florbetapir-f-18 and Cerebral-Hemorrhage

Enlarged perivascular spaces in the centrum semiovale (CSO-EPVS) have been linked to cerebral amyloid angiopathy (CAA). To get insight into the underlying mechanisms of this association, we investigated the relationship between amyloid-β deposition assessed by 18F-florbetapir PET and CSO-EPVS in patients with acute intracerebral hemorrhage (ICH).. We prospectively enrolled 18 patients with lobar ICH (suggesting CAA) and 20 with deep ICH (suggesting hypertensive angiopathy), who underwent brain MRI and 18F-florbetapir PET. EPVS were assessed on MRI using a validated 4-point visual rating scale in the centrum semiovale and the basal ganglia (BG-EPVS). PET images were visually assessed, blind to clinical and MRI data. We evaluated the association between florbetapir PET positivity and high degree (score> 2) of CSO-EPVS and BG-EPVS.. High CSO-EPVS degree was more common in patients with lobar ICH than deep ICH (55.6% vs. 20.0%; p = 0.02). Eight (57.1%) patients with high CSO-EPVS degree had a positive florbetapir PET compared with 4 (16.7%) with low CSO-EPVS degree (p = 0.01). In contrast, prevalence of florbetapir PET positivity was similar between patients with high vs. low BG-EPVS. In multivariable analysis adjusted for age, hypertension, and MRI markers of CAA, florbetapir PET positivity (odds ratio (OR) 6.44, 95% confidence interval (CI) 1.32-38.93; p = 0.03) was independently associated with high CSO-EPVS degree.. Among patients with spontaneous ICH, high degree of CSO-EPVS but not BG-EPVS is associated with amyloid PET positivity. The findings provide further evidence that CSO-EPVS are markers of vascular amyloid burden that may be useful in diagnosing CAA.

Topics: Aged; Amyloid beta-Peptides; Aniline Compounds; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Ethylene Glycols; Female; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Multivariate Analysis; Positron-Emission Tomography; Prevalence; Prospective Studies

Cerebral microbleeds (CMBs) are associated with cognitive decline, but their importance outside of cerebral amyloid angiopathy and the mechanisms of their impact on cognition are poorly understood. We evaluated the cross-sectional association between CMB patterns and cerebral Aβ (amyloid-β) deposition, by florbetapir positron emission tomography.. The longitudinal ARIC study (Atherosclerosis Risk in Communities) recruited individuals from 4 US communities from 1987 to 1989. From 2012 to 2014, the ARIC-PET (Atherosclerosis Risk in Communities - Positron Emission Tomography) ancillary recruited 322 nondemented ARIC participants who completed 3T brain magnetic resonance imaging with T2*GRE as part of ARIC visit 5 to undergo florbetapir positron emission tomography imaging. Magnetic resonance imaging images were read for CMBs and superficial siderosis; on positron emission tomography, global cortical standardized uptake value ratio >1.2 was considered a positive Aβ scan. Multivariable logistic regression models evaluated CMB characteristics in association with Aβ positivity. Effect modification by sex, race,. CMBs were present in 24% of ARIC-PET participants. No significant associations were found between CMBs and Aβ positivity, but a pattern of isolated lobar CMBs or superficial siderosis was associated with over 4-fold higher odds of elevated Aβ when compared with those with no CMBs (odds ratio, 4.72 [95% CI, 1.16-19.16]). A similar elevated risk was not observed in those with isolated subcortical or mixed subcortical and either lobar CMBs or superficial siderosis. Although no significant interactions were found, effect estimates for elevated Aβ were nonsignificantly lower (. In this community-based cohort of nondemented adults, lobar-only pattern of CMBs or superficial siderosis is most strongly associated with brain Aβ, with no elevated risk for a mixed CMB pattern. Further studies are needed to understand differences in CMB patterns and their meaning across subgroups.

Topics: Amyloid beta-Peptides; Atherosclerosis; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Siderosis

Topics: Adult; Amyloid beta-Peptides; Aniline Compounds; Biopsy; Cadaver; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Dura Mater; Ethylene Glycols; Fluorine Radioisotopes; Heart Defects, Congenital; Humans; Iatrogenic Disease; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Recurrence

Topics: Aniline Compounds; Brain; Case-Control Studies; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Ethylene Glycols; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Neuroimaging; Positron-Emission Tomography

To assess whether. Patients with acute CAA-related lobar ICH were prospectively enrolled and compared with patients with deep ICH.. Fifteen patients with acute lobar ICH fulfilling the modified Boston criteria for probable CAA (mean age = 67 ± 12 years) and 18 patients with acute deep ICH (mean age = 63 ± 11 years) were enrolled. Mean global cortical florbetapir SUVr was significantly higher among patients with CAA-related ICH than among patients with deep ICH (1.27 ± 0.12 vs 1.12 ± 0.12,. Cortical florbetapir uptake is increased in patients with CAA-related ICH relative to those with deep ICH. Although

Topics: Aged; Amyloid beta-Peptides; Aniline Compounds; Cerebral Amyloid Angiopathy; Cerebral Cortex; Cerebral Hemorrhage; Ethylene Glycols; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Sensitivity and Specificity