floxuridine has been researched along with Experimental Hepatoma in 32 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a series of novel O-(substituted benzyl) phosphoramidate prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of hepatocellular carcinoma." | 7.83 | Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma. ( Chang, J; Jiang, J; Kang, J; Li, E; Li, L; Liu, B; Peng, Y; Wang, Q; Wang, Y; Wu, J; Yang, Q; Yu, W; Zhang, J, 2016) |
| "We report a series of novel O-(substituted benzyl) phosphoramidate prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of hepatocellular carcinoma." | 3.83 | Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma. ( Chang, J; Jiang, J; Kang, J; Li, E; Li, L; Liu, B; Peng, Y; Wang, Q; Wang, Y; Wu, J; Yang, Q; Yu, W; Zhang, J, 2016) |
| " 5-fluoro-2'-deoxyuridine is an active drug in the treatment of solid tumours, but with toxic effects on intestine and bone marrow." | 1.30 | Conjugation of 5-fluoro-2'-deoxyuridine with lactosaminated poly-l-lysine to reduce extrahepatic toxicity in the treatment of hepatocarcinomas. ( Busi, C; Derenzini, M; Di Stefano, G; Fiume, L; Trerè, D, 1998) |
| " These results provide a rationale for using short duration of FUdR in combination with other drugs." | 1.29 | Short-term intrahepatic FUdR infusion combined with bolus mitomycin C: reduced risk for developing drug resistance. ( Arisawa, Y; Dalton, RR; Sigurdson, ER; Sutanto-Ward, E, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (53.13) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, Y | 1 |
| Yu, W | 1 |
| Li, E | 1 |
| Kang, J | 1 |
| Wang, Y | 1 |
| Yang, Q | 1 |
| Liu, B | 1 |
| Zhang, J | 1 |
| Li, L | 1 |
| Wu, J | 1 |
| Jiang, J | 1 |
| Wang, Q | 1 |
| Chang, J | 1 |
| MORSE, PA | 1 |
| POTTER, VR | 1 |
| Pohlen, U | 2 |
| Binnenhei, M | 2 |
| Reszka, R | 1 |
| Buhr, HJ | 2 |
| Berger, G | 2 |
| Rieger, H | 1 |
| Reszka, RC | 1 |
| Cory, JG | 1 |
| Carter, GL | 1 |
| Jastreboff, MM | 1 |
| Zielińska, ZM | 1 |
| Abe, Y | 3 |
| Fukuda, H | 2 |
| Ishiwata, K | 3 |
| Yoshioka, S | 1 |
| Yamada, K | 1 |
| Endo, S | 1 |
| Kubota, K | 1 |
| Sato, T | 1 |
| Matsuzawa, T | 3 |
| Takahashi, T | 2 |
| Ido, T | 3 |
| Monma, M | 1 |
| Iwata, R | 1 |
| Tsurumi, Y | 1 |
| Kameyama, M | 1 |
| Priest, DG | 1 |
| Ledford, BE | 1 |
| Doig, MT | 1 |
| Woodman, PW | 1 |
| Sarrif, AM | 1 |
| Heidelberger, C | 1 |
| Arisawa, Y | 1 |
| Sutanto-Ward, E | 2 |
| Dalton, RR | 1 |
| Sigurdson, ER | 2 |
| Fujii, Y | 1 |
| Itoyanagi, H | 1 |
| Saegusa, Y | 1 |
| Hasumi, K | 1 |
| Eriguchi, M | 1 |
| Kemeny, MM | 1 |
| Alava, G | 1 |
| Oliver, JM | 1 |
| Kurth, S | 1 |
| Bulian, D | 1 |
| Kreft, B | 1 |
| Riemenschneider, T | 3 |
| Tazawa, K | 1 |
| Sakamoto, T | 1 |
| Kuroki, Y | 1 |
| Yamashita, I | 1 |
| Okamoto, M | 1 |
| Katuyama, S | 1 |
| Fujimaki, M | 1 |
| Di Stefano, G | 1 |
| Busi, C | 1 |
| Derenzini, M | 1 |
| Trerè, D | 1 |
| Fiume, L | 1 |
| Merle, P | 1 |
| Trepo, C | 1 |
| Germann, C | 1 |
| Shields, AF | 1 |
| Grierson, JR | 1 |
| Morr, I | 1 |
| Haberkorn, U | 1 |
| Jackson, RC | 1 |
| Tremiterra, S | 1 |
| Lincer, R | 1 |
| Chapman, D | 1 |
| Niedzwiecki, D | 1 |
| Ruf, C | 2 |
| Kratzsch, HC | 1 |
| Ziegler, M | 1 |
| Späth, G | 2 |
| Naser-Hijazi, B | 1 |
| Berger, MR | 3 |
| Schmähl, D | 2 |
| Schlag, P | 3 |
| Hull, WE | 1 |
| Stetson, PL | 1 |
| Normolle, DP | 1 |
| Knol, JA | 1 |
| Johnson, NJ | 1 |
| Yang, ZM | 1 |
| Sakmar, E | 1 |
| Prieskorn, D | 1 |
| Terrio, P | 1 |
| Knutsen, CA | 1 |
| Ensminger, WD | 1 |
| Butler, JA | 1 |
| Trezona, TP | 1 |
| Nordestgaard, A | 1 |
| State, D | 1 |
| Kawaguchi, T | 1 |
| Fukushima, S | 1 |
| Hayashi, Y | 1 |
| Kaneko, M | 1 |
| Nakano, M | 1 |
| Bartkowski, R | 2 |
| Aguiar, JL | 2 |
| Henne, TH | 2 |
| Dörsam, J | 2 |
| Geelhaar, GH | 2 |
| Herfarth, C | 2 |
| Taguchi, T | 1 |
| Miwa, M | 1 |
| Eda, H | 1 |
| Fujimoto, K | 1 |
| Ishitsuka, H | 1 |
| Stuhldreier, G | 1 |
| Elmouaouy, A | 1 |
| Murakami, M | 1 |
| Kobayashi, T | 1 |
1 review available for floxuridine and Experimental Hepatoma
| Article | Year |
|---|---|
Antiblastic drug targeting to hepatocellular carcinoma cells: a potential therapeutic improvement?
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoco | 1998 |
31 other studies available for floxuridine and Experimental Hepatoma
| Article | Year |
|---|---|
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Carcinoma, Hepatocellular; D | 2016 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liv | 1965 |
Intra-aortal therapy with 5-fluorouracil- polyethylene glycol stealth liposomes: does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on ph value?. An animal study in VX-2 liver tumor-bearing rabbits.
Topics: Animals; Antimetabolites, Antineoplastic; Aorta, Abdominal; Cell Line, Tumor; Chromatography, High P | 2004 |
Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.
Topics: Animals; Biological Availability; Blood Flow Velocity; Chromatography, High Pressure Liquid; Disease | 2005 |
Evidence that 5'-deoxy-5-fluorouridine may not be activated by the same mechanism as 5-fluorouracil.
Topics: Animals; Biotransformation; Cells, Cultured; Floxuridine; Fluorouracil; Inosine; Liver Neoplasms, Ex | 1982 |
Development and characteristics of a subline of Ehrlich ascites carcinoma cells persistently resistant to 5-fluoro-2'-deoxyuridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Female; Floxuridine; Humans; Liver Ne | 1983 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; | 1983 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Ne | 1984 |
Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells.
Topics: Animals; Cells, Cultured; Drug Resistance; Floxuridine; Liver Neoplasms, Experimental; Methyltransfe | 1980 |
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Floxuridine; HeLa Cells; Humans; Isoelectric Poi | 1980 |
Short-term intrahepatic FUdR infusion combined with bolus mitomycin C: reduced risk for developing drug resistance.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration S | 1994 |
[Effects of 5'-DFUR against BALB/c retroperitoneal sarcoma with spontaneous liver metastases].
Topics: Animals; Antineoplastic Agents; Female; Floxuridine; Liver Neoplasms, Experimental; Mice; Mice, Inbr | 1994 |
The effects on liver metastases of circadian patterned continuous hepatic artery infusion of FUDR.
Topics: Adenocarcinoma; Animals; Catheterization, Peripheral; Circadian Rhythm; Drug Administration Schedule | 1994 |
Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.
Topics: Angiography; Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Floxuridin | 1996 |
Inhibitory effects of fluorinated pyrimidines, 5'-DFUR, UFT and T-506, in a model of hepatic metastasis of mouse colon 26 adenocarcinoma-assessment of inhibitory activity and adverse reactions at the maximum tolerated dose.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Dose-Response Relati | 1997 |
Conjugation of 5-fluoro-2'-deoxyuridine with lactosaminated poly-l-lysine to reduce extrahepatic toxicity in the treatment of hepatocarcinomas.
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Disease Models, Animal; Dr | 1998 |
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
Topics: Animals; Antiviral Agents; Floxuridine; Ganciclovir; Genetic Therapy; Liver Neoplasms, Experimental; | 1998 |
The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.
Topics: 3-Deazauridine; Animals; Cell Line; DNA, Neoplasm; Floxuridine; Liver Neoplasms, Experimental; Metho | 1978 |
Adjuvant chemotherapy for colorectal hepatic metastases: role of route of administration and timing.
Topics: Animals; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Floxuridine | 1992 |
Arterial, portal or combined arterio-portal regional chemotherapy in experimental liver tumours?
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Female; Floxuridine; Hepatic Artery; Infusion Pum | 1992 |
Locoregional administration of 5-fluoro-2'-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by 19F-NMR spectroscopy.
Topics: Animals; Drug Administration Schedule; Female; Floxuridine; Fluorine; Infusions, Intra-Arterial; Liv | 1991 |
Biochemical modulation of 5-bromo-2'-deoxyuridine and 5-iodo-2'-deoxyuridine incorporation into DNA in VX2 tumor-bearing rabbits.
Topics: Animals; Bromodeoxyuridine; DNA; Floxuridine; Idoxuridine; Liver Neoplasms, Experimental; Organ Spec | 1991 |
Hepatic artery versus portal vein and systemic infusion of fluorodeoxyuridine of rabbit VX-2 hepatic implants.
Topics: Animals; Female; Floxuridine; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Intravenous; Liv | 1989 |
Selective accumulation of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) and sustained release of its active metabolites in VX-2 rabbit hepatoma following intraarterial administration of FdUrd-C8 solution in Lipiodol.
Topics: Animals; Esterases; Floxuridine; Fluorodeoxyuridylate; Hepatic Artery; Infusions, Intra-Arterial; Io | 1988 |
Experiments on the efficacy and toxicity of locoregional chemotherapy of liver tumors with 5-fluoro-2'-deoxyuridine (FUDR) and 5-fluorouracil (5-FU) in an animal model.
Topics: Animals; DNA, Neoplasm; Floxuridine; Fluorouracil; Liver; Liver Neoplasms; Liver Neoplasms, Experime | 1986 |
Experiments on the toxicity of locoregional liver chemotherapy with 5-fluoro-2'-deoxyuridine and 5-fluorouracil in an animal model.
Topics: Animals; Female; Floxuridine; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Pa | 1986 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
Continuous or bolus chemotherapy with 5-fluoro-2'-deoxyuridine in transplanted experimental liver tumors?
Topics: Animals; Floxuridine; Infusions, Intra-Arterial; Liver Neoplasms, Experimental; Neoplasm Transplanta | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neopl | 1985 |
[New developments in chemotherapy for experimental brain metastasis].
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Daunorubicin; Doxorubicin; Flo | 1985 |