floxuridine has been researched along with Cancer of Gastrointestinal Tract in 27 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| "First, HCT116 human colon cancer cells were cultured with PSK and 5-fluorouracil (5-FU) or 5'-deoxy-5-fluorouridine (5'-DFUR) in the presence or absence of PBMCs, and the antiproliferative effects were compared." | 1.39 | Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers. ( Abe, H; Edamatsu, T; Fujieda, A; Fujioka, M; Mekata, E; Murata, S; Naka, S; Shimizu, T; Shiomi, H; Sonoda, H; Tani, T; Umeda, T; Wada, T; Yamamoto, H, 2013) |
| "The cases of primary hepatic cancer are 2 cases of hepatoma (413, 420 days) and 1 case of cancer of bile-duct (400 days)." | 1.28 | [Evaluation of long survival cases treated with intra-arterial cancer chemotherapy using implantable reservoirs]. ( Katsuki, Y; Nishimura, A; Tsuji, Y; Yasuda, T, 1989) |
| "Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts." | 1.25 | Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (66.67) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mekata, E | 1 |
| Murata, S | 1 |
| Sonoda, H | 1 |
| Shimizu, T | 1 |
| Umeda, T | 1 |
| Shiomi, H | 1 |
| Naka, S | 1 |
| Yamamoto, H | 1 |
| Abe, H | 1 |
| Edamatsu, T | 1 |
| Fujieda, A | 1 |
| Fujioka, M | 1 |
| Wada, T | 1 |
| Tani, T | 1 |
| Wang, WJ | 2 |
| Shi, D | 2 |
| Wang, SM | 2 |
| HEIDELBERGER, C | 1 |
| ANSFIELD, FJ | 1 |
| MOERTEL, CG | 3 |
| REITEMEIER, RJ | 1 |
| BOLTON, CF | 1 |
| SHORTER, RG | 1 |
| LAWTON, RL | 1 |
| Li, LL | 1 |
| Washtien, WL | 1 |
| Yamada, Y | 1 |
| Tsushima, K | 1 |
| Sakata, Y | 1 |
| Saito, S | 1 |
| Ito, T | 1 |
| Sugimoto, N | 1 |
| Ogasawara, H | 1 |
| Tamura, Y | 1 |
| Moriya, N | 1 |
| Komatsu, Y | 1 |
| Taguchi, T | 2 |
| Conroy, T | 1 |
| Paillot, B | 1 |
| Adenis, A | 1 |
| Tong, F | 1 |
| Liu, H | 1 |
| Wang, S | 1 |
| Yang, D | 1 |
| Gu, J | 1 |
| Qiao, X | 1 |
| Zhang, J | 1 |
| Pozniak, MA | 1 |
| Babel, SG | 1 |
| Trump, DL | 1 |
| Lokich, J | 1 |
| Moore, C | 1 |
| Anderson, N | 1 |
| Bern, M | 1 |
| Strohmeyer, G | 1 |
| Porschen, R | 1 |
| Tsuji, Y | 1 |
| Nishimura, A | 1 |
| Katsuki, Y | 1 |
| Yasuda, T | 1 |
| Choong, YS | 1 |
| Lee, SP | 1 |
| Rochlin, DB | 1 |
| Smart, CR | 1 |
| Oberfield, RA | 1 |
| Sullivan, RD | 1 |
| Burrows, JH | 1 |
| Talley, RW | 1 |
| Drake, EH | 1 |
| Tucker, WG | 1 |
| Krakoff, IH | 2 |
| Kaufman, S | 1 |
| DeConti, RC | 1 |
| Kaplan, SR | 1 |
| Papac, RJ | 1 |
| Calabresi, P | 1 |
| Van Dyk, JJ | 1 |
| Clarkson, BD | 1 |
| Duschinsky, R | 1 |
| Keller, O | 1 |
| La Sala, E | 1 |
| Baden, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449] | Phase 3 | 338 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for floxuridine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY.
Topics: Breast Neoplasms; Carbon Isotopes; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Me | 1963 |
[Gastrointestinal cancer and oral anticancer agents].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Com | 1999 |
[New drugs in gastrointestinal oncology. Current status and future directions].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorourac | 1999 |
[Interdisciplinary therapy concepts in primary and secondary neoplasms of the liver].
Topics: Carcinoma, Hepatocellular; Combined Modality Therapy; Floxuridine; Fluorouracil; Follow-Up Studies; | 1989 |
5-Fluorouracil in the treatment of gastrointestinal neoplasia.
Topics: Administration, Oral; Antineoplastic Agents; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; | 1973 |
3 trials available for floxuridine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
[The effect of pre-operative chemotherapy on calpain in cells of gastrointestinal malignant tumors].
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Calpain; Chemotherapy, Adjuvant; | 2004 |
[Randomized controlled study of sequential methotrexate and 5-fluorouracil therapy with or without 5'-deoxy-5-fluorouridine against advanced gastrointestinal cancer. Hirosaki Cooperative Study Group for Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; F | 1994 |
[Clinical evaluation of effects and improvement in quality of life from palliative therapy of combination chemotherapy with Furtulon and consecutive low-dose cisplatin in cases of unresectable advanced gastrointestinal carcinoma].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Femal | 2001 |
19 other studies available for floxuridine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Topics: Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fl | 2013 |
[Effect of preoperative oral 5'-DFUR on PyNPase level in gastrointestinal malignant tumor tissues].
Topics: Administration, Oral; Adult; Aged; Combined Modality Therapy; Female; Floxuridine; Gastrointestinal | 2003 |
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasm | 1964 |
CANCER CHEMOTHERAPY OF THE GASTROINTESTINAL TRACT WITH REFERENCE TO INTRA-ARTERIAL INFUSION AND IRRADIATION.
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cobalt Isotopes; Cyclophosphamide; | 1965 |
Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells.
Topics: Cells, Cultured; Floxuridine; Gastrointestinal Neoplasms; Humans; Methotrexate; Methyltransferases; | 1982 |
Chemotherapy of gastrointestinal cancer.
Topics: Doxorubicin; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Mitomyc | 1976 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther | 1975 |
Complications of hepatic arterial infusion chemotherapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholangitis, Sclerosing; Female; Floxuridine; Gastroin | 1991 |
Infusion of floxuridine plus etoposide plus cisplatin in human malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ci | 1991 |
[Evaluation of long survival cases treated with intra-arterial cancer chemotherapy using implantable reservoirs].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxor | 1989 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil | 1987 |
The degradation of 5'-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues.
Topics: Animals; Colon; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrogen-Ion Concentr | 1985 |
An evaluation of 51 patients with hepatic artery infusion.
Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Hepat | 1966 |
New concepts in chemotherapy of advanced gastrointestinal cancer.
Topics: Aged; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; | 1967 |
Infusion of fluorinated pyrimidines into hepatic artery for treatment of metastatic carcinoma of liver.
Topics: Adenocarcinoma; Catheterization; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Hepatic Arte | 1967 |
Chemotherapy of gastrointestinal cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Esophageal Neoplasms; Floxuridine; Fluorouracil; Gastroint | 1972 |
Continuous intravenous infusions of 5-fluoro-2'-deoxyuridine in the treatment of solid tumors.
Topics: Breast Neoplasms; Diarrhea; Drug Eruptions; Female; Floxuridine; Gastrointestinal Neoplasms; Hemangi | 1973 |
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carci | 1967 |
[Continuous intra-arterial infusion of 5-fluor-2-deoxyuridine in primary and metastatic liver cancer].
Topics: Adenoma, Bile Duct; Adult; Aged; Arteries; Carcinoma, Hepatocellular; Female; Floxuridine; Gastroint | 1968 |