floxuridine has been researched along with Head and Neck Neoplasms in 19 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four human head and neck xenograft (HNX) tumour lines grown in nude mice and two murine colon carcinomas (Colon 26 and 38) were tested for their sensitivity to 5-fluorouracil (5-FU) and its prodrug 5'deoxy-5-fluorouridine (Doxifluridine, 5'd-FUR)." | 3.67 | Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes. ( Braakhuis, BJ; de Bruijn, EA; Laurensse, EJ; Peters, GJ; Pinedo, HM; van Walsum, M, 1989) |
| "We used a human head and neck cancer cell line (CAL33) to examine the influence of cell cycle modifications on TS, TP, and dihydropyrimidine dehydrogenase activity." | 1.32 | ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine. ( Ciccolini, J; Dubreuil, A; Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Magné, N; Marchetti, S; Milano, G; Renée, N; Tiffon, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Specenier, P | 1 |
| Guetens, G | 1 |
| Dyck, J | 1 |
| De Boeck, G | 1 |
| Weyler, J | 1 |
| Van den Weyngaert, D | 1 |
| Aelbrecht, K | 1 |
| Vermorken, JB | 1 |
| WATKINS, E | 2 |
| SULLIVAN, RD | 2 |
| CLIFFORD, P | 1 |
| Magné, N | 1 |
| Fischel, JL | 1 |
| Dubreuil, A | 1 |
| Formento, P | 1 |
| Ciccolini, J | 1 |
| Formento, JL | 1 |
| Tiffon, C | 1 |
| Renée, N | 1 |
| Marchetti, S | 1 |
| Etienne, MC | 1 |
| Milano, G | 1 |
| Abele, R | 1 |
| Kaplan, E | 1 |
| Grossenbacher, R | 1 |
| Schmid, HJ | 1 |
| Cavalli, F | 1 |
| Cao, S | 1 |
| McGuire, JJ | 1 |
| Rustum, YM | 1 |
| Cummings, FJ | 1 |
| Hoovis, ML | 1 |
| Calabresi, P | 1 |
| Oberfield, RA | 2 |
| Peters, GJ | 2 |
| Braakhuis, BJ | 2 |
| de Bruijn, EA | 1 |
| Laurensse, EJ | 2 |
| van Walsum, M | 1 |
| Pinedo, HM | 2 |
| Taguchi, T | 1 |
| Sakai, K | 1 |
| Terasawa, T | 1 |
| Irie, K | 1 |
| Okajima, K | 1 |
| Yamamoto, M | 1 |
| Kawahara, T | 1 |
| Satomi, T | 1 |
| Tomita, K | 1 |
| Yamaguchi, A | 1 |
| Forastiere, AA | 1 |
| Baker, SR | 2 |
| Wheeler, R | 1 |
| Medvec, BR | 2 |
| Wheeler, RH | 1 |
| Goffinet, DR | 1 |
| Bagshaw, MA | 1 |
| Nervi, C | 1 |
| Casale, C | 1 |
| Cortese, M | 1 |
| Couture, J | 1 |
| Deschênes, L | 1 |
| Poulin, F | 1 |
| Cady, B | 1 |
| Booth, JC | 1 |
| Kenis, Y | 1 |
2 reviews available for floxuridine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Clinical use of radiation sensitizing agents.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura | 1974 |
Chemotherapy of residual disease in solid tumours.
Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lun | 1971 |
17 other studies available for floxuridine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Deoxycytidine; | 2011 |
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Re | 1964 |
THE ADMINISTRATION OF CHEMO-THERAPEUTIC AGENTS IN THE TREATMENT OF ADVANCED HEAD AND NECK CANCER.
Topics: Alkylating Agents; Antineoplastic Agents; Aorta; Aorta, Abdominal; Black People; Catheterization; Et | 1964 |
PROTRACTED ARTERIAL INFUSION CANCER CHEMOTHERAPY.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Colonic Neop | 1964 |
ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combine | 2003 |
Phase II study of doxifluridine in advanced squamous cell carcinoma of the head and neck.
Topics: Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Squamous Cell; Drug Administration Sch | 1984 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxur | 1999 |
Phase I study of 5-fluorodeoxyuridine plus cytosine arabinoside infusions in patients with solid tumors.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Cytarabine; Drug Administration Schedule; Drug Evaluation | 1979 |
Current status of regional arterial infusion chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization; | 1975 |
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
Topics: Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Drug Resistance; Female; Floxuridine; | 1989 |
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Topics: Animals; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Head and Ne | 1989 |
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neopla | 1985 |
Intra-arterial cisplatin and FUDR in advanced malignancies confined to the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Drug Implan | 1987 |
Surgical aspects of intra-arterial chemotherapy of outpatients with head and neck cancer.
Topics: Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin | 1985 |
Protracted intra-arterial chemotherapy with sequential courses of antimitotics and hydrogen peroxyde in the treatment of head and neck tumors.
Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; | 1969 |
[Utilization of amethopterin and floxuridine by intra-arterial infusion in treatment of head and neck tumors].
Topics: Drug Synergism; Floxuridine; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Methotrexa | 1970 |
Regional arterial chemotherapy for advanced carcinoma of the head and neck. A ten-year review.
Topics: Antimetabolites; Antineoplastic Agents; Carotid Arteries; Catheterization; Digestive System; Dose-Re | 1973 |