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floxuridine and Cholangitis, Sclerosing

floxuridine has been researched along with Cholangitis, Sclerosing in 9 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.

Research Excerpts

ExcerptRelevanceReference
"Pure hepatocellular cholestasis is mostly observed with sex steroid hormones and anabolic steroids."2.40Drug-induced cholestasis. ( Erlinger, S, 1997)
" If the maximum dose of infusion was changed so that 60% of the infusion was given at night from 3am to 9am the infusion became more toxic and all the animals died in a mean of 5."1.28The effects on toxicity of circadian patterning of continuous hepatic artery infusion. ( Alava, G; Kemeny, MM; Oliver, JM; Smith, FB, 1992)
"Floxuridine 0."1.28Hepatobiliary toxicity of 5-fluoro-2'-deoxyuridine. Intra-arterial versus portal venous routes of infusion. ( Andrews, JC; Ensminger, WD; Kuntsen, C; Priescorn, D; Terio, P, 1991)
"The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation."1.28Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy? ( Kim, CH; Krom, RA; Ludwig, J; Wiesner, RH, 1989)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's5 (55.56)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnett, KT1
Malafa, MP1
Alazmi, WM1
McHenry, L1
Watkins, JL1
Fogel, EL1
Schmidt, S1
Sherman, S1
Lehman, GL1
Campos, LT1
Erlinger, S1
Kemeny, MM1
Alava, G1
Oliver, JM1
Smith, FB1
Pozniak, MA1
Babel, SG1
Trump, DL1
Andrews, JC2
Kuntsen, C1
Terio, P1
Priescorn, D1
Ensminger, WD1
Ludwig, J1
Kim, CH1
Wiesner, RH1
Krom, RA1
Knol, J1
Wollner, I1
Knutsen, C1
Smith, P1
Prieskorn, D1
Ensminger, W1

Reviews

2 reviews available for floxuridine and Cholangitis, Sclerosing

ArticleYear
Complications of hepatic artery infusion: a review of 4580 reported cases.
    International journal of gastrointestinal cancer, 2001, Volume: 30, Issue:3

    Topics: Antimetabolites, Antineoplastic; Arterial Occlusive Diseases; Bone Marrow Diseases; Catheters, Indwe

2001
Drug-induced cholestasis.
    Journal of hepatology, 1997, Volume: 26 Suppl 1

    Topics: Animals; Bile Acids and Salts; Cholangitis, Sclerosing; Cholelithiasis; Cholestasis; Drug-Related Si

1997

Trials

1 trial available for floxuridine and Cholangitis, Sclerosing

ArticleYear
A randomized trial of intrahepatic infusion of fluorodeoxyuridine with dexamethasone versus fluorodeoxyuridine alone in the treatment of metastatic colorectal cancer.
    Cancer, 1993, Feb-01, Volume: 71, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cholangitis, Sclerosing; Colorectal Neoplasms; Dexam

1993

Other Studies

6 other studies available for floxuridine and Cholangitis, Sclerosing

ArticleYear
Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy.
    Journal of clinical gastroenterology, 2006, Volume: 40, Issue:4

    Topics: Adult; Aged; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreat

2006
The effects on toxicity of circadian patterning of continuous hepatic artery infusion.
    HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 1992, Volume: 5, Issue:3

    Topics: Animals; Cholangitis, Sclerosing; Circadian Rhythm; Drug Administration Schedule; Floxuridine; Hepat

1992
Complications of hepatic arterial infusion chemotherapy.
    Radiographics : a review publication of the Radiological Society of North America, Inc, 1991, Volume: 11, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholangitis, Sclerosing; Female; Floxuridine; Gastroin

1991
Hepatobiliary toxicity of 5-fluoro-2'-deoxyuridine. Intra-arterial versus portal venous routes of infusion.
    Investigative radiology, 1991, Volume: 26, Issue:5

    Topics: Animals; Cholangitis, Sclerosing; Dogs; Floxuridine; Hepatic Artery; Infusion Pumps, Implantable; In

1991
Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy?
    Hepatology (Baltimore, Md.), 1989, Volume: 9, Issue:2

    Topics: Adult; Bile Ducts; Cholangitis, Sclerosing; Floxuridine; Humans; Ischemia; Liver Neoplasms; Male; Re

1989
Floxuridine-associated sclerosing cholangitis. A dog model.
    Investigative radiology, 1989, Volume: 24, Issue:1

    Topics: Animals; Bile Ducts; Cholangiography; Cholangitis, Sclerosing; Dogs; Floxuridine; Infusion Pumps; In

1989