floxuridine has been researched along with Cholangitis, Sclerosing in 9 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pure hepatocellular cholestasis is mostly observed with sex steroid hormones and anabolic steroids." | 2.40 | Drug-induced cholestasis. ( Erlinger, S, 1997) |
| " If the maximum dose of infusion was changed so that 60% of the infusion was given at night from 3am to 9am the infusion became more toxic and all the animals died in a mean of 5." | 1.28 | The effects on toxicity of circadian patterning of continuous hepatic artery infusion. ( Alava, G; Kemeny, MM; Oliver, JM; Smith, FB, 1992) |
| "Floxuridine 0." | 1.28 | Hepatobiliary toxicity of 5-fluoro-2'-deoxyuridine. Intra-arterial versus portal venous routes of infusion. ( Andrews, JC; Ensminger, WD; Kuntsen, C; Priescorn, D; Terio, P, 1991) |
| "The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation." | 1.28 | Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy? ( Kim, CH; Krom, RA; Ludwig, J; Wiesner, RH, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnett, KT | 1 |
| Malafa, MP | 1 |
| Alazmi, WM | 1 |
| McHenry, L | 1 |
| Watkins, JL | 1 |
| Fogel, EL | 1 |
| Schmidt, S | 1 |
| Sherman, S | 1 |
| Lehman, GL | 1 |
| Campos, LT | 1 |
| Erlinger, S | 1 |
| Kemeny, MM | 1 |
| Alava, G | 1 |
| Oliver, JM | 1 |
| Smith, FB | 1 |
| Pozniak, MA | 1 |
| Babel, SG | 1 |
| Trump, DL | 1 |
| Andrews, JC | 2 |
| Kuntsen, C | 1 |
| Terio, P | 1 |
| Priescorn, D | 1 |
| Ensminger, WD | 1 |
| Ludwig, J | 1 |
| Kim, CH | 1 |
| Wiesner, RH | 1 |
| Krom, RA | 1 |
| Knol, J | 1 |
| Wollner, I | 1 |
| Knutsen, C | 1 |
| Smith, P | 1 |
| Prieskorn, D | 1 |
| Ensminger, W | 1 |
2 reviews available for floxuridine and Cholangitis, Sclerosing
| Article | Year |
|---|---|
Complications of hepatic artery infusion: a review of 4580 reported cases.
Topics: Antimetabolites, Antineoplastic; Arterial Occlusive Diseases; Bone Marrow Diseases; Catheters, Indwe | 2001 |
Drug-induced cholestasis.
Topics: Animals; Bile Acids and Salts; Cholangitis, Sclerosing; Cholelithiasis; Cholestasis; Drug-Related Si | 1997 |
1 trial available for floxuridine and Cholangitis, Sclerosing
| Article | Year |
|---|---|
A randomized trial of intrahepatic infusion of fluorodeoxyuridine with dexamethasone versus fluorodeoxyuridine alone in the treatment of metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cholangitis, Sclerosing; Colorectal Neoplasms; Dexam | 1993 |
6 other studies available for floxuridine and Cholangitis, Sclerosing
| Article | Year |
|---|---|
Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy.
Topics: Adult; Aged; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreat | 2006 |
The effects on toxicity of circadian patterning of continuous hepatic artery infusion.
Topics: Animals; Cholangitis, Sclerosing; Circadian Rhythm; Drug Administration Schedule; Floxuridine; Hepat | 1992 |
Complications of hepatic arterial infusion chemotherapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholangitis, Sclerosing; Female; Floxuridine; Gastroin | 1991 |
Hepatobiliary toxicity of 5-fluoro-2'-deoxyuridine. Intra-arterial versus portal venous routes of infusion.
Topics: Animals; Cholangitis, Sclerosing; Dogs; Floxuridine; Hepatic Artery; Infusion Pumps, Implantable; In | 1991 |
Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy?
Topics: Adult; Bile Ducts; Cholangitis, Sclerosing; Floxuridine; Humans; Ischemia; Liver Neoplasms; Male; Re | 1989 |
Floxuridine-associated sclerosing cholangitis. A dog model.
Topics: Animals; Bile Ducts; Cholangiography; Cholangitis, Sclerosing; Dogs; Floxuridine; Infusion Pumps; In | 1989 |