Page last updated: 2024-11-06

floxuridine and Cancer of Rectum

floxuridine has been researched along with Cancer of Rectum in 138 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
"All patients had metastatic colorectal cancer, with adjuvant or palliative chemotherapy given to six patients (22%) on schedule A and 12 patients on schedule B (41%)."6.69Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. ( Adam, R; Bismuth, H; Dallemagne, B; Focan, C; Focan-Henrard, D; Jasmin, C; Jehaes, C; Kreutz, F; Levi, F; Lobelle, JP; Markiewicz, S; Misset, JL; Weerts, J, 1999)
" The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group."6.66Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986)
"Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma."5.27Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983)
"Thirty-two consecutive patients with a palpable adenocarcinoma of the rectum received preoperative RT (45 Gy in 25 fractions over 5 weeks) plus continuous chemotherapy with doxifluridine and leucovorin or 5-fluorouracil by continuous intravenous infusion during RT."5.10Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response. ( Andreola, S; Baratti, D; Bozzetti, F; Mariani, L; Spinelli, P; Stani, SC; Valvo, F, 2002)
"The figures in patients with breast cancer were: 1,761 days (58."3.78[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR]. ( Taguchi, T, 1996)
"The action of floxuridine depends greatly on its concentration for treatment of liver metastases of colorectal carcinomas and other tumors."3.66[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors]. ( Balch, CM; Urist, MM, 1983)
"Patients with stage II or stage III colorectal cancer (CRC) were randomly assigned to receive preoperative hepatic and regional arterial chemotherapy (PHRAC group, n = 110) or surgery alone (control group, n = 112)."2.73Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery. ( Jianhua, W; Jiemin, C; Li, R; Weixin, N; Xinyu, Q; Xu, J; Yanhan, L; Zhiping, Y; Zhong, Y, 2007)
"Twenty-eight patients with rectal cancer, staged as over T3N1 or T4 by transrectal ultrasonography between July 1997 and December 1998, were included in this study."2.70Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials. ( Jung, HC; Kim, NK; Min, JS; Park, JK; Roh, JK; Sung, JS; Yun, SH, 2001)
"All patients had metastatic colorectal cancer, with adjuvant or palliative chemotherapy given to six patients (22%) on schedule A and 12 patients on schedule B (41%)."2.69Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. ( Adam, R; Bismuth, H; Dallemagne, B; Focan, C; Focan-Henrard, D; Jasmin, C; Jehaes, C; Kreutz, F; Levi, F; Lobelle, JP; Markiewicz, S; Misset, JL; Weerts, J, 1999)
"Median times to disease progression for the three treatment arms were as follows: 9."2.69Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore ( Lorenz, M; Müller, HH, 2000)
" Continuous floxuridine infusion was given at a dosage of 0."2.66Regional infusion for colorectal hepatic metastases. A randomized trial comparing the hepatic artery with the portal vein. ( Daly, JM; Kemeny, N; Oderman, P; Sigurdson, E; Thom, A, 1987)
" The elimination half-life time for 5-FU was protracted by a factor of 2-3 compared with the direct injection of 5-FU."2.66Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month. ( Aas, M; Flokkmann, A; Fosså, SD; Heier, M; Heintz, R; Linder-Ciccolunghi, S; Moe, B, 1986)
" The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group."2.66Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986)
"Doxifluridine is an active agent in colorectal cancer."2.66A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma. ( Alberto, P; Cavalli, F; Germano, G; Joss, R; Kaplan, S; Martz, G; Mermillod, B; Spati, B; Weber, W, 1988)
"No excess mortality from noncolorectal cancers was apparent, nor were there significant differences by treatment: TSPA (22/22), FdUrd (9/12), and surgery only (50/42)."2.65Late effects of low-dose adjuvant chemotherapy in colorectal cancer. ( Boice, JD; Fraumeni, JF; Greene, MH; Higgins, GA; Keehn, RJ, 1980)
"In 31 patients with a rectal cancer, tumor biopsies were performed before and after pre-operative venous administration of 4 mg/m2, 6 mg/m2, or 10 mg/m2 of MMC."1.33Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C. ( Fukumitsu, T; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Sasatomi, T; Shirouzu, K; Torigoe, S; Yamashita, N; Yanagawa, T, 2006)
"We report a case of unresectable rectal cancer in a 53-year-old male treated with chemoradiation."1.31[Long-term complete response in a case of unresectable rectal cancer following chemoradiation]. ( Musha, N; Oka, K; Saito, H; Sando, N; Sasaki, M; Setu, M; Setu, Y; Sunami, E, 2000)
"We report a 68-year-old man with rectal cancer and recurrent pulmonary metastasis treated with concomitant 5'-DFUR + MMC, which resulted in an extreme reduction of the lesion."1.30[Combination of 5'-DFUR and MMC for recurrent rectal cancer with pulmonary metastasis]. ( Aihara, S; Hiki, Y; Ishikawa, H; Kakita, A; Kanazawa, H; Ohtani, Y, 1999)
"The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation."1.28Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy? ( Kim, CH; Krom, RA; Ludwig, J; Wiesner, RH, 1989)
"A 68-year-old male, who had advanced rectal cancer with multiple pulmonary metastases, had undergone resection of rectal cancer operatively and was treated with a combination chemotherapy using 5'-DFUR (5'-deoxy-5-fluorouridine) and MMC (mitomycin C) for multiple pulmonary metastases."1.28[A case of multiple pulmonary metastases from rectal cancer which responded completely to combination chemotherapy using 5'-DFUR and MMC]. ( Baba, K; Kawano, H; Matsuda, M; Matsuoka, Y; Morinaga, H; Nagao, K; Nagase, H; Nishimura, R; Ueno, Y, 1989)
" When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines."1.28The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines. ( Boven, E; Haisma, HJ; Maas, IW; Pinedo, HM; Schlüper, HM, 1991)
"1% of cases; however, it was easily reduced by decreasing the dosage or discontinuing administration of the drug."1.27[Phase II study of 5'-DFUR in gastrointestinal and breast cancer]. ( Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T, 1985)
" Further pharmacological studies seem warranted to define the optimal dosage schedule and to obtain a better therapeutic index."1.27Phase II clinical evaluation of doxifluridine. ( Armand, JP; Bastit, P; Cappelaere, P; Fargeot, P; Fumoleau, P; Hurteloup, P; Keiling, R; Kerbrat, P; Metz, R; Schraub, S, 1986)
"Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma."1.27Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983)
" In 10 of these tumors, comparative dose-response curves were obtained."1.27Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA). ( Flentje, D; Flentje, M; Schlag, P, 1986)
"Twenty patients with colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant perioperative therapy that included hepatic arterial mitomycin C and floxuridine (FUDR)."1.27Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver. ( Ames, FC; Boddie, AW; Charnsangavej, C; Claghorn, LJ; Cleary, KR; Mavligit, GM; McBride, CM; Patt, YZ, 1987)
"Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period."1.27Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats. ( Berger, MR; Garzon, FT; Keppler, BK; Schmähl, D, 1987)
" Furthermore the differing levels of 5-FU metabolites in normal and malignant tissue could not be correlated with the pharmacokinetic parameters studied."1.27The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer. ( Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L, 1987)
"In patients with metastatic colorectal cancer involving only the liver, hepatic arterial FUDR alone and with the addition of mitomycin C provided excellent control of hepatic tumor."1.27Regional chemotherapy of colorectal cancer metastatic to the liver. ( Cozzi, E; Ensminger, W; Gyves, J; Niederhuber, JE; Thrall, J; Walker, S, 1984)
"Three patients with primary hepatocellular carcinoma demonstrated less than 50% reduction in tumor size."1.27Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump. ( Jones, LS; McCune, CS; Schwartz, SI, 1985)
" The frequency of cerebellopathy may depend on the dosage and type of administration of the drug."1.27Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine. ( Fosså, SD; Heier, MS, 1985)
"Forty patients with colorectal cancer metastatic to the liver were treated with an implanted pump for hepatic artery perfusion."1.27The implanted pump in metastatic colorectal cancer of the liver. Risk versus benefit. ( Johnson, LP; Rivkin, SE, 1985)
"Thirty-five patients with metastatic colon cancer received hepatic arterial FUDR administered with implanted infusion pumps."1.27Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine. ( Hohn, DC; Lewis, BJ; Price, DC; Stagg, RJ, 1985)
"Of 13 patients with hepatoma, nine had clinically significant regression with a median survival of 11 months."1.26The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol. ( Al-Sarraf, M; Baker, L; Izbicki, R; Reed, ML; Sexon-Porte, M; Singhakowinta, A; Straatsma, GW; Vaitkevicius, VK; Vaughn, CB, 1981)
"Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts."1.25Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975)

Research

Studies (138)

TimeframeStudies, this research(%)All Research%
pre-1990105 (76.09)18.7374
1990's9 (6.52)18.2507
2000's23 (16.67)29.6817
2010's0 (0.00)24.3611
2020's1 (0.72)2.80

Authors

AuthorsStudies
Lumish, M1
Thackray, J1
Do, RKG1
Caudle, KE1
Amstutz, U1
Schwab, M1
Diasio, RB1
Jarnagin, WR1
Cercek, A1
Huh, JW1
Kim, HR1
Ojima, E1
Miki, C1
Hatada, T1
Inoue, Y1
Mohri, T1
Azuma, T1
Kusunoki, M1
SULLIVAN, RD2
NORCROSS, JW1
WATKINS, E2
ANSFIELD, FJ2
Kato, T1
Kikkawa, N3
Tsujie, M1
Iijima, S1
Handa, R1
Naoi, Y1
Oshima, S1
Yamamoto, H1
Kurokawa, E1
Haraguchi, Y1
Shimizu, H1
Takahashi, M2
Nakano, M1
Okusawa, A1
Suzuki, M1
Yoshitani, S1
Imaizumi, H1
Kuroda, M1
Yokoi, M1
Tanaka, Y1
Harada, H1
Kosaka, T1
Takashima, S1
Kemeny, N7
Eid, A1
Stockman, J1
Gonen, M1
Schwartz, L1
Tetzlaff, E1
Paty, P1
Ogata, Y2
Matono, K2
Torigoe, S2
Mizobe, T2
Sasatomi, T2
Ishibashi, N2
Shida, S1
Ohkita, A1
Fukumitu, T1
Ikeda, S1
Ogo, S1
Ozasa, H1
Shirouzu, K2
Tanaka, K1
Noura, S1
Ohue, M1
Takachi, K1
Kishi, K1
Eguchi, H1
Yamada, T1
Miyashiro, I1
Yano, M1
Ohigashi, H1
Sasaki, Y1
Ishikawa, O1
Imaoka, S1
Kameyama, M1
Murata, K1
Fukumitsu, T1
Yamashita, N1
Yanagawa, T1
Gotoh, J1
Akabane, H1
Kita, K1
Fujiyoshi, M1
Hirokata, G1
Imai, K1
Kawai, T1
Yanagida, N1
Nakano, S1
Yamane, M1
Mizuta, M1
Kaji, M1
Toyokawa, T1
Miyatani, K1
Udaka, T1
Kubo, M1
Hosokawa, N1
Suwaki, K1
Shirakawa, K1
Roybal, JJ1
Feliberti, EC1
Rouse, L1
Wagman, LD1
Xu, J1
Zhong, Y1
Weixin, N1
Xinyu, Q1
Yanhan, L1
Li, R1
Jianhua, W1
Zhiping, Y1
Jiemin, C1
Sasaki, T2
Balch, CM5
Urist, MM4
Patt, YZ5
Chuang, VP2
Wallace, S4
Hersh, EM2
Freireich, EJ1
Mavligit, GM4
Gilbert, JM1
Au, JL1
Rustum, YM1
Ledesma, EJ1
Mittelman, A2
Creaven, PJ1
McGregor, ML1
Oberfield, RA4
Huberman, MS1
Soong, SJ1
McGregor, M1
Bedikian, AY1
Niederhuber, JE1
Ensminger, W1
Gyves, J1
Thrall, J1
Walker, S1
Cozzi, E1
Abele, R1
Alberto, P2
Kaplan, S2
Siegenthaler, P1
Hofmann, V1
Ryssel, HJ1
Hartmann, D1
Holdener, EE1
Cavalli, F2
Brückner, R2
Rothmund, M3
Hinterberger, R1
Stagg, RJ2
Lewis, BJ2
Friedman, MA2
Ignoffo, RJ1
Hohn, DC2
Daly, J3
Oderman, P3
Shike, M1
Chun, H1
Petroni, G1
Geller, N2
Fujita, F1
Fujita, M1
Taguchi, T4
Trotter, GA1
Morgan, GR1
Goeting, N1
Cooper, AJ1
Taylor, I1
Hottenrott, C1
Lorenz, M2
Paolucci, V1
Encke, A1
Reed, ML1
Vaitkevicius, VK1
Al-Sarraf, M1
Vaughn, CB1
Singhakowinta, A1
Sexon-Porte, M1
Izbicki, R1
Baker, L1
Straatsma, GW1
Boice, JD1
Greene, MH1
Keehn, RJ1
Higgins, GA1
Fraumeni, JF1
Johnston, S1
Benjamin, RS1
Valdivieso, M1
Tilchen, E1
McBride, CM2
Chuang, V1
Mavligit, CM1
Sakai, K2
Irie, K2
Terasawa, T2
Shimoyama, T1
Iwanaga, T1
Fukuda, I1
Okumura, S1
Yasutake, K1
Tsumura, I1
Nishimura, G1
Izumi, R1
Matsuki, N1
Takeyama, S1
Konishi, K1
Fujita, H1
Miyata, R1
Kojima, Y1
Takada, M1
Takita, Y1
Kanno, M1
Ueno, K1
Mura, T1
Asano, K1
Syouji, M1
Yamazaki, H1
Ooto, T1
Ueda, H1
Takigawa, Y1
Sawa, T1
Miyazaki, I1
Focan, C1
Levi, F1
Kreutz, F1
Focan-Henrard, D1
Lobelle, JP1
Adam, R1
Dallemagne, B1
Jehaes, C1
Markiewicz, S1
Weerts, J1
Bismuth, H1
Jasmin, C1
Misset, JL1
Ohtani, Y1
Ishikawa, H1
Aihara, S1
Kanazawa, H1
Hiki, Y1
Kakita, A1
Müller, HH1
Musha, N1
Sunami, E1
Sasaki, M1
Saito, H1
Sando, N1
Setu, Y1
Setu, M1
Oka, K1
Min, JS3
Kim, NK3
Park, JK2
Yun, SH2
Noh, JK1
Katsumoto, Y1
Furukawa, J1
Yoshioka, S1
Shingai, T1
Takekuni, K1
Yukawa, M1
Nakaguchi, K1
Okajima, S1
Sue, F1
Hashimoto, T1
Teshima, S1
Katayama, A1
Mafune, K1
Makuuchi, M1
Sung, JS1
Jung, HC1
Roh, JK1
Seong, J1
Cho, JH1
Suh, CO1
Ogawa, M1
Takao, Y1
Mukai, H1
Satou, K1
Anazawa, S1
Yamazaki, Y1
Aoki, T1
Bozzetti, F1
Andreola, S1
Baratti, D1
Mariani, L1
Stani, SC1
Valvo, F1
Spinelli, P1
Woolley, PV1
Macdonald, JS1
Schein, PS1
Herbsman, H1
Hassan, A1
Gardner, B1
Harshaw, D1
Bohorquez, J1
Alfonso, A1
Newman, J1
Bland, KI1
Garrison, RN1
Knutson, CO1
McCaffrey, JA1
Polio, J1
Clouse, ME1
Hamilton, T1
Moertel, CG3
Canman, CE1
Tang, HY1
Normolle, DP1
Lawrence, TS1
Maybaum, J1
Kato, M1
Sawai, K1
Noguchi, A1
Minato, H1
Takahashi, T1
Maas, IW1
Boven, E1
Pinedo, HM1
Schlüper, HM1
Haisma, HJ1
Gall, FP1
Scheele, J1
Herfarth, C1
Funovics, J1
Siewert, JR1
Ludwig, J1
Kim, CH1
Wiesner, RH1
Krom, RA1
Allen-Mersh, TG1
Matsuda, M1
Nagao, K1
Baba, K1
Nishimura, R1
Matsuoka, Y1
Ueno, Y1
Morinaga, H1
Nagase, H1
Kawano, H1
Schuster, D1
Heim, ME1
Decoster, G1
Queisser, W1
Schwartz, SI1
Jones, LS1
McCune, CS1
Daly, JM6
Butler, J1
Yeh, SD1
Ridge, JA4
Botet, J2
Bading, JR1
DeCosse, JJ1
Benua, RS1
Tominaga, T1
Kitamura, M1
Hayashi, K1
Takahashi, I1
Kosaki, G1
Okajima, K1
Yamamoto, M1
Kawahara, T1
Satomi, T1
Tomita, K1
Yamaguchi, A2
Donegan, WL1
Kemeny, MM2
Goldberg, D1
Beatty, JD1
Blayney, D1
Browning, S1
Doroshow, J1
Ganteaume, L1
Hill, RL1
Kokal, WA1
Riihimaki, DU1
Giles, GR2
Woodhouse, L2
Finan, PJ2
Chisholm, EM2
Hodgson, WJ1
Friedland, M1
Ahmed, T1
Berman, H1
Katz, S1
Morgan, J1
Byrne, D1
Keller, E1
Quint, B1
Knuth, A1
Schicketanz, KH1
Clark, CG1
Pietrafitta, JJ1
Anderson, BG1
O'Brien, MJ1
Deckers, PJ1
Heier, MS2
Fosså, SD4
Hurteloup, P1
Armand, JP1
Cappelaere, P1
Metz, R1
Kerbrat, P1
Keiling, R1
Fumoleau, P1
Fargeot, P1
Schraub, S1
Bastit, P1
Lokich, JJ1
Sigurdson, ER2
Boddie, AW2
Charnsangavej, C2
Ajani, JA1
Soski, M1
Claghorn, L1
Winton, TL1
Ghent, WR1
Murakami, M1
Ota, K1
Yasue, M1
Hoshino, A1
Kamiya, O1
Kinoshita, T1
Yamada, M1
Hiraiwa, K1
Hachisuka, K1
Anderson, SD1
Holley, HC1
Berland, LL1
Van Dyke, JA1
Stanley, RJ1
Trivisionno, DP1
Riether, RD2
Sheets, JA2
Stasik, JJ2
Rosen, L2
Khubchandani, IT2
Ramming, KP1
O'Toole, K1
Flokkmann, A1
Heier, M2
Aas, M1
Moe, B1
Heintz, R1
Linder-Ciccolunghi, S1
Flentje, M1
Flentje, D1
Schlag, P1
Ames, FC1
Claghorn, LJ1
Cleary, KR1
Shepard, KV2
Levin, B3
Faintuch, J2
Doria, MI1
DuBrow, RA2
Riddell, RH1
Garzon, FT1
Berger, MR1
Keppler, BK1
Schmähl, D1
Reichman, B1
Sigurdson, E1
Thom, A1
Chang, AE1
Schneider, PD1
Sugarbaker, PH1
Simpson, C1
Culnane, M1
Steinberg, SM1
Rougier, P1
Lasser, P1
Droz, JP1
Elias, D1
Ghosn, M1
Ducreux, M1
Lumbroso, J1
Sidibe, S1
Valone, FH1
Kohler, M1
Fisher, K1
Hannigan, J1
Flam, M1
Gandara, D1
Hendrickson, C1
Richman, E1
Yu, KP1
Civalleri, D1
Cosimelli, M1
Craus, W1
Doci, R1
Griffanti-Bartoli, F1
Percivale, P1
Repetto, M1
Simoni, G1
Mermillod, B1
Germano, G1
Weber, W1
Joss, R1
Spati, B1
Martz, G1
Koks, CH1
Brouwers, JR1
Sleijfer, DT1
Link, KH1
Aigner, KR1
Peschau, K1
Warthona, M1
Schwemmle, K1
Danenberg, PV1
Janis, LW1
Leming, PD1
Leder, W1
O'Mahony, C1
Dahl, O1
Hoel, R1
Loeb, M1
Blachly, RJ1
Reid, IS1
Hutchins, LF1
Lang, NP1
Neilan, BA1
Ortego, SG1
Hohn, D1
Melnick, J1
Stagg, R1
Altman, D1
Friedman, M1
Ignoffo, R1
Ferrell, L1
Lewis, B1
Karl, RC1
Hagle, M1
Cooper, RM1
Beschorner, J1
Stablein, D1
Johnson, LP1
Rivkin, SE1
Cohen, AM1
Kaufman, SD1
Wood, WC1
Botet, JF1
Watson, RC1
Yeh, S1
Battifora, H1
Blayney, DW1
Cecchi, G1
Goldberg, DA1
Leong, LA1
Margolin, KA1
Terz, JJ1
Price, DC1
Pettavel, J1
Morgenthaler, F1
Brulé, G1
Hane, S1
Swinton, NW2
Nahra, KS2
Khazei, AM1
Scherer, WP1
Reitemeier, RJ2
Hahn, RG2
Meyza, J1
Ramirez, G1
Cady, B1
Lipton, A1
Ratner, LH1
Weiner, MJ1
Cohen, SM1
Greenspan, EM1
Schutt, AJ1
Krakoff, IH2
Miller, E1
Van Dyk, JJ1
Clarkson, BD1
Duschinsky, R1
Keller, O1
La Sala, E1
Morrow, LB1
Burrow, GN1
Kaplan, SR1
Mulrow, PJ1
Kenis, Y1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Trial of Isolated Hepatic Perfusion With Oxaliplatin Followed by Hepatic Arterial Infusion of FUDR and Leucovorin for Patients With Unresectable Colorectal Liver Metastases[NCT01042691]Phase 110 participants (Actual)Interventional2003-05-31Completed
A Humanitarian Device Exemption Use Protocol of Therasphere® for Treatment of Unresectable Hepatocellular and Metastatic Liver Tumors - HDE #980006[NCT00701168]0 participants Expanded AccessNo longer available
A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver[NCT00001576]Phase 128 participants Interventional1997-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for floxuridine and Cancer of Rectum

ArticleYear
Intraarterial hepatic infusion chemotherapy in metastatic liver cancer.
    Seminars in oncology, 1983, Volume: 10, Issue:2

    Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusio

1983
Comparison of systemic chemotherapy with hepatic arterial infusion in metastatic colorectal carcinoma.
    Seminars in oncology, 1983, Volume: 10, Issue:2

    Topics: Antineoplastic Agents; Catheterization; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; F

1983
Regional and systemic chemotherapy for advanced colorectal cancer. A review.
    Diseases of the colon and rectum, 1983, Volume: 26, Issue:5

    Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; D

1983
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
    Annals of internal medicine, 1984, Volume: 100, Issue:5

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridin

1984
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:5

    Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Art

1983
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:8

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia;

1996
Adrenalectomy for solitary adrenal metastasis from colorectal carcinoma.
    Japanese journal of clinical oncology, 2000, Volume: 30, Issue:9

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2000
Chemotherapy of colorectal carcinoma.
    Seminars in oncology, 1976, Volume: 3, Issue:4

    Topics: Administration, Oral; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Drug Administration Sche

1976
Colorectal liver metastases: is 'no treatment' still best?
    Journal of the Royal Society of Medicine, 1989, Volume: 82, Issue:1

    Topics: Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; Rectal Neoplasms

1989
Treatment of colorectal hepatic metastases.
    Surgery, gynecology & obstetrics, 1985, Volume: 161, Issue:6

    Topics: Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; F

1985
[Chemotherapy of cancer of the rectum and the colon].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1970, Nov-16, Volume: 25, Issue:46

    Topics: Antimetabolites; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, I

1970
Chemotherapy of residual disease in solid tumours.
    Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1971, Volume: 16, Issue:2

    Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lun

1971

Trials

28 trials available for floxuridine and Cancer of Rectum

ArticleYear
Hepatic arterial infusion of floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma.
    Journal of surgical oncology, 2005, Aug-01, Volume: 91, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dexamethasone; Dose-

2005
Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery.
    Annals of surgery, 2007, Volume: 245, Issue:4

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocol

2007
Adjuvant chemotherapy of large bowel cancer.
    Cancer treatment reviews, 1982, Volume: 9, Issue:3

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxu

1982
A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump.
    Annals of surgery, 1983, Volume: 198, Issue:5

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial;

1983
Late effects of low-dose adjuvant chemotherapy in colorectal cancer.
    Journal of the National Cancer Institute, 1980, Volume: 64, Issue:3

    Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Hu

1980
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:8

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia;

1996
Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion.
    Anti-cancer drugs, 1999, Volume: 10, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Clocks; Colonic Neoplasms; C

1999
Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy P

2000
A prospective randomized trial comparing intravenous 5-fluorouracil and oral doxifluridine as postoperative adjuvant treatment for advanced rectal cancer.
    Annals of surgical oncology, 2000, Volume: 7, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disea

2000
Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
    Japanese journal of clinical oncology, 2001, Volume: 31, Issue:1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Floxuridin

2001
Preoperative chemoradiotherapy with oral doxifluridine plus low-dose oral leucovorin in unresectable primary rectal cancer.
    International journal of radiation oncology, biology, physics, 2001, Jun-01, Volume: 50, Issue:2

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C

2001
Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
    Annals of surgical oncology, 2002, Volume: 9, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera

2002
Results of a prospective randomized trial of continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries.
    Cancer, 1986, Feb-01, Volume: 57, Issue:3

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Hepatectomy; Hepatic Artery; Humans; Infus

1986
Treatment of colorectal hepatic metastases by intrahepatic chemotherapy alone or as an adjuvant to complete or partial removal of metastatic disease.
    Annals of surgery, 1986, Volume: 203, Issue:4

    Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Embolization, T

1986
[Regional chemotherapy of liver metastases of colorectal carcinoma using implanted gas pressure pumps. Results of a prospective phase II study].
    Deutsche medizinische Wochenschrift (1946), 1986, Apr-25, Volume: 111, Issue:17

    Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human

1986
Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd).
    Acta neurologica Scandinavica, 1986, Volume: 73, Issue:5

    Topics: Adult; Aged; Brain Diseases; Carcinoid Tumor; Carcinoma; Cerebellar Diseases; Colonic Neoplasms; Ele

1986
Systemic infusional chemotherapy for liver metastasis: an improved schedule for 5-fluorouracil.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1986, Volume: 100

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil

1986
Preliminary results of a randomized study of intrahepatic infusion versus systemic infusion of 5-fluoro-2'-deoxyuridine for metastatic colorectal carcinoma.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1986, Volume: 100

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions,

1986
Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Cecal Neoplasms; Colonic Neoplasms; Drug Evaluation; Drug Tol

1986
Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. A randomized trial.
    Annals of internal medicine, 1987, Volume: 107, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepat

1987
Regional infusion for colorectal hepatic metastases. A randomized trial comparing the hepatic artery with the portal vein.
    Archives of surgery (Chicago, Ill. : 1960), 1987, Volume: 122, Issue:11

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Fl

1987
A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases.
    Annals of surgery, 1987, Volume: 206, Issue:6

    Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Infusions, I

1987
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Sc

1987
A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma.
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxurid

1988
Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer.
    Pharmaceutisch weekblad. Scientific edition, 1988, Apr-22, Volume: 10, Issue:2

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infu

1988
Hepatic infusional chemotherapy in metastatic colorectal carcinoma and hepatoma.
    The Journal of the Arkansas Medical Society, 1985, Volume: 82, Issue:7

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuri

1985
Biliary sclerosis in patients receiving hepatic arterial infusions of floxuridine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:1

    Topics: Aged; Bile Ducts; Cholangiography; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; I

1985
Adrenal function in patients treated with testosterone and fluorinated pyrimidines.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:2

    Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormon

1968

Other Studies

99 other studies available for floxuridine and Cancer of Rectum

ArticleYear
Precision Management of a Patient With Dihydropyrimidine Dehydrogenase Deficiency and Liver-Predominant Metastatic Rectal Cancer Using Hepatic Arterial Floxuridine.
    JCO precision oncology, 2023, Volume: 7

    Topics: Dihydropyrimidine Dehydrogenase Deficiency; Floxuridine; Humans; Liver Neoplasms; Rectal Neoplasms

2023
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
    Journal of surgical oncology, 2009, Oct-01, Volume: 100, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuv

2009
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Sc

2002
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
    The New England journal of medicine, 1964, Feb-13, Volume: 270

    Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colo

1964
A LESS TOXIC FLUOROURACIL DOSAGE SCHEDULE.
    JAMA, 1964, Nov-16, Volume: 190

    Topics: Alopecia; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Eruptions; Epistaxis; Female; Floxurid

1964
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administrat

2003
[Two cases of metastatic or recurrent rectal cancer responding to combined chemotherapy of low-dose CPT-11 and 5'-DFUR as second-line chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptoth

2004
[A case of long-term survival after chemo-radiation for postoperative local recurrence of rectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy

2004
The benefit of post-operative adjuvant chemotherapy using oral fluoropyrimidines in rectal cancer.
    The Kurume medical journal, 2005, Volume: 52, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female;

2005
[A case of chemoradiation with tissue expander for local reccurence of rectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:11

    Topics: Adenocarcinoma, Mucinous; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antine

2005
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
    Journal of surgical oncology, 2006, Jan-01, Volume: 93, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Che

2006
[A case of local recurrence of rectal cancer in long-term responding to combined therapy of low-dose CPT-11 and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptoth

2006
[Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Admini

2006
Pump removal in infected patients with hepatic chemotherapy pumps: when is it necessary?
    The American surgeon, 2006, Volume: 72, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colonic Neoplasms; Device Removal;

2006
[An inadvertent contraindicated combined use of newly prescribed TS-1 and unused doxifluridine].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:4

    Topics: Aged; Contraindications; Drug Combinations; Floxuridine; Humans; Male; Medication Errors; Oxonic Aci

2007
[Intra-arterial chemotherapy using an implantable infusion pump in liver metastases of colorectal tumors and hepatomas].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1984, Volume: 55, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxoru

1984
The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver.
    Lancet (London, England), 1981, Feb-14, Volume: 1, Issue:8216

    Topics: Antineoplastic Agents; Colonic Neoplasms; Embolization, Therapeutic; Floxuridine; Gelatin Sponge, Ab

1981
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
    Cancer research, 1982, Volume: 42, Issue:7

    Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenter

1982
Continuous regional chemotherapy for metastatic colorectal cancer using a totally implantable infusion pump. A feasibility study in 50 patients.
    American journal of surgery, 1983, Volume: 145, Issue:2

    Topics: Colonic Neoplasms; Evaluation Studies as Topic; Floxuridine; Hepatic Artery; Humans; Infusions, Intr

1983
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1983, Volume: 86

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality

1983
Regional chemotherapy of colorectal cancer metastatic to the liver.
    Cancer, 1984, Mar-15, Volume: 53, Issue:6

    Topics: Antineoplastic Agents; Catheters, Indwelling; Colonic Neoplasms; Drug Evaluation; Female; Floxuridin

1984
Phase II study of doxifluridine in advanced colorectal adenocarcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms

1983
[Local infusion therapy in liver metastases of colorectal cancers. Results of a phase-II study].
    Deutsche medizinische Wochenschrift (1946), 1984, Apr-06, Volume: 109, Issue:14

    Topics: Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusio

1984
Hepatic artery pump infusion: toxicity and results in patients with metastatic colorectal carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusio

1984
[Effects of 5'-deoxy-5-fluorouridine on human gastrointestinal and breast cancers xenografted to nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:8

    Topics: Adenocarcinoma; Administration, Oral; Animals; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Femal

1984
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
    The British journal of surgery, 1984, Volume: 71, Issue:12

    Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine

1984
[New possibilities in the treatment of hepatic metastasis of colo-rectal carcinomas].
    Minerva chirurgica, 1984, Nov-15, Volume: 39, Issue:21

    Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Rectal Neoplasms

1984
The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol.
    Cancer, 1981, Jan-15, Volume: 47, Issue:2

    Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-

1981
[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-01, Volume: 108, Issue:26

    Topics: Carcinoma, Hepatocellular; Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepa

1983
Percutaneous hepatic arterial infusion (HAI) of mitomycin C and floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver.
    Cancer, 1980, Jul-15, Volume: 46, Issue:2

    Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human

1980
Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.
    Archives of surgery (Chicago, Ill. : 1960), 1981, Volume: 116, Issue:7

    Topics: Adenocarcinoma; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; M

1981
[Combination therapy of high dose doxifluridine (5'-DFUR)+mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5'-DFUR with Other Drugs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms

1993
[A case of bilateral pulmonary metastasis from rectal cancer successfully treated with resection after high-dose 5'-DFUR plus MMC combination chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Flox

1993
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:13

    Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Extracellular Matrix; Female; Floxuridine; Hu

1997
[Combination of 5'-DFUR and MMC for recurrent rectal cancer with pulmonary metastasis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:7

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule;

1999
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy

2000
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:12

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality

2000
[A case report of effective chemoradiation with 5'-DFUR and concomitant preoperative radiotherapy of the lower rectum].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:4

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Floxuridine;

2002
Treatment of hepatic metastases with a combination of hepatic artery infusion chemotherapy and external radiotherapy.
    Surgery, gynecology & obstetrics, 1978, Volume: 147, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Catheterization; Cobalt Radioisotopes; Colonic Neoplasms; Female

1978
Colorectal carcinoma: overview of management techniques.
    Postgraduate medicine, 1979, Volume: 66, Issue:3

    Topics: BCG Vaccine; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Radioth

1979
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
    Cancer, 1979, Volume: 44, Issue:2

    Topics: Adenocarcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusi

1979
Clinical management of advanced gastrointestinal cancer.
    Cancer, 1975, Volume: 36, Issue:2

    Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther

1975
Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-01, Volume: 89, Issue:21

    Topics: Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug

1992
[Two cases of pulmonary metastasis of colorectal cancer successfully treated with oral 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Drug Administration Schedule; Fem

1992
The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines.
    International journal of cancer, 1991, Jul-09, Volume: 48, Issue:5

    Topics: Antibodies, Monoclonal; Carcinoembryonic Antigen; Cell Division; Cell Line; Colonic Neoplasms; Drug

1991
[The concept of therapy in liver metastases].
    Langenbecks Archiv fur Chirurgie, 1985, Volume: 365, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Humans; Infusions, I

1985
Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy?
    Hepatology (Baltimore, Md.), 1989, Volume: 9, Issue:2

    Topics: Adult; Bile Ducts; Cholangitis, Sclerosing; Floxuridine; Humans; Ischemia; Liver Neoplasms; Male; Re

1989
[A case of multiple pulmonary metastases from rectal cancer which responded completely to combination chemotherapy using 5'-DFUR and MMC].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:8 Pt 1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Tolerance; Floxuridine; H

1989
Phase I-II trial of doxifluridine (5'DFUR) administered as long-term continuous infusion using a portable infusion pump for advanced colorectal cancer.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Female; Flox

1989
Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump.
    Annals of surgery, 1985, Volume: 201, Issue:5

    Topics: Adenoma, Islet Cell; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Catheterization; Catheters

1985
Predicting tumor response in patients with colorectal hepatic metastases.
    Annals of surgery, 1985, Volume: 202, Issue:3

    Topics: Adult; Aged; Angiography; Blood Flow Velocity; Colonic Neoplasms; Female; Floxuridine; Humans; Liver

1985
[Phase II study of 5'-DFUR in gastrointestinal and breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarr

1985
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11

    Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neopla

1985
Hepatic artery infusion chemotherapy for colorectal metastases: a personal experience.
    Journal of surgical oncology, 1985, Volume: 30, Issue:3

    Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans

1985
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
    Gut, 1986, Volume: 27, Issue:2

    Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male;

1986
Implantable vascular access devices in the treatment of colorectal liver metastases.
    The British journal of surgery, 1986, Volume: 73, Issue:6

    Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arter

1986
Cholecystitis secondary to infusion chemotherapy.
    Journal of surgical oncology, 1986, Volume: 31, Issue:4

    Topics: Adult; Cholecystitis; Colonic Neoplasms; Drug Implants; Female; Floxuridine; Hepatic Artery; Humans;

1986
Phase II clinical evaluation of doxifluridine.
    Cancer treatment reports, 1986, Volume: 70, Issue:6

    Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Diseases; Col

1986
Fluorodeoxyuridine uptake by human colorectal hepatic metastases after hepatic artery infusion.
    Surgery, 1986, Volume: 100, Issue:2

    Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Int

1986
Hepatic arterial infusion with floxuridine and cisplatin: overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury;

1986
Hepatic artery infusion chemotherapy with the Infusaid pump: a Canadian experience.
    Canadian journal of surgery. Journal canadien de chirurgie, 1986, Volume: 29, Issue:5

    Topics: Aged; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Female; Floxuridine; Hepatic Arte

1986
[Clinical trial of 5'-deoxy-5-fluorouridine in malignant tumors under cooperative study (phase II study)].
    Nihon Gan Chiryo Gakkai shi, 1986, Jun-20, Volume: 21, Issue:5

    Topics: Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine;

1986
Causes of jaundice during hepatic artery infusion chemotherapy.
    Radiology, 1986, Volume: 161, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Bile Ducts, Intrahepatic; Colonic Neoplasms; Female; Floxuridine; Human

1986
Follow-up on a prospective study of continuous hepatic perfusion with implantable pump.
    Diseases of the colon and rectum, 1986, Volume: 29, Issue:11

    Topics: Aged; Aged, 80 and over; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Follow-Up

1986
The use of the implantable chemoinfusion pump in the treatment of hepatic metastases of colorectal cancer.
    Archives of surgery (Chicago, Ill. : 1960), 1986, Volume: 121, Issue:12

    Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Digestive System Diseases; Floxuridine; Hepatic Artery;

1986
Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA).
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3

    Topics: Colonic Neoplasms; Colony-Forming Units Assay; Culture Techniques; Dose-Response Relationship, Drug;

1986
Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver.
    Cancer, 1987, Mar-01, Volume: 59, Issue:5

    Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuri

1987
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
    American journal of clinical oncology, 1987, Volume: 10, Issue:1

    Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine

1987
Distribution of fluorodeoxyuridine uptake in the liver and colorectal hepatic metastases of human beings after arterial infusion.
    Surgery, gynecology & obstetrics, 1987, Volume: 164, Issue:4

    Topics: Adult; Colonic Neoplasms; Floxuridine; Humans; Liver; Liver Neoplasms; Middle Aged; Rectal Neoplasms

1987
Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.
    Cancer chemotherapy and pharmacology, 1987, Volume: 19, Issue:4

    Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylnitrosamine; Floxuridine; Imidazoles; Male; Orga

1987
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1987, Volume: 13, Issue:4

    Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kineti

1987
Regional and systemic chemotherapy for colorectal metastases to the liver.
    World journal of surgery, 1987, Volume: 11, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans

1987
[Locoregional chemotherapy of hepatic metastases of colorectal cancer].
    Annales de gastroenterologie et d'hepatologie, 1987, Volume: 23, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Infusion Pumps; I

1987
[Regional arterial chemotherapy of hepatic metastases secondary to colorectal carcinoma].
    Revista espanola de las enfermedades del aparato digestivo, 1987, Volume: 72, Issue:4 Pt 2

    Topics: Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Mi

1987
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
    Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:1

    Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorour

1988
Nonspecific corticosteroid therapy in patients receiving intra-arterial chemotherapy for hepatic metastases of colorectal origin.
    Cancer investigation, 1988, Volume: 6, Issue:3

    Topics: Adrenal Cortex Hormones; Cholestasis; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-Arter

1988
Can something be done for patients with liver metastases for colorectal cancer?
    The Practitioner, 1988, Sep-08, Volume: 232, Issue:1454 ( Pt

    Topics: Colonic Neoplasms; Floxuridine; Humans; Infusion Pumps; Liver Neoplasms; Rectal Neoplasms

1988
Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Angina Pectoris; Brain Diseases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Evaluation; Elect

1985
Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine.
    Acta neurologica Scandinavica, 1985, Volume: 72, Issue:2

    Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Body Weight; Brain Diseases; Cerebellar Diseases; C

1985
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induc

1985
A prospective study of continuous hepatic perfusion with implantable pump.
    Diseases of the colon and rectum, 1985, Volume: 28, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Chemotherapy, Cancer

1985
The implanted pump in metastatic colorectal cancer of the liver. Risk versus benefit.
    American journal of surgery, 1985, Volume: 149, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio

1985
Treatment of colorectal cancer hepatic metastases by hepatic artery chemotherapy.
    Diseases of the colon and rectum, 1985, Volume: 28, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms; Floxuridine; Fluorour

1985
Cholangitis complicating intraarterial chemotherapy in liver metastasis.
    Radiology, 1985, Volume: 156, Issue:2

    Topics: Alkaline Phosphatase; Bilirubin; Carcinoembryonic Antigen; Cholangiography; Cholangitis; Colonic Neo

1985
Sclerosing cholangitis after continuous hepatic artery infusion of FUDR.
    Annals of surgery, 1985, Volume: 202, Issue:2

    Topics: Aged; Bile Ducts; Cholangitis; Cholestasis; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery;

1985
Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:9

    Topics: Colonic Neoplasms; Duodenitis; Duodenum; Floxuridine; Gastritis; Hepatic Artery; Humans; Infusions,

1985
The treatment of hepatic metastases by long-term chemotherapeutic infusions.
    Aktuelle Probleme in der Chirurgie, 1970, Volume: 14

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Evaluation Studies as Topic; Female;

1970
[Our experience with 5-fluoro-2-desocyuridine].
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Gallbladder Neoplasms; Humans; Liver Neoplasms;

1968
The evolution of colorectal cancer.
    Diseases of the colon and rectum, 1968, Volume: 11, Issue:6

    Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Parenteral; Liver Neoplasms; Lymphatic Metastasis

1968
Comparative response of carcinoma of the rectum and carcinoma of the colon to fluorinated pyrimidine therapy.
    Cancer chemotherapy reports, 1969, Volume: 53, Issue:5

    Topics: Colonic Neoplasms; Floxuridine; Rectal Neoplasms

1969
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:2

    Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin

1971
Arterial infusion chemotherapy of liver metastases arising from rectal and colonic cancer.
    Proceedings of the Royal Society of Medicine, 1970, Volume: 63 Suppl

    Topics: Colonic Neoplasms; Floxuridine; Humans; Injections, Intra-Arterial; Liver Function Tests; Liver Neop

1970
Chemotherapy of cancer of the colon and rectum.
    Pennsylvania medicine, 1972, Volume: 75, Issue:5

    Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds;

1972
Practical aspects of investigation and treatment of colorectal cancer.
    The Medical clinics of North America, 1972, Volume: 56, Issue:3

    Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function

1972
Chemotherapy of colon and rectal cancer.
    The Surgical clinics of North America, 1972, Volume: 52, Issue:4

    Topics: Administration, Oral; Antigens, Neoplasm; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasm

1972
Effect of resection of the primary neoplasm on responsiveness to chemotherapy of patients with large bowel cancer.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:4

    Topics: Adenocarcinoma; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; Rectal

1972
Chemotherapy of gastrointestinal cancer.
    Cancer, 1972, Volume: 30, Issue:6

    Topics: Antineoplastic Agents; Colonic Neoplasms; Esophageal Neoplasms; Floxuridine; Fluorouracil; Gastroint

1972
The clinical effects of prolonged intravenous infusion of 5-fluoro-2'-deoxyuridine.
    Cancer research, 1965, Volume: 25, Issue:7

    Topics: Adenoma, Islet Cell; Aged; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Female; Fl

1965
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
    Cancer research, 1967, Volume: 27, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carci

1967