floxuridine has been researched along with Chromosomal Fragility in 43 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Frequency and distribution of 5-fluorodeoxyuridine (5-FdU) plus caffeine-induced fragile sites on chromosomes of peripheral blood lymphocytes (PBL) from 10 patients with cutaneous melanoma were studied in comparison with 10 PBL samples from normal donors of corresponding sex and age." | 3.68 | Enhanced expression of 1p32 and 1p22 fragile sites in lymphocytes in cutaneous malignant melanomas. ( Chebotarev, AN; Demidov, LV; Kirichenko, OP; Kopnin, BP; Mukeria, AF; Sokova, OI, 1992) |
| " Fragile sites expression induced by 5-fluorodeoxyuridine (FudR) or 5-bromodeoxyuridine (BrdU) was analyzed in 4 healthy individuals and 4 patients affected with lymphoproliferative disorders: one Hodgkin's disease, one mycosis fungoides and two chronic lymphoproliferative disorders." | 3.68 | [Expression of new fragile sites detected in lymphoproliferative processes]. ( Fundia, AF; Larripa, IB; Slavutsky, IR, 1990) |
| "Our findings suggest that chromosomal abnormalities in childhood malignancies cannot generally be explained by the presence of FdU- or FdU plus caffeine-induced fragile sites." | 1.28 | Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children. ( Crist, WM; Douglass, EC; Lewis, S; Raimondi, SC; Ribeiro, RC; Valentine, M; Williams, DL, 1992) |
| " Fibroblast cultures from 10 retarded males expressed fra(X) in a dose-response relationship to increasing concentrations of FUdR." | 1.27 | Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression. ( Nielsen, KB; Tommerup, N, 1984) |
| "The frequencies of chromosome aberrations and development of the bromodeoxyuridine (BrdU)-sensitive fragile site were studied in vitro in Chinese hamster kidney and bone marrow cells and in vivo in Chinese hamster bone marrow cells." | 1.27 | An in vitro and in vivo study of a BrdU-sensitive fragile site in the Chinese hamster. ( Lin, MS; Marchese, CA; Takabayashi, T; Wilson, MG, 1984) |
| "Peripheral blood from six patients with Huntington's disease (HD) and six controls were cultured in three types of media known to produce fragile sites." | 1.27 | Absence of significant autosomal lesions in Huntington's disease. ( Beverstock, GC; Mol, A; Wienhofer, E, 1985) |
| "Caffeine did not enhance the expression of the fra(X) in the PBLC or in the three LCL from fra(X) expressing individuals nor did it elicit fra(X) expression in LCL from a non-expressing obligate-carrier female and a transmitting male." | 1.27 | The effect of caffeine on fragile X expression. ( Abruzzo, MA; Jacobs, PA; Mayer, M; Pettay, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (58.14) | 18.7374 |
| 1990's | 17 (39.53) | 18.2507 |
| 2000's | 1 (2.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumari, D | 1 |
| Somma, V | 1 |
| Nakamura, AJ | 1 |
| Bonner, WM | 1 |
| D'Ambrosio, E | 1 |
| Usdin, K | 1 |
| Daniel, A | 1 |
| Ekblom, L | 1 |
| Phillips, S | 1 |
| Hecht, F | 3 |
| Jacky, PB | 1 |
| Sutherland, GR | 2 |
| Haslam, JS | 1 |
| Chitham, RG | 1 |
| Taylor, JW | 1 |
| Anness, V | 1 |
| Nielsen, KB | 1 |
| Tommerup, N | 3 |
| Lin, MS | 1 |
| Takabayashi, T | 1 |
| Wilson, MG | 1 |
| Marchese, CA | 1 |
| Yunis, JJ | 1 |
| Soreng, AL | 1 |
| Barbi, G | 2 |
| Steinbach, P | 2 |
| Vogel, W | 1 |
| Nielssen, KB | 1 |
| Mikkelsen, M | 1 |
| Poulsen, H | 1 |
| Brøndum-Nielsen, K | 1 |
| Ban, S | 1 |
| Cologne, JB | 1 |
| Neriishi, K | 1 |
| Jenkins, EC | 2 |
| Morys, I | 1 |
| Henderson, J | 1 |
| Genovese, M | 2 |
| Carter, M | 1 |
| Li, SY | 1 |
| Houck, GE | 1 |
| Ding, X | 1 |
| Stark-Houck, SL | 1 |
| Dobkin, CS | 1 |
| Yang, MY | 1 |
| Long, SE | 1 |
| Wenger, SL | 2 |
| Rafi, SK | 1 |
| Surana, RB | 1 |
| Anderson, LH | 1 |
| Wilson, B | 1 |
| Christopher, KL | 1 |
| Mehm, WJ | 1 |
| Fundia, A | 1 |
| Giere, I | 1 |
| Larripa, I | 1 |
| Slavutsky, I | 1 |
| Kubo, K | 2 |
| Matsuyama, S | 2 |
| Sato, K | 1 |
| Shiomi, A | 2 |
| Ono, K | 1 |
| Ito, Y | 1 |
| Ohashi, F | 2 |
| Takamori, Y | 2 |
| Asaeda, A | 1 |
| Ide, H | 1 |
| Güven, GS | 1 |
| Hacihanefioğlu, S | 1 |
| Cenani, A | 1 |
| Fundia, AF | 4 |
| Gorla, NB | 1 |
| Bonduel, MM | 1 |
| Azpilicueta, O | 1 |
| Lejarraga, H | 1 |
| Muriel, FS | 1 |
| Larripa, IB | 4 |
| Ribeiro, RC | 1 |
| Douglass, EC | 1 |
| Williams, DL | 1 |
| Raimondi, SC | 1 |
| Valentine, M | 1 |
| Lewis, S | 1 |
| Crist, WM | 1 |
| Sokova, OI | 2 |
| Kirichenko, OP | 1 |
| Mukeria, AF | 1 |
| Demidov, LV | 1 |
| Chebotarev, AN | 1 |
| Kopnin, BP | 2 |
| Ramos, FJ | 1 |
| Emanuel, BS | 1 |
| Spinner, NB | 1 |
| Slavutsky, IR | 1 |
| Duncan, CJ | 1 |
| Sanz, MM | 1 |
| Gu, H | 1 |
| Schwartz-Richstein, C | 1 |
| Lele, KP | 1 |
| Salandi, ML | 1 |
| Krawczun, MS | 1 |
| Tajara, EH | 2 |
| Lockwood, D | 2 |
| Sandberg, AA | 2 |
| Hecht, BK | 2 |
| Jordan, DK | 1 |
| Divelbiss, JE | 1 |
| Waziri, MH | 1 |
| Burns, TL | 1 |
| Patil, SR | 1 |
| Cantú, ES | 1 |
| Nussbaum, RL | 1 |
| Airhart, SD | 1 |
| Ledbetter, DH | 1 |
| Beverstock, GC | 1 |
| Mol, A | 1 |
| Wienhofer, E | 1 |
| Smeets, DF | 1 |
| Scheres, JM | 1 |
| Hustinx, TW | 1 |
| Baker, E | 1 |
| Abruzzo, MA | 1 |
| Pettay, D | 1 |
| Mayer, M | 1 |
| Jacobs, PA | 1 |
| Rao, PN | 2 |
| Heerema, NA | 2 |
| Palmer, CG | 2 |
| Zollino, M | 1 |
| Neri, G | 1 |
| Robinson, TJ | 1 |
| Elder, FF | 1 |
| Bixenman, H | 1 |
| Berger, CS | 1 |
| Przylepa, KA | 1 |
| von Koskull, H | 1 |
| Aula, P | 1 |
| Ammälä, P | 1 |
| Nordström, AM | 1 |
| Rapola, J | 1 |
| Djalali, M | 1 |
1 review available for floxuridine and Chromosomal Fragility
| Article | Year |
|---|---|
The fragile X chromosome: current methods.
Topics: Cells, Cultured; Chromosome Fragility; Chromosome Mapping; Female; Fibroblasts; Floxuridine; Folic A | 1982 |
1 trial available for floxuridine and Chromosomal Fragility
| Article | Year |
|---|---|
Fragile sites induced by FUdR, caffeine, and aphidicolin. Their frequency, distribution, and analysis.
Topics: Adult; Aphidicolin; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Diter | 1988 |
41 other studies available for floxuridine and Chromosomal Fragility
| Article | Year |
|---|---|
The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.
Topics: Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chromosome Brea | 2009 |
Fragile X expression suppressed in either FUdR or methotrexate treated fibroblasts by pretreatment with 5-azacytidine.
Topics: Azacitidine; Chromosome Fragility; Drug Interactions; Female; Fibroblasts; Floxuridine; Gene Express | 1984 |
Selection and use of a method for the culture of blood leucocytes to reveal the fra(x) site.
Topics: Adult; Cells, Cultured; Child; Chromosome Fragility; Culture Media; Cytological Techniques; Female; | 1984 |
Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression.
Topics: Adolescent; Adult; Bromodeoxyuridine; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile S | 1984 |
An in vitro and in vivo study of a BrdU-sensitive fragile site in the Chinese hamster.
Topics: Animals; Bone Marrow; Bromodeoxyuridine; Cells, Cultured; Chromosome Aberrations; Chromosome Banding | 1984 |
Constitutive fragile sites and cancer.
Topics: Adolescent; Adult; Animals; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome F | 1984 |
Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fr | 1984 |
Marker X chromosome induction in fibroblasts by FUdR.
Topics: Adult; Cells, Cultured; Chromosome Fragility; Female; Floxuridine; Humans; Intellectual Disability; | 1981 |
5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.
Topics: Cells, Cultured; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Female; Floxuri | 1981 |
Effect of radiation and cigarette smoking on expression of FUdR-inducible common fragile sites in human peripheral lymphocytes.
Topics: Aged; Aged, 80 and over; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes; Female; Floxur | 1995 |
Fragile X induction systems in CVS cultures: effect on cytogenetic, PCR, and genomic Southern Blot DNA analyses of the FMR-1 gene.
Topics: Blotting, Southern; Cells, Cultured; Chorionic Villi; Chorionic Villi Sampling; Chromosome Banding; | 1994 |
Folate sensitive common fragile sites in chromosomes of the domestic pig (Sus scrofa).
Topics: Animals; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; Chromosome Fragile Sites; Ch | 1993 |
Chemical induction of sister chromatid exchange at fragile sites.
Topics: Aphidicolin; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; | 1995 |
Effects of hyperoxia and caffeine on the expression of fragile site at Xq27.3.
Topics: Caffeine; Cell Line; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; Floxuridine; Gen | 1996 |
Spontaneous breakage and fragile site expression in chronic lymphocytic leukemia.
Topics: Aged; Aphidicolin; Chromosome Breakage; Chromosome Fragile Sites; Chromosome Fragility; Chromosome M | 1998 |
Novel putative fragile sites observed in feline fibroblasts treated with aphidicolin and fluorodeoxyuridine.
Topics: Animals; Aphidicolin; Cats; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chro | 1998 |
Induction of fragile sites by fluorodeoxyuridine and caffeine accompanies with misincorpolation of endogenous uridine nucleotide into DNA of feline fibroblasts.
Topics: Animals; Caffeine; Cats; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; DNA; DNA G | 1998 |
Expression of aphidicolin, FUdR and caffeine-induced fragile sites in lymphocytes of healthy Turkish individuals.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aphidicolin; Caffeine; Cells, Cultured; Chi | 1999 |
Increased expression of 5q31 fragile site in a Bloom syndrome family.
Topics: Bloom Syndrome; Caffeine; Child; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragil | 1992 |
Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children.
Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Chromosome Aberrations; Chromosome Fragile Sit | 1992 |
Enhanced expression of 1p32 and 1p22 fragile sites in lymphocytes in cutaneous malignant melanomas.
Topics: Adult; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human | 1992 |
Frequency of the common fragile site at Xq27.2 under conditions of thymidylate stress: implications for cytogenetic diagnosis of the fragile-X syndrome.
Topics: Adolescent; Adult; Aged; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromos | 1992 |
[Segments of Djungarian hamster chromosomes, specific for translocation of integration of amplified mdr1 genes, do not possess increased instability].
Topics: Animals; Antineoplastic Agents; Aphidicolin; Aspartic Acid; Chromosome Fragile Sites; Chromosome Fra | 1991 |
[Induction of fragile sites by chemical and physical agents].
Topics: Aphidicolin; Bromodeoxyuridine; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Humans; | 1991 |
[Expression of new fragile sites detected in lymphoproliferative processes].
Topics: Bromodeoxyuridine; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; Floxuridine; | 1990 |
Progress toward an internal control system for fragile-X induction by 5-fluorodeoxyuridine in whole-blood cultures.
Topics: Blood Cells; Chromosome Fragile Sites; Chromosome Fragility; Female; Floxuridine; Fragile X Syndrome | 1990 |
New common fragile sites.
Topics: Aphidicolin; Azacitidine; Bromodeoxyuridine; Cells, Cultured; Chromosome Fragile Sites; Chromosome F | 1988 |
Fragile site expression in families with von Hippel-Lindau disease.
Topics: Adult; Angiomatosis; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome Fragilit | 1989 |
Coincidence in fragile site expression with fluorodeoxyuridine and bromodeoxyuridine.
Topics: Bromodeoxyuridine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Hum | 1989 |
Fragile (X) expression induced by FUdR is transient and inversely related to levels of thymidylate synthase activity.
Topics: Cell Line; Chromosome Fragility; Dose-Response Relationship, Drug; Female; Floxuridine; Gene Express | 1985 |
Absence of significant autosomal lesions in Huntington's disease.
Topics: Adolescent; Adult; Aged; Bromodeoxyuridine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fr | 1985 |
The most common fragile site in man is 3p14.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromo | 1986 |
Induction of fragile sites in fibroblasts.
Topics: Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Female; Fibroblasts; Floxuridine; F | 1986 |
The effect of caffeine on fragile X expression.
Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; F | 1986 |
Protective effect of S-adenosylmethionine against the induction of chromosome fragile sites.
Topics: Caffeine; Chromosome Fragile Sites; Chromosome Fragility; DNA Damage; Floxuridine; Humans; Lymphocyt | 1987 |
Multiple common fragile sites are expressed in the genome of the laboratory rat.
Topics: Animals; Aphidicolin; Caffeine; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Female; | 1987 |
Fragile sites and genitourinary tumors.
Topics: Bromodeoxyuridine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Gen | 1988 |
Chromosome breaks and fragile sites in leukemic bone marrow cells.
Topics: Adolescent; Aged; Bone Marrow; Caffeine; Cells, Cultured; Child; Child, Preschool; Chromosome Aberra | 1988 |
Expression of fragile sites in childhood acute lymphoblastic leukemia patients and normal controls.
Topics: Aphidicolin; Bone Marrow; Caffeine; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mappi | 1988 |
Improved technique for the expression of fragile-X in cultured amniotic fluid cells.
Topics: Adult; Amniotic Fluid; Cells, Cultured; Chromosome Fragility; Diazepam; Female; Floxuridine; Humans; | 1985 |
Folic acid sensitive fragile sites are not limited to the human karyotype. Demonstration of nonrandom gaps and breaks in the Persian vole Ellobius lutescens Th. inducible by methotrexate, fluorodeoxyuridine, and aphidicolin.
Topics: Animals; Aphidicolin; Arvicolinae; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Frag | 1985 |