floxuridine has been researched along with Astrocytoma, Grade IV in 10 studies
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma." | 7.72 | Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004) |
| "Gemcitabine was administered at 500 or 1000 mg/m(2) just before surgery to 10 GBM patients, who were biopsied after 1-4 h." | 6.74 | Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. ( Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ, 2009) |
| ") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma." | 3.72 | Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004) |
| "Positron emission tomography (PET) studies of a multicentric glioma case were undertaken using 11C-methionine (Met) and 18F-fluorodeoxyuridine (FUdR)." | 3.69 | Multicentric glioma studied with positron emission tomography: a case report. ( Ishiwata, K; Ito, M; Kameyama, M; Kayama, T; Sato, K; Yoshimoto, T, 1994) |
| "Gemcitabine was administered at 500 or 1000 mg/m(2) just before surgery to 10 GBM patients, who were biopsied after 1-4 h." | 2.74 | Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. ( Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sigmond, J | 1 |
| Honeywell, RJ | 1 |
| Postma, TJ | 1 |
| Dirven, CM | 1 |
| de Lange, SM | 1 |
| van der Born, K | 1 |
| Laan, AC | 1 |
| Baayen, JC | 1 |
| Van Groeningen, CJ | 1 |
| Bergman, AM | 1 |
| Giaccone, G | 1 |
| Peters, GJ | 1 |
| Perillo-Adamer, F | 2 |
| Kosinski, M | 2 |
| Dupertuis, YM | 5 |
| Viertl, D | 1 |
| Bischof Delaloye, A | 2 |
| Buchegger, F | 5 |
| Vieira, JM | 1 |
| Blaeuenstein, P | 1 |
| Schaffland, AO | 3 |
| Grannavel, C | 2 |
| de Tribolet, N | 3 |
| Slosman, DO | 2 |
| Adamer, F | 1 |
| Mach, JP | 2 |
| Delaloye, AB | 2 |
| Genton, CS | 1 |
| Phillips, TW | 1 |
| Chandler, WF | 1 |
| Kindt, GW | 1 |
| Ensminger, WD | 1 |
| Greenberg, HS | 1 |
| Seeger, JF | 1 |
| Doan, KM | 1 |
| Gyves, JW | 1 |
| Sato, K | 1 |
| Kameyama, M | 1 |
| Ishiwata, K | 1 |
| Kayama, T | 1 |
| Yoshimoto, T | 1 |
| Ito, M | 1 |
| Nakagawa, H | 2 |
| Yamada, M | 1 |
| Maeda, N | 2 |
| Iwatsuki, K | 1 |
| Tsuzuki, T | 2 |
| Hirayama, A | 2 |
| Yamamoto, H | 1 |
| Ikenaka, K | 1 |
| Suzuki, T | 1 |
| Miyahara, E | 1 |
| Wada, K | 1 |
| Vazquez, M | 1 |
| Pichard, C | 1 |
2 trials available for floxuridine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biological Availability; Biopsy; Brain Neoplasms; Cyti | 2009 |
[Clinical application of FdUrd to meningeal dissemination of malignant tumors].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Drug Admin | 1998 |
8 other studies available for floxuridine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Fluorodeoxyuridine mediated cell cycle synchronization in S-phase increases the Auger radiation cell killing with 125I-iododeoxyuridine.
Topics: Apoptosis; Cell Line, Tumor; Cell Nucleus Division; Cell Survival; Floxuridine; Glioblastoma; Humans | 2009 |
Preclinical Auger and gamma radiation dosimetry for fluorodeoxyuridine-enhanced tumour proliferation scintigraphy with [123I]iododeoxyuridine.
Topics: Animals; Body Burden; Computer Simulation; DNA, Neoplasm; Drug Evaluation, Preclinical; Drug Synergi | 2003 |
Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts.
Topics: Animals; Brain Neoplasms; DNA; Floxuridine; Glioblastoma; Humans; Idoxuridine; Iodine Radioisotopes; | 2004 |
Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine.
Topics: Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Floxuridine; Glioblastoma; Humans; I | 2006 |
New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Carotid Arteries; Chemotherapy, | 1982 |
Multicentric glioma studied with positron emission tomography: a case report.
Topics: Brain; Brain Neoplasms; Craniotomy; Floxuridine; Functional Laterality; Glioblastoma; Glioma; Glucos | 1994 |
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Administration Schedule; Fema | 2001 |
Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine.
Topics: Animals; Brain Neoplasms; Cell Cycle; DNA, Neoplasm; Drug Synergism; Floxuridine; Glioblastoma; Huma | 2001 |