floxuridine has been researched along with Colonic Neoplasms in 297 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorine-19 NMR spectrometry was used to monitor the metabolism of two antineoplastic fluoropyrimidines, 5-fluorouracil (5FU) and 5'-deoxy-5-fluorouridine (5'dFUrd), in cell cultures of human pancreatic (Capan-1) and colon (HT-29) adenocarcinoma." | 7.67 | Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma. ( Faure, F; Hollande, E; Malet-Martino, MC; Martino, R; Palevody, C; Vialaneix, JP, 1986) |
| "The present study compared the antitumor activities of chemotherapy with 5-fluorouracil (5-FU) and with its prodrug 5'-deoxy-5-fluorouridine (5'-DFUR) in combination with radiotherapy on a solid colon 26 adenocarcinoma in the mouse." | 7.67 | Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with radiation therapy in mice bearing colon 26 adenocarcinoma. ( Ishikawa, T; Ishitsuka, H; Ohkawa, T; Tanaka, Y, 1989) |
| "Parameters for inhibition of thymidylate synthase (TS) in a DMH-induced transplantable rat colon carcinoma were studied after intraperitoneal administration of bolus doxifluridine (5'-dFUR) 200 mg/kg." | 7.67 | Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. ( Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E, 1988) |
| "All patients had metastatic colorectal cancer, with adjuvant or palliative chemotherapy given to six patients (22%) on schedule A and 12 patients on schedule B (41%)." | 6.69 | Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. ( Adam, R; Bismuth, H; Dallemagne, B; Focan, C; Focan-Henrard, D; Jasmin, C; Jehaes, C; Kreutz, F; Levi, F; Lobelle, JP; Markiewicz, S; Misset, JL; Weerts, J, 1999) |
| " The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group." | 6.66 | Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986) |
| "Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma." | 5.27 | Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983) |
| "The figures in patients with breast cancer were: 1,761 days (58." | 3.78 | [Survival and changes of clinical laboratory data in phase II study with 5'-DFUR]. ( Taguchi, T, 1996) |
| " Using a murine dorsal air sac (DAS) assay, we have previously shown that UFT and its metabolites, gamma-hydroxybutyric acid (GHB) and 5-fluorouracil (5-FU), inhibited the angiogenesis induced by murine renal cell carcinoma." | 3.71 | gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor. ( Aoyagi, K; Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K, 2001) |
| "5-Fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR), a prodrug of 5-FU, are representative of the chemotherapeutic agents for colorectal adenocarcinomas." | 3.71 | Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo. ( Iwahashi, M; Nagata, T; Nakamori, M; Yamaue, H, 2002) |
| "2,2'-Anhydro-5-ethyluridine (ANEUR), a potent inhibitor of uridine phosphorylase, markedly potentiated the antitumor activity of fluorouridine (FUR) against murine mammary adenocarcinoma 755 in BDF1 mice and human colon adenocarcinoma LS174T in athymic-nude mice." | 3.68 | Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine. ( De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z, 1990) |
| "Parameters for inhibition of thymidylate synthase (TS) in a DMH-induced transplantable rat colon carcinoma were studied after intraperitoneal administration of bolus doxifluridine (5'-dFUR) 200 mg/kg." | 3.67 | Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. ( Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E, 1988) |
| " In our previous studies with human gastrointestinal and breast cancers xenografted into nude mice, combination therapy with mitomycin C (MMC) and 5'-deoxy-5-fluorouridine (5'-DFUR) [I] or cisplatin (CDDP), vindesine (VDS) and 5'-DFUR [II] produced higher response rates than single-agent therapy with any one of these drugs." | 3.67 | [Effects of alternating chemotherapy with 2 non-cross-resistant drug combinations on human alimentary and breast cancer xenografts in nude mice]. ( Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T; Yamauchi, T, 1987) |
| " Following our former report in which the combination effects of mitomycin C (MMC) and 5'-deoxy-5-fluorouridine (5'-DFUR) were clarified, combined applications of 4 drugs, vindesine (VDS), methotrexate (MTX), cisplatin (CDDP) and 5'-DFUR against 3 lines of human breast cancer (H-62, H-31, H-71), and one line each of gastric cancer (H-55) and colon cancer (H-110) xenografted into nude mice were evaluated in comparison with CAF (cyclophosphamide, adriamycin and 5-FU) therapy which is commonly used for breast cancer." | 3.67 | [Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)]. ( Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T, 1987) |
| "Fluorine-19 NMR spectrometry was used to monitor the metabolism of two antineoplastic fluoropyrimidines, 5-fluorouracil (5FU) and 5'-deoxy-5-fluorouridine (5'dFUrd), in cell cultures of human pancreatic (Capan-1) and colon (HT-29) adenocarcinoma." | 3.67 | Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma. ( Faure, F; Hollande, E; Malet-Martino, MC; Martino, R; Palevody, C; Vialaneix, JP, 1986) |
| "The present study compared the antitumor activities of chemotherapy with 5-fluorouracil (5-FU) and with its prodrug 5'-deoxy-5-fluorouridine (5'-DFUR) in combination with radiotherapy on a solid colon 26 adenocarcinoma in the mouse." | 3.67 | Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with radiation therapy in mice bearing colon 26 adenocarcinoma. ( Ishikawa, T; Ishitsuka, H; Ohkawa, T; Tanaka, Y, 1989) |
| "When given orally in combination with L-cysteine, 5'-deoxy-5-fluorouridine (DFUR) brought about a significant reduction in the growth of adenocarcinoma 755 and a significant prolongation of life-span in mice bearing Lewis lung carcinoma without increased toxicity to the host as compared with DFUR alone, though L-cysteine alone did not show an appreciable antitumor activity." | 3.67 | Enhanced antitumor effect of 5'-deoxy-5-fluorouridine by oral administration with L-cysteine. ( Araki, E; Hoshi, A; Iigo, M; Nakajima, Y, 1989) |
| "Four human head and neck xenograft (HNX) tumour lines grown in nude mice and two murine colon carcinomas (Colon 26 and 38) were tested for their sensitivity to 5-fluorouracil (5-FU) and its prodrug 5'deoxy-5-fluorouridine (Doxifluridine, 5'd-FUR)." | 3.67 | Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes. ( Braakhuis, BJ; de Bruijn, EA; Laurensse, EJ; Peters, GJ; Pinedo, HM; van Walsum, M, 1989) |
| "The action of floxuridine depends greatly on its concentration for treatment of liver metastases of colorectal carcinomas and other tumors." | 3.66 | [Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors]. ( Balch, CM; Urist, MM, 1983) |
| "Patients with stage II or stage III colorectal cancer (CRC) were randomly assigned to receive preoperative hepatic and regional arterial chemotherapy (PHRAC group, n = 110) or surgery alone (control group, n = 112)." | 2.73 | Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery. ( Jianhua, W; Jiemin, C; Li, R; Weixin, N; Xinyu, Q; Xu, J; Yanhan, L; Zhiping, Y; Zhong, Y, 2007) |
| "5-Fluorouracil (5-FU) is a common anticancer agent used in the treatment of solid tumours, with a reported variability in the pharmacokinetic profile and inter-patient differences in efficacy and toxicity." | 2.71 | Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients. ( Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP, 2004) |
| "All patients had metastatic colorectal cancer, with adjuvant or palliative chemotherapy given to six patients (22%) on schedule A and 12 patients on schedule B (41%)." | 2.69 | Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. ( Adam, R; Bismuth, H; Dallemagne, B; Focan, C; Focan-Henrard, D; Jasmin, C; Jehaes, C; Kreutz, F; Levi, F; Lobelle, JP; Markiewicz, S; Misset, JL; Weerts, J, 1999) |
| "Median times to disease progression for the three treatment arms were as follows: 9." | 2.69 | Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore ( Lorenz, M; Müller, HH, 2000) |
| "Patients with 24 advanced gastric cancers and 36 colonic cancers were randomly divided into a preoperatively administered group and a non-administered group." | 2.68 | [Significance of 5'-deoxy-5-fluorouridine (5'-DFUR) administration before surgery for advanced gastric and colonic cancers--activity of pyrimidine nucleoside phosphorylase (PyNPase) and serum immunosuppressive acidic protein (IAP)]. ( Arano, Y; Hirano, M; Ishikawa, N; Kikuchi, T; Kitsukawa, H; Kurokawa, M; Murakami, N; Nagao, S; Saito, H, 1996) |
| "Gastritis was heralded in these patients by epigastric pain and tenderness, nausea, vomiting, weakness, and anorexia." | 2.67 | Gastric mucosal injury after hepatic arterial infusion chemotherapy with floxuridine. A clinical and pathologic study. ( Doria, LK; Doria, MI; Faintuch, J; Levin, B, 1994) |
| " Continuous floxuridine infusion was given at a dosage of 0." | 2.66 | Regional infusion for colorectal hepatic metastases. A randomized trial comparing the hepatic artery with the portal vein. ( Daly, JM; Kemeny, N; Oderman, P; Sigurdson, E; Thom, A, 1987) |
| " The elimination half-life time for 5-FU was protracted by a factor of 2-3 compared with the direct injection of 5-FU." | 2.66 | Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month. ( Aas, M; Flokkmann, A; Fosså, SD; Heier, M; Heintz, R; Linder-Ciccolunghi, S; Moe, B, 1986) |
| " The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group." | 2.66 | Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986) |
| "Doxifluridine is an active agent in colorectal cancer." | 2.66 | A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma. ( Alberto, P; Cavalli, F; Germano, G; Joss, R; Kaplan, S; Martz, G; Mermillod, B; Spati, B; Weber, W, 1988) |
| "No excess mortality from noncolorectal cancers was apparent, nor were there significant differences by treatment: TSPA (22/22), FdUrd (9/12), and surgery only (50/42)." | 2.65 | Late effects of low-dose adjuvant chemotherapy in colorectal cancer. ( Boice, JD; Fraumeni, JF; Greene, MH; Higgins, GA; Keehn, RJ, 1980) |
| "A PR of hepatic metastases was noted in eight patients (35%) with a median and mean duration of response of 4." | 2.64 | Hepatic artery infusion of 5-FUDR after prior systemic 5-fluorouracil. ( Buroker, T; Correa, J; Fraile, R; Samson, M; Vaitkevicius, VK, 1976) |
| "First, HCT116 human colon cancer cells were cultured with PSK and 5-fluorouracil (5-FU) or 5'-deoxy-5-fluorouridine (5'-DFUR) in the presence or absence of PBMCs, and the antiproliferative effects were compared." | 1.39 | Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers. ( Abe, H; Edamatsu, T; Fujieda, A; Fujioka, M; Mekata, E; Murata, S; Naka, S; Shimizu, T; Shiomi, H; Sonoda, H; Tani, T; Umeda, T; Wada, T; Yamamoto, H, 2013) |
| "Two human colon cancer cell lines LOVO and SW480 were cultured and treated with IFN-α2a at a series of dosage, and fluorescence quantitative PCR was carried out to detect the TP mRNA expression levels in these 2 cell lines." | 1.38 | [Influence of interferon-α2a on thymidine phosphorylase expression and anticancer activity of 5'-deoxy-fluorouridine in human colon carcinoma cell lines LOVO and SW480]. ( Wang, QW; Xia, Q; Zhang, JM, 2012) |
| "Tezacitabine is a nucleoside analogue characterized by a dual mechanism of action." | 1.34 | Tezacitabine enhances the DNA-directed effects of fluoropyrimidines in human colon cancer cells and tumor xenografts. ( Aardalen, K; Doyle, L; Hibner, B; Jekic-McMullen, D; Moler, E; Rendahl, K; Salangsang, F; Shao, Y; Taverna, P, 2007) |
| "In the colon cancer cells 5'DFUR degradation varied from 0." | 1.34 | Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines. ( Cricca, S; de Bruin, M; Laan, AC; Peters, GJ; Temmink, OH; Turksma, AW, 2007) |
| "The Hollow Fibre Assay (HFA) is usually applied as an early in vivo model for anti-cancer drug screening, but is potentially an excellent model for short-term in vivo pharmacodynamic studies." | 1.34 | The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. ( Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E, 2007) |
| "In order to develop a model of liver metastasis of human gastrointestinal cancer cells, we examined the potential of 10 human colon and stomach cancer cell lines (HT-29, WiDr, HCT-116, HCT-15, HCC-2998, MKN7, MKN28, MKN45, MKN74 and St-4) to form liver metastases in nude mice." | 1.34 | Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells. ( Ishizu, K; Makuuchi, H; Sadahiro, S; Sunose, N; Tsuruo, T; Yamazaki, K; Yamori, T, 2007) |
| "Fifty-one patients with postoperative colon cancer (mean 61." | 1.33 | Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer. ( Hayakawa, K; Miyake, K; Morimoto, T; Mukaihara, S; Nishino, M, 2005) |
| "We present a colon cancer patient with the UGT1A1 polymorphism (UGT1A1 *28) as a known high risk for irinotecan, who was treated with a combination of doxifluridine and irinotecan for peritoneal dissemination resulting in stable disease for 2 years without adverse reactions, although the patient initially developed severe adverse effects to the combination of the protracted venous infusion of 5-FU and irinotecan." | 1.33 | Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report. ( Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Nakatani, K; Nobori, T; Ojima, E; Toiyama, Y; Watanabe, H, 2006) |
| " Our hypothesis was that a relatively short and high dosage of TAS-102 results in an additional mechanism of FTD incorporation into DNA other than thymidylate synthase (TS) inhibition." | 1.32 | A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA. ( Emura, T; Fukushima, M; Ohshimo, H; Suzuki, N; Yamaguchi, M, 2004) |
| "In a 79-year-old man with ascending colon cancer, multiple liver metastases were detected by computer tomography." | 1.31 | [A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine]. ( Hotokezaka, M; Ishimitsu, T; Matsumoto, S; Nakamura, K; Takeda, S, 2002) |
| "Human MLH1(-) and MMR-deficient HCT116 colon cancer cells were 18-fold more resistant to 7." | 1.31 | Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. ( Boothman, DA; Hwang, HS; Kinsella, TJ; Meyers, M; Wagner, MW, 2001) |
| "We have reported that HT29 colon cancer cells, which are radiosensitized by fluorodeoxyuridine (FdUrd), exhibit a greater increase in cyclin E-dependent kinase activity and progress further into S phase in the presence of FdUrd than do SW620 colon cancer cells, which are only minimally sensitized by this drug (Cancer Res 56: 3203, 1996)." | 1.30 | HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells. ( Axelson, MD; Davis, MA; Ethier, SP; Lawrence, TS, 1999) |
| "The antitumor activity of recombinant human interleukin 2 (rIL-2) in combination with 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR) against marine colon carcinoma 26 (Colon 26) was studied." | 1.30 | Antitumor effects of 5'-deoxy-5-fluorouridine in combination with recombinant human interleukin 2 on murine colon carcinoma 26. ( Fujiwara, K; Gotoh, K; Houkan, T; Midoro, K; Ootsu, K; Yukishige, K, 1997) |
| "A recurrence of colon cancer developed in the left lower lung 16 months after surgery, and 5'-DFUR was administered at a dose of 1,600 mg/body/day." | 1.29 | [A case of pulmonary metastasis from colon cancer successfully treated with high-dose 5'-DFUR]. ( Fujimoto, T; Iihara, K; Kitada, M; Murotani, M; Okumura, Y; Shibata, T; Takada, T; Takami, M; Tsukahara, Y; Watanabe, T, 1995) |
| "A 71-year-old male with recurrent colon cancer was admitted to our hospital with obstructive jaundice." | 1.29 | [A case of recurrent colon cancer treated markedly effective with 5'-DFUR]. ( Hirano, M; Kato, A; Kikkawa, H; Kitagawa, K; Masuda, S; Mori, H; Murakami, N; Oosawa, T; Saito, H; Watanabe, S, 1993) |
| "Modulation of the therapeutic efficacy of cisplatin (CDDP) and 5-fluoro-2'-deoxyuridine (FdUrd) alone and in combination with N-phosphonacetyl-L-aspartate (PALA) was evaluated in mice bearing colon carcinoma (C-26) using a weekly intravenous (i." | 1.29 | Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl-L-aspartate in murine colon carcinoma no. 26. ( Cao, S; Durrani, FA; Mayhew, EG; Peters, GJ; Rustum, YM; Van Laar, JA, 1995) |
| "A woman born in 1924 with colon cancer initially operated on approximately four years ago showed a second recurrence in the lung." | 1.28 | [A case of pulmonary metastasis from colon cancer responding completely to high-dose 5'-DFUR plus MMC combination chemotherapy]. ( Kawahara, T; Kikkawa, N; Kobayakawa, K; Tsuchiya, Y; Tsumura, I, 1991) |
| "In case of breast cancer, it was 10 times higher than normal tissue." | 1.28 | [A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon]. ( Adachi, I; Douden, K; Hayashi, H; Hikishima, H; Iwa, T; Munemoto, Y; Okada, Y; Omura, K; Watanabe, Y, 1990) |
| "injection against mouse colon cancer, colon 26." | 1.28 | [Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis]. ( Fujimaki, M; Kurokawa, M; Kuroki, Y; Ochiai, H; Okamoto, M; Tazawa, K; Yamashita, I, 1991) |
| " When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines." | 1.28 | The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines. ( Boven, E; Haisma, HJ; Maas, IW; Pinedo, HM; Schlüper, HM, 1991) |
| "Three patients with primary hepatocellular carcinoma demonstrated less than 50% reduction in tumor size." | 1.27 | Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump. ( Jones, LS; McCune, CS; Schwartz, SI, 1985) |
| " Further pharmacological studies seem warranted to define the optimal dosage schedule and to obtain a better therapeutic index." | 1.27 | Phase II clinical evaluation of doxifluridine. ( Armand, JP; Bastit, P; Cappelaere, P; Fargeot, P; Fumoleau, P; Hurteloup, P; Keiling, R; Kerbrat, P; Metz, R; Schraub, S, 1986) |
| " The optimal dosage for a phase II study was suggested to be less than 2,100 mg/body/day." | 1.27 | [Phase I study of 5'-deoxy-5-fluorouridine (5'-DFUR)]. ( Furue, H; Kanamaru, R; Kimura, K; Komita, T; Murakami, M; Nakao, I; Ohta, K; Saito, T; Wakui, A; Yokoyama, M, 1985) |
| "Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma." | 1.27 | Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983) |
| " In 10 of these tumors, comparative dose-response curves were obtained." | 1.27 | Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA). ( Flentje, D; Flentje, M; Schlag, P, 1986) |
| "Twenty patients with colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant perioperative therapy that included hepatic arterial mitomycin C and floxuridine (FUDR)." | 1.27 | Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver. ( Ames, FC; Boddie, AW; Charnsangavej, C; Claghorn, LJ; Cleary, KR; Mavligit, GM; McBride, CM; Patt, YZ, 1987) |
| "In patients with metastatic colorectal cancer involving only the liver, hepatic arterial FUDR alone and with the addition of mitomycin C provided excellent control of hepatic tumor." | 1.27 | Regional chemotherapy of colorectal cancer metastatic to the liver. ( Cozzi, E; Ensminger, W; Gyves, J; Niederhuber, JE; Thrall, J; Walker, S, 1984) |
| "Retreatment of patients with colon cancer and liver metastases by hepatic arterial infusion of fluorodeoxyuridine and mitomycin C can result in significant prolongation of survival in patients with response to this treatment." | 1.27 | Effective retreatment of patients with colorectal cancer and liver metastases. ( Chuang, VP; Mavligit, G; Patt, YZ; Peters, RE; Wallace, S, 1983) |
| " With use of these studies, a therapeutic ratio (concentration that prevented 25% clonal growth compared to untreated control of bone marrow divided by LD50 of tumor) was calculated for each drug in each tumor." | 1.27 | 5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. ( Armstrong, RD; Cadman, E, 1983) |
| " Furthermore the differing levels of 5-FU metabolites in normal and malignant tissue could not be correlated with the pharmacokinetic parameters studied." | 1.27 | The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer. ( Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L, 1987) |
| " A dosage of 0." | 1.27 | Long-term hepatic arterial infusion of 5-fluorodeoxyuridine for liver metastases using an implantable infusion pump. ( Boxt, LM; Garnick, MB; Kandarpa, K; Kaplan, WD; Mayer, RJ; Osteen, RT; Schade, D; Steele, GD; Weiss, GR; Wilson, RE, 1983) |
| "Antitumor effects of oral fluorinated pyrimidines including 5'-DFUR and their combination with recombinant interferon (rIFN) alpha A/D (Bgl) or cytostatics were investigated using various tumor models in mice." | 1.27 | [Antitumor effects of 5'-deoxy-5-fluorouridine (5'-DFUR) against various murine tumors in combination with recombinant interferon alpha or cytostatics]. ( Eda, H; Fukuda, H; Ishikawa, T; Ishitsuka, H; Matsuura, N; Miwa, M; Ninomiya, Y; Tanaka, Y, 1987) |
| "The response rate of gastric cancer was 14." | 1.27 | [Phase II study of 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with malignant cancer--a multi-institutional cooperative study]. ( Abe, O; Kimura, K; Kimura, T; Kurihara, M; Nakao, I; Niitani, H; Ohta, K; Saito, T; Urushizaki, I; Yoshida, Y, 1985) |
| "1% of cases; however, it was easily reduced by decreasing the dosage or discontinuing administration of the drug." | 1.27 | [Phase II study of 5'-DFUR in gastrointestinal and breast cancer]. ( Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T, 1985) |
| "Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period." | 1.27 | Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats. ( Berger, MR; Garzon, FT; Keppler, BK; Schmähl, D, 1987) |
| " The frequency of cerebellopathy may depend on the dosage and type of administration of the drug." | 1.27 | Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine. ( Fosså, SD; Heier, MS, 1985) |
| " 5'-DFUR was administered three or four times a day at a daily dosage of 600 to 1200 mg." | 1.27 | [Clinical phase II study of 5'-DFUR for cancer of the digestive organs by a cooperative study group]. ( Gocho, Y; Ishitani, K; Kogo, Y; Kouda, K; Koyama, R; Matsuda, M; Nagai, T; Niitsu, Y; Saijo, N; Urushizaki, I, 1985) |
| "Chemical cholecystitis has been recognized recently as a complication of hepatic artery infusion chemotherapy." | 1.27 | Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy. ( Dakhil, SR; Housholder, DF; Hynes, HE; Marymont, JV, 1985) |
| "Forty patients with colorectal cancer metastatic to the liver were treated with an implanted pump for hepatic artery perfusion." | 1.27 | The implanted pump in metastatic colorectal cancer of the liver. Risk versus benefit. ( Johnson, LP; Rivkin, SE, 1985) |
| "3 microM dThd was sufficient to completely protect sensitive cells from 5-fluoro-2'-deoxyuridine, and 5,8-dideazaisofolic acid at concentrations that produced over 80% lethality in unprotected cells and the same concentration of dThd in combination with 100 microM hypoxanthine fully protected sensitive cells from greater than 99% methotrexate-induced cell lethality." | 1.27 | Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine. ( Bertino, JR; Handschumacher, RE; Sobrero, AF, 1985) |
| "Thirty-five patients with metastatic colon cancer received hepatic arterial FUDR administered with implanted infusion pumps." | 1.27 | Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine. ( Hohn, DC; Lewis, BJ; Price, DC; Stagg, RJ, 1985) |
| "Of 13 patients with hepatoma, nine had clinically significant regression with a median survival of 11 months." | 1.26 | The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol. ( Al-Sarraf, M; Baker, L; Izbicki, R; Reed, ML; Sexon-Porte, M; Singhakowinta, A; Straatsma, GW; Vaitkevicius, VK; Vaughn, CB, 1981) |
| "Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts." | 1.25 | Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 178 (59.93) | 18.7374 |
| 1990's | 74 (24.92) | 18.2507 |
| 2000's | 37 (12.46) | 29.6817 |
| 2010's | 7 (2.36) | 24.3611 |
| 2020's | 1 (0.34) | 2.80 |
| Authors | Studies |
|---|---|
| Suetsugu, T | 1 |
| Mori, R | 1 |
| Futamura, M | 1 |
| Fukada, M | 1 |
| Tanaka, H | 1 |
| Yasufuku, I | 1 |
| Sato, Y | 1 |
| Iwata, Y | 1 |
| Imai, T | 1 |
| Imai, H | 1 |
| Tanaka, Y | 8 |
| Okumura, N | 1 |
| Matsuhashi, N | 1 |
| Takahashi, T | 1 |
| Yoshida, K | 1 |
| Gao, Q | 2 |
| Zhang, JM | 3 |
| Liu, J | 2 |
| Wang, QW | 3 |
| Ye, DJ | 2 |
| Liu, Y | 2 |
| Mekata, E | 1 |
| Murata, S | 1 |
| Sonoda, H | 1 |
| Shimizu, T | 1 |
| Umeda, T | 1 |
| Shiomi, H | 1 |
| Naka, S | 1 |
| Yamamoto, H | 1 |
| Abe, H | 1 |
| Edamatsu, T | 1 |
| Fujieda, A | 1 |
| Fujioka, M | 1 |
| Wada, T | 1 |
| Tani, T | 1 |
| Condie, AG | 1 |
| Yan, Y | 1 |
| Gerson, SL | 1 |
| Wang, Y | 1 |
| Chang, W | 1 |
| Wei, Y | 1 |
| Ren, L | 1 |
| Zhong, Y | 2 |
| Yu, Y | 1 |
| Chen, J | 1 |
| Zhu, D | 1 |
| Ye, L | 1 |
| Qin, C | 1 |
| Zhao, N | 1 |
| Niu, W | 1 |
| Qin, X | 1 |
| Xu, J | 2 |
| Geng, L | 1 |
| Huehls, AM | 1 |
| Wagner, JM | 1 |
| Huntoon, CJ | 1 |
| Karnitz, LM | 1 |
| Xia, Q | 1 |
| Koning, GA | 3 |
| Kamps, JA | 3 |
| Scherphof, GL | 4 |
| Sakaguchi, Y | 1 |
| Kabashima, A | 1 |
| Kuma, S | 1 |
| Kajiyama, K | 1 |
| Fujiwara, S | 2 |
| Noguchi, T | 2 |
| Suehiro, S | 1 |
| Kikuchi, R | 1 |
| Uchida, Y | 1 |
| ETALA, E | 1 |
| SOFIA, V | 1 |
| ROMERO, LM | 1 |
| SULLIVAN, RD | 4 |
| NORCROSS, JW | 1 |
| WATKINS, E | 3 |
| KENNEDY, BJ | 1 |
| ZUREK, WZ | 1 |
| ANSFIELD, FJ | 2 |
| Maruyama, S | 1 |
| Tamiya, Y | 1 |
| Nihei, K | 1 |
| Kitami, C | 1 |
| Casale, F | 1 |
| Canaparo, R | 1 |
| Serpe, L | 1 |
| Muntoni, E | 1 |
| Pepa, CD | 1 |
| Costa, M | 1 |
| Mairone, L | 1 |
| Zara, GP | 1 |
| Fornari, G | 1 |
| Eandi, M | 1 |
| Mimori, K | 1 |
| Ueo, H | 1 |
| Kuroki, T | 1 |
| Shiraishi, T | 1 |
| Creer, S | 1 |
| Taylor, S | 1 |
| Ishii, H | 1 |
| Mori, M | 1 |
| Patel, M | 1 |
| Agarwal, R | 1 |
| Ardalan, B | 1 |
| Emura, T | 1 |
| Suzuki, N | 1 |
| Yamaguchi, M | 1 |
| Ohshimo, H | 1 |
| Fukushima, M | 1 |
| Parsels, LA | 2 |
| Parsels, JD | 2 |
| Tai, DC | 1 |
| Coughlin, DJ | 1 |
| Maybaum, J | 6 |
| Otvös, L | 1 |
| Sági, G | 1 |
| Noordhuis, P | 3 |
| Holwerda, U | 1 |
| Van Laar, JA | 5 |
| Van der Wilt, CL | 4 |
| Peters, GJ | 10 |
| Miyake, K | 1 |
| Hayakawa, K | 1 |
| Nishino, M | 1 |
| Morimoto, T | 1 |
| Mukaihara, S | 1 |
| Kemeny, N | 9 |
| Eid, A | 1 |
| Stockman, J | 2 |
| Gonen, M | 2 |
| Schwartz, L | 2 |
| Tetzlaff, E | 1 |
| Paty, P | 2 |
| Fukuda, Y | 1 |
| Fujio, N | 1 |
| Ihara, T | 1 |
| Takatori, H | 1 |
| Tsukazaki, T | 1 |
| Koyama, I | 1 |
| Tsukazaki, Y | 1 |
| Osugi, H | 1 |
| Tsujie, M | 1 |
| Kida, H | 1 |
| Hayashi, N | 1 |
| Fukuchi, S | 1 |
| Yoshida, T | 1 |
| Ebisui, C | 1 |
| Sakita, I | 2 |
| Hasuike, Y | 1 |
| Fujimoto, T | 2 |
| Alazmi, WM | 1 |
| McHenry, L | 1 |
| Watkins, JL | 1 |
| Fogel, EL | 1 |
| Schmidt, S | 1 |
| Sherman, S | 1 |
| Lehman, GL | 1 |
| Inoue, Y | 1 |
| Miki, C | 1 |
| Watanabe, H | 1 |
| Hiro, J | 1 |
| Toiyama, Y | 1 |
| Ojima, E | 1 |
| Nakatani, K | 1 |
| Nobori, T | 1 |
| Kusunoki, M | 1 |
| Taverna, P | 1 |
| Rendahl, K | 1 |
| Jekic-McMullen, D | 1 |
| Shao, Y | 1 |
| Aardalen, K | 1 |
| Salangsang, F | 1 |
| Doyle, L | 1 |
| Moler, E | 1 |
| Hibner, B | 1 |
| Roybal, JJ | 1 |
| Feliberti, EC | 1 |
| Rouse, L | 1 |
| Wagman, LD | 1 |
| Temmink, OH | 2 |
| de Bruin, M | 1 |
| Turksma, AW | 1 |
| Cricca, S | 1 |
| Laan, AC | 1 |
| Prins, HJ | 1 |
| van Gelderop, E | 1 |
| Weixin, N | 1 |
| Xinyu, Q | 1 |
| Yanhan, L | 1 |
| Li, R | 1 |
| Jianhua, W | 1 |
| Zhiping, Y | 1 |
| Jiemin, C | 1 |
| Ishizu, K | 1 |
| Sunose, N | 1 |
| Yamazaki, K | 1 |
| Tsuruo, T | 1 |
| Sadahiro, S | 1 |
| Makuuchi, H | 1 |
| Yamori, T | 1 |
| Balch, CM | 5 |
| Urist, MM | 4 |
| Patt, YZ | 6 |
| Chuang, VP | 3 |
| Wallace, S | 5 |
| Hersh, EM | 2 |
| Freireich, EJ | 1 |
| Mavligit, GM | 4 |
| Gilbert, JM | 1 |
| Weiss, GR | 1 |
| Garnick, MB | 1 |
| Osteen, RT | 1 |
| Steele, GD | 1 |
| Wilson, RE | 1 |
| Schade, D | 1 |
| Kaplan, WD | 1 |
| Boxt, LM | 1 |
| Kandarpa, K | 1 |
| Mayer, RJ | 1 |
| Au, JL | 4 |
| Rustum, YM | 11 |
| Ledesma, EJ | 1 |
| Mittelman, A | 2 |
| Creaven, PJ | 2 |
| Barone, RM | 2 |
| Byfield, JE | 2 |
| Goldfarb, PB | 1 |
| Frankel, S | 1 |
| Ginn, C | 1 |
| Greer, S | 1 |
| Sommadossi, JP | 1 |
| Aubert, C | 1 |
| Cano, JP | 2 |
| Gouveia, J | 1 |
| Ribaud, P | 1 |
| Mathé, G | 1 |
| McGregor, ML | 1 |
| Armstrong, RD | 2 |
| Cadman, E | 2 |
| Gesmonde, J | 1 |
| Wu, T | 1 |
| Oberfield, RA | 5 |
| Huberman, MS | 1 |
| Peters, RE | 1 |
| Mavligit, G | 1 |
| Walker, JS | 1 |
| Rustum, Y | 1 |
| Soong, SJ | 1 |
| McGregor, M | 1 |
| Bedikian, AY | 1 |
| Niederhuber, JE | 1 |
| Ensminger, W | 1 |
| Gyves, J | 1 |
| Thrall, J | 1 |
| Walker, S | 1 |
| Cozzi, E | 1 |
| Abele, R | 1 |
| Alberto, P | 2 |
| Kaplan, S | 2 |
| Siegenthaler, P | 1 |
| Hofmann, V | 1 |
| Ryssel, HJ | 1 |
| Hartmann, D | 1 |
| Holdener, EE | 1 |
| Cavalli, F | 2 |
| Brückner, R | 2 |
| Rothmund, M | 3 |
| Hinterberger, R | 1 |
| Stagg, RJ | 2 |
| Lewis, BJ | 2 |
| Friedman, MA | 2 |
| Ignoffo, RJ | 1 |
| Hohn, DC | 2 |
| Daly, J | 3 |
| Oderman, P | 3 |
| Shike, M | 2 |
| Chun, H | 1 |
| Petroni, G | 1 |
| Geller, N | 2 |
| Frankel, SS | 1 |
| Sharp, TR | 1 |
| Fujita, F | 4 |
| Fujita, M | 4 |
| Taguchi, T | 7 |
| Hara, Y | 1 |
| Kono, A | 1 |
| Tanaka, M | 1 |
| Trotter, GA | 1 |
| Morgan, GR | 1 |
| Goeting, N | 1 |
| Cooper, AJ | 1 |
| Taylor, I | 1 |
| Hottenrott, C | 1 |
| Lorenz, M | 2 |
| Paolucci, V | 1 |
| Encke, A | 1 |
| Reed, ML | 1 |
| Vaitkevicius, VK | 2 |
| Al-Sarraf, M | 1 |
| Vaughn, CB | 1 |
| Singhakowinta, A | 1 |
| Sexon-Porte, M | 1 |
| Izbicki, R | 1 |
| Baker, L | 1 |
| Straatsma, GW | 1 |
| Boice, JD | 1 |
| Greene, MH | 1 |
| Keehn, RJ | 2 |
| Higgins, GA | 2 |
| Fraumeni, JF | 1 |
| Houghton, JA | 2 |
| Houghton, PJ | 2 |
| Kimball, PM | 1 |
| Brattain, MG | 1 |
| Johnston, S | 1 |
| Benjamin, RS | 1 |
| Valdivieso, M | 1 |
| Hall, DA | 1 |
| Clouse, ME | 2 |
| Gramm, HF | 1 |
| Tilchen, E | 1 |
| McBride, CM | 2 |
| Chuang, V | 1 |
| Mavligit, CM | 1 |
| Kraybill, WG | 1 |
| Saito, H | 3 |
| Okabe, H | 1 |
| Nakano, K | 1 |
| Fujioka, A | 1 |
| Toko, T | 1 |
| Takeda, S | 2 |
| Unemi, N | 1 |
| Arisawa, Y | 1 |
| Sutanto-Ward, E | 1 |
| Fortunato, L | 1 |
| Sigurdson, ER | 3 |
| Mayhew, EG | 1 |
| Cao, S | 2 |
| Durrani, FA | 2 |
| Smid, K | 3 |
| Muggia, FM | 1 |
| Chan, KK | 1 |
| Davis, MA | 4 |
| Tang, HY | 3 |
| Lawrence, TS | 9 |
| Takami, M | 1 |
| Okumura, Y | 1 |
| Takada, T | 1 |
| Kitada, M | 1 |
| Tsukahara, Y | 1 |
| Shibata, T | 1 |
| Murotani, M | 1 |
| Iihara, K | 1 |
| Watanabe, T | 1 |
| Ashour, OM | 1 |
| Naguib, FN | 1 |
| Khalifa, MM | 1 |
| Abdel-Raheem, MH | 1 |
| Panzica, RP | 1 |
| el Kouni, MH | 1 |
| Laurent, PL | 1 |
| Tevaearai, HT | 1 |
| Eliason, JF | 1 |
| Givel, JC | 1 |
| Odartchenko, N | 1 |
| van der Heyden, S | 1 |
| Gheuens, E | 1 |
| van de Vrie, W | 1 |
| Van Bockstaele, D | 1 |
| Van Oosterom, A | 1 |
| Eggermont, A | 1 |
| De Bruijn, EA | 2 |
| Kelsen, DP | 2 |
| Saltz, L | 2 |
| Cohen, AM | 3 |
| Yao, TJ | 1 |
| Enker, W | 1 |
| Tong, W | 2 |
| Tao, Y | 1 |
| Bertino, JR | 5 |
| Wada, M | 1 |
| Jin, H | 1 |
| Kinugasa, A | 1 |
| Shintani, S | 1 |
| Sawada, K | 1 |
| Yamashita, M | 1 |
| Yamamura, M | 1 |
| Nishigami, T | 1 |
| Kano, M | 1 |
| Shimoyama, T | 2 |
| McGinn, CJ | 1 |
| Miller, EM | 2 |
| Lindstrom, MJ | 1 |
| Kunugi, KA | 1 |
| Johnston, PG | 1 |
| Kinsella, TJ | 3 |
| Doria, MI | 2 |
| Doria, LK | 1 |
| Faintuch, J | 3 |
| Levin, B | 4 |
| Zhang, Z | 1 |
| Eda, H | 6 |
| Fujimoto, K | 4 |
| Watanabe, S | 3 |
| Ura, M | 1 |
| Hino, A | 1 |
| Wada, K | 1 |
| Ishitsuka, H | 8 |
| Kikkawa, N | 2 |
| Sakai, K | 2 |
| Irie, K | 2 |
| Terasawa, T | 2 |
| Iwanaga, T | 1 |
| Fukuda, I | 1 |
| Okumura, S | 1 |
| Yasutake, K | 2 |
| Zhang, ZG | 1 |
| Malmberg, M | 1 |
| Yin, MB | 2 |
| Slocum, HK | 2 |
| Ishikawa, T | 4 |
| Ohiwa, T | 1 |
| Tatsuno, K | 1 |
| Hirano, M | 2 |
| Kato, A | 1 |
| Murakami, N | 2 |
| Oosawa, T | 1 |
| Kikkawa, H | 1 |
| Kitagawa, K | 1 |
| Masuda, S | 1 |
| Mori, H | 1 |
| Weber, KL | 1 |
| Merchant, AK | 2 |
| Doroshow, JH | 1 |
| Tsuji, K | 1 |
| Hori, K | 1 |
| Kimura, S | 1 |
| Takagaki, M | 1 |
| Koumoto, T | 1 |
| Andou, T | 1 |
| Nagao, S | 1 |
| Arano, Y | 1 |
| Kikuchi, T | 1 |
| Ishikawa, N | 1 |
| Kurokawa, M | 2 |
| Kitsukawa, H | 1 |
| Midoro, K | 1 |
| Gotoh, K | 1 |
| Houkan, T | 1 |
| Yukishige, K | 1 |
| Fujiwara, K | 1 |
| Ootsu, K | 1 |
| Tazawa, K | 2 |
| Sakamoto, T | 1 |
| Kuroki, Y | 2 |
| Yamashita, I | 2 |
| Okamoto, M | 2 |
| Katuyama, S | 1 |
| Fujimaki, M | 2 |
| Nishimura, G | 1 |
| Izumi, R | 1 |
| Matsuki, N | 1 |
| Takeyama, S | 1 |
| Konishi, K | 1 |
| Fujita, H | 1 |
| Miyata, R | 1 |
| Sasaki, T | 1 |
| Kojima, Y | 1 |
| Takada, M | 1 |
| Takita, Y | 1 |
| Kanno, M | 1 |
| Ueno, K | 1 |
| Mura, T | 1 |
| Asano, K | 1 |
| Syouji, M | 1 |
| Yamazaki, H | 1 |
| Ooto, T | 1 |
| Ueda, H | 2 |
| Takigawa, Y | 1 |
| Sawa, T | 1 |
| Miyazaki, I | 1 |
| Zellars, RC | 1 |
| Loney, TL | 1 |
| Clarke, MF | 1 |
| Okamura, A | 1 |
| Ohmura, Y | 1 |
| Islam, MM | 1 |
| Tagawa, M | 1 |
| Horitsu, K | 1 |
| Moriyama, Y | 1 |
| Fujimura, S | 1 |
| Ishida, Y | 1 |
| Ohtoshi, M | 1 |
| Yamasaki, Y | 1 |
| Henmi, K | 1 |
| Kaneko, I | 1 |
| Shibagaki, F | 1 |
| Nakamoto, M | 1 |
| Soda, M | 1 |
| Iwai, N | 1 |
| Ono, S | 2 |
| Matsumoto, S | 2 |
| Yamasaki, T | 1 |
| Nabeyama, A | 1 |
| Takao, K | 1 |
| Huang, Y | 1 |
| Waxman, S | 1 |
| Pinedo, HM | 6 |
| Ren, Q | 1 |
| Kao, V | 1 |
| Grem, JL | 2 |
| Ter, RB | 1 |
| Infantolino, A | 1 |
| Leite, LP | 1 |
| Ahtaridis, G | 1 |
| Evrard, A | 1 |
| Cuq, P | 1 |
| Robert, B | 1 |
| Vian, L | 1 |
| Pèlegrin, A | 1 |
| Sumimura, J | 1 |
| Morimoto, Y | 1 |
| Miyazaki, M | 1 |
| Ishikawa, S | 1 |
| Nagai, I | 1 |
| Kanyama, H | 1 |
| Tomita, N | 1 |
| Yamano, T | 1 |
| Miyoshi, Y | 1 |
| Ohue, M | 1 |
| Fujiwara, Y | 1 |
| Sekimoto, M | 1 |
| Tamaki, Y | 1 |
| Monden, M | 1 |
| Focan, C | 1 |
| Levi, F | 1 |
| Kreutz, F | 1 |
| Focan-Henrard, D | 1 |
| Lobelle, JP | 1 |
| Adam, R | 1 |
| Dallemagne, B | 1 |
| Jehaes, C | 1 |
| Markiewicz, S | 1 |
| Weerts, J | 1 |
| Bismuth, H | 1 |
| Jasmin, C | 1 |
| Misset, JL | 1 |
| Morselt, HW | 1 |
| Velinova, MJ | 1 |
| Donga, J | 1 |
| Gorter, A | 2 |
| Allen, TM | 1 |
| Zalipsky, S | 1 |
| Müller, HH | 1 |
| Hussey, HJ | 1 |
| Todorov, PT | 1 |
| Field, WN | 1 |
| Inagaki, N | 1 |
| Tisdale, MJ | 1 |
| Muto, A | 1 |
| Miyazawa, M | 1 |
| Kashimura, S | 1 |
| Kanzaki, N | 1 |
| Kawahara, Y | 1 |
| Sato, M | 1 |
| Kanno, A | 1 |
| Ashino, Y | 1 |
| Burke, R | 1 |
| Axelson, MD | 1 |
| Ethier, SP | 1 |
| Sasaki, K | 1 |
| Takasaka, H | 1 |
| Kawasaki, H | 1 |
| Oono, K | 1 |
| Nakayama, I | 1 |
| Matsunaga, T | 1 |
| Takaoka, A | 1 |
| Aoki, S | 1 |
| Hamamatsu, C | 1 |
| Hirayama, T | 1 |
| Nakagawa, N | 1 |
| Shibata, K | 1 |
| Yabana, T | 1 |
| Yamamoto, Y | 1 |
| Hirata, K | 1 |
| Sullivan, D | 1 |
| Benedetti, F | 1 |
| Fong, Y | 1 |
| Jarnagin, W | 1 |
| Bertino, J | 1 |
| Meyers, M | 1 |
| Wagner, MW | 1 |
| Hwang, HS | 1 |
| Boothman, DA | 1 |
| Marchetti, S | 1 |
| Chazal, M | 1 |
| Dubreuil, A | 1 |
| Fischel, JL | 1 |
| Etienne, MC | 1 |
| Milano, G | 1 |
| Ogata, Y | 1 |
| Sasatomi, T | 1 |
| Araki, Y | 1 |
| Ishibashi, N | 1 |
| Nozoe, Y | 1 |
| Miyagi, Y | 1 |
| Nakagawa, M | 1 |
| Matono, K | 1 |
| Kishimoto, Y | 1 |
| Hayashi, A | 1 |
| Mituoka, M | 1 |
| Konishi, J | 1 |
| Shirouzu, K | 1 |
| Lowy, AM | 1 |
| Culliford, AT | 1 |
| Brooks, AD | 1 |
| Sharma, S | 1 |
| Saltz, LB | 1 |
| Schwartz, GK | 1 |
| O'Reilly, EM | 1 |
| Ilson, DH | 1 |
| Kemeny, NE | 1 |
| Guillem, JG | 1 |
| Wong, WD | 1 |
| Paty, PB | 1 |
| Basaki, Y | 1 |
| Chikahisa, L | 1 |
| Aoyagi, K | 1 |
| Miyadera, K | 1 |
| Yonekura, K | 1 |
| Hashimoto, A | 1 |
| Okabe, S | 1 |
| Wierzba, K | 1 |
| Yamada, Y | 1 |
| Nagata, T | 1 |
| Nakamori, M | 1 |
| Iwahashi, M | 1 |
| Yamaue, H | 1 |
| Hotokezaka, M | 1 |
| Ishimitsu, T | 1 |
| Nakamura, K | 1 |
| Fritze, D | 1 |
| Kern, DH | 1 |
| Drogemuller, CR | 1 |
| Pilch, YH | 1 |
| Woolley, PV | 1 |
| Macdonald, JS | 1 |
| Schein, PS | 1 |
| Buroker, T | 1 |
| Samson, M | 1 |
| Correa, J | 1 |
| Fraile, R | 1 |
| Brockman, RW | 1 |
| Shaddix, SC | 1 |
| Rose, LM | 1 |
| Herbsman, H | 1 |
| Hassan, A | 1 |
| Gardner, B | 1 |
| Harshaw, D | 1 |
| Bohorquez, J | 1 |
| Alfonso, A | 1 |
| Newman, J | 1 |
| Danhauser, L | 1 |
| Wang, G | 1 |
| Bland, KI | 1 |
| Garrison, RN | 1 |
| Knutson, CO | 1 |
| McCaffrey, JA | 1 |
| Polio, J | 1 |
| Hamilton, T | 1 |
| Moertel, CG | 3 |
| Iigo, M | 5 |
| Nishikata, K | 2 |
| Hoshi, A | 2 |
| Daemen, T | 1 |
| Regts, J | 1 |
| Morselt, H | 1 |
| Canman, CE | 1 |
| Normolle, DP | 2 |
| Krauer, KG | 1 |
| McKenzie, IF | 1 |
| Pietersz, GA | 1 |
| Chu, E | 1 |
| Chu, MY | 1 |
| Darnowski, JW | 1 |
| Chen, ZH | 1 |
| Pan, BC | 1 |
| Chu, SH | 1 |
| Aschele, C | 2 |
| Sobrero, A | 3 |
| Faderan, MA | 1 |
| Cloos, J | 1 |
| Tanaka, T | 1 |
| Nozue, M | 1 |
| Todoroki, T | 1 |
| Fukuda, S | 1 |
| Miyamoto, H | 1 |
| Kawai, Y | 1 |
| Iwasaki, Y | 1 |
| Maeda, H | 1 |
| Miyamoto, T | 1 |
| Mochinaga, N | 1 |
| Tsunoda, T | 1 |
| Ochiai, H | 1 |
| Maas, IW | 1 |
| Boven, E | 1 |
| Schlüper, HM | 1 |
| Haisma, HJ | 1 |
| McKeever, PE | 1 |
| Stetson, PL | 1 |
| Ensminger, WD | 1 |
| Moran, RG | 1 |
| Scanlon, KL | 1 |
| Heimburger, DK | 1 |
| Shewach, DS | 2 |
| Tsuchiya, Y | 1 |
| Tsumura, I | 1 |
| Kobayakawa, K | 1 |
| Kawahara, T | 2 |
| Zeiss, J | 1 |
| Merrick, HW | 1 |
| Savolaine, ER | 1 |
| Woldenberg, LS | 1 |
| Kim, K | 1 |
| Schlembach, PJ | 1 |
| Nakajima, Y | 2 |
| Szinai, I | 1 |
| Veres, Z | 1 |
| Szabolcs, A | 1 |
| De Clercq, E | 2 |
| Matherly, LH | 1 |
| Czajkowski, CA | 1 |
| Muench, SP | 1 |
| Psiakis, JT | 1 |
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| de Graaf, SS | 1 |
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| Guglielmi, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective,Randomized Control Trial of Intraoperative Intraportal Chemotherapy (5-FU and Oxaliplatin) Combined With Adjuvant Chemotherapy to Prevent Liver Metastasis in Patients Receiving Curative Colorectal Cancer Resection.[NCT01972503] | Phase 4 | 300 participants (Anticipated) | Interventional | 2008-06-30 | Recruiting | ||
| A Phase I/II Trial of TS-1 and Oxaliplatin in Patients With Advanced Colorectal Cancer[NCT00531245] | Phase 1/Phase 2 | 77 participants (Anticipated) | Interventional | 2006-08-31 | Completed | ||
| Efficacy and Safety of Trifluridine/Tipiracil in Combination With Irinotecan as a Second Line Therapy in Patients With Cholangiocarcinoma[NCT04059562] | Phase 2 | 28 participants (Anticipated) | Interventional | 2021-10-28 | Active, not recruiting | ||
| Phase II Trial of TAS-102 in Patients With Advanced, Refractory Pancreatic Adenocarcinoma[NCT04923529] | Phase 2 | 28 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| A Phase I Trial of Isolated Hepatic Perfusion With Oxaliplatin Followed by Hepatic Arterial Infusion of FUDR and Leucovorin for Patients With Unresectable Colorectal Liver Metastases[NCT01042691] | Phase 1 | 10 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| A Humanitarian Device Exemption Use Protocol of Therasphere® for Treatment of Unresectable Hepatocellular and Metastatic Liver Tumors - HDE #980006[NCT00701168] | 0 participants | Expanded Access | No longer available | ||||
| A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver[NCT00001576] | Phase 1 | 28 participants | Interventional | 1997-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for floxuridine and Colonic Neoplasms
| Article | Year |
|---|---|
[CHEMOTHERAPY BY PERFUSION FOR CANCER OF THE STOMACH AND COLON].
Topics: Antimetabolites; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Cyclophosphamide; Flox | 1963 |
Intraarterial hepatic infusion chemotherapy in metastatic liver cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusio | 1983 |
Comparison of systemic chemotherapy with hepatic arterial infusion in metastatic colorectal carcinoma.
Topics: Antineoplastic Agents; Catheterization; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; F | 1983 |
Regional and systemic chemotherapy for advanced colorectal cancer. A review.
Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; D | 1983 |
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridin | 1984 |
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Art | 1983 |
Treatment of liver metastasis from colon cancer.
Topics: Catheterization; Colonic Neoplasms; Floxuridine; Hepatic Artery; Humans; Liver Neoplasms; Mitomycins | 1981 |
5-Fluoro-2'-deoxyuridine: role of schedule in its therapeutic efficacy.
Topics: Animals; Cell Division; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Tumor | 1993 |
Biochemical modulation of fluoropyrimidines: is there an optimal (6R,S) leucovorin dose and schedule?
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Colorectal Neoplasms; Floxuridine; Fluo | 1996 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; | 1996 |
Chemotherapy of colorectal carcinoma.
Topics: Administration, Oral; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Drug Administration Sche | 1976 |
Colorectal liver metastases: is 'no treatment' still best?
Topics: Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; Rectal Neoplasms | 1989 |
Treatment of colorectal hepatic metastases.
Topics: Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; F | 1985 |
[Chemotherapy of cancer of the rectum and the colon].
Topics: Antimetabolites; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, I | 1970 |
Chemotherapy of residual disease in solid tumours.
Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lun | 1971 |
33 trials available for floxuridine and Colonic Neoplasms
| Article | Year |
|---|---|
Randomized Controlled Trial of Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chem | 2016 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Adminis | 2004 |
Hepatic arterial infusion of floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dexamethasone; Dose- | 2005 |
Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocol | 2007 |
Adjuvant chemotherapy of large bowel cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxu | 1982 |
A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; | 1983 |
Late effects of low-dose adjuvant chemotherapy in colorectal cancer.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Hu | 1980 |
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Th | 1994 |
Gastric mucosal injury after hepatic arterial infusion chemotherapy with floxuridine. A clinical and pathologic study.
Topics: Adult; Aged; Biopsy; Colonic Neoplasms; Female; Floxuridine; Gastric Mucosa; Gastritis; Hepatic Arte | 1994 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; | 1996 |
[Significance of 5'-deoxy-5-fluorouridine (5'-DFUR) administration before surgery for advanced gastric and colonic cancers--activity of pyrimidine nucleoside phosphorylase (PyNPase) and serum immunosuppressive acidic protein (IAP)].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colonic Neoplasms; Drug | 1996 |
[Comparative study of 5'-DFUR administration in patients with elderly cancer].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Colonic Neoplasms; Female; Floxuridine; Humans; Male | 1998 |
Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Clocks; Colonic Neoplasms; C | 1999 |
Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy P | 2000 |
Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Ca | 2001 |
Hepatic artery infusion of 5-FUDR after prior systemic 5-fluorouracil.
Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Injection | 1976 |
[Requirements for the randomized trial of i.a. vs. i.v. administration to reveal the impact of hepatic arterial infusion on survival in the treatment of liver metastases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female; Floxuri | 1990 |
[Clinical trial of 5'-DFUR against various malignant tumors].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Drug Adm | 1985 |
Results of a prospective randomized trial of continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Hepatectomy; Hepatic Artery; Humans; Infus | 1986 |
Treatment of colorectal hepatic metastases by intrahepatic chemotherapy alone or as an adjuvant to complete or partial removal of metastatic disease.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Embolization, T | 1986 |
[Regional chemotherapy of liver metastases of colorectal carcinoma using implanted gas pressure pumps. Results of a prospective phase II study].
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human | 1986 |
Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd).
Topics: Adult; Aged; Brain Diseases; Carcinoid Tumor; Carcinoma; Cerebellar Diseases; Colonic Neoplasms; Ele | 1986 |
Systemic infusional chemotherapy for liver metastasis: an improved schedule for 5-fluorouracil.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil | 1986 |
Preliminary results of a randomized study of intrahepatic infusion versus systemic infusion of 5-fluoro-2'-deoxyuridine for metastatic colorectal carcinoma.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, | 1986 |
Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month.
Topics: Adenocarcinoma; Antineoplastic Agents; Cecal Neoplasms; Colonic Neoplasms; Drug Evaluation; Drug Tol | 1986 |
Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. A randomized trial.
Topics: Adenocarcinoma; Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepat | 1987 |
Regional infusion for colorectal hepatic metastases. A randomized trial comparing the hepatic artery with the portal vein.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Fl | 1987 |
A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases.
Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Infusions, I | 1987 |
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Sc | 1987 |
A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxurid | 1988 |
Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infu | 1988 |
Hepatic infusional chemotherapy in metastatic colorectal carcinoma and hepatoma.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuri | 1985 |
Biliary sclerosis in patients receiving hepatic arterial infusions of floxuridine.
Topics: Aged; Bile Ducts; Cholangiography; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; I | 1985 |
250 other studies available for floxuridine and Colonic Neoplasms
| Article | Year |
|---|---|
Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; C | 2021 |
[Effect of thymidine phosphorylase cDNA transfection on the inhibition of human colon carcinoma cell line by 5'-deoxy-5-fluorouridine].
Topics: Cell Line, Tumor; Colonic Neoplasms; DNA, Complementary; Floxuridine; Humans; Thymidine Phosphorylas | 2013 |
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Topics: Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fl | 2013 |
[Enhanced anticancer effects of 5'-DFUR on colorectal cancer cell lines SW480 and LOVO by transfection with thymidine phosphorylase cDNA].
Topics: Cell Line, Tumor; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Tra | 2013 |
A Fluorescent Probe to Measure DNA Damage and Repair.
Topics: Animals; Base Pairing; Base Sequence; Binding Sites; Cattle; Cell Line, Tumor; Colonic Neoplasms; DN | 2015 |
Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumo | 2011 |
[Influence of interferon-α2a on thymidine phosphorylase expression and anticancer activity of 5'-deoxy-fluorouridine in human colon carcinoma cell lines LOVO and SW480].
Topics: Cell Line, Tumor; Colonic Neoplasms; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Reco | 2012 |
Efficient intracellular delivery of 5-fluorodeoxyuridine into colon cancer cells by targeted immunoliposomes.
Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Carriers; Endocytos | 2002 |
[A case of liver metastasis of colon cancer demonstrating complete remission with combination chemotherapy of 5'-DFUR and MMC].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Combined Modalit | 2003 |
[A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
Topics: Adenocarcinoma; Adjuvants, Immunologic; Aged; Antimetabolites, Antineoplastic; Cimetidine; Colonic N | 2003 |
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colo | 1964 |
CHEMOTHERAPY OF COLON CANCER.
Topics: Androgens; Colonic Neoplasms; Cortisone; Floxuridine; Fluorouracil; Hydrochlorothiazide; Pyrimidines | 1964 |
PROTRACTED ARTERIAL INFUSION CANCER CHEMOTHERAPY.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Colonic Neop | 1964 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exf | 1964 |
A LESS TOXIC FLUOROURACIL DOSAGE SCHEDULE.
Topics: Alopecia; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Eruptions; Epistaxis; Female; Floxurid | 1964 |
[A case of multiple liver metastases of colon cancer with PyNPase-positive successfully treated with 5'-DFUR].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colectomy; Colonic Neoplasms; Combined Modali | 2003 |
Prediction of 5'-deoxy-5-fluorouridine sensitivity in colorectal cancer cases by thymidine phosphorylase activity and preliminary identification of susceptibility related genes.
Topics: Aged; Antimetabolites, Antineoplastic; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Colorecta | 2004 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cam | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neop | 2004 |
5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Topics: Antimetabolites, Antineoplastic; cdc25 Phosphatases; Cell Cycle; Cell Death; Cell Line, Tumor; Check | 2004 |
[Antisense oligonucleotides with antitumor activity].
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Deoxyuridine; Fibrosarco | 2004 |
A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA; Drug Screening A | 2004 |
Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chi-Square | 2005 |
[A case of advanced gastric cancer with direct invasion of the transverse colon responding to paclitaxel/5'-DFUR combined therapy].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Colon, Transverse; Coloni | 2005 |
[A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Ant | 2005 |
Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy.
Topics: Adult; Aged; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreat | 2006 |
Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Floxu | 2006 |
Tezacitabine enhances the DNA-directed effects of fluoropyrimidines in human colon cancer cells and tumor xenografts.
Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; DNA; DNA Damage; Floxuridine; Fluorou | 2007 |
Pump removal in infected patients with hepatic chemotherapy pumps: when is it necessary?
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colonic Neoplasms; Device Removal; | 2006 |
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Huma | 2007 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neopla | 2007 |
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptot | 2007 |
[Intra-arterial chemotherapy using an implantable infusion pump in liver metastases of colorectal tumors and hepatomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxoru | 1984 |
The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver.
Topics: Antineoplastic Agents; Colonic Neoplasms; Embolization, Therapeutic; Floxuridine; Gelatin Sponge, Ab | 1981 |
Long-term hepatic arterial infusion of 5-fluorodeoxyuridine for liver metastases using an implantable infusion pump.
Topics: Adult; Aged; Anorexia; Colonic Neoplasms; Drug Implants; Evaluation Studies as Topic; Female; Floxur | 1983 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenter | 1982 |
Intra-arterial chemotherapy using an implantable infusion pump and liver irradiation for the treatment of hepatic metastases.
Topics: Adult; Aged; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Drug Admin | 1982 |
Kinetics and metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine, in humans.
Topics: Colonic Neoplasms; Drug Evaluation; Floxuridine; Humans; Isomerism; Kinetics; Neoplasm Metastasis; P | 1983 |
Continuous regional chemotherapy for metastatic colorectal cancer using a totally implantable infusion pump. A feasibility study in 50 patients.
Topics: Colonic Neoplasms; Evaluation Studies as Topic; Floxuridine; Hepatic Artery; Humans; Infusions, Intr | 1983 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; | 1983 |
Cytotoxic activity of 5'-deoxy-5-fluorouridine in cultured human tumors.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Female; | 1983 |
Effective retreatment of patients with colorectal cancer and liver metastases.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; Drug Resistan | 1983 |
Pharmacokinetic studies of 5-fluorouracil and 5'-deoxy-5-fluorouridine in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dimethylhydrazines; Female; Floxur | 1983 |
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality | 1983 |
Regional chemotherapy of colorectal cancer metastatic to the liver.
Topics: Antineoplastic Agents; Catheters, Indwelling; Colonic Neoplasms; Drug Evaluation; Female; Floxuridin | 1984 |
[Phase II study of FF-705 by Clinical Cooperative Study Group].
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Capsules; Colonic Neoplasms; Drug Administratio | 1984 |
Phase II study of doxifluridine in advanced colorectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms | 1983 |
[Local infusion therapy in liver metastases of colorectal cancers. Results of a phase-II study].
Topics: Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusio | 1984 |
Hepatic artery pump infusion: toxicity and results in patients with metastatic colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusio | 1984 |
Treatment with combined intra-arterial 5-FUdR infusion and whole-liver radiation for colon carcinoma metastatic to the liver. Preliminary results.
Topics: Adult; Colonic Neoplasms; Combined Modality Therapy; Drug Implants; Evaluation Studies as Topic; Flo | 1984 |
[Effects of 5'-deoxy-5-fluorouridine on human gastrointestinal and breast cancers xenografted to nude mice].
Topics: Adenocarcinoma; Administration, Oral; Animals; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Femal | 1984 |
[Measurement of 5'-deoxy-5-fluorouridine (5'-DFUR) by high-performance liquid chromatography and studies on pharmacokinetics of 5'-DFUR and 5-fluorouracil by oral and intravenous administration].
Topics: Administration, Oral; Aged; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Floxuri | 1984 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine | 1984 |
[New possibilities in the treatment of hepatic metastasis of colo-rectal carcinomas].
Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Rectal Neoplasms | 1984 |
The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol.
Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra- | 1981 |
[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors].
Topics: Carcinoma, Hepatocellular; Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepa | 1983 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate | 1980 |
Isolation of a cellular subpopulation from a human colonic carcinoma cell line.
Topics: Animals; Carcinoembryonic Antigen; Cell Division; Cell Line; Cells, Cultured; Colonic Neoplasms; Dru | 1980 |
Percutaneous hepatic arterial infusion (HAI) of mitomycin C and floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver.
Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human | 1980 |
Gastroduodenal ulceration after hepatic arterial infusion chemotherapy.
Topics: Adenocarcinoma; Colonic Neoplasms; Duodenal Ulcer; Female; Floxuridine; Hepatic Artery; Humans; Infu | 1981 |
Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.
Topics: Adenocarcinoma; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; M | 1981 |
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--growth-inhibitory activity of combination against human tumor xenograft].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols | 1995 |
Hepatic artery dexamethasone infusion inhibits colorectal hepatic metastases: a regional antiangiogenic therapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Capillaries; Cell Line; Che | 1995 |
Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl-L-aspartate in murine colon carcinoma no. 26.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colonic Neoplasms | 1995 |
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Topics: Animals; Biotransformation; Cell Line; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; | 1994 |
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials, Phase I as | 1995 |
Dependence of fluorodeoxyuridine-mediated radiosensitization on S phase progression.
Topics: Cell Separation; Cell Survival; Colonic Neoplasms; DNA Repair; Floxuridine; Humans; In Vitro Techniq | 1995 |
[A case of pulmonary metastasis from colon cancer successfully treated with high-dose 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Agents; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug | 1995 |
Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside.
Topics: Animals; Barbiturates; Colonic Neoplasms; Drug Synergism; Female; Floxuridine; Humans; Immunosuppres | 1995 |
Interferon alpha and 5'-deoxy-5-fluorouridine in colon cancer: effects as single agents and in combination on growth of xenograft tumours.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Floxuridine; Fluoroura | 1994 |
5'-Deoxy-5-fluorouridine increases daunorubicin uptake in multidrug-resistant cells and its activity is related with P-gp 170 expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colon | 1994 |
Simultaneous occurrence of adenomas in stomach, duodenal bulb, and colon: disappearance of gastric and duodenal adenomas during oral administration of 5'-deoxy-5-fluorouridine.
Topics: Adenoma; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Colonic Neoplasms; Duodenal Neoplas | 1994 |
The role of cell cycle redistribution in radiosensitization: implications regarding the mechanism of fluorodeoxyuridine radiosensitization.
Topics: Cell Cycle; Cell Survival; Colonic Neoplasms; Demecolcine; Floxuridine; Humans; Mimosine; Nitrous Ox | 1994 |
Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Antineoplastic Agents; Blotting, Northern; Cell Division; Colonic Neoplasms; Cytokines; Depression, | 1993 |
[Combination therapy of high dose doxifluridine (5'-DFUR)+mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5'-DFUR with Other Drugs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms | 1993 |
Antitumor activity of the weekly intravenous push schedule of 5-fluoro-2'-deoxyuridine +/- N-phosphonacetyl-L-aspartate in mice bearing advanced colon carcinoma 26.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Cytidine Triphosphate; Dose-Respon | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Flu | 1993 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relations | 1993 |
[A case of recurrent colon cancer treated markedly effective with 5'-DFUR].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Humans; Liver Neo | 1993 |
Dependence of fluorodeoxyuridine-induced cytotoxicity and megabase DNA fragment formation on S phase progression in HT29 cells.
Topics: Antimetabolites, Antineoplastic; Base Composition; Cell Cycle; Cell Separation; Cell Survival; Colon | 1996 |
[A case of effective chemotherapy by combination of 5'-DFUR and MMC for recurrent colon cancer with multiple liver metastasis].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Drug A | 1996 |
Antitumor effects of 5'-deoxy-5-fluorouridine in combination with recombinant human interleukin 2 on murine colon carcinoma 26.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Colonic Neoplasms; Drug Therapy, Combinati | 1997 |
Inhibitory effects of fluorinated pyrimidines, 5'-DFUR, UFT and T-506, in a model of hepatic metastasis of mouse colon 26 adenocarcinoma-assessment of inhibitory activity and adverse reactions at the maximum tolerated dose.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Dose-Response Relati | 1997 |
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Extracellular Matrix; Female; Floxuridine; Hu | 1997 |
Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Colonic Neoplasms; DNA Damage; Electrophoresis | 1997 |
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cachexia; Colonic Neoplasms; Floxuridine; Liver; Methyltransferases; Mice; | 1998 |
Enhanced growth inhibition and differentiation of fluorodeoxyuridine-treated human colon carcinoma cells by phenylbutyrate.
Topics: Alkaline Phosphatase; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Colonic | 1998 |
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridyla | 1996 |
Cytotoxicity and DNA fragmentation associated with sequential gemcitabine and 5-fluoro-2'-deoxyuridine in HT-29 colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Colonic | 1998 |
Gastrointestinal ulceration and hemorrhage from hepatic arterial infusion chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Colectomy; Colonic Neoplasms; Duodenal Ulcer; Endoscopy, Dige | 1999 |
Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: in vitro and in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Drug Synergism; Floxuridine; | 1999 |
[Comparative study of 5'-deoxy-5-fluorouridine between older cancer patients versus younger cancer patients].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Colonic Neopla | 1999 |
Enhancement of the anti-tumor effect of 5'-deoxy-5-fluorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Feasibility Studies; F | 1999 |
Selective transfer of a lipophilic prodrug of 5-fluorodeoxyuridine from immunoliposomes to colon cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Agents; Colonic Neoplasms; Dru | 1999 |
Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Cell Division; Cholesterol; Colonic Neoplasms; Drug C | 1999 |
Effect of a fluorinated pyrimidine on cachexia and tumour growth in murine cachexia models: relationship with a proteolysis inducing factor.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Appetite Stimulants; Blood Proteins; Body | 2000 |
[A patient with multiple pulmonary metastases from colonic cancer who survived for 5 years by effectual administration of 5'-DFUR].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neopl | 2000 |
Lack of effect of TP53 status on fluorodeoxyuridine-mediated radiosensitization.
Topics: Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Floxuridine; Humans; Radiation To | 2000 |
HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Cyclin E; Cyclin-Dependent Kinase | 1999 |
[Weekly low dose CPT-11 for multiple lung metastases of colon cancer on an out-patient treatment: a case report].
Topics: Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptoth | 2001 |
Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Carrier Proteins; Ce | 2001 |
Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Resistance, Neoplasm; Floxuridine; | 2001 |
[A case of lung metastasis from colon cancer treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neopla | 2001 |
Surgery as adjuvant therapy? The treatment of peritoneal metastases from gastrointestinal malignancy.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Colonic Neopl | 2001 |
Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Ch | 2001 |
gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma; Carc | 2001 |
Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Combined | 2002 |
[A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Administration | 2002 |
A new micromethod for the detection of HL-A antigens on cultured human tumor cells.
Topics: Adenocarcinoma; Antibody Specificity; Colonic Neoplasms; Culture Techniques; Cytotoxicity Tests, Imm | 1975 |
Biochemical aspects of chemotherapy of mouse colon carcinoma: fluoropyrimidines and pyrazofurin.
Topics: Amidophosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcino | 1977 |
Treatment of hepatic metastases with a combination of hepatic artery infusion chemotherapy and external radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Catheterization; Cobalt Radioisotopes; Colonic Neoplasms; Female | 1978 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans | 1979 |
Colorectal carcinoma: overview of management techniques.
Topics: BCG Vaccine; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Radioth | 1979 |
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
Topics: Adenocarcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusi | 1979 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther | 1975 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Div | 1992 |
The effect of liver macrophages on in vitro cytolytic activity of 5FU and FUdR on colon carcinoma cells: evidence of macrophage activation.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adenocarcinoma; Animals; Colonic Neoplasms; Cytotoxicity, Immunol | 1992 |
Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.
Topics: Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug | 1992 |
Antitumor effect of 2'-deoxy-5-fluorouridine conjugates against a murine thymoma and colon carcinoma xenografts.
Topics: Animals; Antibodies, Monoclonal; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; H | 1992 |
Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.
Topics: Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Dose-Resp | 1992 |
Enhancement of 5-fluoro-2'-deoxyuridine antineoplastic activity by 5-benzyloxybenzyloxybenzylacyclouridine in a human colon carcinoma cell line.
Topics: Antimetabolites, Antineoplastic; Cell Division; Cell Line; Colonic Neoplasms; Deoxyuridine; DNA Repl | 1992 |
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kin | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovo | 1992 |
Anticachectic activity of 5'-deoxy-5-fluorouridine in a murine tumor cachexia model, colon 26 adenocarcinoma.
Topics: Acute-Phase Proteins; Adenocarcinoma; Animals; Antineoplastic Agents; Biomarkers, Tumor; Cachexia; C | 1990 |
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; | 1991 |
[5-fluorouracil concentration in gastroenterological tumor tissues, in adjacent normal tissues, and in serum after preoperative oral administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Colonic Neoplasms; Floxuridine; Fluorouracil; Gallbladder Neoplasms; Humans; S | 1991 |
[5-Fluorouracil level and pyrimidine nucleoside phosphorylase activity in cancer patients after oral administration of doxifluridine (5'-DFUR)].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neop | 1991 |
[Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; F | 1991 |
The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines.
Topics: Antibodies, Monoclonal; Carcinoembryonic Antigen; Cell Division; Cell Line; Colonic Neoplasms; Drug | 1991 |
Fluorodeoxyuridine-mediated modulation of iododeoxyuridine incorporation and radiosensitization in human colon cancer cells in vitro and in vivo.
Topics: Animals; Cell Cycle; Colonic Neoplasms; DNA Damage; DNA Repair; DNA, Neoplasm; Dose-Response Relatio | 1991 |
Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid.
Topics: Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Dr | 1991 |
The effect of fluorodeoxyuridine on sublethal damage repair in human colon cancer cells.
Topics: Cobalt Radioisotopes; Colonic Neoplasms; DNA; DNA Repair; DNA, Neoplasm; Floxuridine; Humans; In Vit | 1991 |
[A case of pulmonary metastasis from colon cancer responding completely to high-dose 5'-DFUR plus MMC combination chemotherapy].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic | 1991 |
5'-Deoxy-5-fluorouridine improves cachexia by a mechanism independent of its antiproliferative action in colon 26 adenocarcinoma-bearing mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cachexia; Cell Division; Colonic Neoplasms; Drug Res | 1991 |
Fatty liver change as a result of hepatic artery infusion chemotherapy.
Topics: Colonic Neoplasms; Dose-Response Relationship, Drug; Fatty Liver; Floxuridine; Hepatic Artery; Human | 1990 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Ki | 1990 |
Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Topics: Adenocarcinoma; Animals; Carrier Proteins; Cell Division; Chromatography, Gel; Colonic Neoplasms; Fl | 1990 |
Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Floxuridine; Half-Life; Humans; Injections, Intr | 1990 |
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Colonic Neoplas | 1990 |
Resistance to 5-fluorouracil and 5-fluoro-2'-deoxyuridine mechanisms and clinical implications.
Topics: Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Hum | 1990 |
[Study of tissue drug concentration of fluorinated pyrimidine anticancer drugs--comparison of 5'DFUR and UFT].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colon; Colonic Neoplasms; Dru | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Flo | 1990 |
Effects of FUdR on primary-cultured colon carcinomas metastatic to the liver.
Topics: Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resis | 1990 |
[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Combined Modality Therapy; F | 1990 |
Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells.
Topics: Cell Survival; Colonic Neoplasms; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Floxurid | 1990 |
[The concept of therapy in liver metastases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Humans; Infusions, I | 1985 |
Increased growth inhibition and DNA lesions in human colon adenocarcinoma cells treated with methotrexate or 5-fluorodeoxyuridine followed by calmodulin inhibitors.
Topics: Adenocarcinoma; Bleomycin; Calmodulin; Cell Survival; Colonic Neoplasms; DNA Damage; Floxuridine; Hu | 1988 |
5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole.
Topics: Adenocarcinoma; Colonic Neoplasms; Dipyridamole; DNA; DNA Damage; Floxuridine; Fluorouracil; Humans; | 1989 |
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
Topics: Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Drug Resistance; Female; Floxuridine; | 1989 |
Modulation of 5-fluoro-2'-deoxyuridine response by folinic acid in human colonic tumor cell lines: the role of thymidylate synthase.
Topics: Cell Division; Colonic Neoplasms; Floxuridine; Humans; In Vitro Techniques; Leucovorin; Pteroylpolyg | 1989 |
Enhanced antitumor effect of 5'-deoxy-5-fluorouridine by oral administration with L-cysteine.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Chrom | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Ne | 1989 |
MTX-5-FU combination therapy compared to FUDR monotherapy in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; | 1989 |
[A study of combined chemotherapy with MMC, ADM, CDDP, VP-16 and 5'DFUR (MAC-VD) in advanced cancers of digestive organs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Coloni | 1989 |
Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: implications for the mechanism of this interaction.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Un | 1989 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with radiation therapy in mice bearing colon 26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Colonic Neoplasms; Combined Modality Th | 1989 |
Phase I-II trial of doxifluridine (5'DFUR) administered as long-term continuous infusion using a portable infusion pump for advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Female; Flox | 1989 |
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Topics: Animals; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Head and Ne | 1989 |
Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.
Topics: Cell Line; Cisplatin; Colonic Neoplasms; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replic | 1989 |
Antagonistic effect of polyinosinic-polycytidylic acid on the cell lethality produced by 5-fluorouracil in human colon carcinoma cells in vitro.
Topics: Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Interferons; P | 1985 |
Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump.
Topics: Adenoma, Islet Cell; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Catheterization; Catheters | 1985 |
Predicting tumor response in patients with colorectal hepatic metastases.
Topics: Adult; Aged; Angiography; Blood Flow Velocity; Colonic Neoplasms; Female; Floxuridine; Humans; Liver | 1985 |
[Phase I study of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Colonic Neoplasms; Drug Administ | 1985 |
[Phase II study of 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with malignant cancer--a multi-institutional cooperative study].
Topics: Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Administration | 1985 |
[Phase II study of 5'-DFUR in gastrointestinal and breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarr | 1985 |
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neopla | 1985 |
Hepatic artery infusion chemotherapy for colorectal metastases: a personal experience.
Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans | 1985 |
The implantable "Infusaid" infusion pump. The Sydney experience using 5-fluorouracil.
Topics: Australia; Colonic Neoplasms; Floxuridine; Fluorouracil; Gastrointestinal Hemorrhage; Humans; Infusi | 1986 |
Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement.
Topics: Adult; Cholecystectomy; Cholecystitis; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; | 1986 |
Common duct stricture associated with hepatic artery infusion of FUDR.
Topics: Adenocarcinoma; Colonic Neoplasms; Common Bile Duct Diseases; Constriction, Pathologic; Floxuridine; | 1986 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; | 1986 |
Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer.
Topics: Acute Disease; Adult; Aged; Cimetidine; Colonic Neoplasms; Drug Therapy, Combination; Duodenal Ulcer | 1986 |
Circulating tumor markers and assessment of response to intrahepatic chemotherapy of colon carcinoma.
Topics: Adult; Aged; Antigens, Neoplasm; Antigens, Tumor-Associated, Carbohydrate; Carcinoembryonic Antigen; | 1985 |
Implantable vascular access devices in the treatment of colorectal liver metastases.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arter | 1986 |
Hepatic abscess following hepatic arterial infusion chemotherapy with an implantable pump.
Topics: Adult; Colonic Neoplasms; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Absc | 1986 |
On the differential affinities of two anticancer analogues to their target.
Topics: Adenocarcinoma; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Floxuridine; Fluoro | 1985 |
Cholecystitis secondary to infusion chemotherapy.
Topics: Adult; Cholecystitis; Colonic Neoplasms; Drug Implants; Female; Floxuridine; Hepatic Artery; Humans; | 1986 |
Phase II clinical evaluation of doxifluridine.
Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Diseases; Col | 1986 |
Fluorodeoxyuridine uptake by human colorectal hepatic metastases after hepatic artery infusion.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Int | 1986 |
Hepatic arterial infusion with floxuridine and cisplatin: overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; | 1986 |
Hepatic artery infusion chemotherapy with the Infusaid pump: a Canadian experience.
Topics: Aged; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Female; Floxuridine; Hepatic Arte | 1986 |
Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma.
Topics: Adenocarcinoma; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorine; Fluorouracil; Humans; Mac | 1986 |
[Clinical trial of 5'-deoxy-5-fluorouridine in malignant tumors under cooperative study (phase II study)].
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine; | 1986 |
Causes of jaundice during hepatic artery infusion chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Bile Ducts, Intrahepatic; Colonic Neoplasms; Female; Floxuridine; Human | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug | 1986 |
Follow-up on a prospective study of continuous hepatic perfusion with implantable pump.
Topics: Aged; Aged, 80 and over; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Follow-Up | 1986 |
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxur | 1986 |
[Combination chemotherapy of human gastrointestinal and breast cancer xenografts in nude mice with 5'-deoxy-5-fluorouridine and mitomycin C].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female | 1986 |
The use of the implantable chemoinfusion pump in the treatment of hepatic metastases of colorectal cancer.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Digestive System Diseases; Floxuridine; Hepatic Artery; | 1986 |
Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA).
Topics: Colonic Neoplasms; Colony-Forming Units Assay; Culture Techniques; Dose-Response Relationship, Drug; | 1986 |
Endoscopic biliary stent placement for bile duct stricture after hepatic artery infusion of 5-FUDR.
Topics: Adenocarcinoma; Aged; Catheters, Indwelling; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; C | 1986 |
Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver.
Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuri | 1987 |
Role of administration route in the therapeutic efficacy of doxifluridine.
Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Female; Floxuridine; Fluo | 1987 |
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine | 1987 |
Bile duct strictures associated with hepatic arterial infusion chemotherapy.
Topics: Bile Duct Diseases; Colonic Neoplasms; Constriction, Pathologic; Floxuridine; Hepatic Artery; Humans | 1987 |
Distribution of fluorodeoxyuridine uptake in the liver and colorectal hepatic metastases of human beings after arterial infusion.
Topics: Adult; Colonic Neoplasms; Floxuridine; Humans; Liver; Liver Neoplasms; Middle Aged; Rectal Neoplasms | 1987 |
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neopla | 1987 |
[Effects of alternating chemotherapy with 2 non-cross-resistant drug combinations on human alimentary and breast cancer xenografts in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neopla | 1987 |
Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylnitrosamine; Floxuridine; Imidazoles; Male; Orga | 1987 |
Excretion of doxifluridine catabolites in human bile assessed by 19F NMR spectrometry.
Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Bile; Colonic Neoplasms; Floxuridine; Humans; Magnetic | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kineti | 1987 |
Regional and systemic chemotherapy for colorectal metastases to the liver.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans | 1987 |
Judging causality.
Topics: Adenocarcinoma; Cholestasis, Intrahepatic; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra- | 1987 |
[Antitumor effects of 5'-deoxy-5-fluorouridine (5'-DFUR) against various murine tumors in combination with recombinant interferon alpha or cytostatics].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; F | 1987 |
Myocardial ischemia with fluorouracil and floxuridine therapy.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Coronary Disease; Electrocardiography; Floxuridine; Fluorou | 1987 |
[Locoregional chemotherapy of hepatic metastases of colorectal cancer].
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Infusion Pumps; I | 1987 |
Neck and shoulder pain associated with hepatic arterial chemotherapy using an implantable infusion pump.
Topics: Anesthetics, Local; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusion Pumps; | 1988 |
[Regional arterial chemotherapy of hepatic metastases secondary to colorectal carcinoma].
Topics: Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Mi | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
Biological activities of 5-fluorouracil and its prodrug 5'-deoxy-5-fluorouridine in rats.
Topics: Animals; Body Weight; Colonic Neoplasms; Drug Therapy; Female; Floxuridine; Fluorouracil; Prodrugs; | 1987 |
Comparison of the pyrimidine nucleoside phosphorylase activity in human tumors and normal tissues.
Topics: Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Pentosyltransferases; Pro | 1988 |
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damag | 1988 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorour | 1988 |
Nonspecific corticosteroid therapy in patients receiving intra-arterial chemotherapy for hepatic metastases of colorectal origin.
Topics: Adrenal Cortex Hormones; Cholestasis; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-Arter | 1988 |
Thymidylate synthase as a determinant of 5-fluoro-2'-deoxyuridine response in human colonic tumor cell lines.
Topics: Blotting, Northern; Blotting, Southern; Colonic Neoplasms; Floxuridine; Genes; Humans; RNA, Messenge | 1988 |
A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.
Topics: Blotting, Northern; Blotting, Southern; Colonic Neoplasms; Drug Resistance; Floxuridine; Gene Amplif | 1988 |
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male | 1988 |
[Our therapy concept in nonresectable liver metastases].
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Com | 1988 |
Can something be done for patients with liver metastases for colorectal cancer?
Topics: Colonic Neoplasms; Floxuridine; Humans; Infusion Pumps; Liver Neoplasms; Rectal Neoplasms | 1988 |
Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.
Topics: Angina Pectoris; Brain Diseases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Evaluation; Elect | 1985 |
Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Body Weight; Brain Diseases; Cerebellar Diseases; C | 1985 |
[Clinical phase II study of 5'-DFUR for cancer of the digestive organs by a cooperative study group].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colo | 1985 |
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induc | 1985 |
A prospective study of continuous hepatic perfusion with implantable pump.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Chemotherapy, Cancer | 1985 |
5'-O-Palmitoyl- and 3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine--novel lipophilic analogues of 5'-fluoro-2'-deoxyuridine: synthesis, incorporation into liposomes and preliminary biological results.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Chemical Phenomena; Chemistry; Colonic Neoplas | 1985 |
Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cholecystitis; Colonic Neoplasms; Do | 1985 |
The implanted pump in metastatic colorectal cancer of the liver. Risk versus benefit.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio | 1985 |
Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Colonic Neoplasms; Diffusion; Drug Resistance; Flox | 1985 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Col | 1985 |
Treatment of colorectal cancer hepatic metastases by hepatic artery chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms; Floxuridine; Fluorour | 1985 |
Iatrogenic sclerosing cholangitis following hepatic arterial chemotherapy infusion.
Topics: Adenocarcinoma; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis; Colonic Neoplasms; Flo | 1985 |
Cholangitis complicating intraarterial chemotherapy in liver metastasis.
Topics: Alkaline Phosphatase; Bilirubin; Carcinoembryonic Antigen; Cholangiography; Cholangitis; Colonic Neo | 1985 |
Sclerosing cholangitis after continuous hepatic artery infusion of FUDR.
Topics: Aged; Bile Ducts; Cholangitis; Cholestasis; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; | 1985 |
Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine.
Topics: Colonic Neoplasms; Duodenitis; Duodenum; Floxuridine; Gastritis; Hepatic Artery; Humans; Infusions, | 1985 |
The treatment of hepatic metastases by long-term chemotherapeutic infusions.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Evaluation Studies as Topic; Female; | 1970 |
[Our experience with 5-fluoro-2-desocyuridine].
Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Gallbladder Neoplasms; Humans; Liver Neoplasms; | 1968 |
The evolution of colorectal cancer.
Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Parenteral; Liver Neoplasms; Lymphatic Metastasis | 1968 |
The value of fluorinated pyrimidines in advanced malignancy.
Topics: Adult; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Female; Floxuridine; Fluorouracil; Humans; Leu | 1968 |
Comparative response of carcinoma of the rectum and carcinoma of the colon to fluorinated pyrimidine therapy.
Topics: Colonic Neoplasms; Floxuridine; Rectal Neoplasms | 1969 |
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin | 1971 |
Arterial infusion chemotherapy of liver metastases arising from rectal and colonic cancer.
Topics: Colonic Neoplasms; Floxuridine; Humans; Injections, Intra-Arterial; Liver Function Tests; Liver Neop | 1970 |
Chemotherapy of cancer of the colon and rectum.
Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; | 1972 |
Practical aspects of investigation and treatment of colorectal cancer.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function | 1972 |
Chemotherapy of colon and rectal cancer.
Topics: Administration, Oral; Antigens, Neoplasm; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasm | 1972 |
Effect of resection of the primary neoplasm on responsiveness to chemotherapy of patients with large bowel cancer.
Topics: Adenocarcinoma; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; Rectal | 1972 |
Chemotherapy of gastrointestinal cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Esophageal Neoplasms; Floxuridine; Fluorouracil; Gastroint | 1972 |
FUDR as an adjuvant to surgery in cancer of the large bowel.
Topics: Adult; Aged; Colonic Neoplasms; Evaluation Studies as Topic; Floxuridine; Follow-Up Studies; Humans; | 1973 |
Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon.
Topics: Age Factors; Aspartate Aminotransferases; Catheterization; Chemotherapy, Cancer, Regional Perfusion; | 1974 |
The clinical effects of prolonged intravenous infusion of 5-fluoro-2'-deoxyuridine.
Topics: Adenoma, Islet Cell; Aged; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Female; Fl | 1965 |
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carci | 1967 |