floxuridine has been researched along with Benign Neoplasms, Brain in 37 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma." | 7.72 | Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004) |
| "Gemcitabine was administered at 500 or 1000 mg/m(2) just before surgery to 10 GBM patients, who were biopsied after 1-4 h." | 6.74 | Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. ( Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ, 2009) |
| "Brain metastases were also found." | 5.30 | [A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide]. ( Aoki, T; Kaise, H; Koyanagi, Y; Kusama, M; Matsunaga, T; Nakamura, Y; Nakayama, S; Yoneda, K, 1999) |
| "The cytotoxic agent Gemcitabine (2',2'-difluoro-2'-deoxycytidine) has been proved to be effective in the treatment of malignant gliomas." | 3.79 | Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy. ( Chen, H; Fan, B; Fang, S; Lu, Q; Sun, Y; Tang, D; Wei, Y; Yin, J; Yin, X; Zhang, B; Zhang, F, 2013) |
| ") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma." | 3.72 | Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004) |
| "Positron emission tomography (PET) studies of a multicentric glioma case were undertaken using 11C-methionine (Met) and 18F-fluorodeoxyuridine (FUdR)." | 3.69 | Multicentric glioma studied with positron emission tomography: a case report. ( Ishiwata, K; Ito, M; Kameyama, M; Kayama, T; Sato, K; Yoshimoto, T, 1994) |
| "Gemcitabine was administered at 500 or 1000 mg/m(2) just before surgery to 10 GBM patients, who were biopsied after 1-4 h." | 2.74 | Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. ( Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ, 2009) |
| " Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0." | 2.68 | Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism. ( Hatazawa, J; Ido, T; Ishiwata, K; Ito, M; Itoh, J; Kameyama, M; Katakura, R; Sato, K; Tsurumi, Y; Yoshimoto, T, 1995) |
| "Brain metastases were also found." | 1.30 | [A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide]. ( Aoki, T; Kaise, H; Koyanagi, Y; Kusama, M; Matsunaga, T; Nakamura, Y; Nakayama, S; Yoneda, K, 1999) |
| "Using positron emission tomography and radio-high performance liquid chromatography, the accumulation of 2'-deoxy-5-18F-fluorouridine in the brain tumors and plasma pharmacokinetic parameters were investigated in 20 patients." | 1.29 | Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine. ( Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Sato, K; Takahashi, T; Tsurumi, Y; Yoshimoto, T, 1993) |
| "Nucleic acid metabolism in brain tumors by [18F]FdUrd-PET may be assessed using normal brain regions as a reference." | 1.28 | Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma. ( Ido, T; Ishiwata, K; Kameyama, M; Sato, K; Yoshimoto, T, 1991) |
| "In metastatic brain tumors from lung, breast, and gastric cancer, the average time from the diagnosis of primary cancer to brain metastasis was shorter in cases with high activities and longer in cases with low activities." | 1.27 | [Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR]. ( Miki, Y; Miwa, M; Nomura, K; Shibui, S; Watanabe, T, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (43.24) | 18.7374 |
| 1990's | 12 (32.43) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, C | 1 |
| Yang, J | 1 |
| Zhao, J | 1 |
| Ren, T | 1 |
| Feng, F | 1 |
| Wan, X | 1 |
| Xiang, Y | 1 |
| Sigmond, J | 1 |
| Honeywell, RJ | 1 |
| Postma, TJ | 1 |
| Dirven, CM | 1 |
| de Lange, SM | 1 |
| van der Born, K | 1 |
| Laan, AC | 1 |
| Baayen, JC | 1 |
| Van Groeningen, CJ | 1 |
| Bergman, AM | 1 |
| Giaccone, G | 1 |
| Peters, GJ | 1 |
| Sun, Y | 1 |
| Tang, D | 1 |
| Chen, H | 1 |
| Zhang, F | 1 |
| Fan, B | 1 |
| Zhang, B | 1 |
| Fang, S | 1 |
| Lu, Q | 1 |
| Wei, Y | 1 |
| Yin, J | 1 |
| Yin, X | 1 |
| ANSFIELD, FJ | 1 |
| CURRERI, AR | 1 |
| WATKINS, E | 1 |
| SULLIVAN, RD | 1 |
| WILSON, WL | 1 |
| DELAGARZA, JG | 1 |
| Buchegger, F | 2 |
| Adamer, F | 1 |
| Schaffland, AO | 1 |
| Kosinski, M | 1 |
| Grannavel, C | 1 |
| Dupertuis, YM | 2 |
| de Tribolet, N | 2 |
| Mach, JP | 2 |
| Delaloye, AB | 1 |
| Nakagawa, H | 6 |
| Miyahara, E | 2 |
| Suzuki, T | 2 |
| Wada, K | 2 |
| Tamura, M | 1 |
| Fukushima, Y | 1 |
| Li, HF | 1 |
| Winkeler, A | 1 |
| Moharram, S | 1 |
| Knaus, EE | 1 |
| Dittmar, K | 1 |
| Stöckle, M | 1 |
| Heiss, WD | 1 |
| Wiebe, LI | 1 |
| Jacobs, AH | 1 |
| Jacob, AJ | 1 |
| Shibui, S | 2 |
| Watanabe, T | 1 |
| Miki, Y | 1 |
| Nomura, K | 1 |
| Miwa, M | 1 |
| Phillips, TW | 1 |
| Chandler, WF | 1 |
| Kindt, GW | 2 |
| Ensminger, WD | 1 |
| Greenberg, HS | 1 |
| Seeger, JF | 1 |
| Doan, KM | 1 |
| Gyves, JW | 1 |
| Kameyama, M | 5 |
| Ishiwata, K | 5 |
| Tsurumi, Y | 3 |
| Itoh, J | 1 |
| Sato, K | 4 |
| Katakura, R | 2 |
| Yoshimoto, T | 4 |
| Hatazawa, J | 1 |
| Ito, M | 2 |
| Ido, T | 4 |
| Kayama, T | 1 |
| Tajima, H | 1 |
| Matsuki, N | 1 |
| Takeda, T | 1 |
| Horichi, H | 1 |
| Kumaki, T | 1 |
| Shima, K | 1 |
| Iwata, R | 1 |
| Takahashi, T | 1 |
| Yamada, M | 4 |
| Fukushima, M | 2 |
| Shimizu, K | 2 |
| Hayakawa, T | 1 |
| Ikenaka, K | 4 |
| Maeda, N | 3 |
| Iwatsuki, K | 2 |
| Tsuzuki, T | 2 |
| Hirayama, A | 3 |
| Yamamoto, H | 1 |
| Kusama, M | 1 |
| Kaise, H | 1 |
| Nakayama, S | 1 |
| Yoneda, K | 1 |
| Aoki, T | 1 |
| Koyanagi, Y | 1 |
| Matsunaga, T | 1 |
| Nakamura, Y | 1 |
| Vazquez, M | 1 |
| Pichard, C | 1 |
| Slosman, DO | 1 |
| Konishi, H | 1 |
| Morita, K | 1 |
| Minouchi, T | 1 |
| Nakajima, M | 1 |
| Matsuda, M | 1 |
| Yamaji, A | 1 |
| Baskin, F | 1 |
| Davis, R | 1 |
| Rosenberg, RN | 1 |
| Damascelli, B | 1 |
| Marchianò, A | 1 |
| Frigerio, LF | 1 |
| Salvetti, M | 1 |
| Spreafico, C | 1 |
| Garbagnati, F | 1 |
| Zanoni, F | 1 |
| Radice, F | 1 |
| Monma, M | 1 |
| Suzuki, J | 1 |
| Yamashita, M | 1 |
| Hashimoto, T | 1 |
| Hirakawa, T | 1 |
| Fukushima, T | 1 |
| Tomonaga, M | 1 |
| Hara, Y | 1 |
| Kono, A | 1 |
| Tanaka, M | 1 |
| Wilson, CB | 1 |
| Mughal, TI | 1 |
| Glode, LM | 1 |
| Braun, TJ | 1 |
| Klingensmith, W | 1 |
| Geier, JM | 1 |
| Kobayashi, T | 1 |
| Mori, K | 1 |
| Handa, H | 1 |
| Onoyama, Y | 1 |
| Sano, K | 1 |
| Hoshino, T | 1 |
| Nagai, M | 1 |
| Goffinet, DR | 1 |
| Brown, JM | 1 |
| Bagshaw, MA | 1 |
| Kaplan, HS | 1 |
| Levin, VA | 1 |
| Chadwick, M | 1 |
| Little, AD | 1 |
| Lokshina, AM | 1 |
| Pelevina, II | 1 |
2 reviews available for floxuridine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Metabolic imaging of human brain tumors.
Topics: Brain Neoplasms; Deoxyglucose; Floxuridine; Fluorodeoxyglucose F18; Glucose; Humans; Nerve Tissue Pr | 1989 |
[Radiation sensitization of brain neoplasms by haloid analogs of pyrimidine bases].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinoma, Ehrlich Tumor; Cricetinae; DNA, Neoplasm; Fe | 1973 |
6 trials available for floxuridine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biological Availability; Biopsy; Brain Neoplasms; Cyti | 2009 |
Continuous intrathecal administration of 5-fluoro-2'-deoxyuridine for the treatment of neoplastic meningitis.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Child; Drug Administration Schedule; | 2005 |
Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.
Topics: Adult; Aged; Brain Neoplasms; DNA, Neoplasm; Female; Floxuridine; Fluorine Radioisotopes; Glioma; Hu | 1995 |
[Clinical application of FdUrd to meningeal dissemination of malignant tumors].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Drug Admin | 1998 |
Clinical trial of intrathecal administration of 5-fluoro-2'-deoxyuridine for treatment of meningeal dissemination of malignant tumors.
Topics: Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Female; Floxuridine; Follow-Up Studies; Huma | 1999 |
Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma.
Topics: Brain Neoplasms; Carcinoma, Renal Cell; Circadian Rhythm; Drug Administration Schedule; Drug Evaluat | 1991 |
29 other studies available for floxuridine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital.
Topics: Adult; Brain Neoplasms; China; Combined Modality Therapy; Dactinomycin; Disease-Free Survival; Drug | 2015 |
Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Chemistry; Brain Neoplasms; Chromatography, High Pre | 2013 |
FURTHER CLINICAL COMPARISON BETWEEN 5-FLUOROURACIL (5-FU) AND 5-FLUORO-2' -DEOXYURIDINE (5-FUDR).
Topics: Brain Neoplasms; Breast Neoplasms; Diarrhea; Floxuridine; Fluorouracil; Geriatrics; Humans; Liver Ne | 1963 |
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Re | 1964 |
SYSTEMIC CHEMOTHERAPY FOR CNS METASTASES OF SOLID TUMORS.
Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy; Floxuridine; Fluo | 1965 |
Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts.
Topics: Animals; Brain Neoplasms; DNA; Floxuridine; Glioblastoma; Humans; Idoxuridine; Iodine Radioisotopes; | 2004 |
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Topics: Animals; Arabinofuranosyluracil; Blood-Brain Barrier; Brain; Brain Neoplasms; Floxuridine; Gene Expr | 2008 |
[Pyrimidine nucleoside phosphorylase in brain tumors and anti-tumor effect of 5'-DFUR].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Floxuridine; Glioma; Isomerism; Mice; Mice, Inbred | 1984 |
[Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR].
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Floxuridine; Glioma; Humans; Meningeal Neoplasm | 1983 |
New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Carotid Arteries; Chemotherapy, | 1982 |
Multicentric glioma studied with positron emission tomography: a case report.
Topics: Brain; Brain Neoplasms; Craniotomy; Floxuridine; Functional Laterality; Glioblastoma; Glioma; Glucos | 1994 |
[A case of cutaneous and brain metastasis of gastric carcinoma, treated effectively by chemotherapy with CDDP, MMC, etoposide and 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Ne | 1994 |
Brain tumor accumulation and plasma pharmacokinetic parameters of 2'-deoxy-5-18F-fluorouridine.
Topics: Adult; Aged; Brain Neoplasms; Child; Chromatography, High Pressure Liquid; Female; Floxuridine; Glio | 1993 |
In vitro study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant brain tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Floxuridine; Glioma; Humans; Injections, | 1998 |
[In vitro study on intrathecal application of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant tumor].
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Carcinoma 256, Walker; Floxuridine; Fluor | 1998 |
[A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide].
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protoc | 1999 |
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Administration Schedule; Fema | 2001 |
Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine.
Topics: Animals; Brain Neoplasms; Cell Cycle; DNA, Neoplasm; Drug Synergism; Floxuridine; Glioblastoma; Huma | 2001 |
Probable metabolic interaction of doxifluridine with phenytoin.
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic | 2002 |
Altered thymidine kinase or thymidylate synthetase activities in 5-fluoro deoxyuridine resistant variants of mouse neuroblastoma.
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Floxuridine; Methyltransferases; Mice; Neo | 1977 |
Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma.
Topics: Animals; Biotransformation; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Humans; Male; Mamm | 1991 |
18F-fluoro-2'-deoxyuridine as a tracer of nucleic acid metabolism in brain tumors.
Topics: Animals; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Neoplasms, Experimental; Nucleic Acid | 1990 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Epen | 1985 |
Phase I clinical trial of intracarotid bis-chloroethylnitrosourea (BCNU) and 2' dioxy-5-fluorouridine (FUDR) in malignant astrocytomas.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Caro | 1986 |
[New developments in chemotherapy for experimental brain metastasis].
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Daunorubicin; Doxorubicin; Flo | 1985 |
[Experience with non-surgical treatment of brain tumors at the authors' department].
Topics: Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Cobalt Isot | 1967 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; | 1968 |
Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.
Topics: Animals; Brain Neoplasms; Bromine; Carotid Arteries; Catheterization; Craniotomy; Cytidine; Deoxyrib | 1972 |
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin | 1972 |