floxuridine has been researched along with Experimental Neoplasms in 90 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In tissue culture experiments, cells derived from glioma 26, a transplantable tumor of C57B1/6 mice, were sensitive to both floxuridine (5-fluorodeoxyuridine) and 5-fluorodeoxyuridine-5'-(5-iodo-3-indolyl)phosphate, an enzyme-mediated drug activated by 5'-nucleotide phosphodiesterase." | 7.65 | 5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma. ( Ledis, SL; Lo, KW; Miller, EE; Tsou, KC, 1976) |
| "The figures in patients with breast cancer were: 1,761 days (58." | 3.78 | [Survival and changes of clinical laboratory data in phase II study with 5'-DFUR]. ( Taguchi, T, 1996) |
| "Treatment of choriocarcinoma cells (JAr line) for 24 hr with methotrexate, fluorodeoxyuridine, 1-beta-D-arabinofuranosylcytosine, or hydroxyurea, in doses that inhibit DNA synthesis, results in a 2." | 3.66 | Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis. ( Azizkhan, JC; Goode, D; Speeg, KV; Stromberg, K, 1979) |
| "In tissue culture experiments, cells derived from glioma 26, a transplantable tumor of C57B1/6 mice, were sensitive to both floxuridine (5-fluorodeoxyuridine) and 5-fluorodeoxyuridine-5'-(5-iodo-3-indolyl)phosphate, an enzyme-mediated drug activated by 5'-nucleotide phosphodiesterase." | 3.65 | 5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma. ( Ledis, SL; Lo, KW; Miller, EE; Tsou, KC, 1976) |
| " As a result, the extent of toxicity of cancer chemotherapy varies by 50% or more according to dosing time in mice or rats." | 2.68 | [Chrono-chemotherapy and dose intensity]. ( Lévi, F, 1995) |
| "Nucleic acid metabolism in brain tumors by [18F]FdUrd-PET may be assessed using normal brain regions as a reference." | 1.28 | Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma. ( Ido, T; Ishiwata, K; Kameyama, M; Sato, K; Yoshimoto, T, 1991) |
| " The administration of 5'-DFUR resulted in damage to the intestinal mucosal membrane and diarrhea in normal mice, whereas Ro 09-1390 was much less toxic to the intestinal tract." | 1.28 | Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine. ( Eda, H; Fujimoto, K; Ishida, M; Ishitsuka, H; Miwa, M; Ninomiya, Y; Sahara, H; Umeda, I; Yokose, K, 1990) |
| " The cytostatic effect of cytosine arabinoside (ara-C) prodrug liposomes against L1210 leukemia showed to be superior to free ara-C treatment in respect to drug dosage and treatment schedule." | 1.27 | [Liposomes as carriers of lipophilic cytosine arabinoside and fluorodeoxyuridine derivatives. Their cytostatic effect and possibilities of tumor cell specific therapy]. ( Hartmann, HR; Hengartner, H; Rubas, W; Schott, H; Schwendener, RA; Supersaxo, A, 1987) |
| "Antitumor effects of oral fluorinated pyrimidines including 5'-DFUR and their combination with recombinant interferon (rIFN) alpha A/D (Bgl) or cytostatics were investigated using various tumor models in mice." | 1.27 | [Antitumor effects of 5'-deoxy-5-fluorouridine (5'-DFUR) against various murine tumors in combination with recombinant interferon alpha or cytostatics]. ( Eda, H; Fukuda, H; Ishikawa, T; Ishitsuka, H; Matsuura, N; Miwa, M; Ninomiya, Y; Tanaka, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (81.11) | 18.7374 |
| 1990's | 15 (16.67) | 18.2507 |
| 2000's | 1 (1.11) | 29.6817 |
| 2010's | 1 (1.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Acosta, J | 1 |
| Wang, W | 1 |
| Feldser, DM | 1 |
| CHEONG, L | 1 |
| RICH, MA | 1 |
| EIDINOFF, ML | 1 |
| HEIDELBERGER, C | 5 |
| ANSFIELD, FJ | 2 |
| CLIFTON, KH | 1 |
| SZYBALSKI, W | 1 |
| GOLLIN, FF | 1 |
| VERMUND, H | 1 |
| THIELE, EH | 1 |
| ARISON, RN | 1 |
| BOXER, GE | 1 |
| SHEININ, R | 1 |
| BROCKMAN, RW | 2 |
| ANDERSON, EP | 1 |
| MARUYAMA, Y | 1 |
| SILINI, G | 1 |
| KAPLAN, HS | 2 |
| LOVE, R | 1 |
| RABSON, AS | 1 |
| WILDY, P | 1 |
| MORSE, PA | 1 |
| POTTER, VR | 1 |
| FISCHER, GA | 1 |
| VONESSEN, CF | 1 |
| Hartmann, HR | 4 |
| Matter, A | 1 |
| Washtien, WL | 1 |
| Fujita, H | 1 |
| Ogawa, K | 1 |
| Nakagawa, H | 1 |
| Kawaguchi, K | 1 |
| Nakagawa, Y | 1 |
| Doi, Y | 1 |
| Bollag, W | 2 |
| Houghton, JA | 1 |
| Houghton, PJ | 1 |
| Miller, EE | 3 |
| Ritter, EJ | 1 |
| Scott, WJ | 1 |
| Wilson, JG | 1 |
| Lampkin, BC | 1 |
| Neely, JE | 1 |
| Lévi, F | 1 |
| Hrushesky, WJ | 1 |
| McLaughlin, PW | 1 |
| Lawrence, TS | 1 |
| Seabury, H | 1 |
| Nguyen, N | 1 |
| Stetson, PL | 1 |
| Greenberg, HS | 1 |
| Mancini, WR | 1 |
| Fujimoto-Ouchi, K | 1 |
| Tamura, S | 1 |
| Mori, K | 1 |
| Ishikawa, T | 2 |
| Eda, H | 4 |
| Tanaka, Y | 2 |
| Ninomiya, Y | 3 |
| Ishitsuka, H | 7 |
| Jansen, WJ | 1 |
| Pinedo, HM | 1 |
| van der Wilt, CL | 1 |
| Feller, N | 1 |
| Bamberger, U | 1 |
| Boven, E | 1 |
| Taguchi, T | 1 |
| Shields, AF | 1 |
| Grierson, JR | 1 |
| Kozawa, SM | 1 |
| Zheng, M | 1 |
| Kakutani, T | 1 |
| Ebara, Y | 1 |
| Kanja, K | 1 |
| Hidaka, M | 1 |
| Matsumoto, Y | 1 |
| Nagano, A | 1 |
| Wataya, Y | 1 |
| Shimma, N | 1 |
| Umeda, I | 2 |
| Arasaki, M | 1 |
| Murasaki, C | 1 |
| Masubuchi, K | 1 |
| Kohchi, Y | 1 |
| Miwa, M | 6 |
| Ura, M | 1 |
| Sawada, N | 1 |
| Tahara, H | 1 |
| Kuruma, I | 1 |
| Horii, I | 1 |
| Baskin, F | 2 |
| Carlin, SC | 1 |
| Kraus, P | 1 |
| Friedkin, M | 1 |
| Rosenberg, RN | 3 |
| Poirier, LA | 1 |
| Stoner, GD | 1 |
| Shimkin, MB | 1 |
| Schabel, FM | 1 |
| Shaddix, SC | 1 |
| Rose, LM | 1 |
| Davis, R | 1 |
| Tsukeda, H | 1 |
| Mizuno, S | 1 |
| Nitta, K | 2 |
| Azizkhan, JC | 1 |
| Speeg, KV | 1 |
| Stromberg, K | 1 |
| Goode, D | 1 |
| Abrams, DN | 1 |
| Knaus, EE | 1 |
| Lentle, BC | 1 |
| Wiebe, LI | 1 |
| Smellie, SG | 1 |
| Parsons, PG | 1 |
| Wilkinson, DS | 2 |
| Tlsty, TD | 1 |
| Hanas, RJ | 1 |
| Ledis, SL | 1 |
| Lo, KW | 1 |
| Tsou, KC | 2 |
| Solomonson, LP | 1 |
| Cory, JG | 1 |
| Ishiwata, K | 5 |
| Takahashi, T | 1 |
| Iwata, R | 1 |
| Tomura, M | 1 |
| Tada, M | 2 |
| Itoh, J | 1 |
| Kameyama, M | 3 |
| Ido, T | 5 |
| Endoh, H | 1 |
| Kawaguchi, T | 1 |
| Seki, T | 1 |
| Hasegawa, T | 1 |
| Juni, K | 1 |
| Sato, K | 1 |
| Yoshimoto, T | 1 |
| Kubota, K | 1 |
| Kubota, R | 1 |
| Yamada, S | 1 |
| Sato, T | 1 |
| Tsurumi, Y | 1 |
| Katakura, R | 1 |
| Monma, M | 1 |
| Suzuki, J | 1 |
| Prior, MJ | 1 |
| Maxwell, RJ | 1 |
| Griffiths, JR | 1 |
| Sahara, H | 1 |
| Fujimoto, K | 2 |
| Ishida, M | 1 |
| Yokose, K | 1 |
| Bramer, SL | 1 |
| Gunnarsson, LC | 1 |
| Au, JL | 1 |
| Gabbert, HE | 1 |
| Gerharz, CD | 1 |
| Engers, R | 1 |
| Müller-Klieser, W | 1 |
| Moll, R | 1 |
| Mekras, JA | 1 |
| Boothman, DA | 1 |
| Greer, SB | 1 |
| Uehara, N | 1 |
| Baba, H | 1 |
| Kunimoto, T | 1 |
| Takeuchi, M | 1 |
| Sasaki, T | 1 |
| Tanaka, T | 1 |
| Cook, A | 1 |
| Nishimura, J | 1 |
| Kamiyama, T | 1 |
| Fujimoto, S | 2 |
| Wang, Y | 2 |
| Ogawa, M | 2 |
| Schwendener, RA | 1 |
| Schott, H | 1 |
| Supersaxo, A | 1 |
| Rubas, W | 1 |
| Hengartner, H | 1 |
| Fukuda, H | 2 |
| Matsuura, N | 1 |
| Abe, Y | 1 |
| Matsuzawa, T | 1 |
| Murakami, M | 1 |
| Inoue, K | 1 |
| Goffinet, DR | 2 |
| Bagshaw, MA | 2 |
| Nishizawa, Y | 2 |
| Casida, JE | 2 |
| Tarnowski, GS | 1 |
| Schmid, FA | 1 |
| Cappuccino, JG | 1 |
| Stock, CC | 1 |
| Bradner, WT | 1 |
| Pindell, MH | 1 |
| Engel, JL | 1 |
| Arata, T | 1 |
| Tanaka, S | 1 |
| Southam, CM | 1 |
| Santora, NJ | 1 |
| Kern, J | 1 |
| Gilden, RV | 1 |
| Huebner, RJ | 1 |
| Everson, R | 1 |
| Kessel, D | 1 |
| Hall, TC | 1 |
| Bergeron, JJ | 1 |
| Brown, JM | 1 |
| Bhuyan, BK | 1 |
| Scheidt, LG | 1 |
| Fraser, TJ | 1 |
| Levin, VA | 1 |
| Chadwick, M | 1 |
| Little, AD | 1 |
| Nishibe, Y | 1 |
| Kimura, T | 1 |
| Inoue, YK | 1 |
| Frankfurt, OS | 1 |
| Lokshina, AM | 1 |
| Pelevina, II | 1 |
| Jato, J | 1 |
| Windheuser, JJ | 1 |
| Myers, CE | 1 |
| Young, RC | 1 |
| Johns, DG | 1 |
| Chabner, BA | 1 |
| Nakajima, S | 1 |
| Hamada, C | 1 |
| Uetake, H | 1 |
| Temin, HM | 1 |
| Pollack, RE | 1 |
| Green, H | 1 |
| Todaro, GJ | 1 |
| Zur Hausen, H | 1 |
| Umeda, M | 1 |
| Wolberg, WH | 2 |
| Girardi, AJ | 1 |
| Defendi, V | 1 |
| Nesnow, S | 1 |
| Mian, AM | 1 |
| Oki, T | 1 |
| Dexter, DL | 1 |
| Fogel, M | 1 |
9 reviews available for floxuridine and Experimental Neoplasms
| Article | Year |
|---|---|
Off and back-on again: a tumor suppressor's tale.
Topics: Alleles; Animals; CRISPR-Cas Systems; Floxuridine; Gene Expression Regulation, Neoplastic; Genes, Tu | 2018 |
EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY.
Topics: Breast Neoplasms; Carbon Isotopes; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Me | 1963 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
Cancer chronotherapy: is there a right time in the day to treat?
Topics: Animals; Antineoplastic Agents; Circadian Rhythm; Floxuridine; Fluorouracil; Humans; Neoplasms; Neop | 1995 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; | 1996 |
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs | 1976 |
Rationale for adjuvant chemotherapy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carmustine; Cyclophosphamide; Cytarabine; Doxorubi | 1977 |
Clinical use of radiation sensitizing agents.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura | 1974 |
[Radiation sensitization of brain neoplasms by haloid analogs of pyrimidine bases].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Cricetinae; DNA, Neoplasm; Fe | 1973 |
2 trials available for floxuridine and Experimental Neoplasms
| Article | Year |
|---|---|
[Chrono-chemotherapy and dose intensity].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chronobiology | 1995 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; | 1996 |
80 other studies available for floxuridine and Experimental Neoplasms
| Article | Year |
|---|---|
Mechanism of growth inhibition of H.Ep. 1 cells by 5-fluorodeoxycytidine and 5-fluorodeoxyuridine.
Topics: Animals; Deoxycytidine; Floxuridine; Neoplasms, Experimental; Nucleosides; Nucleotides | 1960 |
INCORPORATION OF I-125-LABELED IODODEOXYURIDINE INTO THE DEOXYRIBONUCLEIC ACID OF MURINE AND HUMAN TISSUES FOLLOWING THERAPEUTIC DOSES.
Topics: Adenocarcinoma; Animals; DNA; DNA, Neoplasm; Floxuridine; Geriatrics; Idoxuridine; Intestine, Small; | 1963 |
ONCOLYSIS BY CLOSTRIDIA. III. EFFECTS OF CLOSTRIDIA AND CHEMOTHERAPEUTIC AGENTS ON RODENT TUMORS.
Topics: Adenocarcinoma; Animals; Antimetabolites; Antineoplastic Agents; Aziridines; Bacteriological Techniq | 1964 |
STUDIES ON THE EFFECT OF 5-FLUORO-2'-DEOXYURIDINE ON POLYAMA T FORMATION IN MOUSE EMBRYO CELLS.
Topics: Animals; Antigens; Deoxyuridine; DNA; DNA, Viral; Electrons; Embryo, Mammalian; Embryo, Nonmammalian | 1964 |
RATIONALE FOR THE DESIGN OF FLUORINATED PYRIMIDINES.
Topics: Animals; Antimetabolites; DNA; Floxuridine; Fluorouracil; Halogenation; Ligases; Mice; Neoplasms; Ne | 1964 |
STUDIES OF THE LSA ASCITES LYMPHOMA OF C57B1 MICE. II. RADIOSENSITIZATION IN VIVO WITH 5-BROMODEOXYCYTIDINE AND COMBINED 5-FLUORODEOXYURIDINE AND 5-BROMODEOXYCYTIDINE.
Topics: Ascites; Bromodeoxycytidine; DNA; DNA, Neoplasm; Floxuridine; Lymphoma; Mice; Neoplasms; Neoplasms, | 1963 |
CHANGES IN THE NUCLEOLUS OF NORMAL AND NEOPLASTIC CELLS INFECTED WITH RIBOVIRUSES AND DEOXYRIBOVIRUSES.
Topics: Cell Nucleolus; Cell Nucleus; Colchicine; Floxuridine; Herpesviridae; Neoplasms; Neoplasms, Experime | 1964 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liv | 1965 |
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Exper | 1965 |
Antiproliferative action of a novel fluorinated uridine analog, 5'-deoxy-5-fluorouridine, measured in vitro and in vivo on four different murine tumor lines.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Floxuridine; Isomerism; Lung Neoplasms; Lymphoma; | 1982 |
Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells.
Topics: Cells, Cultured; Floxuridine; Gastrointestinal Neoplasms; Humans; Methotrexate; Methyltransferases; | 1982 |
[Pharmacokinetics of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Animals; Cricetinae; Floxuridine; Kinetics; Male; Mice; Neoplasms, Experimenta | 1983 |
Tumor specific conversion of a pyrimidine antimetabolite.
Topics: Animals; Antineoplastic Agents; Cell Line; Floxuridine; Fluorouracil; Isomerism; Mice; Neoplasms, Ex | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate | 1980 |
Immunity and drug resistance in a mouse glioma.
Topics: Animals; Drug Resistance; Floxuridine; Glioma; Immunity, Cellular; Mice; Neoplasm Transplantation; N | 1980 |
Tumor inhibitory effects of a new fluorouracil derivative: 5'-deoxy-5-fluorouridine.
Topics: Animals; Female; Floxuridine; Lethal Dose 50; Lung Neoplasms; Mice; Neoplasms, Experimental; Sarcoma | 1980 |
Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo.
Topics: Animals; Culture Techniques; Deoxyribonucleotides; Embryo, Mammalian; Female; Floxuridine; Humans; M | 1980 |
Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation.
Topics: Animals; Bromodeoxyuridine; Floxuridine; Glioma; Humans; In Vitro Techniques; Mice; Mice, Nude; Neop | 1994 |
[Antitumor activity of various cytostatics in mice bearing murine advanced tumors].
Topics: Animals; Antineoplastic Agents; Cachexia; Cyclophosphamide; Drug Screening Assays, Antitumor; Floxur | 1993 |
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; | 1995 |
Development of labeled thymidine analogs for imaging tumor proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Biotransformation; Dogs; Floxuridi | 1996 |
Different modes of cell death induced by 5-fluoro-2'-deoxyuridine in two clones of the mouse mammary tumor FM3A cell line.
Topics: Animals; Apoptosis; Caspase 1; Caspase 3; Caspases; Clone Cells; Cysteine Endopeptidases; DNA Fragme | 1998 |
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Capecitabine; Carbama | 2000 |
Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma.
Topics: Animals; Cell Division; Clone Cells; Drug Resistance; Floxuridine; Folic Acid; Folic Acid Antagonist | 1975 |
Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.
Topics: Adenoma; Alkanes; Animals; Biological Assay; Bromodeoxyuridine; Carcinogens; Deoxyuridine; Female; F | 1975 |
Neuroblastoma and glioma cell cultures in studies of neurologic functions: the clinician's Rosetta Stone?
Topics: Cell Line; Cells, Cultured; Drug Resistance; Floxuridine; Glioma; Humans; Mercaptopurine; Morphine D | 1977 |
Biochemical aspects of chemotherapy of mouse colon carcinoma: fluoropyrimidines and pyrazofurin.
Topics: Amidophosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcino | 1977 |
Altered thymidine kinase or thymidylate synthetase activities in 5-fluoro deoxyuridine resistant variants of mouse neuroblastoma.
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Floxuridine; Methyltransferases; Mice; Neo | 1977 |
Susceptibilities of normal and malignant human lung cells in culture to the cytocidal action of antitumor agents.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Doxorubicin; Drug Evaluat | 1978 |
Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Cytarabine; DNA, Neoplasm; Dose-R | 1979 |
Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--II. 6-[3H]-5-fluoro-2'-deoxyuridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Half-Life; Lung Neoplasms; Male; Mice; Neoplasm Tran | 1979 |
Effects of thymidine analogues on murine and human cells.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Line; Deoxyuridine; Fibroblasts; Floxuridine; Humans; I | 1979 |
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Floxuridine; Fluorouracil; In Vitro Techniques; | 1975 |
5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Drug Resistance; Floxuridine; Glioma; Mice; Neo | 1976 |
Increased thymidylate synthetase activity in 5-fluorodeoxyuridine-resistant Novikoff hepatoma cells.
Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cell Line; Drug Resistance; Floxuridine; Liver | 1977 |
Tumor diagnosis by PET: potential of seven tracers examined in five experimental tumors including an artificial metastasis model.
Topics: Animals; Carbon Radioisotopes; Deoxyglucose; Diagnosis, Differential; Disease Models, Animal; Floxur | 1992 |
Controlled release of 5-fluoro-2'-deoxyuridine by the combination of prodrug and polymer matrix.
Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Female; Floxuridine; Mice; Mice, In | 1991 |
Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma.
Topics: Animals; Biotransformation; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Humans; Male; Mamm | 1991 |
Tracer feasibility for monitoring tumor radiotherapy: a quadruple tracer study with fluorine-18-fluorodeoxyglucose or fluorine-18-fluorodeoxyuridine, L-[methyl-14C]methionine, [6-3H]thymidine, and gallium-67.
Topics: Animals; Carbon Radioisotopes; Citrates; Citric Acid; Cobalt Radioisotopes; Deoxyglucose; Feasibilit | 1991 |
18F-fluoro-2'-deoxyuridine as a tracer of nucleic acid metabolism in brain tumors.
Topics: Animals; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Neoplasms, Experimental; Nucleic Acid | 1990 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; In | 1990 |
Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Male; Mice; Mi | 1990 |
Biologic activity of 5'-deoxy-5-fluorouridine by rectal administration.
Topics: Administration, Rectal; Animals; Antineoplastic Agents; Female; Floxuridine; Leukocyte Count; Neopla | 1989 |
Terminally differentiated postmitotic tumor cells in a rat rhabdomyosarcoma cell line.
Topics: Animals; Cell Differentiation; Cell Division; Floxuridine; Mitotic Index; Neoplasms, Experimental; R | 1988 |
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxyc | 1985 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experime | 1985 |
Enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.
Topics: Animals; Cell Division; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred Strains; Neoplasms, Ex | 1986 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L | 1987 |
Enhanced antitumor activity of 5'-deoxy-5-fluorouridine against Lewis lung carcinoma in aged hybrid (C57BL/6 x DBA/2) F1 mice.
Topics: Age Factors; Animals; Antineoplastic Agents; Floxuridine; Hybridization, Genetic; Lethal Dose 50; Lu | 1987 |
[Liposomes as carriers of lipophilic cytosine arabinoside and fluorodeoxyuridine derivatives. Their cytostatic effect and possibilities of tumor cell specific therapy].
Topics: Animals; Antibodies, Monoclonal; Cytarabine; Drug Therapy; Floxuridine; Humans; Leukemia L1210; Lipo | 1987 |
[Antitumor effects of 5'-deoxy-5-fluorouridine (5'-DFUR) against various murine tumors in combination with recombinant interferon alpha or cytostatics].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; F | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neopl | 1985 |
Antitumor activity of a new fluoropyrimidine derivative, 5'-deoxy-5-fluorouridine, against murine and human experimental tumors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Humans; Leukemia L1210; Leuke | 1985 |
3',5'-diesters of 5-fluoro-2'-deoxyuridine: synthesis and biological activity.
Topics: Adenocarcinoma; Animals; Chemical Phenomena; Chemistry; Chromatography; Floxuridine; Houseflies; Ins | 1965 |
Chemotherapy studies in an animal tumor spectrum. II. Sensitivity of tumors to fourteen antitumor chemicals.
Topics: Animals; Antineoplastic Agents; Arsenicals; Busulfan; Cyclophosphamide; Dactinomycin; Diethylstilbes | 1966 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophospha | 1966 |
3',5'-Diesters of 5-fluoro-2'-deoxyuridine and thymidine: hydrolysis by esterases in human, mouse, and insect tissue.
Topics: Animals; Esterases; Female; Floxuridine; Humans; Injections, Intraperitoneal; Insecta; Mice; Neoplas | 1966 |
Joint oncogenic action of antimetabolites and 3-methylcholanthrene in mice.
Topics: Animals; Antimetabolites; Chloramphenicol; Drug Synergism; Female; Floxuridine; Idoxuridine; Methylc | 1968 |
Synthesis of 5-fluoro-2'-deoxyuridine-5'-carboxylic acid and its derivatives.
Topics: Animals; Cell Division; Culture Techniques; Depression, Chemical; Floxuridine; Fluorine; Humans; Mag | 1969 |
T antigens of bovine and canine adenoviruses demonstrated by immunofluorescence.
Topics: Adenoviridae; Animals; Antigens; Cattle; Cell Transformation, Neoplastic; Complement Fixation Tests; | 1969 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; N | 1970 |
Different effects of thymidine and 5-fluorouracil 2'-deoxyriboside on biosynthetic events in cultured P815Y mast cells.
Topics: Animals; Cell Division; Cell Line; Culture Techniques; Floxuridine; Mast Cells; Neoplasms, Experimen | 1971 |
Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.
Topics: Animals; Brain Neoplasms; Bromine; Carotid Arteries; Catheterization; Craniotomy; Cytidine; Deoxyrib | 1972 |
Cell cycle phase specificity of antitumor agents.
Topics: Alkaloids; Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbazole | 1972 |
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin | 1972 |
Properties of virus associated with subacute myelo-optico-neuropathy.
Topics: Abdomen; Animals; Cell Line; Centrifugation, Density Gradient; Cerebrospinal Fluid; Cricetinae; Cros | 1973 |
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea; | 1973 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyurid | 1973 |
Assay of 5-fluorodeoxyuridine 5'-monophosphate deoxyuridine 5'-monophosphate pools following 5-fluorouracil.
Topics: Animals; Cell Line; Clinical Enzyme Tests; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Floxur | 1974 |
Tumor-specific transplantation antigen activity of freshly adenovirus-infected cells. Intercurrent immunization against viral tumorigenesis with virus-infected cells.
Topics: Adenoviridae; Animals; Animals, Newborn; Antigens, Neoplasm; Carcinoma; Cell Line; Cricetinae; Floxu | 1974 |
Genetic and possible biochemical mechanisms in viral carcinogenesis.
Topics: Avian Sarcoma Viruses; Culture Techniques; Cytarabine; DNA; Floxuridine; Genetics; Methotrexate; Neo | 1966 |
Growth control in cultured cells: selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability.
Topics: Animals; Cell Transformation, Neoplastic; Clone Cells; Contact Inhibition; Cricetinae; Floxuridine; | 1968 |
Persistence of the viral genome in adenovirus type 12-infected hamster cells.
Topics: Adenoviridae; Adenoviridae Infections; Animals; Antigens; Autoradiography; Cell Transformation, Neop | 1968 |
Comparative studies of fluorinated pyrimidines with various cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA, Neo | 1968 |
Development of resistance of Novikoff hepatoma to 5-fluoro-2'-deoxyuridine.
Topics: Carbon Isotopes; Carcinoma, Hepatocellular; Culture Techniques; DNA, Neoplasm; Floxuridine; Liver Ne | 1970 |
Induction of SV40 transplantation antigen (TrAg) during the lytic cycle.
Topics: Animals; Animals, Newborn; Antigens; Bromodeoxyuridine; Cell Line; Cricetinae; Cycloheximide; Cytara | 1970 |
Considerations in the development of a predictive system for cancer chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; DNA; Floxuridine; Fluorouracil; Liver N | 1971 |
Fluorinated pyrimidines. 41. Syntheses of 5-trifluoromethyl-3'-deoxyuridine and 5-fluoro-3'-deoxyuridine.
Topics: Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Ion Exc | 1972 |
Induction of virus synthesis in polyoma-transformed cells by DNA antimetabolites and by irradiation after pretreatment with 5-bromodeoxyuridine.
Topics: Animals; Antigens, Viral; Antimetabolites; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transfo | 1972 |