floxuridine has been researched along with Experimental Mammary Neoplasms in 29 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The degree of synergism between docetaxel and two oral fluoropyrimidines, tegafur and 5'-deoxy-5-fluorouridine (5'-dFUrd), was investigated in the KPL-4 human breast cancer xenograft model." | 3.71 | Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts. ( Kunisue, H; Kurebayashi, J; Kurosumi, M; Otsuki, T; Sonoo, H; Tanaka, K; Yamamoto, S, 2001) |
| "2,2'-Anhydro-5-ethyluridine (ANEUR), a potent inhibitor of uridine phosphorylase, markedly potentiated the antitumor activity of fluorouridine (FUR) against murine mammary adenocarcinoma 755 in BDF1 mice and human colon adenocarcinoma LS174T in athymic-nude mice." | 3.68 | Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine. ( De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z, 1990) |
| "Nucleic acid metabolism in brain tumors by [18F]FdUrd-PET may be assessed using normal brain regions as a reference." | 1.28 | Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma. ( Ido, T; Ishiwata, K; Kameyama, M; Sato, K; Yoshimoto, T, 1991) |
| " These dose-response data indicate that locally recurrent tumors are frequently, but not always, different from the original primary tumor in response to chemotherapy agents and ionizing X-irradiation." | 1.27 | Development and characterization of a rat model for locally recurring mammary tumors: sensitivities to 5-fluoro-2'-deoxyuridine, adriamycin, and X-irradiation. ( Aeed, PA; Estrada, J; Welch, DR, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (44.83) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, A | 2 |
| Satake, A | 2 |
| Hiramoto, A | 2 |
| Wataya, Y | 7 |
| Kim, HS | 2 |
| Connelly, L | 1 |
| Barham, W | 1 |
| Onishko, HM | 1 |
| Chen, L | 1 |
| Sherrill, TP | 1 |
| Zabuawala, T | 1 |
| Ostrowski, MC | 1 |
| Blackwell, TS | 1 |
| Yull, FE | 1 |
| CLIFTON, KH | 1 |
| SZYBALSKI, W | 1 |
| HEIDELBERGER, C | 1 |
| GOLLIN, FF | 1 |
| ANSFIELD, FJ | 1 |
| VERMUND, H | 1 |
| Hiraga, T | 1 |
| Hata, K | 1 |
| Ikeda, F | 1 |
| Kitagaki, J | 1 |
| Fujimoto-Ouchi, K | 2 |
| Tanaka, Y | 3 |
| Yoneda, T | 1 |
| Wan, L | 1 |
| Cao, D | 1 |
| Zeng, J | 1 |
| Yan, R | 1 |
| Pizzorno, G | 1 |
| Miyazaki, E | 1 |
| Hiraoka, O | 3 |
| Miyake, T | 1 |
| Fujita, F | 1 |
| Fujita, M | 1 |
| Taguchi, T | 1 |
| Ishiwata, K | 3 |
| Ido, T | 3 |
| Takahashi, T | 1 |
| Monma, M | 1 |
| Iwata, R | 1 |
| Abe, Y | 2 |
| Matsuzawa, T | 2 |
| Tsurumi, Y | 1 |
| Kameyama, M | 2 |
| Ayusawa, D | 2 |
| Koyama, H | 1 |
| Seno, T | 2 |
| Wagner, CR | 1 |
| Ballato, G | 1 |
| Akanni, AO | 1 |
| McIntee, EJ | 1 |
| Larson, RS | 1 |
| Chang, S | 1 |
| Abul-Hajj, YJ | 1 |
| Endo, M | 2 |
| Matsumoto, T | 1 |
| Ishitsuka, H | 2 |
| Nagano, A | 1 |
| Kakutani, T | 2 |
| Matumoto, Y | 1 |
| Ebara, Y | 2 |
| Kanja, K | 2 |
| Kankawa, S | 1 |
| Takahashi, K | 1 |
| Shinbori, N | 1 |
| Fukase, Y | 1 |
| Sawada, N | 1 |
| Ishikawa, T | 1 |
| Takeda, Y | 1 |
| Yoshizaki, I | 1 |
| Nonaka, Y | 1 |
| Yanagie, H | 1 |
| Matsuzawa, A | 1 |
| Eriguchi, M | 1 |
| Yamamoto, S | 1 |
| Kurebayashi, J | 1 |
| Kurosumi, M | 1 |
| Kunisue, H | 1 |
| Otsuki, T | 1 |
| Tanaka, K | 1 |
| Sonoo, H | 1 |
| Schabel, FM | 1 |
| Meyer, JS | 1 |
| Connor, RE | 1 |
| Nayak, R | 1 |
| Sato, K | 1 |
| Yoshimoto, T | 1 |
| Iigo, M | 1 |
| Nishikata, K | 1 |
| Nakajima, Y | 1 |
| Szinai, I | 1 |
| Veres, Z | 1 |
| Szabolcs, A | 1 |
| De Clercq, E | 1 |
| Härkönen, PL | 1 |
| Laaksonen, EI | 1 |
| Valve, EM | 1 |
| Solic, N | 1 |
| Darbre, PD | 1 |
| Yoshioka, A | 2 |
| Tanaka, S | 2 |
| Koyama, Y | 2 |
| Hirota, Y | 3 |
| Garrett, C | 1 |
| Welch, DR | 1 |
| Aeed, PA | 1 |
| Estrada, J | 1 |
| Hazawa, T | 1 |
| Watanabe, K | 1 |
| Yoshioka-Hiramoto, A | 1 |
| Murakami, M | 1 |
| Lokshina, AM | 1 |
| Pelevina, II | 1 |
| Tsou, KC | 1 |
| Lo, KW | 1 |
| Ledis, SL | 1 |
| Miller, EE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of an All-Oral Combination of Capecitabine (X) and Cyclophosphamide (C) in Patients With Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer[NCT00589901] | Phase 2 | 60 participants (Anticipated) | Interventional | 2006-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for floxuridine and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Rationale for adjuvant chemotherapy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carmustine; Cyclophosphamide; Cytarabine; Doxorubi | 1977 |
[Radiation sensitization of brain neoplasms by haloid analogs of pyrimidine bases].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Cricetinae; DNA, Neoplasm; Fe | 1973 |
27 other studies available for floxuridine and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Protein expression profiles of necrosis and apoptosis induced by 5-fluoro-2'-deoxyuridine in mouse cancer cells.
Topics: Amino Acid Sequence; Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Size; Electrophor | 2010 |
NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.
Topics: Animals; CD11b Antigen; Chemokine CXCL9; Female; Floxuridine; I-kappa B Kinase; Lung; Lung Neoplasms | 2011 |
INCORPORATION OF I-125-LABELED IODODEOXYURIDINE INTO THE DEOXYRIBONUCLEIC ACID OF MURINE AND HUMAN TISSUES FOLLOWING THERAPEUTIC DOSES.
Topics: Adenocarcinoma; Animals; DNA; DNA, Neoplasm; Floxuridine; Geriatrics; Idoxuridine; Intestine, Small; | 1963 |
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Capec | 2005 |
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
Topics: Animals; Base Sequence; Capecitabine; Deoxycytidine; DNA Primers; Drug Synergism; Electrophoretic Mo | 2006 |
Proteome and transcriptome analysis of cell death induced by 5-fluoro-2'-deoxyuridine.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Floxuridine; Gene Expression | 2007 |
[Effects of 5'-deoxy-5-fluorouridine on human gastrointestinal and breast cancers xenografted to nude mice].
Topics: Adenocarcinoma; Administration, Oral; Animals; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Femal | 1984 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Ne | 1984 |
Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.
Topics: Animals; Cell Line; Drug Resistance; Floxuridine; Mammary Neoplasms, Experimental; Methotrexate; Met | 1981 |
Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Division; Dose-Response Relationshi | 1997 |
[Efficacy of combination chemotherapy of cyclophosphamide and 5'-deoxy-5-fluorouridine in a mammary tumor xenograft model, MX-1].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Cyclophosp | 1997 |
The molecular mechanisms of 5-fluoro-2'-deoxyuridine induced cell death.
Topics: Animals; Apoptosis; Cell Death; Cell Line; Deoxyribonucleases, Type I Site-Specific; Deoxyribonucleo | 1997 |
Activation of c-jun and c-fos genes in dNTP imbalance cell death induced with 5-fluoro-2'-deoxyuridine in mouse mammary tumor FM3A cell line.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Death; Deoxyribonucleosides; Female; Floxuridine; Gen | 1998 |
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother | 1999 |
Docetaxel alone or orally combined with 5-fluorouracil and its derivatives: effects on mouse mammary tumor cell line MM2 in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Docetaxel; | 2001 |
Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cachexia; Docetaxel; Drug Interactions; | 2001 |
In vitro labeling of solid tissues with tritiated thymidine for autoradiographic detection of S-phase nuclei.
Topics: Animals; Cell Cycle; Cell Nucleus; Cold Temperature; DNA; Floxuridine; Histological Techniques; Hype | 1977 |
Thymidine inhibits the incorporation of 5-fluoro-2'-deoxyuridine to DNA of mouse mammary tumour.
Topics: Animals; Centrifugation, Density Gradient; DNA, Neoplasm; Female; Floxuridine; Mammary Neoplasms, Ex | 1992 |
Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma.
Topics: Animals; Biotransformation; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Humans; Male; Mamm | 1991 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Ki | 1990 |
Temperature-sensitive mutants for steroid-sensitive growth of S115 mouse mammary tumor cells.
Topics: Androgens; Animals; Blood; Cell Division; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; C | 1990 |
The mechanism of dNTP-unbalanced cell death induced by 5-fluorouracil and its derivatives.
Topics: Animals; Cell Line; Cell Survival; Deoxyribonucleotides; Floxuridine; Fluorouracil; Kinetics; Mammar | 1985 |
Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.
Topics: Animals; Cell Line; Cycloheximide; Deoxyribonucleotides; DNA Damage; DNA, Neoplasm; DNA, Single-Stra | 1987 |
Development and characterization of a rat model for locally recurring mammary tumors: sensitivities to 5-fluoro-2'-deoxyuridine, adriamycin, and X-irradiation.
Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Femal | 1988 |
Detection of deoxyribonucleoside-triphosphate imbalance death-induced DNA double strand breakage in FM3A cells by orthogonal-field-alternation gel electrophoresis (OFAGE).
Topics: Animals; Cell Line; Deoxyribonucleotides; DNA Damage; DNA, Neoplasm; Floxuridine; Mammary Neoplasms, | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neopl | 1985 |
Indigogenic phosphodiesters as potential chromogenic cancer chemotherapeutic agents.
Topics: Alkaline Phosphatase; Animals; Antineoplastic Agents; Cells, Cultured; Coloring Agents; Escherichia | 1972 |