floxuridine has been researched along with Cancer of Rectum in 138 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "All patients had metastatic colorectal cancer, with adjuvant or palliative chemotherapy given to six patients (22%) on schedule A and 12 patients on schedule B (41%)." | 6.69 | Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. ( Adam, R; Bismuth, H; Dallemagne, B; Focan, C; Focan-Henrard, D; Jasmin, C; Jehaes, C; Kreutz, F; Levi, F; Lobelle, JP; Markiewicz, S; Misset, JL; Weerts, J, 1999) |
| " The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group." | 6.66 | Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986) |
| "Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma." | 5.27 | Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983) |
| "Thirty-two consecutive patients with a palpable adenocarcinoma of the rectum received preoperative RT (45 Gy in 25 fractions over 5 weeks) plus continuous chemotherapy with doxifluridine and leucovorin or 5-fluorouracil by continuous intravenous infusion during RT." | 5.10 | Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response. ( Andreola, S; Baratti, D; Bozzetti, F; Mariani, L; Spinelli, P; Stani, SC; Valvo, F, 2002) |
| "The figures in patients with breast cancer were: 1,761 days (58." | 3.78 | [Survival and changes of clinical laboratory data in phase II study with 5'-DFUR]. ( Taguchi, T, 1996) |
| "The action of floxuridine depends greatly on its concentration for treatment of liver metastases of colorectal carcinomas and other tumors." | 3.66 | [Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors]. ( Balch, CM; Urist, MM, 1983) |
| "Patients with stage II or stage III colorectal cancer (CRC) were randomly assigned to receive preoperative hepatic and regional arterial chemotherapy (PHRAC group, n = 110) or surgery alone (control group, n = 112)." | 2.73 | Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery. ( Jianhua, W; Jiemin, C; Li, R; Weixin, N; Xinyu, Q; Xu, J; Yanhan, L; Zhiping, Y; Zhong, Y, 2007) |
| "Twenty-eight patients with rectal cancer, staged as over T3N1 or T4 by transrectal ultrasonography between July 1997 and December 1998, were included in this study." | 2.70 | Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials. ( Jung, HC; Kim, NK; Min, JS; Park, JK; Roh, JK; Sung, JS; Yun, SH, 2001) |
| "All patients had metastatic colorectal cancer, with adjuvant or palliative chemotherapy given to six patients (22%) on schedule A and 12 patients on schedule B (41%)." | 2.69 | Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. ( Adam, R; Bismuth, H; Dallemagne, B; Focan, C; Focan-Henrard, D; Jasmin, C; Jehaes, C; Kreutz, F; Levi, F; Lobelle, JP; Markiewicz, S; Misset, JL; Weerts, J, 1999) |
| "Median times to disease progression for the three treatment arms were as follows: 9." | 2.69 | Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore ( Lorenz, M; Müller, HH, 2000) |
| " Continuous floxuridine infusion was given at a dosage of 0." | 2.66 | Regional infusion for colorectal hepatic metastases. A randomized trial comparing the hepatic artery with the portal vein. ( Daly, JM; Kemeny, N; Oderman, P; Sigurdson, E; Thom, A, 1987) |
| " The elimination half-life time for 5-FU was protracted by a factor of 2-3 compared with the direct injection of 5-FU." | 2.66 | Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month. ( Aas, M; Flokkmann, A; Fosså, SD; Heier, M; Heintz, R; Linder-Ciccolunghi, S; Moe, B, 1986) |
| " The neurotoxicity was dose related, affecting 7 of 8 patients in the high dosage group and 3 of 9 patients in the low dosage group." | 2.66 | Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd). ( Fosså, SD; Heier, MS, 1986) |
| "Doxifluridine is an active agent in colorectal cancer." | 2.66 | A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma. ( Alberto, P; Cavalli, F; Germano, G; Joss, R; Kaplan, S; Martz, G; Mermillod, B; Spati, B; Weber, W, 1988) |
| "No excess mortality from noncolorectal cancers was apparent, nor were there significant differences by treatment: TSPA (22/22), FdUrd (9/12), and surgery only (50/42)." | 2.65 | Late effects of low-dose adjuvant chemotherapy in colorectal cancer. ( Boice, JD; Fraumeni, JF; Greene, MH; Higgins, GA; Keehn, RJ, 1980) |
| "In 31 patients with a rectal cancer, tumor biopsies were performed before and after pre-operative venous administration of 4 mg/m2, 6 mg/m2, or 10 mg/m2 of MMC." | 1.33 | Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C. ( Fukumitsu, T; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Sasatomi, T; Shirouzu, K; Torigoe, S; Yamashita, N; Yanagawa, T, 2006) |
| "We report a case of unresectable rectal cancer in a 53-year-old male treated with chemoradiation." | 1.31 | [Long-term complete response in a case of unresectable rectal cancer following chemoradiation]. ( Musha, N; Oka, K; Saito, H; Sando, N; Sasaki, M; Setu, M; Setu, Y; Sunami, E, 2000) |
| "We report a 68-year-old man with rectal cancer and recurrent pulmonary metastasis treated with concomitant 5'-DFUR + MMC, which resulted in an extreme reduction of the lesion." | 1.30 | [Combination of 5'-DFUR and MMC for recurrent rectal cancer with pulmonary metastasis]. ( Aihara, S; Hiki, Y; Ishikawa, H; Kakita, A; Kanazawa, H; Ohtani, Y, 1999) |
| "The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation." | 1.28 | Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy? ( Kim, CH; Krom, RA; Ludwig, J; Wiesner, RH, 1989) |
| "A 68-year-old male, who had advanced rectal cancer with multiple pulmonary metastases, had undergone resection of rectal cancer operatively and was treated with a combination chemotherapy using 5'-DFUR (5'-deoxy-5-fluorouridine) and MMC (mitomycin C) for multiple pulmonary metastases." | 1.28 | [A case of multiple pulmonary metastases from rectal cancer which responded completely to combination chemotherapy using 5'-DFUR and MMC]. ( Baba, K; Kawano, H; Matsuda, M; Matsuoka, Y; Morinaga, H; Nagao, K; Nagase, H; Nishimura, R; Ueno, Y, 1989) |
| " When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines." | 1.28 | The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines. ( Boven, E; Haisma, HJ; Maas, IW; Pinedo, HM; Schlüper, HM, 1991) |
| "1% of cases; however, it was easily reduced by decreasing the dosage or discontinuing administration of the drug." | 1.27 | [Phase II study of 5'-DFUR in gastrointestinal and breast cancer]. ( Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T, 1985) |
| " Further pharmacological studies seem warranted to define the optimal dosage schedule and to obtain a better therapeutic index." | 1.27 | Phase II clinical evaluation of doxifluridine. ( Armand, JP; Bastit, P; Cappelaere, P; Fargeot, P; Fumoleau, P; Hurteloup, P; Keiling, R; Kerbrat, P; Metz, R; Schraub, S, 1986) |
| "Doxifluridine has therapeutic activity, albeit limited, in advanced rectosigmoid adenocarcinoma." | 1.27 | Phase II study of doxifluridine in advanced colorectal adenocarcinoma. ( Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P, 1983) |
| " In 10 of these tumors, comparative dose-response curves were obtained." | 1.27 | Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA). ( Flentje, D; Flentje, M; Schlag, P, 1986) |
| "Twenty patients with colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant perioperative therapy that included hepatic arterial mitomycin C and floxuridine (FUDR)." | 1.27 | Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver. ( Ames, FC; Boddie, AW; Charnsangavej, C; Claghorn, LJ; Cleary, KR; Mavligit, GM; McBride, CM; Patt, YZ, 1987) |
| "Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period." | 1.27 | Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats. ( Berger, MR; Garzon, FT; Keppler, BK; Schmähl, D, 1987) |
| " Furthermore the differing levels of 5-FU metabolites in normal and malignant tissue could not be correlated with the pharmacokinetic parameters studied." | 1.27 | The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer. ( Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L, 1987) |
| "In patients with metastatic colorectal cancer involving only the liver, hepatic arterial FUDR alone and with the addition of mitomycin C provided excellent control of hepatic tumor." | 1.27 | Regional chemotherapy of colorectal cancer metastatic to the liver. ( Cozzi, E; Ensminger, W; Gyves, J; Niederhuber, JE; Thrall, J; Walker, S, 1984) |
| "Three patients with primary hepatocellular carcinoma demonstrated less than 50% reduction in tumor size." | 1.27 | Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump. ( Jones, LS; McCune, CS; Schwartz, SI, 1985) |
| " The frequency of cerebellopathy may depend on the dosage and type of administration of the drug." | 1.27 | Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine. ( Fosså, SD; Heier, MS, 1985) |
| "Forty patients with colorectal cancer metastatic to the liver were treated with an implanted pump for hepatic artery perfusion." | 1.27 | The implanted pump in metastatic colorectal cancer of the liver. Risk versus benefit. ( Johnson, LP; Rivkin, SE, 1985) |
| "Thirty-five patients with metastatic colon cancer received hepatic arterial FUDR administered with implanted infusion pumps." | 1.27 | Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine. ( Hohn, DC; Lewis, BJ; Price, DC; Stagg, RJ, 1985) |
| "Of 13 patients with hepatoma, nine had clinically significant regression with a median survival of 11 months." | 1.26 | The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol. ( Al-Sarraf, M; Baker, L; Izbicki, R; Reed, ML; Sexon-Porte, M; Singhakowinta, A; Straatsma, GW; Vaitkevicius, VK; Vaughn, CB, 1981) |
| "Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts." | 1.25 | Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 105 (76.09) | 18.7374 |
| 1990's | 9 (6.52) | 18.2507 |
| 2000's | 23 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (0.72) | 2.80 |
| Authors | Studies |
|---|---|
| Lumish, M | 1 |
| Thackray, J | 1 |
| Do, RKG | 1 |
| Caudle, KE | 1 |
| Amstutz, U | 1 |
| Schwab, M | 1 |
| Diasio, RB | 1 |
| Jarnagin, WR | 1 |
| Cercek, A | 1 |
| Huh, JW | 1 |
| Kim, HR | 1 |
| Ojima, E | 1 |
| Miki, C | 1 |
| Hatada, T | 1 |
| Inoue, Y | 1 |
| Mohri, T | 1 |
| Azuma, T | 1 |
| Kusunoki, M | 1 |
| SULLIVAN, RD | 2 |
| NORCROSS, JW | 1 |
| WATKINS, E | 2 |
| ANSFIELD, FJ | 2 |
| Kato, T | 1 |
| Kikkawa, N | 3 |
| Tsujie, M | 1 |
| Iijima, S | 1 |
| Handa, R | 1 |
| Naoi, Y | 1 |
| Oshima, S | 1 |
| Yamamoto, H | 1 |
| Kurokawa, E | 1 |
| Haraguchi, Y | 1 |
| Shimizu, H | 1 |
| Takahashi, M | 2 |
| Nakano, M | 1 |
| Okusawa, A | 1 |
| Suzuki, M | 1 |
| Yoshitani, S | 1 |
| Imaizumi, H | 1 |
| Kuroda, M | 1 |
| Yokoi, M | 1 |
| Tanaka, Y | 1 |
| Harada, H | 1 |
| Kosaka, T | 1 |
| Takashima, S | 1 |
| Kemeny, N | 7 |
| Eid, A | 1 |
| Stockman, J | 1 |
| Gonen, M | 1 |
| Schwartz, L | 1 |
| Tetzlaff, E | 1 |
| Paty, P | 1 |
| Ogata, Y | 2 |
| Matono, K | 2 |
| Torigoe, S | 2 |
| Mizobe, T | 2 |
| Sasatomi, T | 2 |
| Ishibashi, N | 2 |
| Shida, S | 1 |
| Ohkita, A | 1 |
| Fukumitu, T | 1 |
| Ikeda, S | 1 |
| Ogo, S | 1 |
| Ozasa, H | 1 |
| Shirouzu, K | 2 |
| Tanaka, K | 1 |
| Noura, S | 1 |
| Ohue, M | 1 |
| Takachi, K | 1 |
| Kishi, K | 1 |
| Eguchi, H | 1 |
| Yamada, T | 1 |
| Miyashiro, I | 1 |
| Yano, M | 1 |
| Ohigashi, H | 1 |
| Sasaki, Y | 1 |
| Ishikawa, O | 1 |
| Imaoka, S | 1 |
| Kameyama, M | 1 |
| Murata, K | 1 |
| Fukumitsu, T | 1 |
| Yamashita, N | 1 |
| Yanagawa, T | 1 |
| Gotoh, J | 1 |
| Akabane, H | 1 |
| Kita, K | 1 |
| Fujiyoshi, M | 1 |
| Hirokata, G | 1 |
| Imai, K | 1 |
| Kawai, T | 1 |
| Yanagida, N | 1 |
| Nakano, S | 1 |
| Yamane, M | 1 |
| Mizuta, M | 1 |
| Kaji, M | 1 |
| Toyokawa, T | 1 |
| Miyatani, K | 1 |
| Udaka, T | 1 |
| Kubo, M | 1 |
| Hosokawa, N | 1 |
| Suwaki, K | 1 |
| Shirakawa, K | 1 |
| Roybal, JJ | 1 |
| Feliberti, EC | 1 |
| Rouse, L | 1 |
| Wagman, LD | 1 |
| Xu, J | 1 |
| Zhong, Y | 1 |
| Weixin, N | 1 |
| Xinyu, Q | 1 |
| Yanhan, L | 1 |
| Li, R | 1 |
| Jianhua, W | 1 |
| Zhiping, Y | 1 |
| Jiemin, C | 1 |
| Sasaki, T | 2 |
| Balch, CM | 5 |
| Urist, MM | 4 |
| Patt, YZ | 5 |
| Chuang, VP | 2 |
| Wallace, S | 4 |
| Hersh, EM | 2 |
| Freireich, EJ | 1 |
| Mavligit, GM | 4 |
| Gilbert, JM | 1 |
| Au, JL | 1 |
| Rustum, YM | 1 |
| Ledesma, EJ | 1 |
| Mittelman, A | 2 |
| Creaven, PJ | 1 |
| McGregor, ML | 1 |
| Oberfield, RA | 4 |
| Huberman, MS | 1 |
| Soong, SJ | 1 |
| McGregor, M | 1 |
| Bedikian, AY | 1 |
| Niederhuber, JE | 1 |
| Ensminger, W | 1 |
| Gyves, J | 1 |
| Thrall, J | 1 |
| Walker, S | 1 |
| Cozzi, E | 1 |
| Abele, R | 1 |
| Alberto, P | 2 |
| Kaplan, S | 2 |
| Siegenthaler, P | 1 |
| Hofmann, V | 1 |
| Ryssel, HJ | 1 |
| Hartmann, D | 1 |
| Holdener, EE | 1 |
| Cavalli, F | 2 |
| Brückner, R | 2 |
| Rothmund, M | 3 |
| Hinterberger, R | 1 |
| Stagg, RJ | 2 |
| Lewis, BJ | 2 |
| Friedman, MA | 2 |
| Ignoffo, RJ | 1 |
| Hohn, DC | 2 |
| Daly, J | 3 |
| Oderman, P | 3 |
| Shike, M | 1 |
| Chun, H | 1 |
| Petroni, G | 1 |
| Geller, N | 2 |
| Fujita, F | 1 |
| Fujita, M | 1 |
| Taguchi, T | 4 |
| Trotter, GA | 1 |
| Morgan, GR | 1 |
| Goeting, N | 1 |
| Cooper, AJ | 1 |
| Taylor, I | 1 |
| Hottenrott, C | 1 |
| Lorenz, M | 2 |
| Paolucci, V | 1 |
| Encke, A | 1 |
| Reed, ML | 1 |
| Vaitkevicius, VK | 1 |
| Al-Sarraf, M | 1 |
| Vaughn, CB | 1 |
| Singhakowinta, A | 1 |
| Sexon-Porte, M | 1 |
| Izbicki, R | 1 |
| Baker, L | 1 |
| Straatsma, GW | 1 |
| Boice, JD | 1 |
| Greene, MH | 1 |
| Keehn, RJ | 1 |
| Higgins, GA | 1 |
| Fraumeni, JF | 1 |
| Johnston, S | 1 |
| Benjamin, RS | 1 |
| Valdivieso, M | 1 |
| Tilchen, E | 1 |
| McBride, CM | 2 |
| Chuang, V | 1 |
| Mavligit, CM | 1 |
| Sakai, K | 2 |
| Irie, K | 2 |
| Terasawa, T | 2 |
| Shimoyama, T | 1 |
| Iwanaga, T | 1 |
| Fukuda, I | 1 |
| Okumura, S | 1 |
| Yasutake, K | 1 |
| Tsumura, I | 1 |
| Nishimura, G | 1 |
| Izumi, R | 1 |
| Matsuki, N | 1 |
| Takeyama, S | 1 |
| Konishi, K | 1 |
| Fujita, H | 1 |
| Miyata, R | 1 |
| Kojima, Y | 1 |
| Takada, M | 1 |
| Takita, Y | 1 |
| Kanno, M | 1 |
| Ueno, K | 1 |
| Mura, T | 1 |
| Asano, K | 1 |
| Syouji, M | 1 |
| Yamazaki, H | 1 |
| Ooto, T | 1 |
| Ueda, H | 1 |
| Takigawa, Y | 1 |
| Sawa, T | 1 |
| Miyazaki, I | 1 |
| Focan, C | 1 |
| Levi, F | 1 |
| Kreutz, F | 1 |
| Focan-Henrard, D | 1 |
| Lobelle, JP | 1 |
| Adam, R | 1 |
| Dallemagne, B | 1 |
| Jehaes, C | 1 |
| Markiewicz, S | 1 |
| Weerts, J | 1 |
| Bismuth, H | 1 |
| Jasmin, C | 1 |
| Misset, JL | 1 |
| Ohtani, Y | 1 |
| Ishikawa, H | 1 |
| Aihara, S | 1 |
| Kanazawa, H | 1 |
| Hiki, Y | 1 |
| Kakita, A | 1 |
| Müller, HH | 1 |
| Musha, N | 1 |
| Sunami, E | 1 |
| Sasaki, M | 1 |
| Saito, H | 1 |
| Sando, N | 1 |
| Setu, Y | 1 |
| Setu, M | 1 |
| Oka, K | 1 |
| Min, JS | 3 |
| Kim, NK | 3 |
| Park, JK | 2 |
| Yun, SH | 2 |
| Noh, JK | 1 |
| Katsumoto, Y | 1 |
| Furukawa, J | 1 |
| Yoshioka, S | 1 |
| Shingai, T | 1 |
| Takekuni, K | 1 |
| Yukawa, M | 1 |
| Nakaguchi, K | 1 |
| Okajima, S | 1 |
| Sue, F | 1 |
| Hashimoto, T | 1 |
| Teshima, S | 1 |
| Katayama, A | 1 |
| Mafune, K | 1 |
| Makuuchi, M | 1 |
| Sung, JS | 1 |
| Jung, HC | 1 |
| Roh, JK | 1 |
| Seong, J | 1 |
| Cho, JH | 1 |
| Suh, CO | 1 |
| Ogawa, M | 1 |
| Takao, Y | 1 |
| Mukai, H | 1 |
| Satou, K | 1 |
| Anazawa, S | 1 |
| Yamazaki, Y | 1 |
| Aoki, T | 1 |
| Bozzetti, F | 1 |
| Andreola, S | 1 |
| Baratti, D | 1 |
| Mariani, L | 1 |
| Stani, SC | 1 |
| Valvo, F | 1 |
| Spinelli, P | 1 |
| Woolley, PV | 1 |
| Macdonald, JS | 1 |
| Schein, PS | 1 |
| Herbsman, H | 1 |
| Hassan, A | 1 |
| Gardner, B | 1 |
| Harshaw, D | 1 |
| Bohorquez, J | 1 |
| Alfonso, A | 1 |
| Newman, J | 1 |
| Bland, KI | 1 |
| Garrison, RN | 1 |
| Knutson, CO | 1 |
| McCaffrey, JA | 1 |
| Polio, J | 1 |
| Clouse, ME | 1 |
| Hamilton, T | 1 |
| Moertel, CG | 3 |
| Canman, CE | 1 |
| Tang, HY | 1 |
| Normolle, DP | 1 |
| Lawrence, TS | 1 |
| Maybaum, J | 1 |
| Kato, M | 1 |
| Sawai, K | 1 |
| Noguchi, A | 1 |
| Minato, H | 1 |
| Takahashi, T | 1 |
| Maas, IW | 1 |
| Boven, E | 1 |
| Pinedo, HM | 1 |
| Schlüper, HM | 1 |
| Haisma, HJ | 1 |
| Gall, FP | 1 |
| Scheele, J | 1 |
| Herfarth, C | 1 |
| Funovics, J | 1 |
| Siewert, JR | 1 |
| Ludwig, J | 1 |
| Kim, CH | 1 |
| Wiesner, RH | 1 |
| Krom, RA | 1 |
| Allen-Mersh, TG | 1 |
| Matsuda, M | 1 |
| Nagao, K | 1 |
| Baba, K | 1 |
| Nishimura, R | 1 |
| Matsuoka, Y | 1 |
| Ueno, Y | 1 |
| Morinaga, H | 1 |
| Nagase, H | 1 |
| Kawano, H | 1 |
| Schuster, D | 1 |
| Heim, ME | 1 |
| Decoster, G | 1 |
| Queisser, W | 1 |
| Schwartz, SI | 1 |
| Jones, LS | 1 |
| McCune, CS | 1 |
| Daly, JM | 6 |
| Butler, J | 1 |
| Yeh, SD | 1 |
| Ridge, JA | 4 |
| Botet, J | 2 |
| Bading, JR | 1 |
| DeCosse, JJ | 1 |
| Benua, RS | 1 |
| Tominaga, T | 1 |
| Kitamura, M | 1 |
| Hayashi, K | 1 |
| Takahashi, I | 1 |
| Kosaki, G | 1 |
| Okajima, K | 1 |
| Yamamoto, M | 1 |
| Kawahara, T | 1 |
| Satomi, T | 1 |
| Tomita, K | 1 |
| Yamaguchi, A | 2 |
| Donegan, WL | 1 |
| Kemeny, MM | 2 |
| Goldberg, D | 1 |
| Beatty, JD | 1 |
| Blayney, D | 1 |
| Browning, S | 1 |
| Doroshow, J | 1 |
| Ganteaume, L | 1 |
| Hill, RL | 1 |
| Kokal, WA | 1 |
| Riihimaki, DU | 1 |
| Giles, GR | 2 |
| Woodhouse, L | 2 |
| Finan, PJ | 2 |
| Chisholm, EM | 2 |
| Hodgson, WJ | 1 |
| Friedland, M | 1 |
| Ahmed, T | 1 |
| Berman, H | 1 |
| Katz, S | 1 |
| Morgan, J | 1 |
| Byrne, D | 1 |
| Keller, E | 1 |
| Quint, B | 1 |
| Knuth, A | 1 |
| Schicketanz, KH | 1 |
| Clark, CG | 1 |
| Pietrafitta, JJ | 1 |
| Anderson, BG | 1 |
| O'Brien, MJ | 1 |
| Deckers, PJ | 1 |
| Heier, MS | 2 |
| Fosså, SD | 4 |
| Hurteloup, P | 1 |
| Armand, JP | 1 |
| Cappelaere, P | 1 |
| Metz, R | 1 |
| Kerbrat, P | 1 |
| Keiling, R | 1 |
| Fumoleau, P | 1 |
| Fargeot, P | 1 |
| Schraub, S | 1 |
| Bastit, P | 1 |
| Lokich, JJ | 1 |
| Sigurdson, ER | 2 |
| Boddie, AW | 2 |
| Charnsangavej, C | 2 |
| Ajani, JA | 1 |
| Soski, M | 1 |
| Claghorn, L | 1 |
| Winton, TL | 1 |
| Ghent, WR | 1 |
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| Riether, RD | 2 |
| Sheets, JA | 2 |
| Stasik, JJ | 2 |
| Rosen, L | 2 |
| Khubchandani, IT | 2 |
| Ramming, KP | 1 |
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| Heier, M | 2 |
| Aas, M | 1 |
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| Flentje, M | 1 |
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| Cleary, KR | 1 |
| Shepard, KV | 2 |
| Levin, B | 3 |
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| Doria, MI | 1 |
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| Riddell, RH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Trial of Isolated Hepatic Perfusion With Oxaliplatin Followed by Hepatic Arterial Infusion of FUDR and Leucovorin for Patients With Unresectable Colorectal Liver Metastases[NCT01042691] | Phase 1 | 10 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| A Humanitarian Device Exemption Use Protocol of Therasphere® for Treatment of Unresectable Hepatocellular and Metastatic Liver Tumors - HDE #980006[NCT00701168] | 0 participants | Expanded Access | No longer available | ||||
| A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver[NCT00001576] | Phase 1 | 28 participants | Interventional | 1997-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for floxuridine and Cancer of Rectum
| Article | Year |
|---|---|
Intraarterial hepatic infusion chemotherapy in metastatic liver cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusio | 1983 |
Comparison of systemic chemotherapy with hepatic arterial infusion in metastatic colorectal carcinoma.
Topics: Antineoplastic Agents; Catheterization; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; F | 1983 |
Regional and systemic chemotherapy for advanced colorectal cancer. A review.
Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; D | 1983 |
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridin | 1984 |
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Art | 1983 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; | 1996 |
Adrenalectomy for solitary adrenal metastasis from colorectal carcinoma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy | 2000 |
Chemotherapy of colorectal carcinoma.
Topics: Administration, Oral; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Drug Administration Sche | 1976 |
Colorectal liver metastases: is 'no treatment' still best?
Topics: Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; Rectal Neoplasms | 1989 |
Treatment of colorectal hepatic metastases.
Topics: Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; F | 1985 |
[Chemotherapy of cancer of the rectum and the colon].
Topics: Antimetabolites; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, I | 1970 |
Chemotherapy of residual disease in solid tumours.
Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lun | 1971 |
28 trials available for floxuridine and Cancer of Rectum
| Article | Year |
|---|---|
Hepatic arterial infusion of floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dexamethasone; Dose- | 2005 |
Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocol | 2007 |
Adjuvant chemotherapy of large bowel cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxu | 1982 |
A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; | 1983 |
Late effects of low-dose adjuvant chemotherapy in colorectal cancer.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Hu | 1980 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; | 1996 |
Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Clocks; Colonic Neoplasms; C | 1999 |
Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy P | 2000 |
A prospective randomized trial comparing intravenous 5-fluorouracil and oral doxifluridine as postoperative adjuvant treatment for advanced rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disea | 2000 |
Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Floxuridin | 2001 |
Preoperative chemoradiotherapy with oral doxifluridine plus low-dose oral leucovorin in unresectable primary rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C | 2001 |
Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera | 2002 |
Results of a prospective randomized trial of continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Hepatectomy; Hepatic Artery; Humans; Infus | 1986 |
Treatment of colorectal hepatic metastases by intrahepatic chemotherapy alone or as an adjuvant to complete or partial removal of metastatic disease.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Embolization, T | 1986 |
[Regional chemotherapy of liver metastases of colorectal carcinoma using implanted gas pressure pumps. Results of a prospective phase II study].
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human | 1986 |
Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd).
Topics: Adult; Aged; Brain Diseases; Carcinoid Tumor; Carcinoma; Cerebellar Diseases; Colonic Neoplasms; Ele | 1986 |
Systemic infusional chemotherapy for liver metastasis: an improved schedule for 5-fluorouracil.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil | 1986 |
Preliminary results of a randomized study of intrahepatic infusion versus systemic infusion of 5-fluoro-2'-deoxyuridine for metastatic colorectal carcinoma.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, | 1986 |
Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month.
Topics: Adenocarcinoma; Antineoplastic Agents; Cecal Neoplasms; Colonic Neoplasms; Drug Evaluation; Drug Tol | 1986 |
Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. A randomized trial.
Topics: Adenocarcinoma; Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepat | 1987 |
Regional infusion for colorectal hepatic metastases. A randomized trial comparing the hepatic artery with the portal vein.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Fl | 1987 |
A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases.
Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Infusions, I | 1987 |
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Sc | 1987 |
A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxurid | 1988 |
Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infu | 1988 |
Hepatic infusional chemotherapy in metastatic colorectal carcinoma and hepatoma.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuri | 1985 |
Biliary sclerosis in patients receiving hepatic arterial infusions of floxuridine.
Topics: Aged; Bile Ducts; Cholangiography; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; I | 1985 |
Adrenal function in patients treated with testosterone and fluorinated pyrimidines.
Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormon | 1968 |
99 other studies available for floxuridine and Cancer of Rectum
| Article | Year |
|---|---|
Precision Management of a Patient With Dihydropyrimidine Dehydrogenase Deficiency and Liver-Predominant Metastatic Rectal Cancer Using Hepatic Arterial Floxuridine.
Topics: Dihydropyrimidine Dehydrogenase Deficiency; Floxuridine; Humans; Liver Neoplasms; Rectal Neoplasms | 2023 |
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuv | 2009 |
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Sc | 2002 |
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colo | 1964 |
A LESS TOXIC FLUOROURACIL DOSAGE SCHEDULE.
Topics: Alopecia; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Eruptions; Epistaxis; Female; Floxurid | 1964 |
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administrat | 2003 |
[Two cases of metastatic or recurrent rectal cancer responding to combined chemotherapy of low-dose CPT-11 and 5'-DFUR as second-line chemotherapy].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptoth | 2004 |
[A case of long-term survival after chemo-radiation for postoperative local recurrence of rectal cancer].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy | 2004 |
The benefit of post-operative adjuvant chemotherapy using oral fluoropyrimidines in rectal cancer.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; | 2005 |
[A case of chemoradiation with tissue expander for local reccurence of rectal cancer].
Topics: Adenocarcinoma, Mucinous; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antine | 2005 |
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Che | 2006 |
[A case of local recurrence of rectal cancer in long-term responding to combined therapy of low-dose CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptoth | 2006 |
[Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Admini | 2006 |
Pump removal in infected patients with hepatic chemotherapy pumps: when is it necessary?
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colonic Neoplasms; Device Removal; | 2006 |
[An inadvertent contraindicated combined use of newly prescribed TS-1 and unused doxifluridine].
Topics: Aged; Contraindications; Drug Combinations; Floxuridine; Humans; Male; Medication Errors; Oxonic Aci | 2007 |
[Intra-arterial chemotherapy using an implantable infusion pump in liver metastases of colorectal tumors and hepatomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxoru | 1984 |
The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver.
Topics: Antineoplastic Agents; Colonic Neoplasms; Embolization, Therapeutic; Floxuridine; Gelatin Sponge, Ab | 1981 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenter | 1982 |
Continuous regional chemotherapy for metastatic colorectal cancer using a totally implantable infusion pump. A feasibility study in 50 patients.
Topics: Colonic Neoplasms; Evaluation Studies as Topic; Floxuridine; Hepatic Artery; Humans; Infusions, Intr | 1983 |
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality | 1983 |
Regional chemotherapy of colorectal cancer metastatic to the liver.
Topics: Antineoplastic Agents; Catheters, Indwelling; Colonic Neoplasms; Drug Evaluation; Female; Floxuridin | 1984 |
Phase II study of doxifluridine in advanced colorectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms | 1983 |
[Local infusion therapy in liver metastases of colorectal cancers. Results of a phase-II study].
Topics: Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusio | 1984 |
Hepatic artery pump infusion: toxicity and results in patients with metastatic colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusio | 1984 |
[Effects of 5'-deoxy-5-fluorouridine on human gastrointestinal and breast cancers xenografted to nude mice].
Topics: Adenocarcinoma; Administration, Oral; Animals; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Femal | 1984 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine | 1984 |
[New possibilities in the treatment of hepatic metastasis of colo-rectal carcinomas].
Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Rectal Neoplasms | 1984 |
The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol.
Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra- | 1981 |
[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors].
Topics: Carcinoma, Hepatocellular; Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepa | 1983 |
Percutaneous hepatic arterial infusion (HAI) of mitomycin C and floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver.
Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Human | 1980 |
Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.
Topics: Adenocarcinoma; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; M | 1981 |
[Combination therapy of high dose doxifluridine (5'-DFUR)+mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5'-DFUR with Other Drugs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms | 1993 |
[A case of bilateral pulmonary metastasis from rectal cancer successfully treated with resection after high-dose 5'-DFUR plus MMC combination chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Flox | 1993 |
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Extracellular Matrix; Female; Floxuridine; Hu | 1997 |
[Combination of 5'-DFUR and MMC for recurrent rectal cancer with pulmonary metastasis].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; | 1999 |
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy | 2000 |
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality | 2000 |
[A case report of effective chemoradiation with 5'-DFUR and concomitant preoperative radiotherapy of the lower rectum].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Floxuridine; | 2002 |
Treatment of hepatic metastases with a combination of hepatic artery infusion chemotherapy and external radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Catheterization; Cobalt Radioisotopes; Colonic Neoplasms; Female | 1978 |
Colorectal carcinoma: overview of management techniques.
Topics: BCG Vaccine; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Radioth | 1979 |
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
Topics: Adenocarcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusi | 1979 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther | 1975 |
Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.
Topics: Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug | 1992 |
[Two cases of pulmonary metastasis of colorectal cancer successfully treated with oral 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Drug Administration Schedule; Fem | 1992 |
The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines.
Topics: Antibodies, Monoclonal; Carcinoembryonic Antigen; Cell Division; Cell Line; Colonic Neoplasms; Drug | 1991 |
[The concept of therapy in liver metastases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Humans; Infusions, I | 1985 |
Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy?
Topics: Adult; Bile Ducts; Cholangitis, Sclerosing; Floxuridine; Humans; Ischemia; Liver Neoplasms; Male; Re | 1989 |
[A case of multiple pulmonary metastases from rectal cancer which responded completely to combination chemotherapy using 5'-DFUR and MMC].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Tolerance; Floxuridine; H | 1989 |
Phase I-II trial of doxifluridine (5'DFUR) administered as long-term continuous infusion using a portable infusion pump for advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Female; Flox | 1989 |
Assessment of treatment of intrahepatic malignancies using chemotherapy via an implantable pump.
Topics: Adenoma, Islet Cell; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Catheterization; Catheters | 1985 |
Predicting tumor response in patients with colorectal hepatic metastases.
Topics: Adult; Aged; Angiography; Blood Flow Velocity; Colonic Neoplasms; Female; Floxuridine; Humans; Liver | 1985 |
[Phase II study of 5'-DFUR in gastrointestinal and breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarr | 1985 |
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neopla | 1985 |
Hepatic artery infusion chemotherapy for colorectal metastases: a personal experience.
Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans | 1985 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; | 1986 |
Implantable vascular access devices in the treatment of colorectal liver metastases.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arter | 1986 |
Cholecystitis secondary to infusion chemotherapy.
Topics: Adult; Cholecystitis; Colonic Neoplasms; Drug Implants; Female; Floxuridine; Hepatic Artery; Humans; | 1986 |
Phase II clinical evaluation of doxifluridine.
Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Diseases; Col | 1986 |
Fluorodeoxyuridine uptake by human colorectal hepatic metastases after hepatic artery infusion.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Int | 1986 |
Hepatic arterial infusion with floxuridine and cisplatin: overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; | 1986 |
Hepatic artery infusion chemotherapy with the Infusaid pump: a Canadian experience.
Topics: Aged; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Female; Floxuridine; Hepatic Arte | 1986 |
[Clinical trial of 5'-deoxy-5-fluorouridine in malignant tumors under cooperative study (phase II study)].
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine; | 1986 |
Causes of jaundice during hepatic artery infusion chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Bile Ducts, Intrahepatic; Colonic Neoplasms; Female; Floxuridine; Human | 1986 |
Follow-up on a prospective study of continuous hepatic perfusion with implantable pump.
Topics: Aged; Aged, 80 and over; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Floxuridine; Follow-Up | 1986 |
The use of the implantable chemoinfusion pump in the treatment of hepatic metastases of colorectal cancer.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Digestive System Diseases; Floxuridine; Hepatic Artery; | 1986 |
Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA).
Topics: Colonic Neoplasms; Colony-Forming Units Assay; Culture Techniques; Dose-Response Relationship, Drug; | 1986 |
Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver.
Topics: Adult; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuri | 1987 |
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine | 1987 |
Distribution of fluorodeoxyuridine uptake in the liver and colorectal hepatic metastases of human beings after arterial infusion.
Topics: Adult; Colonic Neoplasms; Floxuridine; Humans; Liver; Liver Neoplasms; Middle Aged; Rectal Neoplasms | 1987 |
Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylnitrosamine; Floxuridine; Imidazoles; Male; Orga | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kineti | 1987 |
Regional and systemic chemotherapy for colorectal metastases to the liver.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans | 1987 |
[Locoregional chemotherapy of hepatic metastases of colorectal cancer].
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Infusion Pumps; I | 1987 |
[Regional arterial chemotherapy of hepatic metastases secondary to colorectal carcinoma].
Topics: Colonic Neoplasms; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Mi | 1987 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorour | 1988 |
Nonspecific corticosteroid therapy in patients receiving intra-arterial chemotherapy for hepatic metastases of colorectal origin.
Topics: Adrenal Cortex Hormones; Cholestasis; Colonic Neoplasms; Floxuridine; Humans; Infusions, Intra-Arter | 1988 |
Can something be done for patients with liver metastases for colorectal cancer?
Topics: Colonic Neoplasms; Floxuridine; Humans; Infusion Pumps; Liver Neoplasms; Rectal Neoplasms | 1988 |
Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.
Topics: Angina Pectoris; Brain Diseases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Evaluation; Elect | 1985 |
Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Body Weight; Brain Diseases; Cerebellar Diseases; C | 1985 |
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induc | 1985 |
A prospective study of continuous hepatic perfusion with implantable pump.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Chemotherapy, Cancer | 1985 |
The implanted pump in metastatic colorectal cancer of the liver. Risk versus benefit.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio | 1985 |
Treatment of colorectal cancer hepatic metastases by hepatic artery chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms; Floxuridine; Fluorour | 1985 |
Cholangitis complicating intraarterial chemotherapy in liver metastasis.
Topics: Alkaline Phosphatase; Bilirubin; Carcinoembryonic Antigen; Cholangiography; Cholangitis; Colonic Neo | 1985 |
Sclerosing cholangitis after continuous hepatic artery infusion of FUDR.
Topics: Aged; Bile Ducts; Cholangitis; Cholestasis; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; | 1985 |
Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine.
Topics: Colonic Neoplasms; Duodenitis; Duodenum; Floxuridine; Gastritis; Hepatic Artery; Humans; Infusions, | 1985 |
The treatment of hepatic metastases by long-term chemotherapeutic infusions.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Evaluation Studies as Topic; Female; | 1970 |
[Our experience with 5-fluoro-2-desocyuridine].
Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Gallbladder Neoplasms; Humans; Liver Neoplasms; | 1968 |
The evolution of colorectal cancer.
Topics: Colonic Neoplasms; Floxuridine; Humans; Infusions, Parenteral; Liver Neoplasms; Lymphatic Metastasis | 1968 |
Comparative response of carcinoma of the rectum and carcinoma of the colon to fluorinated pyrimidine therapy.
Topics: Colonic Neoplasms; Floxuridine; Rectal Neoplasms | 1969 |
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin | 1971 |
Arterial infusion chemotherapy of liver metastases arising from rectal and colonic cancer.
Topics: Colonic Neoplasms; Floxuridine; Humans; Injections, Intra-Arterial; Liver Function Tests; Liver Neop | 1970 |
Chemotherapy of cancer of the colon and rectum.
Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; | 1972 |
Practical aspects of investigation and treatment of colorectal cancer.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function | 1972 |
Chemotherapy of colon and rectal cancer.
Topics: Administration, Oral; Antigens, Neoplasm; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasm | 1972 |
Effect of resection of the primary neoplasm on responsiveness to chemotherapy of patients with large bowel cancer.
Topics: Adenocarcinoma; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; Rectal | 1972 |
Chemotherapy of gastrointestinal cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Esophageal Neoplasms; Floxuridine; Fluorouracil; Gastroint | 1972 |
The clinical effects of prolonged intravenous infusion of 5-fluoro-2'-deoxyuridine.
Topics: Adenoma, Islet Cell; Aged; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Female; Fl | 1965 |
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carci | 1967 |