Page last updated: 2024-11-06

floxuridine and EHS Tumor

floxuridine has been researched along with EHS Tumor in 16 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
"We found that this conversion in human tumors was catalyzed not by uridine phosphorylase but by thymidine phosphorylase."1.27[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues]. ( Hara, Y, 1984)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199012 (75.00)18.7374
1990's3 (18.75)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hara, Y1
Fujii, S3
Shirasaka, T2
Fujii, Y1
Itoyanagi, H1
Saegusa, Y1
Hasumi, K1
Eriguchi, M1
Morin, KW2
Knaus, EE2
Wiebe, LI2
Xia, H1
McEwan, AJ1
Jones, PA1
Benedict, WF1
Baker, MS1
Mondal, S1
Rapp, U1
Heidelberger, C1
Takeshita, S1
Nagatomi, H1
Ando, K1
Takimoto, CH1
Cadman, EC1
Armstrong, RD1
Taguchi, T1
Modest, EJ1
Reiner, J1
Southam, CM1
Brown, JM1
Goffinet, DR1
Cleaver, JE1
Kallman, RF1
Barbanti-Brodano, G1
Fiume, L1

Reviews

1 review available for floxuridine and EHS Tumor

ArticleYear
Radiation sensitizers.
    Cancer, 1976, Volume: 37, Issue:4 Suppl

    Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs

1976

Other Studies

15 other studies available for floxuridine and EHS Tumor

ArticleYear
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:10

    Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine;

1984
[Development of fluoropyrimidine derivatives].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides;

1984
[Effects of 5'-DFUR against BALB/c retroperitoneal sarcoma with spontaneous liver metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:10

    Topics: Animals; Antineoplastic Agents; Female; Floxuridine; Liver Neoplasms, Experimental; Mice; Mice, Inbr

1994
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
    Nuclear medicine communications, 1997, Volume: 18, Issue:7

    Topics: Animals; Antiviral Agents; Cell Line; Floxuridine; Gene Transfer Techniques; Genetic Therapy; Herpes

1997
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
    Nuclear medicine communications, 2000, Volume: 21, Issue:2

    Topics: Animals; Antiviral Agents; Cell Hypoxia; Floxuridine; Ganciclovir; Genes, Reporter; Genetic Therapy;

2000
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
    Cancer research, 1976, Volume: 36, Issue:1

    Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplast

1976
Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice.
    Biochemical pharmacology, 1992, Mar-17, Volume: 43, Issue:6

    Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Body Wei

1992
[Studies of the antitumor activity and enzymology of 2'-deoxy-5-fluorouridine (FdUrd) derivatives].
    Gan no rinsho. Japan journal of cancer clinics, 1986, Volume: 32, Issue:4

    Topics: Animals; Antineoplastic Agents; Floxuridine; Intestine, Small; Liver; Male; Mice; Rats; Rats, Inbred

1986
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
    Molecular pharmacology, 1986, Volume: 29, Issue:6

    Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Ex

1986
[5'-DFUR (doxifluridine)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil

1987
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou

1987
Formal discussion: future prospects in leukemia chemotherapy.
    Cancer research, 1965, Volume: 25, Issue:9

    Topics: Animals; Dactinomycin; Floxuridine; Leukemia; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; N

1965
Increased growth of tumor isotransplants after immunosuppression of the recipient mice by methotrexate or 5-fluoro-2'-deoxyuridine.
    Journal of the National Cancer Institute, 1967, Volume: 38, Issue:5

    Topics: Animals; Fibrosarcoma; Floxuridine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Multipl

1967
Preferential radiosensitization of mouse sarcoma relative to normal skin by chronic intra-arterial infusion of halogenated pyrimidine analogs.
    Journal of the National Cancer Institute, 1971, Volume: 47, Issue:1

    Topics: Animals; Bromine; Carbon Isotopes; Chromatography; Cytosine; DNA, Neoplasm; Floxuridine; Injections,

1971
In vitro effect of a 5-fluorodeoxyuridine albumin conjugate on tumour cells and on peritoneal macrophages.
    Experientia, 1974, Oct-15, Volume: 30, Issue:10

    Topics: Animals; Carbodiimides; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured;

1974