floxuridine has been researched along with Experimental Leukemia in 29 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mouse T-lymphoma (S-49) cell line is useful for individually studying RNA- and DNA-directed effects of 5-fluoropyrimidines." | 7.66 | Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells. ( Day, JL; Mandel, HG; Maybaum, J; Sadee, W; Ullman, B, 1980) |
| "The mouse T-lymphoma (S-49) cell line is useful for individually studying RNA- and DNA-directed effects of 5-fluoropyrimidines." | 3.66 | Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells. ( Day, JL; Mandel, HG; Maybaum, J; Sadee, W; Ullman, B, 1980) |
| "The mechanism of antitumor activity of 5-fluorouracil (FU) was studied in mouse leukemia L5178Y cells in vitro." | 3.66 | The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells. ( Hoshi, A; Kuretani, K; Yoshida, M, 1980) |
| " The increase in lifespan (ILS) of mice treated with 5'-DFUR was augmented by the combination with guanosine or inosine in a dose-dependent fashion, and the maximum ILS was about 160% with the combination, while that in the case of 5'-DFUR alone was only 48% in the P388 leukemia system." | 1.27 | Potentiation of the chemotherapeutic action of 5'-deoxy-5-fluorouridine in combination with guanosine and related compounds. ( Iigo, M; Ishitsuka, H; Miwa, M; Nitta, K, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (96.55) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Phelps, ME | 1 |
| Woodman, PW | 1 |
| Danenberg, PV | 2 |
| BURCHENAL, JH | 1 |
| HOLMBERG, EA | 1 |
| FOX, JJ | 1 |
| HEMPHILL, SC | 1 |
| REPPERT, JA | 1 |
| FISCHER, GA | 1 |
| VONESSEN, CF | 1 |
| Moran, RG | 2 |
| Heidelberger, C | 5 |
| Rode, W | 1 |
| Jastreboff, MM | 1 |
| Flickinger, RA | 1 |
| Richman, R | 1 |
| Iigo, M | 2 |
| Hoshi, A | 5 |
| Honma, Y | 2 |
| Kasukabe, T | 1 |
| Hozumi, M | 2 |
| Kanzawa, F | 3 |
| Kuretani, K | 4 |
| Maybaum, J | 1 |
| Ullman, B | 1 |
| Mandel, HG | 1 |
| Day, JL | 1 |
| Sadee, W | 1 |
| Yoshida, M | 1 |
| Lee, SH | 1 |
| Sartorelli, AC | 1 |
| Mulkins, MA | 1 |
| Wigler, PW | 1 |
| Schluter, DN | 1 |
| Riccardi, C | 2 |
| Giampietri, A | 2 |
| Puccetti, P | 2 |
| Biancifiori, F | 1 |
| Fioretti, MC | 2 |
| Goldin, A | 1 |
| Okabe, J | 1 |
| Hayashi, M | 1 |
| Mulkins, M | 1 |
| Mini, E | 1 |
| Coronnello, M | 1 |
| Carotti, S | 1 |
| Gerli, A | 1 |
| Pesciullesi, A | 1 |
| Moroson, BA | 1 |
| Mazzei, T | 1 |
| Periti, P | 1 |
| Bertino, JR | 1 |
| Miwa, M | 1 |
| Ishitsuka, H | 1 |
| Nitta, K | 1 |
| Bradner, WT | 1 |
| Pindell, MH | 1 |
| Kessel, D | 1 |
| Bruns, R | 1 |
| Hall, TC | 1 |
| Fujiwara, Y | 1 |
| Oldham, RK | 1 |
| Siwarski, D | 1 |
| McCoy, JL | 1 |
| Plata, EJ | 1 |
| Herberman, RB | 1 |
| Chu, MY | 1 |
| Hoovis, ML | 1 |
| Khwaja, TA | 1 |
| Umeda, M | 1 |
1 review available for floxuridine and Experimental Leukemia
| Article | Year |
|---|---|
Biochemical modulation of fluoropyrimidines by antifolates and folates in an in vitro model of human leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Folic Acid; Folic Acid An | 1990 |
28 other studies available for floxuridine and Experimental Leukemia
| Article | Year |
|---|---|
Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Deoxyuracil Nucleoti | 1980 |
The effects of 5-fluorodeoxycytidine, 5-fluorodeoxyuridine, and related compounds on transplanted mouse leukemias.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Leukemia; Leukemia, Experimental; Mice; | 1959 |
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Exper | 1965 |
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytosol; Deoxyuracil Nucleotides; Flo | 1982 |
Effects of Mg2+ and adenine nucleotides on thymidylate synthetase from different mouse tumors.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Enzyme Activatio | 1984 |
The effect of induction of hemoglobin synthesis in cultured Friend cells on the number of initiation sites for replication and transcription.
Topics: Acetamides; Aminoisobutyric Acids; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; DNA | 1984 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; | 1984 |
Changes in phospholipid composition during differentiation of cultured mouse myeloid leukemia cells.
Topics: Animals; Cell Differentiation; Cell Line; Dexamethasone; Drug Resistance; Floxuridine; Leukemia, Exp | 1980 |
Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; | 1980 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Leu | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemi | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leuke | 1980 |
The effects of inhibitors of DNA biosynthesis on the cytotoxicity of 6-thioguanine.
Topics: Animals; Cells, Cultured; Cytarabine; DNA; DNA Replication; Floxuridine; Hydroxyurea; Interphase; Le | 1981 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug R | 1982 |
Inhibition of membrane transport of 5-fluoro[6-3H]deoxyuridine into L5178Y mouse leukemia cells.
Topics: Animals; Biological Transport; Bromodeoxyuridine; Cell Line; Cell Membrane; Deoxyuridine; Floxuridin | 1976 |
Murine leukemia growth inhibition or enhancement following immunization with tumor cells antigenically altered by drug treatment.
Topics: Animals; Antigens, Neoplasm; Cells, Cultured; Dacarbazine; Female; Floxuridine; Gamma Rays; Idoxurid | 1977 |
Growth and rejection patterns of murine lymphoma cells antigenically altered following drug treatment in vivo.
Topics: Animals; Antigens, Neoplasm; Dacarbazine; DNA; Floxuridine; Graft Rejection; Leukemia, Experimental; | 1978 |
Differentiation of mouse myeloid leukemia cells is inhibited by a factor from non-differentiating leukemia cells.
Topics: Animals; Ascitic Fluid; Cell Line; Clone Cells; Culture Media; Dactinomycin; Drug Resistance; Floxur | 1978 |
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, E | 1979 |
Potentiation of the chemotherapeutic action of 5'-deoxy-5-fluorouridine in combination with guanosine and related compounds.
Topics: Animals; Drug Synergism; Floxuridine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Inosi | 1987 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophospha | 1966 |
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell | 1971 |
Effect of cycloheximide on regulatory protein for initiating mammalian DNA replication at the nuclear membrane.
Topics: Animals; Antimetabolites; Cell Line; Cell Nucleus; Cells, Cultured; Centrifugation, Density Gradient | 1972 |
Evaluation of a cell-mediated cytotoxicity assay utilizing 125 iododeoxyuridine-labeled tissue-culture target cells.
Topics: Adult; AKR murine leukemia virus; Animals; Antigens, Neoplasm; Breast Neoplasms; Cell Line; Cells, C | 1973 |
Sensitivity of human leukemic cells to anti-cancer agents in culture.
Topics: Animals; Antineoplastic Agents; Azauridine; Cells; Cells, Cultured; Chlorambucil; Culture Media; Cyc | 1974 |
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Escherichia coli; Floxuridine; HeLa Ce | 1967 |
Comparative studies of fluorinated pyrimidines with various cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA, Neo | 1968 |