Page last updated: 2024-11-06

floxuridine and Deficiency, Mental

floxuridine has been researched along with Deficiency, Mental in 8 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
"The main clinical features are mental retardation, typical facial dysmorphism and macroorchidism."2.37[Mental retardation linked to fragility of chromosome X: current knowledge]. ( Auger, M; Giraud, F; Mattei, JF; Mattei, MG, 1984)
" Fibroblast cultures from 10 retarded males expressed fra(X) in a dose-response relationship to increasing concentrations of FUdR."1.27Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression. ( Nielsen, KB; Tommerup, N, 1984)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19908 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hecht, F1
Jacky, PB1
Sutherland, GR1
Jacobs, PA1
Hunt, PA1
Mayer, M1
Wang, JC1
Boss, GR1
Erbe, RW1
Nielsen, KB1
Tommerup, N3
Mattei, JF1
Mattei, MG1
Auger, M1
Giraud, F1
Glover, TW1
Nielssen, KB1
Mikkelsen, M1
Poulsen, H1
Brøndum-Nielsen, K1
von Koskull, H1
Aula, P1
Ammälä, P1
Nordström, AM1
Rapola, J1

Reviews

2 reviews available for floxuridine and Deficiency, Mental

ArticleYear
The fragile X chromosome: current methods.
    American journal of medical genetics, 1982, Volume: 11, Issue:4

    Topics: Cells, Cultured; Chromosome Fragility; Chromosome Mapping; Female; Fibroblasts; Floxuridine; Folic A

1982
[Mental retardation linked to fragility of chromosome X: current knowledge].
    Journal de genetique humaine, 1984, Volume: 32, Issue:3

    Topics: Bromodeoxyuridine; Child; Chromosome Banding; Ear, External; Face; Floxuridine; Folic Acid; Fragile

1984

Other Studies

6 other studies available for floxuridine and Deficiency, Mental

ArticleYear
Expression of the marker (X) (q28) in lymphoblastoid cell lines.
    American journal of human genetics, 1982, Volume: 34, Issue:4

    Topics: Cell Line; Culture Media; Female; Floxuridine; Gene Expression Regulation; Genetic Linkage; Genetic

1982
Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression.
    Human genetics, 1984, Volume: 66, Issue:2-3

    Topics: Adolescent; Adult; Bromodeoxyuridine; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile S

1984
FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.
    American journal of human genetics, 1981, Volume: 33, Issue:2

    Topics: Cells, Cultured; DNA; Female; Floxuridine; Folic Acid; Humans; Intellectual Disability; Lymphocytes;

1981
Marker X chromosome induction in fibroblasts by FUdR.
    American journal of medical genetics, 1981, Volume: 9, Issue:3

    Topics: Adult; Cells, Cultured; Chromosome Fragility; Female; Floxuridine; Humans; Intellectual Disability;

1981
5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.
    Journal of medical genetics, 1981, Volume: 18, Issue:5

    Topics: Cells, Cultured; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Female; Floxuri

1981
Improved technique for the expression of fragile-X in cultured amniotic fluid cells.
    Human genetics, 1985, Volume: 69, Issue:3

    Topics: Adult; Amniotic Fluid; Cells, Cultured; Chromosome Fragility; Diazepam; Female; Floxuridine; Humans;

1985