Page last updated: 2024-11-06

floxuridine and Acute Myelogenous Leukemia

floxuridine has been researched along with Acute Myelogenous Leukemia in 5 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
" With use of these studies, a therapeutic ratio (concentration that prevented 25% clonal growth compared to untreated control of bone marrow divided by LD50 of tumor) was calculated for each drug in each tumor."1.275'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. ( Armstrong, RD; Cadman, E, 1983)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Armstrong, RD2
Cadman, E2
Gesmonde, J1
Wu, T1
Tanaka, M1
Kimura, K1
Yoshida, S1
Munch-Petersen, B1
Völker, C1
Cloos, L1
Hofbauer, R1
Mortensen, BT1
Tyrsted, G1
Elias, L1
Crissman, HA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal Cancer[NCT00001428]Phase 265 participants Interventional1995-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for floxuridine and Acute Myelogenous Leukemia

ArticleYear
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
    Cancer research, 1983, Volume: 43, Issue:6

    Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine;

1983
Cytotoxic activity of 5'-deoxy-5-fluorouridine in cultured human tumors.
    Cancer treatment reports, 1983, Volume: 67, Issue:6

    Topics: Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Female;

1983
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylat

1983
Altered substrate and inhibitor specificity of purified human adult thymidine kinases (TK2) from leukemic cells.
    Advances in experimental medicine and biology, 1994, Volume: 370

    Topics: Adult; Cell Line; Floxuridine; Humans; Isoenzymes; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic

1994
Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.
    Cancer research, 1988, Sep-01, Volume: 48, Issue:17

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Division; Drug Synergism; Floxuridine; Fluorou

1988