floxuridine has been researched along with Fra(X) Syndrome in 21 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The main clinical features are mental retardation, typical facial dysmorphism and macroorchidism." | 2.37 | [Mental retardation linked to fragility of chromosome X: current knowledge]. ( Auger, M; Giraud, F; Mattei, JF; Mattei, MG, 1984) |
| "Caffeine did not enhance the expression of the fra(X) in the PBLC or in the three LCL from fra(X) expressing individuals nor did it elicit fra(X) expression in LCL from a non-expressing obligate-carrier female and a transmitting male." | 1.27 | The effect of caffeine on fragile X expression. ( Abruzzo, MA; Jacobs, PA; Mayer, M; Pettay, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (61.90) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumari, D | 1 |
| Somma, V | 1 |
| Nakamura, AJ | 1 |
| Bonner, WM | 1 |
| D'Ambrosio, E | 1 |
| Usdin, K | 1 |
| Mixon, JC | 1 |
| Dev, VG | 1 |
| Nielsen, KB | 1 |
| Tommerup, N | 1 |
| Dyggve, HV | 1 |
| Schou, C | 1 |
| Brookwell, R | 1 |
| Daniel, A | 1 |
| Turner, G | 1 |
| Fishburn, J | 1 |
| Glover, TW | 1 |
| Howard-Peebles, PN | 1 |
| Jacky, PB | 1 |
| Sutherland, GR | 2 |
| Gardiner, GB | 1 |
| Wenger, SL | 1 |
| Steele, MW | 1 |
| Cantú, ES | 1 |
| Jacobs, PA | 2 |
| Mattei, JF | 1 |
| Mattei, MG | 1 |
| Auger, M | 1 |
| Giraud, F | 1 |
| Jenkins, EC | 3 |
| Morys, I | 1 |
| Henderson, J | 1 |
| Genovese, M | 2 |
| Carter, M | 1 |
| Li, SY | 1 |
| Houck, GE | 1 |
| Ding, X | 1 |
| Stark-Houck, SL | 1 |
| Dobkin, CS | 1 |
| Vianna-Morgante, AM | 1 |
| Mingroni-Netto, RC | 1 |
| Barbosa, AC | 1 |
| Otto, PA | 1 |
| Rosenberg, C | 1 |
| Dewald, GW | 1 |
| Buckley, DD | 1 |
| Spurbeck, JL | 1 |
| Jalal, SM | 1 |
| Ramos, FJ | 1 |
| Emanuel, BS | 1 |
| Spinner, NB | 1 |
| Krawczun, MS | 2 |
| Brooks, SE | 1 |
| Brooks, SL | 1 |
| Sherman, SL | 1 |
| Brown, WT | 2 |
| Zaslav, AL | 1 |
| Duncan, CJ | 1 |
| Sanz, MM | 1 |
| Gu, H | 1 |
| Schwartz-Richstein, C | 1 |
| Lele, KP | 1 |
| Salandi, ML | 1 |
| Duncan, AM | 1 |
| Abruzzo, MA | 1 |
| Pettay, D | 1 |
| Mayer, M | 1 |
| Baker, E | 1 |
| Purvis-Smith, S | 1 |
| Hockey, A | 1 |
| Krumins, E | 1 |
| Eichenbaum, SZ | 1 |
| Vandamme, B | 1 |
| Liebaers, I | 1 |
| Hens, L | 1 |
| Bernheim, JL | 1 |
| Roobol, C | 1 |
| Wang, JC | 1 |
| Beardsley, GP | 1 |
| Erbe, RW | 1 |
2 reviews available for floxuridine and Fra(X) Syndrome
| Article | Year |
|---|---|
[Mental retardation linked to fragility of chromosome X: current knowledge].
Topics: Bromodeoxyuridine; Child; Chromosome Banding; Ear, External; Face; Floxuridine; Folic Acid; Fragile | 1984 |
Cytogenetic guidelines for fragile X studies tested in routine practice.
Topics: Adolescent; Adult; Cell Count; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; Cul | 1992 |
19 other studies available for floxuridine and Fra(X) Syndrome
| Article | Year |
|---|---|
The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.
Topics: Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chromosome Brea | 2009 |
Fragile X expression is decreased by 5-azacytidine and S-adenosylhomocysteine.
Topics: Azacitidine; Cell Line; Culture Media; DNA; Dose-Response Relationship, Drug; Floxuridine; Fragile X | 1983 |
Macroorchidism and fragile X in mentally retarded males. Clinical, cytogenetic, and some hormonal investigations in mentally retarded males, including two with the fragile site at Xq28, fra(X)(q28).
Topics: Adult; Aged; Birth Weight; Body Height; Body Weight; Chromosome Banding; Chromosome Mapping; Electro | 1982 |
The fragile X(q27) form of X-linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts, and amniocytes.
Topics: Cells, Cultured; Female; Floxuridine; Fragile X Syndrome; Humans; Lymphocytes; Male; Pedigree; Pheno | 1982 |
The combined effects of FUdR addition and methionine depletion on the X-chromosome fragile site.
Topics: Cells, Cultured; Culture Media; Female; Floxuridine; Fragile X Syndrome; Gene Expression Regulation; | 1983 |
Thymidylate synthetase inhibitors and fragile site expression in lymphocytes.
Topics: Adolescent; Adult; Cells, Cultured; Child; Child, Preschool; Culture Media; Deoxycytidine; Female; F | 1983 |
In vitro reversal of fragile-X expression by exogenous thymidine.
Topics: Culture Media; Floxuridine; Fragile X Syndrome; Humans; In Vitro Techniques; Lymphocytes; Male; Sex | 1984 |
Fragile (X) expression: relationship to the cell cycle.
Topics: Base Sequence; Bromodeoxyuridine; Cell Cycle; Chromosome Banding; Floxuridine; Fragile X Syndrome; H | 1984 |
Fragile X induction systems in CVS cultures: effect on cytogenetic, PCR, and genomic Southern Blot DNA analyses of the FMR-1 gene.
Topics: Blotting, Southern; Cells, Cultured; Chorionic Villi; Chorionic Villi Sampling; Chromosome Banding; | 1994 |
FRAXF in a patient with chromosome 8 duplication.
Topics: Blotting, Southern; Child; Chromosome Banding; Chromosomes, Human, Pair 8; Cytogenetics; Female; Flo | 1996 |
Frequency of the common fragile site at Xq27.2 under conditions of thymidylate stress: implications for cytogenetic diagnosis of the fragile-X syndrome.
Topics: Adolescent; Adult; Aged; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromos | 1992 |
Laboratory aspects of prenatal fra(X) detection.
Topics: Amniocentesis; Cells, Cultured; Chorionic Villi Sampling; Dose-Response Relationship, Drug; False Ne | 1991 |
Simultaneous expression of the rare and common fragile sites on the X chromosome.
Topics: Aphidicolin; Chromosome Aberrations; Chromosome Banding; Ethanol; Female; Floxuridine; Fragile X Syn | 1991 |
Progress toward an internal control system for fragile-X induction by 5-fluorodeoxyuridine in whole-blood cultures.
Topics: Blood Cells; Chromosome Fragile Sites; Chromosome Fragility; Female; Floxuridine; Fragile X Syndrome | 1990 |
Enhanced sensitivity of lymphoblastoid cells from individuals carrying the mutation for the fragile X syndrome to the clastogenic effects of FUdR.
Topics: Cell Nucleus; Cells, Cultured; Chromosomes; Female; Floxuridine; Folic Acid; Fragile X Syndrome; Gen | 1986 |
The effect of caffeine on fragile X expression.
Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; F | 1986 |
Prenatal diagnosis of the fragile X using thymidine induction.
Topics: Adult; Amniocentesis; Australia; Chorionic Villi; Female; Floxuridine; Fragile X Syndrome; Humans; M | 1987 |
The role of fluorinated pyrimidine analogues in the induction of the in vitro expression of the fragile X chromosome.
Topics: Base Composition; Cell Division; Cells, Cultured; Deoxycytidine; DNA; DNA Damage; Floxuridine; Fragi | 1988 |
Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA by cells from patients with the fragile X syndrome.
Topics: Cells, Cultured; Deoxyuracil Nucleotides; DNA; DNA Glycosylases; Floxuridine; Folic Acid Antagonists | 1985 |