floxuridine has been researched along with Gestational Trophoblastic Disease in 13 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Gestational Trophoblastic Disease: A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The most commonly used multiagent chemotherapy for high-risk gestational trophoblastic neoplasia (GTN) is etoposide, methotrexate and actinomycin D/cyclophosphamide and vincristine (EMA/CO) worldwide." | 8.02 | Results with Floxuridine, Actinomycin D, Etoposide, and Vincristine in Gestational Trophoblastic Neoplasias with International Federation of Gynecology and Obstetrics Scores ≥5. ( Feng, F; Kong, Y; Li, Y; Ren, T; Wan, X; Xiang, Y; Yang, J; Zhao, J, 2021) |
| "To analyze the reproductive outcomes of gestational trophoblastic neoplasia (GTN) patients who were cured only by floxuridine-based regimens." | 7.96 | Reproductive outcomes after floxuridine-based regimens for gestational trophoblastic neoplasia: A retrospective cohort study in a national referral center in China. ( Feng, FZ; Jiang, F; Ren, T; Wan, XR; Xiang, Y; Yang, JJ; Yang, K; Zhao, J, 2020) |
| "To evaluate the efficacy and toxicity profile of floxuridine, dactinomycin, etoposide and vincristine (FAEV) regimen as primary treatment in stage IV gestational trophoblastic neoplasia (GTN)." | 7.83 | Primary treatment of stage IV gestational trophoblastic neoplasia with floxuridine, dactinomycin, etoposide and vincristine (FAEV): A report based on our 10-year clinical experiences. ( Feng, F; Ren, T; Wan, X; Xiang, Y; Yang, J, 2016) |
| "To evaluate the combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) as primary treatment for gestational trophoblastic neoplasia (GTN)." | 7.80 | Combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine as primary treatment for gestational trophoblastic neoplasia. ( Feng, FZ; Ren, T; Wan, XR; Wang, T; Xiang, Y, 2014) |
| "Guidelines recommend etoposide, methotrexate, actinomycin D (EMA)/cyclophosphamide, vincristine (CO) as first-line treatment for high-risk gestational trophoblastic neoplasia (GTN)." | 5.51 | Efficacies of FAEV and EMA/CO regimens as primary treatment for gestational trophoblastic neoplasia. ( Feng, F; Ji, M; Jiang, S; Ren, T; Wan, X; Xiang, Y; Yang, J; Zhao, J, 2022) |
| "Although most patients with gestational trophoblastic neoplasia (GTN) are cured by conventional chemotherapy, some develop drug resistance or relapse." | 5.37 | Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia. ( Feng, F; Geng, S; Wan, X; Wang, T; Xiang, Y, 2011) |
| "The most commonly used multiagent chemotherapy for high-risk gestational trophoblastic neoplasia (GTN) is etoposide, methotrexate and actinomycin D/cyclophosphamide and vincristine (EMA/CO) worldwide." | 4.02 | Results with Floxuridine, Actinomycin D, Etoposide, and Vincristine in Gestational Trophoblastic Neoplasias with International Federation of Gynecology and Obstetrics Scores ≥5. ( Feng, F; Kong, Y; Li, Y; Ren, T; Wan, X; Xiang, Y; Yang, J; Zhao, J, 2021) |
| "To analyze the reproductive outcomes of gestational trophoblastic neoplasia (GTN) patients who were cured only by floxuridine-based regimens." | 3.96 | Reproductive outcomes after floxuridine-based regimens for gestational trophoblastic neoplasia: A retrospective cohort study in a national referral center in China. ( Feng, FZ; Jiang, F; Ren, T; Wan, XR; Xiang, Y; Yang, JJ; Yang, K; Zhao, J, 2020) |
| "To evaluate the efficacy and toxicity profile of floxuridine, dactinomycin, etoposide and vincristine (FAEV) regimen as primary treatment in stage IV gestational trophoblastic neoplasia (GTN)." | 3.83 | Primary treatment of stage IV gestational trophoblastic neoplasia with floxuridine, dactinomycin, etoposide and vincristine (FAEV): A report based on our 10-year clinical experiences. ( Feng, F; Ren, T; Wan, X; Xiang, Y; Yang, J, 2016) |
| "To evaluate the combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) as primary treatment for gestational trophoblastic neoplasia (GTN)." | 3.80 | Combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine as primary treatment for gestational trophoblastic neoplasia. ( Feng, FZ; Ren, T; Wan, XR; Wang, T; Xiang, Y, 2014) |
| " To determine the plasma dihydrouracil/uracil ratio (DUUR) as a potential index for setting 5-FU/FUDR doses, the authors conducted a prospective study on the relationships of the DUUR with 5-FU/FUDR pharmacokinetic and pharmacodynamic parameters." | 2.71 | Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics. ( Hu, P; Jiang, H; Jiang, J; Lu, J, 2004) |
| "Although most patients with gestational trophoblastic neoplasia (GTN) are cured by conventional chemotherapy, some develop drug resistance or relapse." | 1.37 | Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia. ( Feng, F; Geng, S; Wan, X; Wang, T; Xiang, Y, 2011) |
| "Spinal canal metastasis secondary to gestational trophoblastic neoplasia (GTN) is a rare condition." | 1.35 | Metastasis of gestational trophoblastic neoplasia to the spinal canal: a case report. ( Cao, Y; Feng, F; Xiang, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, M | 1 |
| Jiang, S | 1 |
| Zhao, J | 5 |
| Wan, X | 7 |
| Feng, F | 7 |
| Ren, T | 7 |
| Yang, J | 5 |
| Xiang, Y | 12 |
| Jiang, F | 2 |
| Yang, K | 1 |
| Wan, XR | 4 |
| Feng, FZ | 2 |
| Yang, JJ | 1 |
| Li, Y | 1 |
| Kong, Y | 2 |
| Li, J | 2 |
| Wang, X | 1 |
| Wang, T | 2 |
| Xiao, C | 1 |
| Cao, Y | 1 |
| Geng, S | 1 |
| Yang, XY | 2 |
| Wu, Y | 3 |
| Yang, YM | 1 |
| Yin, SJ | 1 |
| Jiang, H | 1 |
| Lu, J | 1 |
| Jiang, J | 1 |
| Hu, P | 1 |
| Liu, N | 2 |
| Chen, L | 2 |
| Dong, RF | 1 |
| Yang, X | 1 |
| Dong, R | 1 |
3 trials available for floxuridine and Gestational Trophoblastic Disease
| Article | Year |
|---|---|
Efficacies of FAEV and EMA/CO regimens as primary treatment for gestational trophoblastic neoplasia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Etoposide; Female; Floxuridine; Gestat | 2022 |
Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Antimetabolites, Antineoplastic; Chorionic Gonadotropin; Female; Floxuridine; Fluorouracil; G | 2004 |
Efficacy of the FAEV regimen in the treatment of high-risk, drug-resistant gestational trophoblastic tumor.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin; Dactinomycin; Drug Re | 2007 |
10 other studies available for floxuridine and Gestational Trophoblastic Disease
| Article | Year |
|---|---|
Reproductive outcomes after floxuridine-based regimens for gestational trophoblastic neoplasia: A retrospective cohort study in a national referral center in China.
Topics: Adult; Antimetabolites, Antineoplastic; China; Female; Fertility Preservation; Floxuridine; Gestatio | 2020 |
Results with Floxuridine, Actinomycin D, Etoposide, and Vincristine in Gestational Trophoblastic Neoplasias with International Federation of Gynecology and Obstetrics Scores ≥5.
Topics: Dactinomycin; Etoposide; Female; Floxuridine; Gestational Trophoblastic Disease; Humans; Obstetrics; | 2021 |
Clinical characteristics and prognosis of ultra high-risk gestational trophoblastic neoplasia patients: A retrospective cohort study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dactinomycin; Eto | 2017 |
Combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine as primary treatment for gestational trophoblastic neoplasia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Etoposide; Female; Floxuridine; | 2014 |
Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital.
Topics: Adult; Brain Neoplasms; China; Combined Modality Therapy; Dactinomycin; Disease-Free Survival; Drug | 2015 |
Primary treatment of stage IV gestational trophoblastic neoplasia with floxuridine, dactinomycin, etoposide and vincristine (FAEV): A report based on our 10-year clinical experiences.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Etoposide; Female; Floxuridine; | 2016 |
Metastasis of gestational trophoblastic neoplasia to the spinal canal: a case report.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta | 2009 |
Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Dactinomycin; Dru | 2011 |
[Floxuridine-containing regime in the treatment of gestational trophoblastic tumor].
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; | 2003 |
[Efficacy of FAEV regimen in treatment of high-risk drug-resistant gestational trophoblastic tumor].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human; | 2006 |