floxuridine has been researched along with Glioma in 22 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In tissue culture experiments, cells derived from glioma 26, a transplantable tumor of C57B1/6 mice, were sensitive to both floxuridine (5-fluorodeoxyuridine) and 5-fluorodeoxyuridine-5'-(5-iodo-3-indolyl)phosphate, an enzyme-mediated drug activated by 5'-nucleotide phosphodiesterase." | 7.65 | 5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma. ( Ledis, SL; Lo, KW; Miller, EE; Tsou, KC, 1976) |
| "The cytotoxic agent Gemcitabine (2',2'-difluoro-2'-deoxycytidine) has been proved to be effective in the treatment of malignant gliomas." | 3.79 | Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy. ( Chen, H; Fan, B; Fang, S; Lu, Q; Sun, Y; Tang, D; Wei, Y; Yin, J; Yin, X; Zhang, B; Zhang, F, 2013) |
| "Positron emission tomography (PET) studies of a multicentric glioma case were undertaken using 11C-methionine (Met) and 18F-fluorodeoxyuridine (FUdR)." | 3.69 | Multicentric glioma studied with positron emission tomography: a case report. ( Ishiwata, K; Ito, M; Kameyama, M; Kayama, T; Sato, K; Yoshimoto, T, 1994) |
| "To shed light on the metabolic changes in glioma following therapy, uptake changes among 18F-fluoro-2'-deoxyuridine (18FUdR), 14C-thymidine (dThd), 14C-methionine (Met) and 3H-deoxyglucose (DG) in glioma model after chemotherapy were studied, as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine (BUdR) labeling index." | 3.68 | Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers. ( Ishiwata, K; Kameyama, M; Katakura, R; Sato, K; Yoshimoto, T, 1992) |
| "In tissue culture experiments, cells derived from glioma 26, a transplantable tumor of C57B1/6 mice, were sensitive to both floxuridine (5-fluorodeoxyuridine) and 5-fluorodeoxyuridine-5'-(5-iodo-3-indolyl)phosphate, an enzyme-mediated drug activated by 5'-nucleotide phosphodiesterase." | 3.65 | 5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma. ( Ledis, SL; Lo, KW; Miller, EE; Tsou, KC, 1976) |
| " Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0." | 2.68 | Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism. ( Hatazawa, J; Ido, T; Ishiwata, K; Ito, M; Itoh, J; Kameyama, M; Katakura, R; Sato, K; Tsurumi, Y; Yoshimoto, T, 1995) |
| "Using positron emission tomography and radio-high performance liquid chromatography, the accumulation of 2'-deoxy-5-18F-fluorouridine in the brain tumors and plasma pharmacokinetic parameters were investigated in 20 patients." | 1.29 | Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine. ( Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Sato, K; Takahashi, T; Tsurumi, Y; Yoshimoto, T, 1993) |
| "In metastatic brain tumors from lung, breast, and gastric cancer, the average time from the diagnosis of primary cancer to brain metastasis was shorter in cases with high activities and longer in cases with low activities." | 1.27 | [Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR]. ( Miki, Y; Miwa, M; Nomura, K; Shibui, S; Watanabe, T, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (54.55) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Tang, D | 1 |
| Chen, H | 1 |
| Zhang, F | 1 |
| Fan, B | 1 |
| Zhang, B | 1 |
| Fang, S | 1 |
| Lu, Q | 1 |
| Wei, Y | 1 |
| Yin, J | 1 |
| Yin, X | 1 |
| Li, HF | 1 |
| Winkeler, A | 1 |
| Moharram, S | 1 |
| Knaus, EE | 1 |
| Dittmar, K | 1 |
| Stöckle, M | 1 |
| Heiss, WD | 1 |
| Wiebe, LI | 1 |
| Jacobs, AH | 1 |
| Jacob, AJ | 1 |
| Shibui, S | 2 |
| Watanabe, T | 1 |
| Miki, Y | 1 |
| Nomura, K | 1 |
| Miwa, M | 1 |
| Ishiwata, K | 5 |
| Ido, T | 3 |
| Takahashi, T | 2 |
| Monma, M | 1 |
| Iwata, R | 2 |
| Abe, Y | 1 |
| Matsuzawa, T | 1 |
| Tsurumi, Y | 3 |
| Kameyama, M | 5 |
| Miller, EE | 2 |
| Itoh, J | 1 |
| Sato, K | 4 |
| Katakura, R | 2 |
| Yoshimoto, T | 4 |
| Hatazawa, J | 1 |
| Ito, M | 2 |
| McLaughlin, PW | 1 |
| Lawrence, TS | 2 |
| Seabury, H | 1 |
| Nguyen, N | 1 |
| Stetson, PL | 2 |
| Greenberg, HS | 2 |
| Mancini, WR | 2 |
| Kayama, T | 1 |
| Yamada, M | 2 |
| Nakagawa, H | 2 |
| Fukushima, M | 2 |
| Shimizu, K | 2 |
| Hayakawa, T | 1 |
| Ikenaka, K | 2 |
| Rosenberg, RN | 1 |
| Ledis, SL | 1 |
| Lo, KW | 1 |
| Tsou, KC | 1 |
| Wagner, JG | 1 |
| Ensminger, WD | 1 |
| Yamashita, M | 1 |
| Hashimoto, T | 1 |
| Hirakawa, T | 1 |
| Fukushima, T | 1 |
| Tomonaga, M | 1 |
| Hara, Y | 1 |
| Kono, A | 1 |
| Tanaka, M | 1 |
| Mori, K | 1 |
| Handa, H | 1 |
| Onoyama, Y | 1 |
| Sano, K | 1 |
| Hoshino, T | 1 |
| Nagai, M | 1 |
| Goffinet, DR | 1 |
| Brown, JM | 1 |
| Bagshaw, MA | 1 |
| Kaplan, HS | 1 |
| Levin, VA | 1 |
| Chadwick, M | 1 |
| Little, AD | 1 |
| Patterson, PH | 1 |
| Chun, LL | 1 |
1 trial available for floxuridine and Glioma
| Article | Year |
|---|---|
Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.
Topics: Adult; Aged; Brain Neoplasms; DNA, Neoplasm; Female; Floxuridine; Fluorine Radioisotopes; Glioma; Hu | 1995 |
21 other studies available for floxuridine and Glioma
| Article | Year |
|---|---|
Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Chemistry; Brain Neoplasms; Chromatography, High Pre | 2013 |
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Topics: Animals; Arabinofuranosyluracil; Blood-Brain Barrier; Brain; Brain Neoplasms; Floxuridine; Gene Expr | 2008 |
[Pyrimidine nucleoside phosphorylase in brain tumors and anti-tumor effect of 5'-DFUR].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Floxuridine; Glioma; Isomerism; Mice; Mice, Inbred | 1984 |
[Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR].
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Floxuridine; Glioma; Humans; Meningeal Neoplasm | 1983 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Ne | 1984 |
Immunity and drug resistance in a mouse glioma.
Topics: Animals; Drug Resistance; Floxuridine; Glioma; Immunity, Cellular; Mice; Neoplasm Transplantation; N | 1980 |
Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation.
Topics: Animals; Bromodeoxyuridine; Floxuridine; Glioma; Humans; In Vitro Techniques; Mice; Mice, Nude; Neop | 1994 |
Multicentric glioma studied with positron emission tomography: a case report.
Topics: Brain; Brain Neoplasms; Craniotomy; Floxuridine; Functional Laterality; Glioblastoma; Glioma; Glucos | 1994 |
Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine.
Topics: Adult; Aged; Brain Neoplasms; Child; Chromatography, High Pressure Liquid; Female; Floxuridine; Glio | 1993 |
In vitro study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant brain tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Floxuridine; Glioma; Humans; Injections, | 1998 |
[In vitro study on intrathecal application of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant tumor].
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Carcinoma 256, Walker; Floxuridine; Fluor | 1998 |
Neuroblastoma and glioma cell cultures in studies of neurologic functions: the clinician's Rosetta Stone?
Topics: Cell Line; Cells, Cultured; Drug Resistance; Floxuridine; Glioma; Humans; Mercaptopurine; Morphine D | 1977 |
5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Drug Resistance; Floxuridine; Glioma; Mice; Neo | 1976 |
Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers.
Topics: Animals; Body Weight; Carbon Radioisotopes; Deoxyglucose; DNA Replication; DNA, Neoplasm; Dose-Respo | 1992 |
Variability of 5-bromo-2'-deoxyuridine incorporation into DNA of human glioma cell lines and modulation with fluoropyrimidines.
Topics: Bromodeoxyuridine; DNA, Neoplasm; Floxuridine; Fluorouracil; Glioma; Humans; Tumor Cells, Cultured | 1991 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Epen | 1985 |
[Experience with non-surgical treatment of brain tumors at the authors' department].
Topics: Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Cobalt Isot | 1967 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; | 1968 |
Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.
Topics: Animals; Brain Neoplasms; Bromine; Carotid Arteries; Catheterization; Craniotomy; Cytidine; Deoxyrib | 1972 |
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin | 1972 |
The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons.
Topics: Acetylcholine; Animals; Catecholamines; Cells, Cultured; Choline; Cytarabine; Fibroblasts; Floxuridi | 1974 |