floxuridine has been researched along with Carcinoma, Ehrlich Tumor in 35 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of the oral clinical use for human cancer of 5-FU, HCFU, 5'-DFUR and UFT as tegafur (FT) is 200-300mg/d, 600mg/d, 800-1,200mg/d and 300-600mg/d respectively." | 1.31 | Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. ( Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M, 2001) |
| " 5'-dFUrd was a more effective antitumor agent and was less toxic over a wide dosage range (50 to 400 mg/kg) than the other agents tested as measured by: (a) the ability to prevent gross development of inoculated tumor; (b) 45-day survival; and (c) weight change over the treatment period." | 1.26 | Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine. ( Armstrong, RD; Diasio, RB, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (88.57) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 1 (2.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bretner, M | 1 |
| Kulikowski, T | 1 |
| Dzik, JM | 1 |
| Balińska, M | 2 |
| Rode, W | 3 |
| Shugar, D | 1 |
| LINDNER, A | 1 |
| KUTKAM, T | 1 |
| SANKARANARAYANAN, K | 1 |
| RUCKER, R | 1 |
| ARRADONDO, J | 1 |
| HEIDELBERGER, C | 10 |
| BIRNIE, GD | 2 |
| BOOHAR, J | 3 |
| WENTLAND, D | 1 |
| BROCKMAN, RW | 1 |
| ANDERSON, EP | 1 |
| REYES, P | 2 |
| Armstrong, RD | 3 |
| Diasio, RB | 3 |
| Iapalucci-Espinoza, S | 1 |
| Franze-Fernandez, MT | 1 |
| Jastreboff, MM | 3 |
| Zielińska, ZM | 1 |
| Kedzierska, B | 1 |
| Connolly, KM | 1 |
| Kaplan, AM | 1 |
| Cadman, E | 1 |
| Bowen, D | 4 |
| Bailey, BD | 1 |
| Guernsey, LA | 3 |
| Fölsch, E | 2 |
| Woodman, PW | 1 |
| Sarrif, AM | 1 |
| Ooi, A | 1 |
| Ohkubo, T | 1 |
| Higashigawa, M | 1 |
| Kawasaki, H | 1 |
| Kakito, H | 1 |
| Kagawa, Y | 1 |
| Kojima, M | 1 |
| Sakurai, M | 1 |
| Goldman, ID | 1 |
| Abrams, DN | 1 |
| Knaus, EE | 1 |
| Lentle, BC | 1 |
| Wiebe, LI | 1 |
| Bose, S | 1 |
| Guha, S | 1 |
| Paul, P | 1 |
| Chowdhury, M | 1 |
| Chowdhury, SR | 1 |
| Sen, U | 1 |
| Miyata, S | 1 |
| Mikami, H | 1 |
| Tai, M | 1 |
| Hori, T | 1 |
| Fujita, H | 1 |
| Taguchi, T | 1 |
| Thiry, M | 1 |
| Dombrowicz, D | 1 |
| De Lozzio, CB | 1 |
| Valencia, JI | 1 |
| Weitzel, G | 1 |
| Warnecke, P | 1 |
| Seeber, S | 1 |
| Kent, RJ | 1 |
| Khwaja, TA | 2 |
| Frankfurt, OS | 1 |
| Lokshina, AM | 1 |
| Pelevina, II | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of TAS-102 in Patients With Advanced, Refractory Pancreatic Adenocarcinoma[NCT04923529] | Phase 2 | 28 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for floxuridine and Carcinoma, Ehrlich Tumor
| Article | Year |
|---|---|
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
Fluorinated pyrimidines.
Topics: Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; DNA; DNA Viruses; Enzyme Induction; Flo | 1965 |
[Radiation sensitization of brain neoplasms by haloid analogs of pyrimidine bases].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Cricetinae; DNA, Neoplasm; Fe | 1973 |
1 trial available for floxuridine and Carcinoma, Ehrlich Tumor
| Article | Year |
|---|---|
Fluorinated pyrimidines.
Topics: Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; DNA; DNA Viruses; Enzyme Induction; Flo | 1965 |
32 other studies available for floxuridine and Carcinoma, Ehrlich Tumor
| Article | Year |
|---|---|
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Binding, Competitive; Carcinoma, Ehrlich Tumor; Cell Divi | 1993 |
INHIBITION OF EHRLICH ASCITES TUMOR WITH 5-FLUOROURACIL AND OTHER AGENTS.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorouracil; Hydr | 1963 |
FLUORINATED PYRIMIDINES. XX. INHIBITION OF THE NUCLEOSIDE PHOSPHORYLASE CLEAVAGE OF 5-FLUORO-2'-DEOXYURIDINE BY 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; Enzyme Inhibitors; Floxuridine; Fl | 1963 |
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS.
Topics: Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; | 1964 |
FLUORINATED PYRIMIDINES. 23. FURTHER STUDIES ON NUCLEOSIDE PHOSPHORYLASE.
Topics: Adenocarcinoma; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Enzyme Inhibitors; Floxuridine; | 1964 |
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS.
Topics: Adenosine Triphosphate; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Enzyme Inhibitors; Fl | 1965 |
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
Topics: Animals; Biotransformation; Bone Marrow; Carcinoma, Ehrlich Tumor; Cells, Cultured; Floxuridine; Flu | 1981 |
Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues.
Topics: Animals; Azaguanine; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricetinae; Floxuridine; Kidney; Rib | 1982 |
Development and characteristics of a subline of Ehrlich ascites carcinoma cells persistently resistant to 5-fluoro-2'-deoxyuridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Female; Floxuridine; Humans; Liver Ne | 1983 |
Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant Ehrlich ascites carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Electrophoresis, Polyacrylamide Gel; | 1983 |
Mechanism of cytotoxic activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Floxuridine; Neoplasm Prote | 1983 |
Effects of Mg2+ and adenine nucleotides on thymidylate synthetase from different mouse tumors.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Enzyme Activatio | 1984 |
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; | 1984 |
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Liquid; F | 1980 |
The interaction between fluoropyrimidines and methotrexate, and [4C]-formate incorporation into nucleic acids and protein.
Topics: Animals; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interaction | 1980 |
fluoropyrimidine-induced antagonism to free and tightly bound methotrexate: suppression of [14C] formate incorporation into RNA and protein.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Floxuridine; F | 1980 |
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Floxuridine; HeLa Cells; Humans; Isoelectric Poi | 1980 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; F | 2001 |
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High | 1979 |
Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--II. 6-[3H]-5-fluoro-2'-deoxyuridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Half-Life; Lung Neoplasms; Male; Mice; Neoplasm Tran | 1979 |
The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Count; Female; Floxuridine; Fluorouracil; Glutathione; Liver | 1991 |
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.
Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lactic | 1991 |
Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Floxuridine; Half-Life; Methotrexate; | 1986 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil | 1987 |
Anti-bromodeoxyuridine monoclonal antibody: an alternative tool for the identification of replicated DNA at the electron microscope level.
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; DNA; DNA Replication; | 1988 |
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.
Topics: Animals; Carcinoma, Ehrlich Tumor; Dialysis; Enzymes; Floxuridine; Formaldehyde; In Vitro Techniques | 1965 |
Modification of breakage and reunion in relation to lethal damage.
Topics: Animals; Antimetabolites; Azides; Carcinoma, Ehrlich Tumor; Cell Division; Chloramphenicol; Culture | 1965 |
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression, | 1969 |
Fluorinated pyrimidines. 34. Structure-activity studies of methylated 5-fluoro-2'-deoxyuridine derivatives.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Chemical Phenomena; Chemistry; | 1970 |
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea; | 1973 |
The nucleotides of fluorinated pyrimidines and their biological activities.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Ion Exchange; F | 1971 |
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Escherichia coli; Floxuridine; HeLa Ce | 1967 |