floxuridine has been researched along with Fibrosarcoma in 5 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Growth inhibition assays indicated that the IC50 values for methotrexate (MTX) and 5-fluorodeoxyuridine (FdUrd) in HS-18, a liposarcoma cell line lacking retinoblastoma protein (pRB), and SaOS-2, an osteosarcoma cell line with a truncated and nonfunctional pRB, were 10- to 12-fold and 4- to 11-fold higher, respectively, than for the HT-1080 (fibrosarcoma) cell line, which has wild-type pRB." | 3.69 | Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. ( Almasan, A; Banerjee, D; Bertino, JR; Fan, J; Hochhauser, D; Kelly, R; Li, W; Wahl, GM; Yin, Y; Zielinski, Z, 1995) |
| "Cimetidine (6 mg/kg) was used to decrease (76)Br-BFU elimination and increase its bioavailability." | 1.31 | Use of 5-[(76)Br]bromo-2'-fluoro-2'-deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model. ( Bergström, M; Borbath, I; Grégoire, V; Långström, B; Laryea, D; Pauwels, S, 2002) |
| "There were seven malignant fibrous histiocytomas, four liposarcomas, two fibrosarcomas, one leiomyosarcoma, and one rhabdomyosarcoma; 73% were grade III." | 1.28 | Intraarterial chemotherapy with limb-sparing resection of large soft-tissue sarcomas of the extremities. ( Bonn, J; Gardiner, GA; Lackman, RD; Shapiro, MJ; Soulen, MC; Sullivan, KL; Weiss, AJ; Weissmann, JR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Otvös, L | 1 |
| Sági, G | 1 |
| Li, W | 1 |
| Fan, J | 1 |
| Hochhauser, D | 1 |
| Banerjee, D | 1 |
| Zielinski, Z | 1 |
| Almasan, A | 1 |
| Yin, Y | 1 |
| Kelly, R | 1 |
| Wahl, GM | 1 |
| Bertino, JR | 1 |
| Borbath, I | 1 |
| Grégoire, V | 1 |
| Bergström, M | 1 |
| Laryea, D | 1 |
| Långström, B | 1 |
| Pauwels, S | 1 |
| Soulen, MC | 1 |
| Weissmann, JR | 1 |
| Sullivan, KL | 1 |
| Lackman, RD | 1 |
| Shapiro, MJ | 1 |
| Bonn, J | 1 |
| Weiss, AJ | 1 |
| Gardiner, GA | 1 |
| Reiner, J | 1 |
| Southam, CM | 1 |
5 other studies available for floxuridine and Fibrosarcoma
| Article | Year |
|---|---|
[Antisense oligonucleotides with antitumor activity].
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Deoxyuridine; Fibrosarco | 2004 |
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Base Sequence; Bone Neoplasms; Cell Division | 1995 |
Use of 5-[(76)Br]bromo-2'-fluoro-2'-deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Carbon Radioisotopes; Cell Division; Cimetidine; Deoxyc | 2002 |
Intraarterial chemotherapy with limb-sparing resection of large soft-tissue sarcomas of the extremities.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; D | 1992 |
Increased growth of tumor isotransplants after immunosuppression of the recipient mice by methotrexate or 5-fluoro-2'-deoxyuridine.
Topics: Animals; Fibrosarcoma; Floxuridine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Multipl | 1967 |