floxuridine has been researched along with Choriocarcinoma in 6 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate changes of protein expression profiles between human choriocarcinoma JeG-3 cell line and its floxuridine (FUDR)-resistant sub-line." | 7.79 | [Role of endoplasmic reticulum protein folding molecular chaperones in floxuridine-resistance choriocarcinoma JeG-3/FUDRA cell line]. ( Feng, FZ; Han, B; Lin, C; Meng, XT; Qian, HL; Wan, XR; Xiang, Y; Zhang, XY, 2013) |
| "To establish human choriocarcinoma JeG-3 cell line resistant to floxuridine (FUDR) and describe the characteristics of this FUDR-resistant subline." | 3.75 | [Establishment of floxuridine-resistant JeG-3 subline and the role of thymidylate synthetase mRNA expression in chem-resistant-prediction.]. ( Han, B; Liu, X; Sha, GH; Xiang, Y; Zhang, H, 2009) |
| "Treatment of choriocarcinoma cells (JAr line) for 24 hr with methotrexate, fluorodeoxyuridine, 1-beta-D-arabinofuranosylcytosine, or hydroxyurea, in doses that inhibit DNA synthesis, results in a 2." | 3.66 | Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis. ( Azizkhan, JC; Goode, D; Speeg, KV; Stromberg, K, 1979) |
| "Chemotherapy is typically used to treat choriocarcinoma." | 1.46 | CLIC1 Induces Drug Resistance in Human Choriocarcinoma Through Positive Regulation of MRP1. ( Wang, D; Wu, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, B | 2 |
| Xiang, Y | 4 |
| Feng, FZ | 1 |
| Wan, XR | 2 |
| Qian, HL | 1 |
| Zhang, XY | 1 |
| Meng, XT | 1 |
| Lin, C | 1 |
| Wu, J | 1 |
| Wang, D | 1 |
| Sha, GH | 1 |
| Zhang, H | 1 |
| Liu, X | 1 |
| Yang, XY | 1 |
| Wu, Y | 2 |
| Yang, YM | 1 |
| Yin, SJ | 1 |
| Li, J | 2 |
| Wan, X | 1 |
| Yang, X | 1 |
| Yang, Y | 1 |
| Ying, S | 1 |
| Azizkhan, JC | 1 |
| Speeg, KV | 1 |
| Stromberg, K | 1 |
| Goode, D | 1 |
1 trial available for floxuridine and Choriocarcinoma
| Article | Year |
|---|---|
Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Fe | 2004 |
5 other studies available for floxuridine and Choriocarcinoma
| Article | Year |
|---|---|
[Role of endoplasmic reticulum protein folding molecular chaperones in floxuridine-resistance choriocarcinoma JeG-3/FUDRA cell line].
Topics: Calreticulin; Cell Line, Tumor; Choriocarcinoma; Drug Resistance, Neoplasm; Endoplasmic Reticulum Ch | 2013 |
CLIC1 Induces Drug Resistance in Human Choriocarcinoma Through Positive Regulation of MRP1.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chloride Channels; Choriocarcinoma; Drug | 2017 |
[Establishment of floxuridine-resistant JeG-3 subline and the role of thymidylate synthetase mRNA expression in chem-resistant-prediction.].
Topics: Cell Line, Tumor; Choriocarcinoma; Floxuridine; Humans; RNA, Messenger; Thymidylate Synthase | 2009 |
[Floxuridine-containing regime in the treatment of gestational trophoblastic tumor].
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; | 2003 |
Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Cytarabine; DNA, Neoplasm; Dose-R | 1979 |