Page last updated: 2024-11-06

floxuridine and Ascites

floxuridine has been researched along with Ascites in 5 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Ascites: Accumulation or retention of free fluid within the peritoneal cavity.

Research Excerpts

ExcerptRelevanceReference
" The efficacy of weekly paclitaxel in combination with doxifluridine (5'-DFUR) in gastric cancer patients with malignant ascites was evaluated."9.15Weekly paclitaxel in combination with doxifluridine for peritoneally disseminated gastric cancer with malignant ascites. ( Ishikawa, H; Iwazaki, S; Izumi, M; Kakinuma, S; Kamoshita, N; Kawate, S; Kobayashi, I; Kobayashi, J; Makita, F; Nakagami, K; Ohya, T; Okabe, T; Sakamoto, I; Sato, Y; Sunose, Y; Takeyoshi, I; Tanahashi, Y; Tomizawa, N; Yamada, T; Yoshinari, D, 2011)
"Gemcitabine (dFdC) is a prodrug that undergoes metabolism by cytidine deaminase to form an inactive metabolite, 2',2'-difluorodeoxyuridine (dFdU)."5.31Pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in a patient with ascites. ( Delauter, BJ; Egorin, MJ; Plunkett, W; Ramanathan, RK; Stover, LL; Zamboni, WC; Zuhowski, EG, 2000)
" The efficacy of weekly paclitaxel in combination with doxifluridine (5'-DFUR) in gastric cancer patients with malignant ascites was evaluated."5.15Weekly paclitaxel in combination with doxifluridine for peritoneally disseminated gastric cancer with malignant ascites. ( Ishikawa, H; Iwazaki, S; Izumi, M; Kakinuma, S; Kamoshita, N; Kawate, S; Kobayashi, I; Kobayashi, J; Makita, F; Nakagami, K; Ohya, T; Okabe, T; Sakamoto, I; Sato, Y; Sunose, Y; Takeyoshi, I; Tanahashi, Y; Tomizawa, N; Yamada, T; Yoshinari, D, 2011)
"Gemcitabine (dFdC) is a prodrug that undergoes metabolism by cytidine deaminase to form an inactive metabolite, 2',2'-difluorodeoxyuridine (dFdU)."1.31Pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in a patient with ascites. ( Delauter, BJ; Egorin, MJ; Plunkett, W; Ramanathan, RK; Stover, LL; Zamboni, WC; Zuhowski, EG, 2000)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Takeyoshi, I1
Makita, F1
Iwazaki, S1
Ishikawa, H1
Kakinuma, S1
Sato, Y1
Ohya, T1
Nakagami, K1
Tomizawa, N1
Izumi, M1
Kobayashi, I1
Tanahashi, Y1
Kobayashi, J1
Kamoshita, N1
Kawate, S1
Sunose, Y1
Sakamoto, I1
Yoshinari, D1
Yamada, T1
Okabe, T1
MARUYAMA, Y1
SILINI, G1
KAPLAN, HS1
HEIDELBERGER, C2
BOOHAR, J1
BIRNIE, GD1
REYES, P1
Delauter, BJ1
Ramanathan, RK1
Egorin, MJ1
Stover, LL1
Zuhowski, EG1
Plunkett, W1
Zamboni, WC1

Trials

1 trial available for floxuridine and Ascites

ArticleYear
Weekly paclitaxel in combination with doxifluridine for peritoneally disseminated gastric cancer with malignant ascites.
    Anticancer research, 2011, Volume: 31, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Dose-Response Relationship, Dr

2011

Other Studies

4 other studies available for floxuridine and Ascites

ArticleYear
STUDIES OF THE LSA ASCITES LYMPHOMA OF C57B1 MICE. II. RADIOSENSITIZATION IN VIVO WITH 5-BROMODEOXYCYTIDINE AND COMBINED 5-FLUORODEOXYURIDINE AND 5-BROMODEOXYCYTIDINE.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1963, Volume: 7

    Topics: Ascites; Bromodeoxycytidine; DNA; DNA, Neoplasm; Floxuridine; Lymphoma; Mice; Neoplasms; Neoplasms,

1963
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS.
    Biochimica et biophysica acta, 1964, Dec-16, Volume: 91

    Topics: Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA;

1964
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS.
    Biochimica et biophysica acta, 1965, May-11, Volume: 103

    Topics: Adenosine Triphosphate; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Enzyme Inhibitors; Fl

1965
Pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in a patient with ascites.
    Pharmacotherapy, 2000, Volume: 20, Issue:10

    Topics: Abdominal Pain; Adenocarcinoma; Antimetabolites, Antineoplastic; Ascites; Catheters, Indwelling; Chr

2000