floxuridine has been researched along with EHS Tumor in 16 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that this conversion in human tumors was catalyzed not by uridine phosphorylase but by thymidine phosphorylase." | 1.27 | [5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues]. ( Hara, Y, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hara, Y | 1 |
| Fujii, S | 3 |
| Shirasaka, T | 2 |
| Fujii, Y | 1 |
| Itoyanagi, H | 1 |
| Saegusa, Y | 1 |
| Hasumi, K | 1 |
| Eriguchi, M | 1 |
| Morin, KW | 2 |
| Knaus, EE | 2 |
| Wiebe, LI | 2 |
| Xia, H | 1 |
| McEwan, AJ | 1 |
| Jones, PA | 1 |
| Benedict, WF | 1 |
| Baker, MS | 1 |
| Mondal, S | 1 |
| Rapp, U | 1 |
| Heidelberger, C | 1 |
| Takeshita, S | 1 |
| Nagatomi, H | 1 |
| Ando, K | 1 |
| Takimoto, CH | 1 |
| Cadman, EC | 1 |
| Armstrong, RD | 1 |
| Taguchi, T | 1 |
| Modest, EJ | 1 |
| Reiner, J | 1 |
| Southam, CM | 1 |
| Brown, JM | 1 |
| Goffinet, DR | 1 |
| Cleaver, JE | 1 |
| Kallman, RF | 1 |
| Barbanti-Brodano, G | 1 |
| Fiume, L | 1 |
1 review available for floxuridine and EHS Tumor
| Article | Year |
|---|---|
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs | 1976 |
15 other studies available for floxuridine and EHS Tumor
| Article | Year |
|---|---|
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine; | 1984 |
[Development of fluoropyrimidine derivatives].
Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; | 1984 |
[Effects of 5'-DFUR against BALB/c retroperitoneal sarcoma with spontaneous liver metastases].
Topics: Animals; Antineoplastic Agents; Female; Floxuridine; Liver Neoplasms, Experimental; Mice; Mice, Inbr | 1994 |
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
Topics: Animals; Antiviral Agents; Cell Line; Floxuridine; Gene Transfer Techniques; Genetic Therapy; Herpes | 1997 |
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
Topics: Animals; Antiviral Agents; Cell Hypoxia; Floxuridine; Ganciclovir; Genes, Reporter; Genetic Therapy; | 2000 |
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplast | 1976 |
Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Body Wei | 1992 |
[Studies of the antitumor activity and enzymology of 2'-deoxy-5-fluorouridine (FdUrd) derivatives].
Topics: Animals; Antineoplastic Agents; Floxuridine; Intestine, Small; Liver; Male; Mice; Rats; Rats, Inbred | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Ex | 1986 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil | 1987 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou | 1987 |
Formal discussion: future prospects in leukemia chemotherapy.
Topics: Animals; Dactinomycin; Floxuridine; Leukemia; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; N | 1965 |
Increased growth of tumor isotransplants after immunosuppression of the recipient mice by methotrexate or 5-fluoro-2'-deoxyuridine.
Topics: Animals; Fibrosarcoma; Floxuridine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Multipl | 1967 |
Preferential radiosensitization of mouse sarcoma relative to normal skin by chronic intra-arterial infusion of halogenated pyrimidine analogs.
Topics: Animals; Bromine; Carbon Isotopes; Chromatography; Cytosine; DNA, Neoplasm; Floxuridine; Injections, | 1971 |
In vitro effect of a 5-fluorodeoxyuridine albumin conjugate on tumour cells and on peritoneal macrophages.
Topics: Animals; Carbodiimides; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; | 1974 |