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floxuridine and Acute Liver Injury, Drug-Induced

floxuridine has been researched along with Acute Liver Injury, Drug-Induced in 15 studies

Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Research Excerpts

ExcerptRelevanceReference
" In the present study the therapeutic effect and metabolism of 5-FU and its masked compounds: FT, UFT (uracil + FT), HCFU (Carmofur), 5'-DFUR (Doxifluridine) were assessed by using MOPC-104E plasmacytoma transplanted subcutaneously in BALB/c mice with CCl4-induced chronic liver dysfunction."3.68[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction]. ( Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1990)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
" Toxic effects were hepatocyte necrosis, steatosis, cholestasis, central vein sclerosis, and alterations in the portal triad."1.27Liver pathology following hepatic arterial infusion chemotherapy. Hepatic toxicity with FUDR. ( Doria, MI; Levin, B; Riddell, RH; Shepard, KV, 1986)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19906 (40.00)18.7374
1990's4 (26.67)18.2507
2000's0 (0.00)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Chabner, BA1
Myers, CE1
Coleman, CN1
Johns, DG1
Kemeny, NE1
Pozniak, MA1
Babel, SG1
Trump, DL1
Schlag, P1
Yi, J1
Friedl, P1
Hull, W1
Berger, M1
Tsubono, M1
Nio, Y1
Imai, S1
Shiraishi, T1
Morimoto, H1
Tseng, CC1
Tobe, T1
Lorenz, M1
Hottenrott, C1
Inglis, R1
Kirkowa-Reimann, M1
Doria, MI2
Shepard, KV3
Levin, B3
Riddell, RH2
Patt, YZ1
Boddie, AW1
Charnsangavej, C1
Ajani, JA1
Wallace, S1
Soski, M1
Claghorn, L1
Mavligit, GM1
Faintuch, J2
DuBrow, RA2
Karl, RC1
Hagle, M1
Cooper, RM1
Beschorner, J1
Stablein, D1

Reviews

2 reviews available for floxuridine and Acute Liver Injury, Drug-Induced

ArticleYear
The clinical pharmacology of antineoplastic agents (first of two parts).
    The New England journal of medicine, 1975, May-22, Volume: 292, Issue:21

    Topics: Animals; Antineoplastic Agents; Asparaginase; Binding Sites; Biological Transport; Chemical and Drug

1975
Is hepatic infusion of chemotherapy effective treatment for liver metastases? Yes!
    Important advances in oncology, 1992

    Topics: Actuarial Analysis; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Fl

1992

Trials

2 trials available for floxuridine and Acute Liver Injury, Drug-Induced

ArticleYear
Is hepatic infusion of chemotherapy effective treatment for liver metastases? Yes!
    Important advances in oncology, 1992

    Topics: Actuarial Analysis; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Fl

1992
Prevention of extrahepatic disease during intraarterial floxuridine of colorectal liver metastases by simultaneous systemic 5-fluorouracil treatment? A prospective multicenter study.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Inju

1989

Other Studies

12 other studies available for floxuridine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Complications of hepatic arterial infusion chemotherapy.
    Radiographics : a review publication of the Radiological Society of North America, Inc, 1991, Volume: 11, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholangitis, Sclerosing; Female; Floxuridine; Gastroin

1991
[Animal experiment studies of the toxicity of fluorodeoxyuridine (FUDR) and 5-fluorouracil (FU) within the scope of regional liver infusion chemotherapy].
    Langenbecks Archiv fur Chirurgie, 1990, Volume: 375, Issue:2

    Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Female; Floxuridine; Fluorouracil; Inactivati

1990
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
    Nihon Gan Chiryo Gakkai shi, 1990, Mar-20, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride

1990
Liver pathology following hepatic arterial infusion chemotherapy. Hepatic toxicity with FUDR.
    Cancer, 1986, Aug-15, Volume: 58, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bile Ducts, Intrahepatic; Chemical and Drug I

1986
Hepatic arterial infusion with floxuridine and cisplatin: overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury;

1986
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
    American journal of clinical oncology, 1987, Volume: 10, Issue:1

    Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine

1987
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induc

1985