Page last updated: 2024-11-06

floxuridine and Carcinoma, Ehrlich Tumor

floxuridine has been researched along with Carcinoma, Ehrlich Tumor in 35 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Research Excerpts

ExcerptRelevanceReference
" The dosage of the oral clinical use for human cancer of 5-FU, HCFU, 5'-DFUR and UFT as tegafur (FT) is 200-300mg/d, 600mg/d, 800-1,200mg/d and 300-600mg/d respectively."1.31Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. ( Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M, 2001)
" 5'-dFUrd was a more effective antitumor agent and was less toxic over a wide dosage range (50 to 400 mg/kg) than the other agents tested as measured by: (a) the ability to prevent gross development of inoculated tumor; (b) 45-day survival; and (c) weight change over the treatment period."1.26Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine. ( Armstrong, RD; Diasio, RB, 1980)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199031 (88.57)18.7374
1990's3 (8.57)18.2507
2000's1 (2.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bretner, M1
Kulikowski, T1
Dzik, JM1
Balińska, M2
Rode, W3
Shugar, D1
LINDNER, A1
KUTKAM, T1
SANKARANARAYANAN, K1
RUCKER, R1
ARRADONDO, J1
HEIDELBERGER, C10
BIRNIE, GD2
BOOHAR, J3
WENTLAND, D1
BROCKMAN, RW1
ANDERSON, EP1
REYES, P2
Armstrong, RD3
Diasio, RB3
Iapalucci-Espinoza, S1
Franze-Fernandez, MT1
Jastreboff, MM3
Zielińska, ZM1
Kedzierska, B1
Connolly, KM1
Kaplan, AM1
Cadman, E1
Bowen, D4
Bailey, BD1
Guernsey, LA3
Fölsch, E2
Woodman, PW1
Sarrif, AM1
Ooi, A1
Ohkubo, T1
Higashigawa, M1
Kawasaki, H1
Kakito, H1
Kagawa, Y1
Kojima, M1
Sakurai, M1
Goldman, ID1
Abrams, DN1
Knaus, EE1
Lentle, BC1
Wiebe, LI1
Bose, S1
Guha, S1
Paul, P1
Chowdhury, M1
Chowdhury, SR1
Sen, U1
Miyata, S1
Mikami, H1
Tai, M1
Hori, T1
Fujita, H1
Taguchi, T1
Thiry, M1
Dombrowicz, D1
De Lozzio, CB1
Valencia, JI1
Weitzel, G1
Warnecke, P1
Seeber, S1
Kent, RJ1
Khwaja, TA2
Frankfurt, OS1
Lokshina, AM1
Pelevina, II1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Trial of TAS-102 in Patients With Advanced, Refractory Pancreatic Adenocarcinoma[NCT04923529]Phase 228 participants (Anticipated)Interventional2021-03-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for floxuridine and Carcinoma, Ehrlich Tumor

ArticleYear
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
    Annual review of biochemistry, 1963, Volume: 32

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum

1963
Fluorinated pyrimidines.
    Progress in nucleic acid research and molecular biology, 1965, Volume: 4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; DNA; DNA Viruses; Enzyme Induction; Flo

1965
[Radiation sensitization of brain neoplasms by haloid analogs of pyrimidine bases].
    Meditsinskaia radiologiia, 1973, Volume: 18, Issue:3

    Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Cricetinae; DNA, Neoplasm; Fe

1973

Trials

1 trial available for floxuridine and Carcinoma, Ehrlich Tumor

ArticleYear
Fluorinated pyrimidines.
    Progress in nucleic acid research and molecular biology, 1965, Volume: 4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; DNA; DNA Viruses; Enzyme Induction; Flo

1965

Other Studies

32 other studies available for floxuridine and Carcinoma, Ehrlich Tumor

ArticleYear
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
    Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23

    Topics: 3T3 Cells; Animals; Antineoplastic Agents; Binding, Competitive; Carcinoma, Ehrlich Tumor; Cell Divi

1993
INHIBITION OF EHRLICH ASCITES TUMOR WITH 5-FLUOROURACIL AND OTHER AGENTS.
    Experimental cell research, 1963, Volume: 24

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorouracil; Hydr

1963
FLUORINATED PYRIMIDINES. XX. INHIBITION OF THE NUCLEOSIDE PHOSPHORYLASE CLEAVAGE OF 5-FLUORO-2'-DEOXYURIDINE BY 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.
    Biochimica et biophysica acta, 1963, Oct-15, Volume: 76

    Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; Enzyme Inhibitors; Floxuridine; Fl

1963
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS.
    Biochimica et biophysica acta, 1964, Dec-16, Volume: 91

    Topics: Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA;

1964
FLUORINATED PYRIMIDINES. 23. FURTHER STUDIES ON NUCLEOSIDE PHOSPHORYLASE.
    Biochimica et biophysica acta, 1964, Dec-16, Volume: 91

    Topics: Adenocarcinoma; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Enzyme Inhibitors; Floxuridine;

1964
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS.
    Biochimica et biophysica acta, 1965, May-11, Volume: 103

    Topics: Adenosine Triphosphate; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Enzyme Inhibitors; Fl

1965
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
    Cancer research, 1981, Volume: 41, Issue:12 Pt 1

    Topics: Animals; Biotransformation; Bone Marrow; Carcinoma, Ehrlich Tumor; Cells, Cultured; Floxuridine; Flu

1981
Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues.
    The Biochemical journal, 1982, Feb-15, Volume: 202, Issue:2

    Topics: Animals; Azaguanine; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricetinae; Floxuridine; Kidney; Rib

1982
Development and characteristics of a subline of Ehrlich ascites carcinoma cells persistently resistant to 5-fluoro-2'-deoxyuridine.
    Acta biochimica Polonica, 1983, Volume: 30, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Female; Floxuridine; Humans; Liver Ne

1983
Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant Ehrlich ascites carcinoma cells.
    Biochemical pharmacology, 1983, Jul-15, Volume: 32, Issue:14

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Electrophoresis, Polyacrylamide Gel;

1983
Mechanism of cytotoxic activity of 5'-deoxy-5-fluorouridine.
    Cancer chemotherapy and pharmacology, 1983, Volume: 11, Issue:2

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Floxuridine; Neoplasm Prote

1983
Effects of Mg2+ and adenine nucleotides on thymidylate synthetase from different mouse tumors.
    Molecular and cellular biochemistry, 1984, Volume: 60, Issue:1

    Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Enzyme Activatio

1984
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:5

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions;

1984
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Liquid; F

1980
The interaction between fluoropyrimidines and methotrexate, and [4C]-formate incorporation into nucleic acids and protein.
    Cancer chemotherapy and pharmacology, 1980, Volume: 4, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interaction

1980
fluoropyrimidine-induced antagonism to free and tightly bound methotrexate: suppression of [14C] formate incorporation into RNA and protein.
    European journal of cancer, 1980, Volume: 16, Issue:7

    Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Floxuridine; F

1980
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.
    Cancer research, 1980, Volume: 40, Issue:3

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Floxuridine; HeLa Cells; Humans; Isoelectric Poi

1980
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; F

2001
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
    The Journal of biological chemistry, 1979, Jun-25, Volume: 254, Issue:12

    Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High

1979
Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--II. 6-[3H]-5-fluoro-2'-deoxyuridine.
    International journal of nuclear medicine and biology, 1979, Volume: 6, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Half-Life; Lung Neoplasms; Male; Mice; Neoplasm Tran

1979
The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors.
    Neoplasma, 1991, Volume: 38, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Count; Female; Floxuridine; Fluorouracil; Glutathione; Liver

1991
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:6

    Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lactic

1991
Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells.
    Drugs under experimental and clinical research, 1986, Volume: 12, Issue:6-7

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Floxuridine; Half-Life; Methotrexate;

1986
[5'-DFUR (doxifluridine)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil

1987
Anti-bromodeoxyuridine monoclonal antibody: an alternative tool for the identification of replicated DNA at the electron microscope level.
    Biology of the cell, 1988, Volume: 62, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; DNA; DNA Replication;

1988
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.
    Molecular pharmacology, 1965, Volume: 1, Issue:1

    Topics: Animals; Carcinoma, Ehrlich Tumor; Dialysis; Enzymes; Floxuridine; Formaldehyde; In Vitro Techniques

1965
Modification of breakage and reunion in relation to lethal damage.
    National Cancer Institute monograph, 1965, Volume: 18

    Topics: Animals; Antimetabolites; Azides; Carcinoma, Ehrlich Tumor; Cell Division; Chloramphenicol; Culture

1965
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1969, Volume: 350, Issue:6

    Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression,

1969
Fluorinated pyrimidines. 34. Structure-activity studies of methylated 5-fluoro-2'-deoxyuridine derivatives.
    Journal of medicinal chemistry, 1970, Volume: 13, Issue:1

    Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Chemical Phenomena; Chemistry;

1970
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea;

1973
The nucleotides of fluorinated pyrimidines and their biological activities.
    Ciba Foundation symposium, 1971, Volume: 2

    Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Ion Exchange; F

1971
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.
    Journal of medicinal chemistry, 1967, Volume: 10, Issue:6

    Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Escherichia coli; Floxuridine; HeLa Ce

1967