floxuridine has been researched along with Disease Models, Animal in 28 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Docetaxel and capecitabine are being prescribed for the treatment of breast cancer." | 7.71 | Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models. ( Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T, 2001) |
| "To evaluate the antitumor efficacy against metastatic breast cancer of fluoropyrimidines alone and combined with other chemotherapeutic agents, we developed a murine model of breast cancer metastatic to the lung by orthotopically implanting MDA-MB-435S breast tumors into mice." | 5.31 | [Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]. ( Fujioka, A; Fukushima, M; Nakagawa, F; Nukatsuka, M; Ohshimo, H, 2002) |
| "We have investigated the effect of istradefylline on depression-like behaviors using the rat learned helplessness (LH) model." | 3.80 | Antidepressant activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) on learned helplessness in rats. ( Jenner, P; Kanda, T; Kobayashi, M; Mori, A; Ohta, T; Shiozaki, S; Yamada, K, 2014) |
| "Hepatic intra-arterial infusion chemotherapy of 5-fluorouracil (5-FU) or fluorodeoxyuridine (FUDR) has been a treatment option for liver metastasis from colorectal cancer." | 3.72 | Pharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model. ( Ishikawa, K; Makuuchi, H; Masuda, T; Murayama, C; Nakamura, T; Sadahiro, S; Suzuki, T; Tanaka, Y; Yasuda, S, 2003) |
| "Consistent synergistic interactions of trastuzumab plus carboplatin, 4-hydroxycyclophosphamide, docetaxel, or vinorelbine across a wide range of clinically relevant concentrations in HER2-overexpressing breast cancer cells indicate that these are rational combinations to test in human clinical trials." | 3.72 | Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. ( Beryt, M; Konecny, GE; O'Callaghan, C; Pegram, MD; Pietras, R; Slamon, DJ, 2004) |
| "Docetaxel and capecitabine are being prescribed for the treatment of breast cancer." | 3.71 | Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models. ( Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T, 2001) |
| "Pancreatic ductal adenocarcinoma tumour tissue from genetically engineered mouse models of pancreatic cancer (KP ( FL/FL ) C and KP ( R172H/+) C) was collected after dosing the mice with gemcitabine." | 1.37 | A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy. ( Bapiro, TE; Cook, N; Frese, KK; Goldgraben, MA; Griffiths, JR; Jacobetz, MA; Jodrell, DI; Madhu, B; Olive, KP; Richards, FM; Smith, DM; Tuveson, DA, 2011) |
| "Animals with pancreatic cancer displayed focal uptake of both tracers." | 1.31 | In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model. ( Glatting, G; Greten, FR; Neumaier, B; Reske, SN; Schmid, RM; Seitz, U; Vogg, AT; Wagner, M, 2001) |
| "To evaluate the antitumor efficacy against metastatic breast cancer of fluoropyrimidines alone and combined with other chemotherapeutic agents, we developed a murine model of breast cancer metastatic to the lung by orthotopically implanting MDA-MB-435S breast tumors into mice." | 1.31 | [Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]. ( Fujioka, A; Fukushima, M; Nakagawa, F; Nukatsuka, M; Ohshimo, H, 2002) |
| " 5-fluoro-2'-deoxyuridine is an active drug in the treatment of solid tumours, but with toxic effects on intestine and bone marrow." | 1.30 | Conjugation of 5-fluoro-2'-deoxyuridine with lactosaminated poly-l-lysine to reduce extrahepatic toxicity in the treatment of hepatocarcinomas. ( Busi, C; Derenzini, M; Di Stefano, G; Fiume, L; Trerè, D, 1998) |
| " These dose-response data indicate that locally recurrent tumors are frequently, but not always, different from the original primary tumor in response to chemotherapy agents and ionizing X-irradiation." | 1.27 | Development and characterization of a rat model for locally recurring mammary tumors: sensitivities to 5-fluoro-2'-deoxyuridine, adriamycin, and X-irradiation. ( Aeed, PA; Estrada, J; Welch, DR, 1988) |
| "Cleft palate was induced in rat foetuses using 5-fluoro-2-desoxyuridine and was associated with greatly decreased mucopolysaccharide synthesis." | 1.26 | Developmental mechanisms in normal and abnormal palate formation with particular reference to the aetiology, pathogenesis and prevention of cleft palate. ( Ferguson, MW, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.29) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Céspedes, MV | 1 |
| Unzueta, U | 1 |
| Aviñó, A | 1 |
| Gallardo, A | 1 |
| Álamo, P | 1 |
| Sala, R | 1 |
| Sánchez-Chardi, A | 1 |
| Casanova, I | 1 |
| Mangues, MA | 1 |
| Lopez-Pousa, A | 1 |
| Eritja, R | 1 |
| Villaverde, A | 1 |
| Vázquez, E | 1 |
| Mangues, R | 1 |
| Wang, H | 1 |
| Zhao, Y | 1 |
| Zhang, Z | 1 |
| Fischer, MA | 1 |
| Smith, JL | 1 |
| Shum, D | 1 |
| Stein, DA | 1 |
| Parkins, C | 1 |
| Bhinder, B | 1 |
| Radu, C | 1 |
| Hirsch, AJ | 1 |
| Djaballah, H | 1 |
| Nelson, JA | 1 |
| Früh, K | 1 |
| Yamada, K | 1 |
| Kobayashi, M | 1 |
| Shiozaki, S | 1 |
| Ohta, T | 1 |
| Mori, A | 2 |
| Jenner, P | 1 |
| Kanda, T | 1 |
| Sun, XE | 1 |
| Sharling, L | 1 |
| Muthalagi, M | 1 |
| Mudeppa, DG | 1 |
| Pankiewicz, KW | 1 |
| Felczak, K | 1 |
| Rathod, PK | 1 |
| Mead, J | 1 |
| Striepen, B | 1 |
| Hedstrom, L | 1 |
| Bapiro, TE | 1 |
| Richards, FM | 1 |
| Goldgraben, MA | 1 |
| Olive, KP | 1 |
| Madhu, B | 1 |
| Frese, KK | 1 |
| Cook, N | 1 |
| Jacobetz, MA | 1 |
| Smith, DM | 1 |
| Tuveson, DA | 1 |
| Griffiths, JR | 1 |
| Jodrell, DI | 1 |
| Yanagi, Y | 1 |
| Tamaki, Y | 1 |
| Inoue, Y | 1 |
| Obata, R | 1 |
| Muranaka, K | 1 |
| Homma, N | 1 |
| Sadahiro, S | 1 |
| Suzuki, T | 1 |
| Ishikawa, K | 1 |
| Tanaka, Y | 3 |
| Masuda, T | 1 |
| Nakamura, T | 1 |
| Yasuda, S | 1 |
| Makuuchi, H | 1 |
| Murayama, C | 1 |
| Pegram, MD | 1 |
| Konecny, GE | 1 |
| O'Callaghan, C | 1 |
| Beryt, M | 1 |
| Pietras, R | 1 |
| Slamon, DJ | 1 |
| Pohlen, U | 1 |
| Rieger, H | 1 |
| Binnenhei, M | 1 |
| Reszka, RC | 1 |
| Buhr, HJ | 1 |
| Berger, G | 1 |
| Ferguson, MW | 1 |
| Arisawa, Y | 1 |
| Sutanto-Ward, E | 1 |
| Fortunato, L | 1 |
| Sigurdson, ER | 1 |
| Kennel, SJ | 1 |
| van Borssum Waalkes, M | 1 |
| Scherphof, GL | 1 |
| Huang, L | 1 |
| Di Stefano, G | 2 |
| Busi, C | 2 |
| Derenzini, M | 2 |
| Trerè, D | 2 |
| Fiume, L | 2 |
| Merle, P | 1 |
| Trepo, C | 1 |
| Cao, S | 1 |
| McGuire, JJ | 1 |
| Rustum, YM | 1 |
| Endo, M | 1 |
| Shinbori, N | 1 |
| Fukase, Y | 1 |
| Sawada, N | 1 |
| Ishikawa, T | 1 |
| Ishitsuka, H | 1 |
| Camerino, A | 1 |
| Morita, T | 1 |
| Matsuzaki, A | 1 |
| Tokue, A | 1 |
| Fujimoto-Ouchi, K | 1 |
| Tominaga, T | 1 |
| Seitz, U | 1 |
| Wagner, M | 1 |
| Vogg, AT | 1 |
| Glatting, G | 1 |
| Neumaier, B | 1 |
| Greten, FR | 1 |
| Schmid, RM | 1 |
| Reske, SN | 1 |
| Smart, T | 1 |
| Nukatsuka, M | 1 |
| Fujioka, A | 1 |
| Nakagawa, F | 1 |
| Ohshimo, H | 1 |
| Fukushima, M | 1 |
| Ishiwata, K | 1 |
| Takahashi, T | 1 |
| Iwata, R | 1 |
| Tomura, M | 1 |
| Tada, M | 1 |
| Itoh, J | 1 |
| Kameyama, M | 1 |
| Ido, T | 1 |
| Welch, DR | 1 |
| Aeed, PA | 1 |
| Estrada, J | 1 |
| Everson, R | 1 |
| Kessel, D | 1 |
| Hall, TC | 1 |
| Goffinet, DR | 1 |
| Brown, JM | 1 |
| Bagshaw, MA | 1 |
| Kaplan, HS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of an All-Oral Combination of Capecitabine (X) and Cyclophosphamide (C) in Patients With Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer[NCT00589901] | Phase 2 | 60 participants (Anticipated) | Interventional | 2006-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for floxuridine and Disease Models, Animal
| Article | Year |
|---|---|
Antiblastic drug targeting to hepatocellular carcinoma cells: a potential therapeutic improvement?
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoco | 1998 |
27 other studies available for floxuridine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Selective depletion of metastatic stem cells as therapy for human colorectal cancer.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Disease Models, Animal; Drug Therapy; Floxurid | 2018 |
Age-dependent effects of floxuridine (FUdR) on senescent pathology and mortality in the nematode Caenorhabditis elegans.
Topics: Age Factors; Animals; Antimetabolites, Antineoplastic; Caenorhabditis elegans; Disease Models, Anima | 2019 |
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DN | 2013 |
Antidepressant activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) on learned helplessness in rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Brain; Depressi | 2014 |
Prodrug activation by Cryptosporidium thymidine kinase.
Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Cryptosporidiosis; Cryptosporidium parvum; Disease | 2010 |
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
Topics: Animals; Antineoplastic Agents; Calibration; Cytidine Triphosphate; Deoxycytidine; Disease Models, A | 2011 |
Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Choroidal Neovascularization; Chroma | 2003 |
Pharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Drug Adminis | 2003 |
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothe | 2004 |
Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.
Topics: Animals; Biological Availability; Blood Flow Velocity; Chromatography, High Pressure Liquid; Disease | 2005 |
Developmental mechanisms in normal and abnormal palate formation with particular reference to the aetiology, pathogenesis and prevention of cleft palate.
Topics: Alligators and Crocodiles; Animals; Cleft Palate; Disease Models, Animal; Female; Floxuridine; Micro | 1981 |
Hepatic artery dexamethasone infusion inhibits colorectal hepatic metastases: a regional antiangiogenic therapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Capillaries; Cell Line; Che | 1995 |
Characterization of organ-specific immunoliposomes for delivery of 3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine in a mouse lung-metastasis model.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Agents; Binding Sites, Antibod | 1995 |
Conjugation of 5-fluoro-2'-deoxyuridine with lactosaminated poly-l-lysine to reduce extrahepatic toxicity in the treatment of hepatocarcinomas.
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Disease Models, Animal; Dr | 1998 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxur | 1999 |
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother | 1999 |
Coupling of 5-fluoro 2'-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases.
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Carriers; Drug | 2001 |
Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Renal Cell; Cell Survival; Deoxyc | 2001 |
Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidi | 2001 |
In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.
Topics: Animals; Cell Division; Disease Models, Animal; Disease Progression; Floxuridine; Fluorodeoxyglucose | 2001 |
Beyond hydroxyurea.
Topics: Animals; Antiviral Agents; Benzamidines; Dipyridamole; Disease Models, Animal; Floxuridine; Fluorour | 1995 |
[Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung].
Topics: Aminoacridines; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brea | 2002 |
Tumor diagnosis by PET: potential of seven tracers examined in five experimental tumors including an artificial metastasis model.
Topics: Animals; Carbon Radioisotopes; Deoxyglucose; Diagnosis, Differential; Disease Models, Animal; Floxur | 1992 |
Development and characterization of a rat model for locally recurring mammary tumors: sensitivities to 5-fluoro-2'-deoxyuridine, adriamycin, and X-irradiation.
Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Femal | 1988 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; N | 1970 |
Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.
Topics: Animals; Brain Neoplasms; Bromine; Carotid Arteries; Catheterization; Craniotomy; Cytidine; Deoxyrib | 1972 |