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floxuridine and Benign Neoplasms, Brain

floxuridine has been researched along with Benign Neoplasms, Brain in 37 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma."7.72Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004)
"Gemcitabine was administered at 500 or 1000 mg/m(2) just before surgery to 10 GBM patients, who were biopsied after 1-4 h."6.74Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. ( Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ, 2009)
"Brain metastases were also found."5.30[A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide]. ( Aoki, T; Kaise, H; Koyanagi, Y; Kusama, M; Matsunaga, T; Nakamura, Y; Nakayama, S; Yoneda, K, 1999)
"The cytotoxic agent Gemcitabine (2',2'-difluoro-2'-deoxycytidine) has been proved to be effective in the treatment of malignant gliomas."3.79Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy. ( Chen, H; Fan, B; Fang, S; Lu, Q; Sun, Y; Tang, D; Wei, Y; Yin, J; Yin, X; Zhang, B; Zhang, F, 2013)
") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma."3.72Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004)
"Positron emission tomography (PET) studies of a multicentric glioma case were undertaken using 11C-methionine (Met) and 18F-fluorodeoxyuridine (FUdR)."3.69Multicentric glioma studied with positron emission tomography: a case report. ( Ishiwata, K; Ito, M; Kameyama, M; Kayama, T; Sato, K; Yoshimoto, T, 1994)
"Gemcitabine was administered at 500 or 1000 mg/m(2) just before surgery to 10 GBM patients, who were biopsied after 1-4 h."2.74Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. ( Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ, 2009)
" Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0."2.68Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism. ( Hatazawa, J; Ido, T; Ishiwata, K; Ito, M; Itoh, J; Kameyama, M; Katakura, R; Sato, K; Tsurumi, Y; Yoshimoto, T, 1995)
"Brain metastases were also found."1.30[A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide]. ( Aoki, T; Kaise, H; Koyanagi, Y; Kusama, M; Matsunaga, T; Nakamura, Y; Nakayama, S; Yoneda, K, 1999)
"Using positron emission tomography and radio-high performance liquid chromatography, the accumulation of 2'-deoxy-5-18F-fluorouridine in the brain tumors and plasma pharmacokinetic parameters were investigated in 20 patients."1.29Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine. ( Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Sato, K; Takahashi, T; Tsurumi, Y; Yoshimoto, T, 1993)
"Nucleic acid metabolism in brain tumors by [18F]FdUrd-PET may be assessed using normal brain regions as a reference."1.28Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma. ( Ido, T; Ishiwata, K; Kameyama, M; Sato, K; Yoshimoto, T, 1991)
"In metastatic brain tumors from lung, breast, and gastric cancer, the average time from the diagnosis of primary cancer to brain metastasis was shorter in cases with high activities and longer in cases with low activities."1.27[Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR]. ( Miki, Y; Miwa, M; Nomura, K; Shibui, S; Watanabe, T, 1983)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199016 (43.24)18.7374
1990's12 (32.43)18.2507
2000's7 (18.92)29.6817
2010's2 (5.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xiao, C1
Yang, J1
Zhao, J1
Ren, T1
Feng, F1
Wan, X1
Xiang, Y1
Sigmond, J1
Honeywell, RJ1
Postma, TJ1
Dirven, CM1
de Lange, SM1
van der Born, K1
Laan, AC1
Baayen, JC1
Van Groeningen, CJ1
Bergman, AM1
Giaccone, G1
Peters, GJ1
Sun, Y1
Tang, D1
Chen, H1
Zhang, F1
Fan, B1
Zhang, B1
Fang, S1
Lu, Q1
Wei, Y1
Yin, J1
Yin, X1
ANSFIELD, FJ1
CURRERI, AR1
WATKINS, E1
SULLIVAN, RD1
WILSON, WL1
DELAGARZA, JG1
Buchegger, F2
Adamer, F1
Schaffland, AO1
Kosinski, M1
Grannavel, C1
Dupertuis, YM2
de Tribolet, N2
Mach, JP2
Delaloye, AB1
Nakagawa, H6
Miyahara, E2
Suzuki, T2
Wada, K2
Tamura, M1
Fukushima, Y1
Li, HF1
Winkeler, A1
Moharram, S1
Knaus, EE1
Dittmar, K1
Stöckle, M1
Heiss, WD1
Wiebe, LI1
Jacobs, AH1
Jacob, AJ1
Shibui, S2
Watanabe, T1
Miki, Y1
Nomura, K1
Miwa, M1
Phillips, TW1
Chandler, WF1
Kindt, GW2
Ensminger, WD1
Greenberg, HS1
Seeger, JF1
Doan, KM1
Gyves, JW1
Kameyama, M5
Ishiwata, K5
Tsurumi, Y3
Itoh, J1
Sato, K4
Katakura, R2
Yoshimoto, T4
Hatazawa, J1
Ito, M2
Ido, T4
Kayama, T1
Tajima, H1
Matsuki, N1
Takeda, T1
Horichi, H1
Kumaki, T1
Shima, K1
Iwata, R1
Takahashi, T1
Yamada, M4
Fukushima, M2
Shimizu, K2
Hayakawa, T1
Ikenaka, K4
Maeda, N3
Iwatsuki, K2
Tsuzuki, T2
Hirayama, A3
Yamamoto, H1
Kusama, M1
Kaise, H1
Nakayama, S1
Yoneda, K1
Aoki, T1
Koyanagi, Y1
Matsunaga, T1
Nakamura, Y1
Vazquez, M1
Pichard, C1
Slosman, DO1
Konishi, H1
Morita, K1
Minouchi, T1
Nakajima, M1
Matsuda, M1
Yamaji, A1
Baskin, F1
Davis, R1
Rosenberg, RN1
Damascelli, B1
Marchianò, A1
Frigerio, LF1
Salvetti, M1
Spreafico, C1
Garbagnati, F1
Zanoni, F1
Radice, F1
Monma, M1
Suzuki, J1
Yamashita, M1
Hashimoto, T1
Hirakawa, T1
Fukushima, T1
Tomonaga, M1
Hara, Y1
Kono, A1
Tanaka, M1
Wilson, CB1
Mughal, TI1
Glode, LM1
Braun, TJ1
Klingensmith, W1
Geier, JM1
Kobayashi, T1
Mori, K1
Handa, H1
Onoyama, Y1
Sano, K1
Hoshino, T1
Nagai, M1
Goffinet, DR1
Brown, JM1
Bagshaw, MA1
Kaplan, HS1
Levin, VA1
Chadwick, M1
Little, AD1
Lokshina, AM1
Pelevina, II1

Reviews

2 reviews available for floxuridine and Benign Neoplasms, Brain

ArticleYear
Metabolic imaging of human brain tumors.
    Seminars in neurology, 1989, Volume: 9, Issue:4

    Topics: Brain Neoplasms; Deoxyglucose; Floxuridine; Fluorodeoxyglucose F18; Glucose; Humans; Nerve Tissue Pr

1989
[Radiation sensitization of brain neoplasms by haloid analogs of pyrimidine bases].
    Meditsinskaia radiologiia, 1973, Volume: 18, Issue:3

    Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Cricetinae; DNA, Neoplasm; Fe

1973

Trials

6 trials available for floxuridine and Benign Neoplasms, Brain

ArticleYear
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biological Availability; Biopsy; Brain Neoplasms; Cyti

2009
Continuous intrathecal administration of 5-fluoro-2'-deoxyuridine for the treatment of neoplastic meningitis.
    Neurosurgery, 2005, Volume: 57, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Child; Drug Administration Schedule;

2005
Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.
    Journal of neuro-oncology, 1995, Volume: 23, Issue:1

    Topics: Adult; Aged; Brain Neoplasms; DNA, Neoplasm; Female; Floxuridine; Fluorine Radioisotopes; Glioma; Hu

1995
[Clinical application of FdUrd to meningeal dissemination of malignant tumors].
    No shinkei geka. Neurological surgery, 1998, Volume: 26, Issue:11

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Drug Admin

1998
Clinical trial of intrathecal administration of 5-fluoro-2'-deoxyuridine for treatment of meningeal dissemination of malignant tumors.
    Journal of neuro-oncology, 1999, Volume: 45, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Female; Floxuridine; Follow-Up Studies; Huma

1999
Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma.
    Cancer, 1991, Sep-01, Volume: 68, Issue:5

    Topics: Brain Neoplasms; Carcinoma, Renal Cell; Circadian Rhythm; Drug Administration Schedule; Drug Evaluat

1991

Other Studies

29 other studies available for floxuridine and Benign Neoplasms, Brain

ArticleYear
Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital.
    BMC cancer, 2015, Apr-28, Volume: 15

    Topics: Adult; Brain Neoplasms; China; Combined Modality Therapy; Dactinomycin; Disease-Free Survival; Drug

2015
Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Mar-01, Volume: 919-920

    Topics: Animals; Antimetabolites, Antineoplastic; Brain Chemistry; Brain Neoplasms; Chromatography, High Pre

2013
FURTHER CLINICAL COMPARISON BETWEEN 5-FLUOROURACIL (5-FU) AND 5-FLUORO-2' -DEOXYURIDINE (5-FUDR).
    Cancer chemotherapy reports, 1963, Volume: 32

    Topics: Brain Neoplasms; Breast Neoplasms; Diarrhea; Floxuridine; Fluorouracil; Geriatrics; Humans; Liver Ne

1963
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
    Surgery, gynecology & obstetrics, 1964, Volume: 118

    Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Re

1964
SYSTEMIC CHEMOTHERAPY FOR CNS METASTASES OF SOLID TUMORS.
    Archives of internal medicine, 1965, Volume: 115

    Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy; Floxuridine; Fluo

1965
Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts.
    International journal of cancer, 2004, May-20, Volume: 110, Issue:1

    Topics: Animals; Brain Neoplasms; DNA; Floxuridine; Glioblastoma; Humans; Idoxuridine; Iodine Radioisotopes;

2004
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:1

    Topics: Animals; Arabinofuranosyluracil; Blood-Brain Barrier; Brain; Brain Neoplasms; Floxuridine; Gene Expr

2008
[Pyrimidine nucleoside phosphorylase in brain tumors and anti-tumor effect of 5'-DFUR].
    Neurologia medico-chirurgica, 1984, Volume: 24, Issue:2

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Floxuridine; Glioma; Isomerism; Mice; Mice, Inbred

1984
[Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR].
    No to shinkei = Brain and nerve, 1983, Volume: 35, Issue:10

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Floxuridine; Glioma; Humans; Meningeal Neoplasm

1983
New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.
    Neurosurgery, 1982, Volume: 11, Issue:2

    Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Carotid Arteries; Chemotherapy,

1982
Multicentric glioma studied with positron emission tomography: a case report.
    Surgical neurology, 1994, Volume: 42, Issue:1

    Topics: Brain; Brain Neoplasms; Craniotomy; Floxuridine; Functional Laterality; Glioblastoma; Glioma; Glucos

1994
[A case of cutaneous and brain metastasis of gastric carcinoma, treated effectively by chemotherapy with CDDP, MMC, etoposide and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:15

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Ne

1994
Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine.
    Annals of nuclear medicine, 1993, Volume: 7, Issue:3

    Topics: Adult; Aged; Brain Neoplasms; Child; Chromatography, High Pressure Liquid; Female; Floxuridine; Glio

1993
In vitro study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant brain tumors.
    Journal of neuro-oncology, 1998, Volume: 37, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Floxuridine; Glioma; Humans; Injections,

1998
[In vitro study on intrathecal application of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant tumor].
    No shinkei geka. Neurological surgery, 1998, Volume: 26, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Carcinoma 256, Walker; Floxuridine; Fluor

1998
[A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:9

    Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protoc

1999
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
    Japanese journal of clinical oncology, 2001, Volume: 31, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Administration Schedule; Fema

2001
Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine.
    Cancer research, 2001, Nov-01, Volume: 61, Issue:21

    Topics: Animals; Brain Neoplasms; Cell Cycle; DNA, Neoplasm; Drug Synergism; Floxuridine; Glioblastoma; Huma

2001
Probable metabolic interaction of doxifluridine with phenytoin.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic

2002
Altered thymidine kinase or thymidylate synthetase activities in 5-fluoro deoxyuridine resistant variants of mouse neuroblastoma.
    Journal of neurochemistry, 1977, Volume: 29, Issue:6

    Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Floxuridine; Methyltransferases; Mice; Neo

1977
Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1991, Volume: 18, Issue:5

    Topics: Animals; Biotransformation; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Humans; Male; Mamm

1991
18F-fluoro-2'-deoxyuridine as a tracer of nucleic acid metabolism in brain tumors.
    Journal of neurosurgery, 1990, Volume: 72, Issue:1

    Topics: Animals; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Neoplasms, Experimental; Nucleic Acid

1990
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
    Neurologia medico-chirurgica, 1985, Volume: 25, Issue:8

    Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Epen

1985
Phase I clinical trial of intracarotid bis-chloroethylnitrosourea (BCNU) and 2' dioxy-5-fluorouridine (FUDR) in malignant astrocytomas.
    Journal of neuro-oncology, 1986, Volume: 3, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Caro

1986
[New developments in chemotherapy for experimental brain metastasis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:3 Pt 2

    Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Daunorubicin; Doxorubicin; Flo

1985
[Experience with non-surgical treatment of brain tumors at the authors' department].
    No to shinkei = Brain and nerve, 1967, Volume: 19, Issue:4

    Topics: Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Cobalt Isot

1967
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
    Journal of neurosurgery, 1968, Volume: 28, Issue:6

    Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil;

1968
Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1972, Volume: 114, Issue:1

    Topics: Animals; Brain Neoplasms; Bromine; Carotid Arteries; Catheterization; Craniotomy; Cytidine; Deoxyrib

1972
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
    Journal of the National Cancer Institute, 1972, Volume: 49, Issue:6

    Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin

1972