florbenazine-f-18 and Body-Weight

Diabetic retinopathy (DR) is characterized by dopaminergic neuron loss in the retina of the eyes. [. The DM rat model was established by a single intraperitoneal injection of streptozotocin (STZ) (65 mg/kg). After 4 weeks, 8 weeks, and 12 weeks of STZ injection, the retinas of the rats were evaluated by electroretinogram (ERG), color fundus photography (CFP), fundus fluorescein angiography (FFA), and small animal PET scan with [. ERG dysfunction was observed at 8 weeks in STZ-diabetic rats, evidenced by smaller amplitudes of oscillatory potentials (OPs) when compared with OPs in normal rats. CFP and FFA showed no significant difference in vascular leakage and neovascularization between STZ-diabetic retinas and normal ones until 8 weeks. PET imaging revealed that the SUV of [. Early DR can be non-invasively detected with PET imaging using [

Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Fluorescein Angiography; Fluorine Radioisotopes; Fundus Oculi; Male; Positron-Emission Tomography; Rats, Sprague-Dawley; Retinal Vessels; Tetrabenazine; Tomography, X-Ray Computed; Vesicular Monoamine Transport Proteins