floxuridine has been researched along with Cerebellar Diseases in 3 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Cerebellar Diseases: Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group." | 6.66 | Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986) |
| " The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group." | 2.66 | Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986) |
| " The frequency of cerebellopathy may depend on the dosage and type of administration of the drug." | 1.27 | Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine. ( Fosså, SD; Heier, MS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MOERTEL, CG | 1 |
| REITEMEIER, RJ | 1 |
| BOLTON, CF | 1 |
| SHORTER, RG | 1 |
| Heier, MS | 2 |
| Fosså, SD | 2 |
1 trial available for floxuridine and Cerebellar Diseases
| Article | Year |
|---|---|
Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd).
Topics: Adult; Aged; Brain Diseases; Carcinoid Tumor; Carcinoma; Cerebellar Diseases; Colonic Neoplasms; Ele | 1986 |
2 other studies available for floxuridine and Cerebellar Diseases
| Article | Year |
|---|---|
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasm | 1964 |
Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Body Weight; Brain Diseases; Cerebellar Diseases; C | 1985 |