic Agents; Aorta; Aorta, Abdominal; Black People; Catheterization; Et

1964
PROTRACTED ARTERIAL INFUSION CANCER CHEMOTHERAPY.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Colonic Neop

1964
ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-15, Volume: 9, Issue:13

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combine

2003
Phase II study of doxifluridine in advanced squamous cell carcinoma of the head and neck.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:3

    Topics: Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Squamous Cell; Drug Administration Sch

1984
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:7

    Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxur

1999
Phase I study of 5-fluorodeoxyuridine plus cytosine arabinoside infusions in patients with solid tumors.
    Cancer treatment reports, 1979, Volume: 63, Issue:8

    Topics: Adolescent; Adult; Aged; Breast Neoplasms; Cytarabine; Drug Administration Schedule; Drug Evaluation

1979
Current status of regional arterial infusion chemotherapy.
    The Medical clinics of North America, 1975, Volume: 59, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization;

1975
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
    British journal of cancer, 1989, Volume: 59, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Drug Resistance; Female; Floxuridine;

1989
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Animals; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Head and Ne

1989
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11

    Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neopla

1985
Intra-arterial cisplatin and FUDR in advanced malignancies confined to the head and neck.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Drug Implan

1987
Surgical aspects of intra-arterial chemotherapy of outpatients with head and neck cancer.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1985, Volume: 93, Issue:2

    Topics: Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin

1985
Protracted intra-arterial chemotherapy with sequential courses of antimitotics and hydrogen peroxyde in the treatment of head and neck tumors.
    Revue francaise d'etudes cliniques et biologiques, 1969, Volume: 14, Issue:1

    Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans;

1969
[Utilization of amethopterin and floxuridine by intra-arterial infusion in treatment of head and neck tumors].
    L'union medicale du Canada, 1970, Volume: 99, Issue:6

    Topics: Drug Synergism; Floxuridine; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Methotrexa

1970
Regional arterial chemotherapy for advanced carcinoma of the head and neck. A ten-year review.
    Cancer, 1973, Volume: 32, Issue:1

    Topics: Antimetabolites; Antineoplastic Agents; Carotid Arteries; Catheterization; Digestive System; Dose-Re

1973